Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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Cordycepin
CAS:Cordycepin (3'-Deoxyadenosine) is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplasticFormula:C10H13N5O3Purity:100% - 99.78%Color and Shape:Crystalline SolidMolecular weight:251.24KJ Pyr 9
CAS:KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).Formula:C22H15N3O4Purity:98.07% - ≥98%Color and Shape:SolidMolecular weight:385.37Ref: TM-T15665
2mg39.00€5mg57.00€10mg81.00€25mg145.00€50mg279.00€100mg510.00€200mg683.00€500mg1,064.00€1mL*10mM (DMSO)63.00€Clotrimazole
CAS:Clotrimazole (FB 5097), an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol.Formula:C22H17ClN2Purity:99.24%Color and Shape:Crystals SolidMolecular weight:344.84Amsacrine
CAS:Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.Formula:C21H19N3O3SPurity:98.59%Color and Shape:Yellow Crystalline Powder SolidMolecular weight:393.46Quizartinib
CAS:Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.Formula:C29H32N6O4SPurity:98% - 99.42%Color and Shape:SolidMolecular weight:560.67Ref: TM-T2066
5mg58.00€10mg79.00€25mg97.00€50mg127.00€100mg202.00€200mg300.00€500mg507.00€1mL*10mM (DMSO)71.00€Peptide R TFA
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.Formula:C39H57N13O8S2·xC2HF3O2Molecular weight:900.08 (free base)Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Formula:C23H28N8OSPurity:99.99%Color and Shape:SolidMolecular weight:464.59Autophagy agonist-1
Autophagyagonist-1 (compound 22) is an autophagy agonist. It exhibits significant anticancer activity against HepG2 cells and normal cells, with IC50 values of 8.8 μM and > 50 μM, respectively. The compound induces G1/S phase cell cycle arrest, suppresses the expression of CDK4 and CyclinD1, and upregulates P21. Additionally, Autophagyagonist-1 enhances autophagosome, LC3, and PINK1 accumulation, thereby promoting autophagy and mitophagy in HepG2 cells.Formula:C33H41N3O5Color and Shape:SolidMolecular weight:559.7Bromocriptine mesylate
CAS:Bromocriptine mesylate (CB-154) is a potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM)Formula:C33H44BrN5O8SPurity:99.76% - 99.87%Color and Shape:White SolidMolecular weight:750.7Clofarabine
CAS:Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotideFormula:C10H11ClFN5O3Purity:100% - 99.94%Color and Shape:White SolidMolecular weight:303.68Ref: TM-T0297
5mg43.00€10mg59.00€25mg95.00€50mg133.00€100mg172.00€200mg215.00€500mg360.00€1mL*10mM (DMSO)55.00€3'-Hydroxypterostilbene
CAS:3'-Hydroxypterostilbene suppresses colon cancer cell growth (COLO 205, HCT-116, HT-29) by triggering apoptosis and autophagy, affecting key pathways.Formula:C16H16O4Purity:98.25% - 99.19%Color and Shape:SolidMolecular weight:272.3RSVA405
CAS:RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitorFormula:C17H20N4O2Purity:99.30%Color and Shape:SolidMolecular weight:312.37Ethyl 3,4-dihydroxybenzoate
CAS:Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.Formula:C9H10O4Purity:99.88%Color and Shape:White Crystal Or PowderMolecular weight:182.173BDO
CAS:3BDO is a new mTOR activator. 3BDO inhibits autophagy.Formula:C18H17NO5Purity:96.00%Color and Shape:SolidMolecular weight:327.33Ref: TM-T14033
2mg47.00€5mg69.00€10mg97.00€25mg208.00€50mg331.00€100mg520.00€200mg777.00€500mg1,188.00€1mL*10mM (DMSO)74.00€Sitagliptin
CAS:Sitagliptin (MK0431), an oral DPP-4 inhibitor, treats type 2 diabetes alone or with metformin/thiazolidinedione by increasing incretins and insulin.Formula:C16H15F6N5OPurity:99.33% - 99.4%Color and Shape:Yellow GreaseMolecular weight:407.31Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Formula:C25H35ClN4O2SPurity:99.36%Color and Shape:SolidMolecular weight:491.09Ref: TM-T8480
1mg39.00€2mg51.00€5mg70.00€10mg88.00€25mg140.00€50mg226.00€100mg376.00€1mL*10mM (DMSO)73.00€Esmolol hydrochloride
CAS:Esmolol is a cardioselective beta-blocker used in parenteral forms in the treatment of arrhythmias and severe hypertension.Formula:C16H25NO4·HClPurity:98.72% - 99.48%Color and Shape:White SolidMolecular weight:331.15GSK2656157
CAS:GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.Formula:C23H21FN6OPurity:100% - 99.89%Color and Shape:SolidMolecular weight:416.45Ref: TM-T2654
2mg35.00€5mg50.00€10mg81.00€25mg142.00€50mg259.00€100mg467.00€200mg632.00€1mL*10mM (DMSO)56.00€Norepinephrine bitartrate monohydrate
CAS:Norepinephrine bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.Formula:C8H11NO3·C4H6O6·H2OPurity:97.88% - ≥95%Color and Shape:SolidMolecular weight:337.28JZL195
CAS:JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.Formula:C24H23N3O5Purity:99.81%Color and Shape:SolidMolecular weight:433.46
