Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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Linifanib
CAS:Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) andFormula:C21H18FN5OPurity:98% - 98.24%Color and Shape:SolidMolecular weight:375.4Ref: TM-T2514
5mg50.00€10mg85.00€25mg126.00€50mg188.00€100mg274.00€200mg505.00€500mg815.00€1mL*10mM (DMSO)52.00€Metformin hydrochloride
CAS:Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) is an AMPK activator. Metformin is used in type 2 diabetes research. Cost-effective and quality-assured.Formula:C4H12ClN5Purity:97.53% - 99.00%Color and Shape:White Or Almost White Crystals Solid CrystallineMolecular weight:165.63HG-10-102-01
CAS:HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).Formula:C17H20ClN5O3Purity:99.59%Color and Shape:SolidMolecular weight:377.83Ref: TM-T7196
2mg38.00€5mg58.00€10mg94.00€25mg170.00€50mg264.00€100mg380.00€200mg540.00€1mL*10mM (DMSO)65.00€Quercitrin
CAS:Quercitrin (3-rhamnosyl quercetin) is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities.Formula:C21H20O11Purity:98.4% - 98.89%Color and Shape:Yellow Crystals From Dil Methanol Or Ethanol SolidMolecular weight:448.38Cysmethynil
CAS:Cysmethynil is an indole-based Icmt inhibitor with antitumor activity, induces cell cycle arrest in G1 phase, and can be used for the study of solid tumors.Formula:C25H32N2OPurity:99%Color and Shape:SolidMolecular weight:376.53Ref: TM-T36082
1mg47.00€2mg60.00€5mg87.00€10mg140.00€25mg274.00€50mg439.00€100mg707.00€500mg1,415.00€Dehydropachymic acid
CAS:Dehydropachymic acid shows antiinflammatory activity.Formula:C33H50O5Purity:98.22% - 99.78%Color and Shape:SolidMolecular weight:526.75Crizotinib hydrochloride
CAS:Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)Formula:C21H23Cl3FN5OPurity:98.73% - 98.87%Color and Shape:SolidMolecular weight:486.8Ref: TM-T8399
5mg37.00€10mg52.00€25mg82.00€50mg99.00€100mg138.00€200mg171.00€500mg227.00€1mL*10mM (DMSO)59.00€Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).Formula:C30H23N5OPurity:97.64% - 99.85%Color and Shape:SolidMolecular weight:469.54Salirasib
CAS:Salirasib: Competitive PPMTase inhibitor, blocks Ras methylation, potential cancer treatment, Ki=2.6 μM.Formula:C22H30O2SPurity:99.45%Color and Shape:SolidMolecular weight:358.54Ref: TM-T6163
5mg35.00€10mg52.00€25mg96.00€50mg159.00€100mg221.00€200mg364.00€500mg597.00€1mL*10mM (DMSO)59.00€Apostatin-1
CAS:Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.Formula:C19H27N3OSPurity:100%Color and Shape:SolidMolecular weight:345.5Ref: TM-T9079
1mg37.00€2mg52.00€5mg79.00€10mg119.00€25mg235.00€50mg378.00€100mg560.00€500mg1,216.00€1mL*10mM (DMSO)87.00€Pepstatin
CAS:Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.Formula:C34H63N5O9Purity:96.74% - 99.94%Color and Shape:SolidMolecular weight:685.89Hydroxyprogesterone caproate
CAS:Hydroxyprogesterone caproate (Delalutin) is a synthetic progestin that activates progesterone receptors and inhibits ovulation.Formula:C27H40O4Purity:99.70%Color and Shape:White Or Almost White Crystalline PowerMolecular weight:428.6(E)-Daporinad
CAS:(E)-Daporinad (FK866) is a highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .Cost-effective and quality-assured.Formula:C24H29N3O2Purity:100% - 99.96%Color and Shape:SolidMolecular weight:391.51Ref: TM-T2644
2mg43.00€5mg65.00€10mg96.00€25mg188.00€50mg368.00€100mg557.00€500mg1,169.00€1mL*10mM (DMSO)70.00€Glucosamine hydrochloride
CAS:Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.Formula:C6H13NO5·HClPurity:99.77%Color and Shape:White Solid CrystallineMolecular weight:215.63SR9009
CAS:SR9009, a REV-ERB agonist, modulates genes and circadian rhythms, reducing fat mass and improving metabolism in obese mice.Formula:C20H24ClN3O4SPurity:99.53% - 99.8%Color and Shape:SolidMolecular weight:437.94Daunorubicin hydrochloride
CAS:Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and proteinFormula:C27H29NO10·HClPurity:96.21% - 99.53%Color and Shape:Cancer DrugMolecular weight:563.99Ref: TM-T1511
5mg37.00€10mg56.00€25mg92.00€50mg119.00€100mg187.00€200mg298.00€500mg467.00€1mL*10mM (DMSO)63.00€Dorsomorphin
CAS:Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive.Formula:C24H25N5OPurity:98% - 99.06%Color and Shape:SolidMolecular weight:399.49740 Y-P
CAS:740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K.Formula:C141H222N43O39PS3Purity:98.3% - 99.87%Color and Shape:SolidMolecular weight:3270.7S29434
CAS:S29434 (NMDPEF) is a potent, competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).Formula:C21H18N4O3Purity:99.92%Color and Shape:SolidMolecular weight:374.39Telmisartan
CAS:Telmisartan (BIBR 277) is an Angiotensin 2 Receptor Blocker. The mechanism of action of telmisartan is as an Angiotensin 2 Receptor Antagonist.Formula:C33H30N4O2Purity:99.88% - 99.96%Color and Shape:White Or Off White Crystalline PowderMolecular weight:514.62VO-Ohpic trihydrate
CAS:VO-Ohpic trihydrate (VO-Ohpic) is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.Formula:C12H9N2O8V·3H2O·HPurity:100%Color and Shape:SolidMolecular weight:415.2Samotolisib
CAS:Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.Formula:C23H26N4O3Purity:98.41% - 99.69%Color and Shape:SolidMolecular weight:406.48Vinblastine sulfate
CAS:Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).Formula:C46H58N4O9·H2SO4Purity:97.81% - 99.38%Color and Shape:White PowderMolecular weight:909.06Isodeoxyelephantopin
CAS:Isodeoxyelephantopin can inhibit the growth of various tumor cells.Formula:C19H20O6Purity:99.88%Color and Shape:SolidMolecular weight:344.36Lonafarnib
CAS:Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).Formula:C27H31Br2ClN4O2Purity:98% - 99.04%Color and Shape:SolidMolecular weight:638.82Taurine
CAS:Taurine (2-Aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues and is one of the constituents of bile acids. Cost-effective and quality-assured.Formula:C2H7NO3SPurity:98.05% - 99.81%Color and Shape:White Crystalline PowderMolecular weight:125.15PD146176
CAS:PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM.Formula:C15H11NSPurity:98.00%Color and Shape:SolidMolecular weight:237.32SR9011
CAS:SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).Formula:C23H31ClN4O3SPurity:99.64% - 99.65%Color and Shape:SolidMolecular weight:479.04Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Formula:C25H34N4O2SPurity:100% - 97.71%Color and Shape:SolidMolecular weight:454.63Ref: TM-T1818
1mg43.00€2mg56.00€5mg77.00€10mg87.00€25mg157.00€50mg230.00€100mg393.00€500mg930.00€1mL*10mM (DMSO)79.00€NBDHEX
CAS:NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).Formula:C12H15N3O4SPurity:97.38%Color and Shape:SolidMolecular weight:297.33Gemcitabine hydrochloride
CAS:Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis.Formula:C9H11F2N3O4·HClPurity:99.28% - 99.98%Color and Shape:White Crystalline Granular OdorlessMolecular weight:299.66Lovastatin
CAS:Lovastatin (MK-803) is an HMG-CoA reductase inhibitor. Lovastatin lowers cholesterol and is used as a lipid-lowering agent. Cost-effective and quality-assured.Formula:C24H36O5Purity:99.59% - 99.72%Color and Shape:The Substance Is A White-Yellowish To Yellow Powder Solid PowderMolecular weight:404.54CFTR(inh)-172
CAS:CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.Formula:C18H10F3NO3S2Purity:98% - 99.72%Color and Shape:SolidMolecular weight:409.4Ref: TM-T2355
1mg35.00€2mg46.00€5mg66.00€10mg97.00€25mg188.00€50mg359.00€100mg530.00€1mL*10mM (DMSO)69.00€Cilengitide TFA
CAS:Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.Formula:C29H41F3N8O9Color and Shape:SolidMolecular weight:702.68Wogonoside
CAS:Wogonoside (Wogonin 7-O-glucuronide) acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.Formula:C22H20O11Purity:98.24% - 98.66%Color and Shape:SolidMolecular weight:460.39KAN0438757
CAS:KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.Formula:C21H18FNO7SPurity:99.34%Color and Shape:SolidMolecular weight:447.43Ref: TM-T11741
1mg101.00€5mg192.00€10mg306.00€25mg553.00€50mg760.00€100mg1,035.00€1mL*10mM (DMSO)207.00€PF-3845
CAS:PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.Formula:C24H23F3N4O2Purity:99.54% - 99.58%Color and Shape:SolidMolecular weight:456.46Ref: TM-T6043
2mg42.00€5mg59.00€10mg97.00€25mg205.00€50mg354.00€100mg560.00€200mg800.00€1mL*10mM (DMSO)59.00€Genipin
CAS:Genipin ((+)-Genipin), an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis.Formula:C11H14O5Purity:99.09% - 99.21%Color and Shape:SolidMolecular weight:226.23SAR405
CAS:SAR-405 inhibits PIK3C3/Vps34 (IC50: 1.2 nM, Kd: 1.5 nM), blocks autophagy, and enhances MTOR inhibitor effects on cancer cells.Formula:C19H21ClF3N5O2Purity:99.42% - 99.79%Color and Shape:SolidMolecular weight:443.85Ref: TM-T12831L
1mg149.00€2mg217.00€5mg368.00€10mg580.00€25mg882.00€50mg1,596.00€1mL*10mM (DMSO)444.00€Azithromycin hydrate
CAS:Azithromycin hydrate (CP-62993 dihydrate) is a semi-synthetic macrolide antibiotic structurally related to erythromycin.Formula:C38H72N2O12·2H2OPurity:99.83% - 99.92%Color and Shape:White Or Almost White Crystalline PowderMolecular weight:785.03Clioquinol
CAS:Clioquinol: oral, lipophilic copper-binder; halogenated quinoline with antifungal, antiparasitic, and possible antitumor uses.Formula:C9H5ClINOPurity:97.02%Color and Shape:Brownish-Yellow Bulky Powder Decomposes At 178-179°C Used As A Topical Anti-InfectiveMolecular weight:305.5Chelerythrine chloride
CAS:Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect toFormula:C21H18ClNO4Purity:95% - 99.19%Color and Shape:Yellow To Orange SolidMolecular weight:383.83Clematichinenoside AR
CAS:Clematichinenoside AR is anti-inflammatory, immunosuppressive, and combats arthritis via PI3K/Akt and TNF-α pathways.Formula:C82H134O43Purity:99.49% - 99.69%Color and Shape:SolidMolecular weight:1807.92ISOGINKGETIN
CAS:ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.Formula:C32H22O10Purity:98% - 99.72%Color and Shape:SolidMolecular weight:566.51SF1670
CAS:SF1670 (PTPase CD45 Inhibitor) is a specific PTEN inhibitor with IC50 of 2 μM.Formula:C19H17NO3Purity:98.25% - 98.54%Color and Shape:SolidMolecular weight:307.34Ref: TM-T6667
1mg44.00€2mg55.00€5mg88.00€10mg125.00€25mg273.00€50mg500.00€100mg740.00€1mL*10mM (DMSO)97.00€Idelalisib
CAS:Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).Formula:C22H18FN7OPurity:98% - 99.39%Color and Shape:SolidMolecular weight:415.42Ref: TM-T1894
5mg35.00€10mg50.00€25mg74.00€50mg93.00€100mg108.00€200mg140.00€500mg225.00€1mL*10mM (DMSO)52.00€Veliparib
CAS:Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.Formula:C13H16N4OPurity:98.66% - 99%Color and Shape:SolidMolecular weight:244.29Ref: TM-T2591
5mg57.00€10mg81.00€25mg127.00€50mg207.00€100mg331.00€200mg540.00€500mg852.00€1mL*10mM (DMSO)64.00€Vancomycin
CAS:Vancomycin is a glycopeptide antibiotic that exerts its antimicrobial activity by altering the permeability of cell membranes and selectively inhibitingFormula:C66H75Cl2N9O24Purity:99.24%Color and Shape:Almost White PowderMolecular weight:1449.25Vps34-IN-1
CAS:Vps34-IN-1: potent, selective Vps34 inhibitor, 25 nM IC50, spares class I/II PI3Ks.Formula:C21H24ClN7OPurity:97.04%Color and Shape:SolidMolecular weight:425.91Ref: TM-T7015
1mg46.00€2mg59.00€5mg93.00€10mg131.00€25mg219.00€50mg350.00€100mg505.00€1mL*10mM (DMSO)92.00€ST-539
CAS:ST-539 is an inhibitor of the deubiquitinating enzyme USP30, with an IC50 of 0.37 μM. It enhances the ubiquitination of mitochondrial proteins and induces mitophagy (autophagy), thereby regulating mitochondrial homeostasis. ST-539 is applicable for research in neurodegenerative diseases.Formula:C30H31N3O4SColor and Shape:SolidMolecular weight:529.65
