Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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Silibinin
CAS:Silibinin, main component in milk thistle, offers liver protection and shows anti-cancer potential in various human cells.Formula:C25H22O10Purity:97.98% - 98.35%Color and Shape:SolidMolecular weight:482.44Oroxin B
CAS:Oroxin B (Hypocretin-2) has antioxidant activity.Formula:C27H30O15Purity:98.22% - 98.33%Color and Shape:SolidMolecular weight:594.52Pictilisib
CAS:Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).Formula:C23H27N7O3S2Purity:99% - 99.97%Color and Shape:SolidMolecular weight:513.64BC1618
CAS:BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling.Formula:C24H24F3NO2Purity:99.95%Color and Shape:SolidMolecular weight:415.45SR12813
CAS:SR12813 (GW 485801) is a pregnane X receptor (PXR) agonist.Formula:C24H42O7P2Purity:99.43%Color and Shape:SolidMolecular weight:504.53Ipsalazide
CAS:Ipsalazide is a novel salicylazosulfapyridine analog for the treatment of inflammatory bowel disease.Formula:C16H11N3Na2O6Purity:99.43%Color and Shape:SolidMolecular weight:387.25DBEQ
CAS:DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.Formula:C22H20N4Purity:98.89% - ≥95%Color and Shape:SolidMolecular weight:340.42Ref: TM-T1969
5mg58.00€10mg95.00€25mg180.00€50mg324.00€100mg410.00€200mg607.00€500mg938.00€1mL*10mM (DMSO)59.00€VLX600
CAS:VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent.Formula:C17H15N7Purity:98.62%Color and Shape:SolidMolecular weight:317.35HDAC10-IN-2 hydrochloride
HDAC10-IN-2 hydrochloride (compound 10c) is an HDAC10 inhibitor with high potency and selectivity, exhibiting an IC50 of 20 nM.Formula:C19H23ClN2O2Purity:98%Color and Shape:SolidMolecular weight:346.85Carfilzomib
CAS:Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome.Formula:C40H57N5O7Purity:99.6% - 99.84%Color and Shape:SolidMolecular weight:719.91Shogaol
CAS:6-Shogaol: anti-inflammatory, analgesic, antipyretic, protects cartilage, arrests cancer cell growth, inhibits metastasis.Formula:C17H24O3Purity:98.26% - 99.39%Color and Shape:SolidMolecular weight:276.37Ref: TM-T6S1699
2mg43.00€5mg62.00€10mg92.00€25mg180.00€50mg283.00€100mg432.00€500mg938.00€1mL*10mM (DMSO)67.00€PF-04457845
CAS:PF-04457845 is a greatly and effctive FAAH inhibitor, and for hFAAH(IC50=7.2±0.63 nM) and rFAAH(IC50=7.4±0.62 nM).Formula:C23H20F3N5O2Purity:100%Color and Shape:SolidMolecular weight:455.43Ref: TM-T4323
2mg35.00€5mg52.00€10mg88.00€25mg163.00€50mg235.00€100mg419.00€200mg545.00€1mL*10mM (DMSO)58.00€Dansylcadaverine
CAS:Dansylcadaverine (Monodansyl cadaverine) is a fluorescent probe.Formula:C17H25N3O2SPurity:98.33% - 98.99%Color and Shape:SolidMolecular weight:335.46PF-04691502
CAS:PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.Formula:C22H27N5O4Purity:96.27% - ≥95%Color and Shape:SolidMolecular weight:425.48Sinomenine hydrochloride
CAS:Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.Formula:C19H24ClNO4Purity:99.43%Color and Shape:SolidMolecular weight:365.851Fenretinide
CAS:Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.Formula:C26H33NO2Purity:98% - 99.72%Color and Shape:Yellow PowderMolecular weight:391.55AZ304
CAS:AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).Formula:C27H25N5O2Purity:99.82%Color and Shape:SolidMolecular weight:451.52MHY1485
CAS:MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.Formula:C17H21N7O4Purity:100% - 99.6%Color and Shape:SolidMolecular weight:387.39Lapatinib
CAS:Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.Formula:C29H26ClFN4O4SPurity:99.00% - 99.81%Color and Shape:PowderMolecular weight:581.06PHY34
CAS:PHY34 inhibits autophagy at nanomolar potency, with anti-tumor effects on HGSOC in vivo.Formula:C30H30O12Purity:98.32%Color and Shape:SolidMolecular weight:582.55Ref: TM-T37376
1mg164.00€2mg235.00€5mg369.00€10mg548.00€25mg879.00€50mg1,198.00€100mg1,596.00€500mg3,212.00€JNJ-42165279
CAS:JNJ-42165279 selectively inactivates FAAH without notably affecting other enzymes, ion channels, receptors, or CYPs/hERG at 10 μM.Formula:C18H17ClF2N4O3Purity:99.88% - 99.89%Color and Shape:SolidMolecular weight:410.8Ref: TM-T3215
2mg46.00€5mg65.00€10mg96.00€25mg170.00€50mg246.00€100mg363.00€200mg512.00€1mL*10mM (DMSO)75.00€Saracatinib
CAS:Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.Formula:C27H32ClN5O5Purity:98% - 99.63%Color and Shape:SolidMolecular weight:542.03ZX-29
CAS:ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.Formula:C23H28ClN7O3SPurity:98.32%Color and Shape:SolidMolecular weight:518.03Ref: TM-T13416
1mg92.00€5mg230.00€10mg364.00€25mg620.00€50mg848.00€100mg1,121.00€1mL*10mM (DMSO)296.00€Berbamine dihydrochloride
CAS:Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.Formula:C37H42Cl2N2O6Purity:95% - 99.38%Color and Shape:SolidMolecular weight:681.65Chloroquine
CAS:Chloroquine: antimalarial, anti-inflammatory, autophagy/TLRs inhibitor, treats arthritis, effective against COVID-19 in vitro. EC50: 1.13 μM.Formula:C18H26ClN3Purity:99.82% - 99.98%Color and Shape:White To Slightly Yellow Crystalline Powder SolidMolecular weight:319.875-Aminolevulinic acid hydrochloride
CAS:5-Aminolevulinic acid hydrochloride (5-ALA) serves as an intermediate in the body's heme biosynthesis and is the universal precursor of tetrapyrroles.Formula:C5H10ClNO3Purity:98% - 99.97%Color and Shape:White To Pale Yellow Crystals OrMolecular weight:167.59ULK-101
CAS:ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy.Formula:C22H16F4N4OSPurity:97.55% - 99.66%Color and Shape:SolidMolecular weight:460.45Ref: TM-T5403
1mg111.00€5mg274.00€10mg432.00€25mg747.00€50mg1,121.00€100mg1,510.00€1mL*10mM (DMSO)279.00€Tolvaptan
CAS:Tolvaptan (OPC-41061) is an orally bioavailable, selective, arginine vasopressin receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia.Formula:C26H25ClN2O3Purity:97% - 99.91%Color and Shape:SolidMolecular weight:448.94ALA-A2 peptide
ALA-A2, a cancer peptide found in α-lactalbumin, selectively kills cancer cells by inducing autophagy (Autophagy). It possesses cell-penetrating properties, allowing it to enter cells effectively without relying on membrane solubilization effects. In A549 lung cancer cells, ALA-A2 demonstrates significant dose-dependent anticancer activity. This peptide shows promise for research in cancer treatment and autophagy regulation.Formula:C67H111N21O19SColor and Shape:SolidMolecular weight:1546.79GCN2iB
CAS:GCN2iB is an ATP-competitive inhibitor of serine/threonine protein kinase, stress-responsive kinase (GCN2).Cost-effective and quality-assured.Formula:C18H12ClF2N5O3SPurity:99.08%Color and Shape:SolidMolecular weight:451.83Ref: TM-T11375
1mg85.00€5mg170.00€10mg274.00€25mg547.00€50mg783.00€100mg1,074.00€1mL*10mM (DMSO)187.00€Sepantronium bromide
CAS:Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.Formula:C20H19BrN4O3Purity:99.68% - 99.82%Color and Shape:SolidMolecular weight:443.26Mirdametinib
CAS:Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity.Formula:C16H14F3IN2O4Purity:99.18% - 99.63%Color and Shape:White PowderMolecular weight:482.19Ref: TM-T6189
1g898.00€5mg51.00€10mg74.00€25mg127.00€50mg175.00€100mg273.00€200mg406.00€500mg662.00€1mL*10mM (DMSO)55.00€Ligustilide
CAS:3-Butylidene-4,5-dihydrophthalide is an effective constituent extracted from Angelica sinensis.Formula:C12H14O2Purity:96.03% - 98.14%Color and Shape:Yellow Brown PowderMolecular weight:190.24Nilotinib monohydrochloride monohydrate
CAS:Nilotinib monohydrochloride monohydrate (Nilotinib (monohydrochloride monohydrate)) is significantly potent BCR-ABL against, is a second generation tyrosineFormula:C28H22F3N7O·HCl·H2OPurity:99.93%Color and Shape:SolidMolecular weight:583.99Vorinostat
CAS:Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11.Formula:C14H20N2O3Purity:99.47% - 99.65%Color and Shape:White Crystalline SolidMolecular weight:264.32Isradipine
CAS:Isradipine (PN 200-110), a dihydropyridine, is an antihypertensive calcium channel blocker that dilates arteries and reduces resistance.Formula:C19H21N3O5Purity:99.65% - 99.84%Color and Shape:Yellow SolidMolecular weight:371.39LRRK2-IN-1
CAS:LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.Formula:C31H38N8O3Purity:98% - 98.82%Color and Shape:SolidMolecular weight:570.69TG101209
CAS:TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.Formula:C26H35N7O2SPurity:100% - 99.36%Color and Shape:SolidMolecular weight:509.67SR-18292
CAS:SR-18292 inhibits PGC-1α, enhances acetylation, lowers gluconeogenesis, and cuts hepatic glucose production.Formula:C23H30N2O2Purity:99% - 99.36%Color and Shape:SolidMolecular weight:366.5Ref: TM-T4353
2mg40.00€5mg60.00€10mg87.00€25mg180.00€50mg283.00€100mg449.00€500mg938.00€1mL*10mM (DMSO)71.00€Mito-LND
CAS:Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.Formula:C43H45BrCl2N3OPPurity:97.25% - 98.34%Color and Shape:SolidMolecular weight:801.62MRT68921 HCl
CAS:MRT68921 hydrochloride is a potent inhibitor of both ULK1 and ULK2 (IC50s: 2.9 and 1.1 nM, respectively).Formula:C25H34N6O·HClPurity:99.86% - 99.98%Color and Shape:SolidMolecular weight:471.04GW786034B
CAS:Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.Formula:C21H23N7O2S·HClPurity:99.87%Color and Shape:SolidMolecular weight:473.98Ref: TM-T6930
10mg52.00€25mg90.00€50mg96.00€100mg140.00€200mg229.00€500mg359.00€1mL*10mM (DMSO)52.00€Fexaramine
CAS:Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.Formula:C32H36N2O3Purity:98.87% - 99.61%Color and Shape:SolidMolecular weight:496.64Danusertib
CAS:Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.Formula:C26H30N6O3Purity:97.88% - 98.44%Color and Shape:White PowderMolecular weight:474.55Ref: TM-T2094
1mg59.00€2mg85.00€5mg116.00€10mg188.00€25mg365.00€50mg555.00€100mg795.00€500mg1,605.00€1mL*10mM (DMSO)120.00€UNBS5162
CAS:UNBS5162 (UNBS-5162) is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.Formula:C17H18N4O3Purity:98.37% - 99.97%Color and Shape:SolidMolecular weight:326.35Ref: TM-T2477
1mg39.00€5mg81.00€10mg116.00€25mg215.00€50mg340.00€100mg540.00€200mg787.00€1mL*10mM (DMSO)89.00€PFK-015
CAS:PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).Formula:C17H12N2OPurity:98.94% - 99.7%Color and Shape:SolidMolecular weight:260.29Ref: TM-T2455
5mg57.00€10mg88.00€25mg159.00€50mg283.00€100mg419.00€200mg582.00€500mg928.00€1mL*10mM (DMSO)57.00€TPEN
CAS:TPEN (TPEDA) is a specific cell-permeable heavy metal chelator.Formula:C26H28N6Purity:98% - 99.72%Color and Shape:White Crystalline PowderMolecular weight:424.54Gemcitabine elaidate
CAS:Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, withFormula:C27H43F2N3O5Color and Shape:SolidMolecular weight:527.64FB49
FB49 is a selective Bcl-2-associated athanogene 3 (BAG3) inhibitor with a Ki of 45 μM.Formula:C17H18N2O6SPurity:98%Color and Shape:SolidMolecular weight:378.4Vandetanib
CAS:Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 (IC50: 40 nM). It also inhibits VEGFR3 and EGFR.Formula:C22H24BrFN4O2Purity:100% - 99.84%Color and Shape:White SolidMolecular weight:475.35Ref: TM-T1656
10mg49.00€25mg69.00€50mg97.00€100mg170.00€200mg235.00€500mg379.00€1mL*10mM (DMSO)55.00€
