Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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Cordycepin
CAS:Cordycepin (3'-Deoxyadenosine) is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplasticFormula:C10H13N5O3Purity:100% - 99.78%Color and Shape:Crystalline SolidMolecular weight:251.24KJ Pyr 9
CAS:KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).Formula:C22H15N3O4Purity:98.07% - ≥98%Color and Shape:SolidMolecular weight:385.37Ref: TM-T15665
2mg39.00€5mg57.00€10mg81.00€25mg145.00€50mg279.00€100mg510.00€200mg683.00€500mg1,064.00€1mL*10mM (DMSO)63.00€Clotrimazole
CAS:Clotrimazole (FB 5097), an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol.Formula:C22H17ClN2Purity:99.24%Color and Shape:Crystals SolidMolecular weight:344.84Amsacrine
CAS:Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.Formula:C21H19N3O3SPurity:98.59%Color and Shape:Yellow Crystalline Powder SolidMolecular weight:393.46Quizartinib
CAS:Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.Formula:C29H32N6O4SPurity:98% - 99.42%Color and Shape:SolidMolecular weight:560.67Ref: TM-T2066
5mg58.00€10mg79.00€25mg97.00€50mg127.00€100mg202.00€200mg300.00€500mg507.00€1mL*10mM (DMSO)71.00€Peptide R TFA
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.Formula:C39H57N13O8S2·xC2HF3O2Molecular weight:900.08 (free base)Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Formula:C23H28N8OSPurity:99.99%Color and Shape:SolidMolecular weight:464.59Autophagy agonist-1
Autophagyagonist-1 (compound 22) is an autophagy agonist. It exhibits significant anticancer activity against HepG2 cells and normal cells, with IC50 values of 8.8 μM and > 50 μM, respectively. The compound induces G1/S phase cell cycle arrest, suppresses the expression of CDK4 and CyclinD1, and upregulates P21. Additionally, Autophagyagonist-1 enhances autophagosome, LC3, and PINK1 accumulation, thereby promoting autophagy and mitophagy in HepG2 cells.Formula:C33H41N3O5Color and Shape:SolidMolecular weight:559.7Bromocriptine mesylate
CAS:Bromocriptine mesylate (CB-154) is a potent dopamine receptor agonist that binds the D2 receptor with highest affinity (Ki = 2.5 nM)Formula:C33H44BrN5O8SPurity:99.76% - 99.87%Color and Shape:White SolidMolecular weight:750.7Clofarabine
CAS:Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotideFormula:C10H11ClFN5O3Purity:100% - 99.94%Color and Shape:White SolidMolecular weight:303.68Ref: TM-T0297
5mg43.00€10mg59.00€25mg95.00€50mg133.00€100mg172.00€200mg215.00€500mg360.00€1mL*10mM (DMSO)55.00€3'-Hydroxypterostilbene
CAS:3'-Hydroxypterostilbene suppresses colon cancer cell growth (COLO 205, HCT-116, HT-29) by triggering apoptosis and autophagy, affecting key pathways.Formula:C16H16O4Purity:98.25% - 99.19%Color and Shape:SolidMolecular weight:272.3RSVA405
CAS:RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitorFormula:C17H20N4O2Purity:99.30%Color and Shape:SolidMolecular weight:312.37Ethyl 3,4-dihydroxybenzoate
CAS:Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.Formula:C9H10O4Purity:99.88%Color and Shape:White Crystal Or PowderMolecular weight:182.173BDO
CAS:3BDO is a new mTOR activator. 3BDO inhibits autophagy.Formula:C18H17NO5Purity:96.00%Color and Shape:SolidMolecular weight:327.33Ref: TM-T14033
2mg47.00€5mg69.00€10mg97.00€25mg208.00€50mg331.00€100mg520.00€200mg777.00€500mg1,188.00€1mL*10mM (DMSO)74.00€Sitagliptin
CAS:Sitagliptin (MK0431), an oral DPP-4 inhibitor, treats type 2 diabetes alone or with metformin/thiazolidinedione by increasing incretins and insulin.Formula:C16H15F6N5OPurity:99.33% - 99.4%Color and Shape:Yellow GreaseMolecular weight:407.31Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Formula:C25H35ClN4O2SPurity:99.36%Color and Shape:SolidMolecular weight:491.09Ref: TM-T8480
1mg39.00€2mg51.00€5mg70.00€10mg88.00€25mg140.00€50mg226.00€100mg376.00€1mL*10mM (DMSO)73.00€Esmolol hydrochloride
CAS:Esmolol is a cardioselective beta-blocker used in parenteral forms in the treatment of arrhythmias and severe hypertension.Formula:C16H25NO4·HClPurity:98.72% - 99.48%Color and Shape:White SolidMolecular weight:331.15GSK2656157
CAS:GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.Formula:C23H21FN6OPurity:100% - 99.89%Color and Shape:SolidMolecular weight:416.45Ref: TM-T2654
2mg35.00€5mg50.00€10mg81.00€25mg142.00€50mg259.00€100mg467.00€200mg632.00€1mL*10mM (DMSO)56.00€Norepinephrine bitartrate monohydrate
CAS:Norepinephrine bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.Formula:C8H11NO3·C4H6O6·H2OPurity:97.88% - ≥95%Color and Shape:SolidMolecular weight:337.28JZL195
CAS:JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.Formula:C24H23N3O5Purity:99.81%Color and Shape:SolidMolecular weight:433.46Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formula:C14H18ClN3O2SPurity:100% - ≥95%Color and Shape:White SolidMolecular weight:327.83Perifosine
CAS:Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity.Formula:C25H52NO4PPurity:100% - 99.94%Color and Shape:SolidMolecular weight:461.66Sitagliptin phosphate monohydrate
CAS:Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.Formula:C16H15F6N5O·H3PO4·H2OPurity:99.65% - 99.85%Color and Shape:White Or Almost White Crystalline PowderMolecular weight:523.33Enzastaurin
CAS:Enzastaurin (LY317615) (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε.Formula:C32H29N5O2Purity:100% - 99.24%Color and Shape:SolidMolecular weight:515.6Guggulsterone
CAS:Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Formula:C21H28O2Purity:99.40% - 99.8%Color and Shape:Light Yellow PowderMolecular weight:312.45Ref: TM-T5574
1mg35.00€5mg55.00€10mg93.00€25mg178.00€50mg245.00€100mg360.00€200mg532.00€1mL*10mM (DMSO)60.00€Oxidopamine hydrochloride
CAS:Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.Formula:C8H12ClNO3Purity:96.17% - 99.85%Color and Shape:Physical Description Beige Solid (Ntp 1992)Molecular weight:205.64CA77.1
CAS:CA77.1(CA) is a novel chaperon-mediated autophagy (CMA) activator for the treatment of Alzheimer's disease (AD).Formula:C16H12ClN3OPurity:99.50%Color and Shape:SolidMolecular weight:297.74Cilengitide
CAS:Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Formula:C27H40N8O7Purity:98% - 99.8%Color and Shape:SolidMolecular weight:588.66Ref: TM-T2494
1mg49.00€2mg70.00€5mg96.00€10mg160.00€25mg274.00€50mg439.00€100mg632.00€1mL*10mM (DMSO)137.00€Ginkgolide K
CAS:Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.Formula:C20H22O9Purity:99.44% - 99.72%Color and Shape:SolidMolecular weight:406.38Pemetrexed disodium
CAS:Pemetrexed disodium treats lung cancer/mesothelioma; may cause moderate serum enzyme elevation, rarely acute liver injury.Formula:C20H19N5Na2O6Purity:99.29% - 99.49%Color and Shape:Crystalline SolidMolecular weight:471.37Sunitinib
CAS:Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM).Formula:C22H27FN4O2Purity:98% - 99.67%Color and Shape:Yellow SolidMolecular weight:398.47Entinostat
CAS:Entinostat (MS-275) is an HDAC class I with oral activity. Entinostat has antitumor activity. Cost-effective and quality-assured.Formula:C21H20N4O3Purity:98% - 99.52%Color and Shape:SolidMolecular weight:376.41Bergapten
CAS:Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.Formula:C12H8O4Purity:99.48% - ≥95%Color and Shape:Needles From Alcohol; Soln In Sulfuric Acid Is Yellow-Gold Physical Description Grayish-White Micr°Crystalline Powder Or Yellow Fluffy Solid (Ntp 1992)Molecular weight:216.19Dacinostat
CAS:LAQ824 (Dacinostat (NVP-LAQ824)) is a novel HDAC inhibitor with IC50 of 32 nM and is an activator of the p21 promoter.Formula:C22H25N3O3Purity:95.28% - 95.28%Color and Shape:SolidMolecular weight:379.45Ref: TM-T2454
1mg49.00€2mg67.00€5mg110.00€10mg180.00€25mg323.00€50mg487.00€100mg705.00€500mg1,444.00€1mL*10mM (DMSO)110.00€Luminespib
CAS:Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β. Luminespib has antitumor activity. Cost-effective and quality-assured.Formula:C26H31N3O5Purity:98% - 99.26%Color and Shape:SolidMolecular weight:465.54Ref: TM-T1989
5mg57.00€10mg81.00€25mg145.00€50mg221.00€100mg363.00€200mg540.00€500mg872.00€1mL*10mM (DMSO)63.00€Leonurine hydrochloride
CAS:Leonurine hydrochloride (SCM-198 hydrochloride) , a major alkaloid compound extracted from Leonurus japonicas Houtt.Formula:C14H22ClN3O5Purity:99.07%Color and Shape:SolidMolecular weight:347.79Isobavachalcone
CAS:Isobavachalcone (Corylifolinin) is a chalcone constituent of Angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury inFormula:C20H20O4Purity:98% - 99.76%Color and Shape:SolidMolecular weight:324.37AMDE-1
CAS:AMDE-1, an autophagy modulator, triggers Atg5-dependent autophagy, recruits Atg16, and induces LC3 lipidation.Formula:C18H8ClF6N3Purity:90%Color and Shape:SolidMolecular weight:415.72Forskolin
CAS:Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).Formula:C22H34O7Purity:98.83% - 99.86%Color and Shape:Less Crystalline Solid Colorless Crystalline SolidMolecular weight:410.5Ref: TM-T2939
5mg43.00€10mg56.00€25mg86.00€50mg96.00€100mg144.00€200mg182.00€500mg306.00€1mL*10mM (DMSO)56.00€VPS34 inhibitor 1 (Compound 19, PIK-III analogue)
CAS:VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)Formula:C21H25N7OPurity:98.60%Color and Shape:SolidMolecular weight:391.47Ref: TM-T7944
1mg66.00€5mg144.00€10mg227.00€25mg399.00€50mg567.00€100mg753.00€200mg1,035.00€1mL*10mM (DMSO)166.00€trifarotene
CAS:Trifarotene (CD5789) is a RARγ agonist, 65x more selective than RARα and 16x than RARβ, with EC50 of 7.7 nM.Formula:C29H33NO4Purity:99.78%Color and Shape:SolidMolecular weight:459.58CCT128930 hydrochloride
CAS:CCT128930 hydrochloride: Potent AKT inhibitor (IC50=6 nM), 28x selective over PKA, 20x over p70S6K, induces cell cycle arrest & DNA damage.Formula:C18H21Cl2N5Purity:98.55%Color and Shape:SolidMolecular weight:378.3Dexamethasone
CAS:Dexamethasone: a glucocorticoid agonist; modulates IL receptors; reduces inflammatory miRNA-155 exosomes in macrophage responses.Formula:C22H29FO5Purity:98% - 99.91%Color and Shape:Crystals From Ether (Ntp 1992)Molecular weight:392.46Deoxypodophyllotoxin
CAS:Deoxypodophyllotoxin is cytotoxic, antineoplastic, anti-tumor, anti-angiogenic, antiviral, and anti-inflammatory.Formula:C22H22O7Purity:99.21% - 99.84%Color and Shape:SolidMolecular weight:398.41Mefloquine hydrochloride
CAS:Mefloquine hydrochloride (Mefloquin hydrochloride) is a quinoline derivative used for the prevention and therapy of P. falciparum malaria.Formula:C17H17ClF6N2OPurity:99% - 99.74%Color and Shape:Off-White To Yellow SolidMolecular weight:414.77SLF
CAS:SLF is a synthetic ligand for FKBP12 and increases Ca2+ efflux and protein synthesis.Formula:C30H40N2O6Purity:99.91%Color and Shape:SolidMolecular weight:524.65Trifluoperazine dihydrochloride
CAS:Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Formula:C21H26Cl2F3N3SPurity:99.57% - 99.96%Color and Shape:Cream Fine PowderMolecular weight:480.43Calcineurin substrate acetate
Calcineurin substrate acetate is from the regulatory RII subunit of cAMP-dependent protein kinase.Formula:C94H154N28O31Purity:97.59%Color and Shape:SolidMolecular weight:2172.4Metformin
CAS:Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability.Formula:C4H11N5Purity:100% - 99.78Color and Shape:SolidMolecular weight:129.16Bosutinib
CAS:Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.Formula:C26H29Cl2N5O3Purity:98.98% - 99.9%Color and Shape:Yellowish-Orange Or Pink To Brownish Solid Solid PowderMolecular weight:530.45
