Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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Enzalutamide
CAS:Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP).Formula:C21H16F4N4O2SPurity:100% - 99.7%Color and Shape:SolidMolecular weight:464.44Ref: TM-T6002
5mg48.00€10mg56.00€25mg74.00€50mg96.00€100mg154.00€200mg187.00€500mg274.00€1mL*10mM (DMSO)52.00€A-484954
CAS:A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.Formula:C13H15N5O3Purity:97.47%Color and Shape:SolidMolecular weight:289.29Ref: TM-TQ0137
1mg43.00€2mg56.00€5mg88.00€10mg144.00€25mg305.00€50mg543.00€100mg775.00€1mL*10mM (DMSO)103.00€Anti-LRRK2 Antibody (1C773)
Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.Color and Shape:Odour Liquid(R)-(-)-Gossypol acetic acid
CAS:(R)-(-)-Gossypol acetic acid binds Bcl-2, Bcl-xL, Mcl-1 (Ki: 0.32, 0.48, 0.18 μM); no BIR3/BID inhibition. Phase 2.Formula:C30H30O8·C2H4O2Purity:96.73% - 99.5%Color and Shape:SolidMolecular weight:578.61Ref: TM-T6396
1g1,359.00€2mg39.00€5mg57.00€10mg87.00€25mg170.00€50mg283.00€100mg464.00€500mg1,008.00€Niacin
CAS:Niacin is a water-soluble B vitamin with antihyperlipidemic effects, found in food and converted to niacinamide for coenzyme activity.Formula:C6H5NO2Purity:100% - 99.68%Color and Shape:White Solid PowderMolecular weight:123.11CA-5f
CAS:CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.Formula:C24H24N2O3Purity:99.69%Color and Shape:SolidMolecular weight:388.46Glaucocalyxin B
CAS:Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).Formula:C22H30O5Purity:99.13% - 99.13%Color and Shape:SolidMolecular weight:374.47Hesperidin
CAS:Hesperidin (Cirantin), a citrus-fruit flavanone glycoside, boasts antioxidant, anti-inflammatory, anti-carcinogenic, and cardiovascular benefits.Formula:C28H34O15Purity:97.74% - 97.75%Color and Shape:Fine Brownish Powder Solid PowderMolecular weight:610.56Ridaforolimus
CAS:Ridaforolimus (AP23573) 是亲脂性大环内酯类抗生素雷帕霉素的小分子非前药类似物,具有潜在的抗肿瘤活性。它是一种有效和选择性的 mTOR 抑制剂,在 HT-1080 细胞中抑制 S6 磷酸化的 IC50值为 0.2 nM。Formula:C53H84NO14PPurity:90.00% - 98.55%Color and Shape:Off-White SolidMolecular weight:990.21Danshensu
CAS:Danshensu (Dan shen suan A) is an active ingredient of Salvia miltiorrhiza with wide cardiovascular benefit.Formula:C9H10O5Purity:98.4% - 99.74%Color and Shape:SolidMolecular weight:198.17Fulvestrant
CAS:Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30.Formula:C32H47F5O3SPurity:100% - 99.87%Color and Shape:White PowderMolecular weight:606.77SB 242235
CAS:SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.Formula:C19H20FN5OPurity:99.13% - 99.68%Color and Shape:SolidMolecular weight:353.39FAAH-IN-2
CAS:FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent inhibitor of FAAH(fatty acid amide hydrolase).Formula:C15H11ClFN3O2Purity:99.18%Color and Shape:Tan SolidMolecular weight:319.72Schaftoside
CAS:Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.Formula:C26H28O14Purity:100% - 99.32%Color and Shape:SolidMolecular weight:564.49Ref: TM-T3898
1mg42.00€5mg85.00€10mg111.00€25mg210.00€50mg311.00€100mg467.00€200mg653.00€1mL*10mM (DMSO)95.00€Fluvastatin sodium
CAS:Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterolFormula:C24H25FNNaO4Purity:98.54% - 99.46%Color and Shape:Light Yellow Solid PowderMolecular weight:433.45Myricetin
CAS:Myricetin (Cannabiscetin) is a natural flavonoid and MEK1 inhibitor. Myricetin has hypoglycemic and antioxidant activities. Cost-effective and quality-assured.Formula:C15H10O8Purity:97.92% - 99.85%Color and Shape:Yellow Needles From Dilute Alcohol SolidMolecular weight:318.24Alisol A
CAS:Alisol A: induces autophagy, anti-cancer, inhibits HepG2, MDA-MB-231, MCF-7 cells.Formula:C30H50O5Purity:99.77% - 99.94%Color and Shape:SolidMolecular weight:490.71SD 0006
CAS:SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.Formula:C20H20ClN5O2Purity:98.32%Color and Shape:SolidMolecular weight:397.86Ref: TM-T7276
2mg38.00€5mg58.00€10mg90.00€25mg145.00€50mg226.00€100mg338.00€200mg472.00€1mL*10mM (DMSO)65.00€Sertaconazole
CAS:Sertaconazole is a broad-spectrum antifungal.Formula:C20H15Cl3N2OSPurity:95.00%Color and Shape:SolidMolecular weight:437.77Ref: TM-T50005
5mg58.00€10mg82.00€25mg126.00€50mg182.00€100mg273.00€200mg409.00€1mL*10mM (DMSO)84.00€Liensinine
CAS:1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.Formula:C37H42N2O6Purity:98.92% - 99.93%Color and Shape:White-Like PowderMolecular weight:610.74Mycro 3
CAS:Mycro 3 is potent and selective for c-Myc in whole cell assays.Formula:C24H17ClF2N6O4Purity:97.87% - 99.51%Color and Shape:SolidMolecular weight:526.88Ref: TM-T4367
1mg49.00€5mg99.00€10mg168.00€25mg335.00€50mg477.00€100mg662.00€200mg892.00€1mL*10mM (DMSO)116.00€PD168393
CAS:PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Formula:C17H13BrN4OPurity:99.13% - 99.7%Color and Shape:SolidMolecular weight:369.22Ref: TM-T6932
1mg39.00€2mg49.00€5mg66.00€10mg89.00€25mg155.00€50mg222.00€100mg310.00€1mL*10mM (DMSO)56.00€AC-73
CAS:AC-73, an oral CD147 inhibitor, blocks ERK1/2/STAT3/MMP-2 pathway, reducing liver cancer progression and leukemia cell growth.Formula:C21H21NO2Purity:98.95%Color and Shape:SolidMolecular weight:319.4Ref: TM-T14091
1mg49.00€5mg97.00€10mg173.00€25mg305.00€50mg513.00€100mg909.00€500mg1,825.00€1mL*10mM (DMSO)108.00€EN6
CAS:EN6, a small molecule, activates autophagy by modifying ATP6V1A, inhibiting mTORC1 and enhancing lysosomal function to clear TDP-43 aggregates.Formula:C19H14F2N4O2Purity:95.16% - 97.04%Color and Shape:SolidMolecular weight:368.34Ref: TM-T11191
1mg47.00€5mg88.00€10mg137.00€25mg205.00€50mg264.00€100mg400.00€500mg909.00€1mL*10mM (DMSO)70.00€Dilmapimod
CAS:Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.Formula:C23H19F3N4O3Purity:97.53%Color and Shape:SolidMolecular weight:456.421-Monomyristin
CAS:1-Monomyristin (2,3-Dihydroxypropyl tetradecanoate) , a 1-monoglyceride of myristic acid, has antibacterial activity against several Gram-positive bacterialFormula:C17H34O4Purity:99.58%Color and Shape:SolidMolecular weight:302.45IITZ-01
CAS:IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)Formula:C26H23FN8OPurity:99.31%Color and Shape:SolidMolecular weight:482.51Schisandrin B
CAS:Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart.Formula:C23H28O6Purity:100% - 99.84%Color and Shape:SolidMolecular weight:400.46Ref: TM-T2925
1mg42.00€5mg88.00€10mg127.00€25mg230.00€50mg414.00€100mg600.00€500mg1,254.00€1mL*10mM (DMSO)94.00€GNE-9605
CAS:GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).Formula:C17H20ClF4N7OPurity:98.55% - 98.75%Color and Shape:SolidMolecular weight:449.83β-Lapachone
CAS:β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.Formula:C15H14O3Purity:99.64% - 99.85%Color and Shape:SolidMolecular weight:242.27Ref: TM-T6407
5mg48.00€10mg60.00€25mg97.00€50mg185.00€100mg305.00€200mg460.00€500mg753.00€1mL*10mM (DMSO)63.00€Isotretinoin
CAS:Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promoteFormula:C20H28O2Purity:98.06% - 99.61%Color and Shape:Reddish-Orange Plates From Isopropyl Alcohol (Ntp 1992)Molecular weight:300.44Dihydromyricetin
CAS:Dihydromyricetin, a flavonoid from Ampelopsis, is an antioxidant that blocks dihydropyrimidinase (IC50: 48 μM) and activates autophagy via mTOR inhibition.Formula:C15H12O8Purity:96.68% - 98.13%Color and Shape:SolidMolecular weight:320.25Neflamapimod
CAS:Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.Formula:C19H9Cl2F2N3OSPurity:99.02% - ≥95%Color and Shape:SolidMolecular weight:436.26Cabazitaxel
CAS:Cabazitaxel (XRP6258) is a taxane used for castration-resistant metastatic prostate cancer post-docetaxel failure.Formula:C45H57NO14Purity:98% - 99.93%Color and Shape:SolidMolecular weight:835.93LY2562175
CAS:LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).Formula:C28H27Cl2N3O4Purity:99.16% - 99.78%Color and Shape:SolidMolecular weight:540.44Ref: TM-T15806
1mg104.00€5mg227.00€10mg369.00€25mg740.00€50mg1,169.00€100mg1,568.00€200mg2,118.00€1mL*10mM (DMSO)269.00€Tizoxanide
CAS:Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.Formula:C10H7N3O4SPurity:98.89% - 99.28%Color and Shape:SolidMolecular weight:265.25Ambroxol
CAS:Ambroxol treats respiratory diseases by thinning mucus. Active in Mucosolvan, it enhances mucus clearance and protects lungs.Formula:C13H18Br2N2OPurity:99.72%Color and Shape:SolidMolecular weight:378.1Gimeracil
CAS:Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.Formula:C5H4ClNO2Purity:99.80%Color and Shape:SolidMolecular weight:145.54Bortezomib
CAS:Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.Formula:C19H25BN4O4Purity:100% - 99.97%Color and Shape:Yellow SolidMolecular weight:384.24Ref: TM-T2399
5mg52.00€10mg64.00€25mg80.00€50mg96.00€100mg144.00€200mg225.00€500mg373.00€1mL*10mM (DMSO)52.00€Pogostone
CAS:Pogostone: anti-bacterial/fungal, blocks T-cells, modulates cytokines, protects against gastric ulcers, boosts antioxidants/PGE2/NP-SH.Formula:C12H16O4Purity:98.46% - 99.03%Color and Shape:SolidMolecular weight:224.25Rosuvastatin calcium
CAS:Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemicFormula:(C22H27FN3O6S)CaPurity:98.85% - 99.68%Color and Shape:White To Off-White Crystalline SolidMolecular weight:1001.14SKF-96365 hydrochloride
CAS:SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal YFormula:C22H27ClN2O3Purity:99.48% - 99.85%Color and Shape:SolidMolecular weight:402.91Ref: TM-T2170
5mg57.00€10mg86.00€25mg138.00€50mg243.00€100mg470.00€200mg717.00€500mg1,111.00€1mL*10mM (DMSO)63.00€Hydroxychloroquine
CAS:HCQ, an anti-malarial, may induce cancer cell death and is being explored for COVID-19.Formula:C18H26ClN3OPurity:99.79%Color and Shape:SolidMolecular weight:335.87Cilostazol
CAS:Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.Formula:C20H27N5O2Purity:99.58% - 99.90%Color and Shape:Off-White SolidMolecular weight:369.46Gambogic Acid
CAS:Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases.Formula:C38H44O8Purity:97.16% - 98.67%Color and Shape:SolidMolecular weight:628.75Ref: TM-T6185
2mg39.00€5mg55.00€10mg77.00€25mg111.00€50mg160.00€100mg227.00€500mg560.00€1mL*10mM (DMSO)88.00€Sofalcone
CAS:Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.Formula:C27H30O6Purity:97.55%Color and Shape:SolidMolecular weight:450.52SB 202190
CAS:SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably.Formula:C20H14FN3OPurity:98% - 99.84%Color and Shape:Pale YellowMolecular weight:331.34Diazoxide
CAS:Diazoxide (Proglycem) is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies.Formula:C8H7ClN2O2SPurity:99% - 99.83%Color and Shape:SolidMolecular weight:230.67Nitazoxanide
CAS:Nitazoxanide (NSC-697855) is a synthetic benzamide antiprotozoal; it disrupts pyruvate electron transfer reactions.Formula:C12H9N3O5SPurity:97.20% - 99.53%Color and Shape:SolidMolecular weight:307.28Ref: TM-T1546
1g750.00€5mg35.00€10mg51.00€25mg90.00€50mg139.00€100mg207.00€200mg311.00€500mg520.00€1mL*10mM (DMSO)55.00€Belinostat
CAS:Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.Formula:C15H14N2O4SPurity:100% - 99.75%Color and Shape:SolidMolecular weight:318.35Ref: TM-T8517
5mg48.00€10mg69.00€25mg97.00€50mg144.00€100mg207.00€200mg306.00€500mg518.00€1mL*10mM (DMSO)63.00€AS1842856
CAS:AS1842856 is a Foxo1 inhibitor that blocks the transcriptional activity of Foxo1. AS1842856 has autophagy inhibitory activity. Cost-effective and quality-assured.Formula:C18H22FN3O3Purity:100% - 99.56%Color and Shape:SolidMolecular weight:347.38SP-8356
CAS:SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.Formula:C18H20O4Purity:98.24%Color and Shape:SolidMolecular weight:300.35Ref: TM-T12981
1mg70.00€5mg156.00€10mg238.00€25mg449.00€50mg610.00€100mg815.00€200mg1,103.00€1mL*10mM (DMSO)170.00€Megestrol acetate
CAS:Megestrol acetate (BDH1298) is an oral progestogen with anti-androgenic properties, used for endometrial and breast cancer, anorexia, and cachexia.Formula:C24H32O4Purity:99.46%Color and Shape:Crystalline SolidMolecular weight:384.51GANT 61
CAS:GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2.Formula:C27H35N5Purity:100% - ≥95%Color and Shape:SolidMolecular weight:429.6TTNPB
CAS:TTNPB (Ro 13-7410,AGN-191183), a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM),Formula:C24H28O2Purity:99.55%Color and Shape:White SolidMolecular weight:348.48Ref: TM-T1288
2mg39.00€5mg57.00€10mg87.00€25mg162.00€50mg306.00€100mg464.00€500mg1,008.00€1mL*10mM (DMSO)59.00€Valproic acid sodium salt
CAS:Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.Formula:C8H15NaO2Purity:99% - 99.78%Color and Shape:White PowderMolecular weight:166.2Dinoprost tromethamine salt
CAS:Dinoprost tromethamine salt (PGF2α THAM) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.Formula:C24H45NO8Purity:99.73%Color and Shape:Natural Form Crystals SolidMolecular weight:475.62BIX-01294 trihydrochloride
CAS:BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.Formula:C28H38N6O2·3HClPurity:99.41% - 99.95%Color and Shape:SolidMolecular weight:600.02Ref: TM-T1959
1mg44.00€2mg55.00€5mg71.00€10mg107.00€25mg192.00€50mg274.00€100mg492.00€500mg1,103.00€1mL*10mM (DMSO)139.00€Salicylic acid
CAS:Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.Formula:C7H6O3Purity:98.04% - 98.83%Color and Shape:White Solid PowderMolecular weight:138.12CFTR corrector 2
CAS:CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.Formula:C27H23FN4O4Purity:99.66%Color and Shape:SolidMolecular weight:486.49Ref: TM-T5312
2mg39.00€5mg58.00€10mg85.00€25mg156.00€50mg226.00€100mg335.00€200mg469.00€1mL*10mM (DMSO)63.00€LRRK2-IN-7
CAS:LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, >1000x selectivity vs kinases/channels/CYPs.Formula:C24H26N6OPurity:99.26%Color and Shape:SolidMolecular weight:414.5BX795
CAS:BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.Formula:C23H26IN7O2SPurity:98% - 99.57%Color and Shape:SolidMolecular weight:591.47Ref: TM-T1830
5mg59.00€10mg97.00€25mg210.00€50mg343.00€100mg513.00€200mg740.00€500mg1,121.00€1mL*10mM (DMSO)88.00€Apocynin
CAS:Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM).Formula:C9H10O3Purity:99.71% - 99.98%Color and Shape:Yellowish To Brown PowderMolecular weight:166.17Trametinib
CAS:Trametinib (GSK1120212), an ATP-noncompetitive MEK 1/2 inhibitor (IC50: 0.7/0.9 nM), weakly inhibits >180 kinases.Formula:C26H23FIN5O4Purity:98% - 99.88%Color and Shape:SolidMolecular weight:615.39GSK2578215A
CAS:GSK2578215A is a potent and selective LRRK2 kinase inhibitor.Formula:C24H18FN3O2Purity:97.93% - 99.94%Color and Shape:SolidMolecular weight:399.42Indomethacin farnesil
CAS:Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug.Formula:C34H40ClNO4Purity:99.84%Color and Shape:SolidMolecular weight:562.14Clarithromycin
CAS:Clarithromycin (A-56268), a macrolide antibiotic, inhibits Cytochrome P450 3A4 and P-Glycoprotein.Formula:C38H69NO13Purity:99.89% - 99.89%Color and Shape:White To Off-White Crystalline PowderMolecular weight:747.95Dioscin
CAS:Dioscin (Collettiside III) is a saponin with antitumor activities.Formula:C45H72O16Purity:98.35% - 99.85%Color and Shape:SolidMolecular weight:869.04Torin 1
CAS:Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.Formula:C35H28F3N5O2Purity:98.3% - 99.38%Color and Shape:SolidMolecular weight:607.62AT9283
CAS:AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Formula:C19H23N7O2Purity:99.83% - 99.98%Color and Shape:SolidMolecular weight:381.43Ref: TM-T3068
1mg47.00€2mg60.00€5mg95.00€10mg170.00€25mg299.00€50mg499.00€100mg723.00€1mL*10mM (DMSO)97.00€LC3B recruiter 2
CAS:LC3B recruiter 2 (34R) is an LC3B recruiting agent incorporated into the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), with a direct binding affinity for LC3B. It connects via a linker to the CDK9 inhibitor SNS-032, creating an ATTEC capable of targeting and degrading the CDK9 and Cyclin T1 complex, while also inhibiting them. Consequently, LC3B recruiter 2 exerts its function through an LC3B-dependent autophagy-lysosome pathway, interfering with the cancer cell cycle progression, thereby demonstrating antitumor activity.Formula:C10H9ClN2O2Color and Shape:SolidMolecular weight:224.644Pifithrin-μ
CAS:Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.Formula:C8H7NO2SPurity:99.33% - 99.79%Color and Shape:SolidMolecular weight:181.21Flavopiridol hydrochloride
CAS:Flavopiridol hydrochloride (MDL 107826A), an inhibitor of cyclin-dependent kinase, is a synthetic N-methylpiperidinyl chlorophenyl flavone compound.Formula:C21H21Cl2NO5Purity:98.87% - 99.88%Color and Shape:SolidMolecular weight:438.3Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Formula:C51H82O21Purity:99.51% - 99.63%Color and Shape:SolidMolecular weight:1031.18Pexmetinib
CAS:Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor.Cost-effective and quality-assured.Formula:C31H33FN6O3Purity:98.41% - 99.66%Color and Shape:SolidMolecular weight:556.63Ref: TM-T6934
1mg47.00€5mg97.00€10mg139.00€25mg271.00€50mg435.00€100mg567.00€200mg810.00€1mL*10mM (DMSO)118.00€Nur77 modulator 1
CAS:Nur77 modulator 1: binds at 3.58 μM, boosts expression, alters location, triggers ER stress/autophagy, induces apoptosis, and fights hepatoma.Formula:C28H25N5O2SPurity:98.11%Color and Shape:SolidMolecular weight:495.6Ref: TM-T40130
1mg96.00€5mg227.00€10mg376.00€25mg620.00€50mg847.00€100mg1,169.00€1mL*10mM (DMSO)245.00€Aspirin
CAS:Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Formula:C9H8O4Purity:99.78% - 99.91%Color and Shape:White Solid CrystallineMolecular weight:180.16Degrasyn
CAS:Degrasyn (WP1130) inhibits DUBs (USP5, UCH-L1, USP9x, USP14, UCH37) and Bcr/Abl without affecting the 20S proteasome.Formula:C19H18BrN3OPurity:98.32% - 99.98%Color and Shape:SolidMolecular weight:384.27Ref: TM-T6300
2mg44.00€5mg64.00€10mg97.00€25mg198.00€50mg340.00€100mg532.00€200mg747.00€1mL*10mM (DMSO)69.00€Bilobalide
CAS:Bilobalide ((-)-Bilobalide), a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.Formula:C15H18O8Purity:98.27% - 99.91%Color and Shape:White SolidMolecular weight:326.3Bigelovin
CAS:Bigelovin: RXRα agonist, inhibits mTOR via ROS, induces apoptosis/autophagy, anti-tumor sesquiterpene from Inula sp.Formula:C17H20O5Purity:99.72% - 99.72%Color and Shape:SolidMolecular weight:304.34Ref: TM-TN6735
1mg92.00€5mg216.00€10mg283.00€25mg490.00€50mg700.00€100mg938.00€1mL*10mM (DMSO)215.00€Br-DAPI
CAS:IST5-002 (N6-Benzyladenosine-5'-phosphate) is a Stat5a/b inhibitor with anticancer activity and is used in cancer research.Formula:C16H14BrN5Purity:100%Color and Shape:SolidMolecular weight:356.22Apigenin
CAS:Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants.Formula:C15H10O5Purity:97.95% - 99.66%Color and Shape:Yellow Needles From Aqueous Pyridine SolidMolecular weight:270.24Divalproex Sodium
CAS:Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted byFormula:C8H16O2·C8H15O2·NaPurity:99.84%Color and Shape:A White Powder With A Characteristic OdorMolecular weight:310.41Ref: TM-T6474
10mg39.00€25mg55.00€50mg79.00€100mg116.00€200mg188.00€500mg335.00€1mL*10mM (DMSO)55.00€Torin 2
CAS:Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.Formula:C24H15F3N4OPurity:98.31% - 99.32%Color and Shape:SolidMolecular weight:432.4Ginkgetin
CAS:Ginkgetin: antiviral, antifungal, anti-inflammatory; COX-2 reducer; STAT3 inhibitor; pro-apoptotic in cancer; neuroprotective in Parkinson's.Formula:C32H22O10Purity:98.91% - 99.94%Color and Shape:SolidMolecular weight:566.51Ref: TM-T4S2126
1mg58.00€5mg118.00€10mg172.00€25mg278.00€50mg411.00€100mg607.00€200mg847.00€1mL*10mM (DMSO)153.00€Maprotiline hydrochloride
CAS:Maprotiline hydrochloride (Psymion) is a tetracyclic antidepressant akin to tricyclics with similar side effects.Formula:C20H24ClNPurity:99.68% - 99.84%Color and Shape:White PowderMolecular weight:313.864Hydroxyurea
CAS:Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.Formula:CH4N2O2Purity:99.85% - 99.92%Color and Shape:SolidMolecular weight:76.05Carbamazepine
CAS:Carbamazepine: a tricyclic with anticonvulsant and analgesic effects, treats trigeminal neuralgia.Formula:C15H12N2OPurity:99.79% - 99.88%Color and Shape:SolidMolecular weight:236.27Saquinavir mesylate
CAS:Saquinavir mesylate (Ro 31-8959/003) is an Inhibitor of HIV Proteaseused in antiretroviral therapyFormula:C39H54N6O8SPurity:99.19%Color and Shape:White Or Pale Yellow PowderMolecular weight:766.9Imatinib
CAS:Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kitFormula:C29H31N7OPurity:100% - 99.94%Color and Shape:Off White PowderMolecular weight:493.6Polyphyllin I
CAS:Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Formula:C44H70O16Purity:98% - 99.5%Color and Shape:SolidMolecular weight:855.02Troglitazone
CAS:Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.Formula:C24H27NO5SPurity:98% - 99.62%Color and Shape:Yellow SolidMolecular weight:441.54Ref: TM-T3170
2mg42.00€5mg62.00€10mg88.00€25mg172.00€50mg305.00€100mg558.00€500mg1,169.00€1mL*10mM (DMSO)85.00€Liensinine diperchlorate
CAS:Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus.Formula:C37H44Cl2N2O14Purity:99.8% - ≥95%Color and Shape:SolidMolecular weight:811.67Tripterin
CAS:Tripterin (Celastrol) is an proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with antioxidant and anti-inflammatory effects.Formula:C29H38O4Purity:98.56% - 99.8%Color and Shape:Red Crystalline PowderMolecular weight:450.61LYN-1604 dihydrochloride
CAS:LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.Formula:C33H45Cl4N3O2Purity:98.95% - 99.80%Color and Shape:SolidMolecular weight:657.54Ref: TM-T8808L
1mg35.00€5mg78.00€10mg117.00€25mg212.00€50mg316.00€100mg447.00€200mg628.00€1mL*10mM (DMSO)101.00€BIA 10-2474
CAS:BIA 10-2474 is a long-acting reversible inhibitor of FAAH that increases levels of the neurotransmitter anandamide in the nervous system.Formula:C16H20N4O2Purity:99.27%Color and Shape:SolidMolecular weight:300.36Xylitol
CAS:Xylitol (Ribitol) is a five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group.Formula:C5H12O5Purity:99.89% - 99.96%Color and Shape:White Solid PowderMolecular weight:152.15Ivacaftor
CAS:Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,Formula:C24H28N2O3Purity:99% - 99.98%Color and Shape:SolidMolecular weight:392.49Ref: TM-T2588
1mg38.00€5mg81.00€10mg127.00€25mg205.00€50mg304.00€100mg455.00€500mg998.00€1mL*10mM (DMSO)88.00€MDK-6983
CAS:MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.Formula:C22H18Cl2N2O3Purity:97.55%Color and Shape:SolidMolecular weight:429.3Ref: TM-T28001
1mg115.00€5mg249.00€10mg368.00€25mg562.00€50mg787.00€100mg1,054.00€500mgTo inquire1mL*10mM (DMSO)284.00€Dorsomorphin dihydrochloride
CAS:Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity onFormula:C24H25N5O·2HClPurity:97.74% - 99.89%Color and Shape:SolidMolecular weight:472.41Ref: TM-T6146
2mg35.00€5mg51.00€10mg70.00€25mg135.00€50mg235.00€100mg424.00€500mg938.00€1mL*10mM (DMSO)57.00€
