Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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Fluoxetine
CAS:Fluoxetine (LY-110140), a specific serotonin inhibitor, serves as an antidepressant with fewer side-effects.Formula:C17H18F3NOPurity:99.07% - 99.28%Color and Shape:SolidMolecular weight:309.33Rottlerin
CAS:Rottlerin (NSC-56346), a Mallotus Philippinensis extract, inhibits PKC (3-100 μM IC50); triggers apoptosis by activating caspase 3.Formula:C30H28O8Purity:97.41% - 99.44%Color and Shape:Orange To Brown PowderMolecular weight:516.54Daurisoline
CAS:Daurisoline ((R,R)-Daurisoline) is a hERG inhibitor. Daurisoline is also an autophagy blocker.Formula:C37H42N2O6Purity:98% - 99.92%Color and Shape:Light Yellow PowderMolecular weight:610.74SU11274
CAS:SU11274 (Met Kinase Inhibitor)(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.Formula:C28H30ClN5O4SPurity:98.62% - 99.44%Color and Shape:Orange PowderMolecular weight:568.09Ref: TM-T6154
1mg47.00€2mg59.00€5mg97.00€10mg150.00€25mg283.00€50mg465.00€100mg688.00€1mL*10mM (DMSO)150.00€EACC
CAS:EACC inhibits Stx17, blocking autophagosome-lysosome fusion, and is a reversible autophagy inhibitor.Formula:C13H11N3O6S2Purity:98.89%Color and Shape:SolidMolecular weight:369.37AZ PFKFB3 26
CAS:AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.Formula:C24H26N4O2Purity:98.91%Color and Shape:SolidMolecular weight:402.49GSK4112
CAS:GSK4112 (SR6452) is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.Formula:C18H21ClN2O4SPurity:99.63%Color and Shape:SolidMolecular weight:396.89Silmitasertib sodium salt
CAS:Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).Formula:C19H11ClN3NaO2Purity:99.49% - 99.62%Color and Shape:SolidMolecular weight:371.75Ataluren
CAS:Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.Formula:C15H9FN2O3Purity:99.16% - 99.84%Color and Shape:SolidMolecular weight:284.24Ref: TM-T1805
5mg38.00€10mg57.00€25mg93.00€50mg124.00€100mg188.00€200mg225.00€500mg379.00€1mL*10mM (DMSO)48.00€Streptozocin
CAS:Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation.Formula:C8H15N3O7Purity:100% - 99.56%Color and Shape:Pale Yellow Crystalline PowderMolecular weight:265.22Bergenin
CAS:Bergenin (Bengenin) is a polyphenol, which is an effective antinarcotic agent with antioxidant action.Formula:C14H16O9Purity:99.55% - 99.60%Color and Shape:The Loose White Needle Crystal Powder Or CrystallineMolecular weight:328.27NL-1
CAS:NL-1 is a mitoNEET inhibitor with antileukemic effect.Formula:C18H25NO3SPurity:98.64%Color and Shape:SolidMolecular weight:335.46PH-797804
CAS:PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.Formula:C22H19BrF2N2O3Purity:97.79% - 97.90%Color and Shape:SolidMolecular weight:477.3Ref: TM-T1974
1mg46.00€5mg94.00€10mg144.00€25mg255.00€50mg406.00€100mg628.00€500mg1,320.00€1mL*10mM (DMSO)97.00€Purvalanol A
CAS:Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.Formula:C19H25ClN6OPurity:98.13% - 98.91%Color and Shape:PowderMolecular weight:388.89Quinacrine dihydrochloride
CAS:Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplasticFormula:C23H30CLN3O·2HClPurity:98.24% - 99.72%Color and Shape:Yellow Crystals Or PowderMolecular weight:472.88Avermectin B1
CAS:Avermectin B1 is served as anthelmintic and insecticide.Formula:C48H72O14Purity:mixture - mixtureColor and Shape:White PowderMolecular weight:873.09ICCB-19 hydrochloride
CAS:ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the TRADD-N.Formula:C12H22ClN3OSPurity:99.30%Color and Shape:SolidMolecular weight:291.84Ref: TM-T8931L
5mg35.00€10mg52.00€25mg96.00€50mg145.00€100mg210.00€200mg313.00€500mg495.00€1mL*10mM (DMSO)35.00€Sertindole
CAS:Sertindole, atypical antipsychotic, targets D2, 5-HT1D, 5-HT2A, 5-HT2C receptors (Kds: 2.7, 20, 0.14, 6 nM).Formula:C24H26ClFN4OPurity:99.74%Color and Shape:Off-White To Pale Yellow SolidMolecular weight:440.94Ruxolitinib
CAS:Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.Formula:C17H18N6Purity:100% - 99.99%Color and Shape:SolidMolecular weight:306.36Ref: TM-T1829
5mg58.00€10mg74.00€25mg92.00€50mg116.00€100mg155.00€200mg245.00€500mg414.00€1mL*10mM (DMSO)65.00€Acacetin
CAS:Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidantFormula:C16H12O5Purity:96.26% - ≥98%Color and Shape:Pale-Yellow NeedlesMolecular weight:284.26WYE-354
CAS:WYE-354 is a selective mTOR inhibitor (IC50=5 nM), targeting mTORC1/C2 over PI3Kα (>100x) and PI3Kγ (>500x), sparing P-AKT(T308).Formula:C24H29N7O5Purity:97.86% - 99.61%Color and Shape:SolidMolecular weight:495.53N6-Isopentenyladenosine
CAS:N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.Formula:C15H21N5O4Purity:99.51%Color and Shape:SolidMolecular weight:335.36Chloramphenicol
CAS:Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.Formula:C11H12Cl2N2O5Purity:99.6% - 99.84%Color and Shape:Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidMolecular weight:323.13EB-42486
CAS:EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.Formula:C22H22N8OPurity:98.06%Color and Shape:SolidMolecular weight:414.46Ref: TM-T39972
1mg70.00€2mg93.00€5mg156.00€10mg226.00€25mg409.00€50mg610.00€100mg867.00€200mg1,159.00€1mL*10mM (DMSO)170.00€Sanguinarine
CAS:Sanguinarine (Pseudochelerythrine) is a specific inhibitor of Rac1b with anti-microbial, anti-oxidant and anti-inflammatory properties.Formula:C20H14NO4Purity:99.04% - 99.18%Color and Shape:SolidMolecular weight:332.33Regorafenib Hydrochloride
CAS:Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.Formula:C21H16Cl2F4N4O3Purity:99.56%Color and Shape:SolidMolecular weight:519.289-ING-41
CAS:9-ING-41 is a glycogen synthase kinase-3 inhibitor.Formula:C22H13FN2O5Purity:99.32%Color and Shape:SolidMolecular weight:404.35Ref: TM-T14066
1mg49.00€2mg70.00€5mg99.00€10mg163.00€25mg325.00€50mg472.00€100mg705.00€1mL*10mM (DMSO)116.00€N-Benzyllinolenamide
CAS:N-Benzyllinolenamide is a natural product. It is an inhibitor of fatty acid amide hydrolase (FAAH, IC50 of 41.8 μM).Formula:C25H37NOPurity:98.00% - 99.92%Color and Shape:SolidMolecular weight:367.57Ref: TM-TN1965
1mg88.00€5mg187.00€10mg281.00€25mg475.00€50mg692.00€100mg935.00€200mg1,264.00€1mL*10mM (DMSO)188.00€Omipalisib
CAS:Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Formula:C25H17F2N5O3SPurity:98% - 99.8%Color and Shape:SolidMolecular weight:505.5Melatonin
CAS:Melatonin (Melatonine) is a natural hormone that activates melatonin receptors. Melatonin regulates the biological clock. Cost-effective and quality-assured.Formula:C13H16N2O2Purity:98% - 99.79%Color and Shape:Pale Yellow Leaflets From Benzene SolidMolecular weight:232.28Triclosan
CAS:Triclosan (Irgasan) is an antibacterial and antifungal agent.Formula:C12H7Cl3O2Purity:99.63%Color and Shape:White Solid CrystallineMolecular weight:289.54Galangin
CAS:Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.Formula:C15H10O5Purity:98.24% - 99.93%Color and Shape:Yellowish Needle-Like CrystalMolecular weight:270.24Briciclib
CAS:Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.Formula:C19H23O10PSPurity:98% - 99.84%Color and Shape:SolidMolecular weight:474.42Ref: TM-T3207
1mg47.00€2mg57.00€5mg88.00€10mg126.00€25mg250.00€50mg376.00€100mg560.00€500mg1,216.00€1mL*10mM (DMSO)87.00€PFE-360
CAS:PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).Formula:C16H16N6OPurity:98.14% - 99.73%Color and Shape:SolidMolecular weight:308.34Sorafenib
CAS:Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57Formula:C21H16ClF3N4O3Purity:98% - 99.89%Color and Shape:SolidMolecular weight:464.82Dasatinib
CAS:Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive.Formula:C22H26ClN7O2SPurity:99.59% - 99.86%Color and Shape:Pale-Yellow SolidMolecular weight:488.01Bacilotetrin C analogue
Bacilotetrin C analogue is a variant of Bacilotetrin C. It exhibits cytotoxicity against the triple-negative breast cancer cell line MDA-MB-231, with an IC50 of 0.48 μM. This compound induces autophagy (autophagy) in tumor cells and possesses antitumor activity.Formula:C44H76N6O10Color and Shape:SolidMolecular weight:849.11Indophagolin
CAS:Indophagolin: autophagy inhibitor, IC50 140 nM; blocks P2X4, P2X1, P2X3 receptors, IC50s 2.71, 2.40, 3.49 μM.Formula:C19H15BrClF3N2O3SPurity:99.76%Color and Shape:SolidMolecular weight:523.75Ref: TM-T8946
1mg58.00€5mg111.00€10mg170.00€25mg284.00€50mg393.00€100mg552.00€200mg748.00€1mL*10mM (DMSO)129.00€Hesperetin
CAS:Hesperetin belongs to the flavanone class of flavonoids.Formula:C16H14O6Purity:99.27%Color and Shape:SolidMolecular weight:302.28SN-38
CAS:SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Formula:C22H20N2O5Purity:98% - 99.97%Color and Shape:Light-Yellow SolidMolecular weight:392.44,4'-Dimethoxychalcone
CAS:4,4'-Dimethoxychalcone (4,4-Dimethoxychalcone) is a natural product.Formula:C17H16O3Purity:99.57%Color and Shape:SolidMolecular weight:268.31Linagliptin
CAS:Linagliptin (BI 1356) is a potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.Formula:C25H28N8O2Purity:99.15% - 99.95%Color and Shape:SolidMolecular weight:472.54FTO-IN-10
FTO-IN-10 (compound 7), a potent inhibitor of the human demethylase FTO (fat mass and obesity-associated protein), exhibits an IC50 of 4.5 μM.Purity:98%Color and Shape:Odour SolidBIX 02565
CAS:BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).Formula:C26H30N6O2Purity:97.44% - 99.61%Color and Shape:SolidMolecular weight:458.56Felodipine
CAS:Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor.Formula:C18H19Cl2NO4Purity:99.91%Color and Shape:SolidMolecular weight:384.25Ref: TM-T0145
5mg51.00€10mg82.00€25mg124.00€50mg180.00€100mg264.00€200mg398.00€500mg647.00€1mL*10mM (DMSO)90.00€(+)-JQ-1
CAS:(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility.Formula:C23H25ClN4O2SPurity:97.57% - ≥95%Color and Shape:SolidMolecular weight:456.99Ref: TM-T2110
1mg35.00€2mg44.00€5mg60.00€10mg79.00€25mg96.00€50mg144.00€100mg188.00€200mg283.00€500mg512.00€1mL*10mM (DMSO)66.00€ISRIB (trans-isomer)
CAS:ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.Formula:C22H24Cl2N2O4Purity:97.86% - 99.27%Color and Shape:SolidMolecular weight:451.34Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formula:C23H28ClN3O5SPurity:99.05% - 99.75%Color and Shape:SolidMolecular weight:494Binimetinib
CAS:Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.Formula:C17H15BrF2N4O3Purity:100% - 99%Color and Shape:SolidMolecular weight:441.23Hydroxychloroquine sulfate
CAS:Hydroxychloroquine sulfate (Acidum iopanoicum) inhibits plasmodial heme polymerase.Formula:C18H26ClN3O·H2SO4Purity:98.92% - 99.88%Color and Shape:Odorless SolidMolecular weight:433.95
