Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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Irinotecan hydrochloride trihydrate
CAS:Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.Formula:C33H45ClN4O9Purity:98.22% - 99.79%Color and Shape:Pale Yellow To Yellow Crystalline PowderMolecular weight:677.18Sunitinib Malate
CAS:Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor.Formula:C26H33FN4O7Purity:98% - 99.26%Color and Shape:SolidMolecular weight:532.56Autophinib
CAS:Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay andFormula:C14H11ClN6O3Purity:99.25% - 99.41%Color and Shape:SolidMolecular weight:346.73Doxazosin mesylate
CAS:Doxazosin mesylate (UK 33274 mesylate)(UK 33274) is a quinazoline-derivative. It is a selectively antagonizes postsynaptic α1-adrenergic receptors.Formula:C24H29N5O8SPurity:99.92%Color and Shape:White To Off-White Crystalline PowderMolecular weight:547.58palovarotene
CAS:Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).Formula:C27H30N2O2Purity:96.89% - 98.05%Color and Shape:SolidMolecular weight:414.54Lucanthone
CAS:Lucanthone (Lucanthonum) is an inhibitor of Apurinic endonuclease-1 (APE-1).Formula:C20H24N2OSPurity:99.92%Color and Shape:Yellow Crystals From Alcohol SolidMolecular weight:340.48Ref: TM-T4569
1mg56.00€2mg80.00€5mg126.00€10mg188.00€25mg400.00€50mg592.00€100mg837.00€1mL*10mM (DMSO)140.00€AZD-8055
CAS:AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.Formula:C25H31N5O4Purity:98% - 99.69%Color and Shape:SolidMolecular weight:465.54Syringin
CAS:Syringin (eleutheroside-b) is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects.Formula:C17H24O9Purity:98.89% - 99.56%Color and Shape:SolidMolecular weight:372.37CCT007093
CAS:CCT007093 is an effective PPM1D (WIP1) inhibitor (IC50: 8.4 μM).Formula:C15H12OS2Purity:98% - 99.75%Color and Shape:SolidMolecular weight:272.39ML-SA1
CAS:ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity.Formula:C22H22N2O3Purity:99.71%Color and Shape:SolidMolecular weight:362.42Ref: TM-T23004
2mg37.00€5mg51.00€10mg81.00€25mg150.00€50mg244.00€100mg364.00€200mg550.00€1mL*10mM (DMSO)58.00€WYC-209
CAS:WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).Formula:C20H20N2O3SPurity:99.77%Color and Shape:SolidMolecular weight:368.45CZC-54252 hydrochloride
CAS:CZC-54252 hydrochloride: selective LRRK2 inhibitor; IC50 = 1.85/1.28 nM (wild-type/G2019S); neuroprotective; EC50 = 1 nM for G2019S injury.Formula:C22H26Cl2N6O4SPurity:98.21%Color and Shape:SolidMolecular weight:541.45Ref: TM-T39202
5mg52.00€10mg75.00€25mg135.00€50mg215.00€100mg319.00€200mg449.00€1mL*10mM (DMSO)64.00€VER-155008
CAS:VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively.Formula:C25H23Cl2N7O4Purity:98.88% - 99.55%Color and Shape:SolidMolecular weight:556.4Ref: TM-T7010
2mg47.00€5mg69.00€10mg93.00€25mg163.00€50mg283.00€100mg467.00€200mg653.00€1mL*10mM (DMSO)85.00€Rhein
CAS:Rhein (NSC 38629) is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities.Formula:C15H8O6Purity:99.04%Color and Shape:Physical Description Yellow Needles (From Methanol) Or Yellow-Brown Powder (Ntp 1992)Molecular weight:284.22Rotenone
CAS:Rotenone, a plant-derived insecticide, inhibits mitochondrial electron transport, found in Leguminosae.Formula:C23H22O6Purity:89.58% - 99.88%Color and Shape:Less To Brownish Crystals Or A White To Brownish-White Crystalline Powder Has Neither Odor Nor Taste (Ntp 1992)Molecular weight:394.42Tacrolimus
CAS:Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent proteinFormula:C44H69NO12Purity:98% - 99.94%Color and Shape:White Or Off-White Crystalline PowderMolecular weight:804.02Ref: TM-T2144
10mg46.00€25mg60.00€50mg74.00€100mg104.00€200mg147.00€500mg244.00€1mL*10mM (DMSO)50.00€Lapatinib Ditosylate
CAS:Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).Formula:C29H26ClFN4O4S·2C7H8O3SPurity:99.41%Color and Shape:Yellow SolidMolecular weight:925.46CZC-54252
CAS:CZC-54252 is a potent inhibitor of LRRK2.Formula:C22H25ClN6O4SPurity:99.39%Color and Shape:SolidMolecular weight:504.99Fenofibrate
CAS:Fenofibrate (Lipanthyl) is a PPARα agonist. Fenofibrate inhibits cytochrome P450 isoforms. Fenofibrate exhibits antihyperlipidemic activity. Cost-effective and quality-assured.Formula:C20H21ClO4Purity:99.13% - 99.95%Color and Shape:Crystals From Isopropanol SolidMolecular weight:360.83Amiodarone hydrochloride
CAS:Amiodarone HCl: Antianginal, class III antiarrhythmic. Lengthens heart muscle action, slows heart rate, reduces vascular resistance.Formula:C25H29I2NO3·HClPurity:99.49% - ≥95%Color and Shape:White To Cream Crystalline PowderMolecular weight:681.78STO-609
CAS:STO-609 inhibits CaM-KKα/KKβ (Ki: 80/15 ng/mL), is specific, cell-permeable, and targets Ca2+/calmodulin-dependent protein kinase kinase.Formula:C19H10N2O3Purity:97.14% - 98.95%Color and Shape:SolidMolecular weight:314.29Ref: TM-T3546
1mg42.00€5mg88.00€10mg127.00€25mg264.00€50mg423.00€100mg655.00€500mg1,359.00€1mL*10mM (DMSO)113.00€Isoniazid
CAS:Isoniazid (Isonicotinic hydrazide) is an antibacterial agent used primarily as a tuberculostatic.Formula:C6H7N3OPurity:98.49% - 99.21%Color and Shape:Colorless Or White Crystals Or A White Crystalline Powder Slightly Sweet At First And Then Bitter Ph (1% Aqueous Solution) 5 5-6 5 Ph (5% Aqueous Solution) 6-Molecular weight:137.14GLPG1837
CAS:GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.Formula:C16H20N4O3SPurity:98.75% - 99.73%Color and Shape:SolidMolecular weight:348.42Ref: TM-T7083
1mg35.00€5mg80.00€10mg120.00€25mg188.00€50mg354.00€100mg537.00€200mg750.00€1mL*10mM (DMSO)88.00€Isosorbide Mononitrate
CAS:Isosorbide Mononitrate (Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.Formula:C6H9NO6Purity:98.16%Color and Shape:Isosorbide-5-Mononitrate Is A Crystalline Solid It Is Very Flammable And May Be Toxic By IngestionMolecular weight:191.14Sulfabenzamide
CAS:Sulfabenzamide (N-Sulfanilylbenzamide) is a sulfonamide antibacterial agent used alone or with sulfathiazole and sulfacetamide as a topical, intravaginalFormula:C13H12N2O3SPurity:99.82%Color and Shape:White To Off-White SolidMolecular weight:276.31UBCS039
CAS:UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)Formula:C16H13N3Purity:99.75%Color and Shape:SolidMolecular weight:247.29Ref: TM-T7679
1mg40.00€5mg81.00€10mg116.00€25mg226.00€50mg324.00€100mg452.00€200mg632.00€1mL*10mM (DMSO)100.00€U0126
CAS:U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively.Formula:C18H16N6S2Purity:98%Color and Shape:White SolidMolecular weight:380.49AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formula:C24H25ClN6OPurity:99.13%Color and Shape:SolidMolecular weight:448.95Vacuolin-1
CAS:Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane.Formula:C26H24IN7OPurity:97.20% - 98.45%Color and Shape:SolidMolecular weight:577.42Nictide
CAS:Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.Formula:C123H193N45O28Color and Shape:SolidMolecular weight:2750.13RAF265
CAS:RAF265 (CHIR-265) inhibits C-Raf/B-Raf/V600E (IC50: 3-60 nM), blocks VEGFR2 (EC50: 30 nM), in Phase 2 trials.Formula:C24H16F6N6OPurity:99.56%Color and Shape:SolidMolecular weight:518.41Ref: TM-T6296
1mg47.00€2mg63.00€5mg87.00€10mg147.00€25mg266.00€50mg435.00€100mg640.00€1mL*10mM (DMSO)99.00€Wortmannin
CAS:Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.Formula:C23H24O8Purity:95.84% - 99.76%Color and Shape:White SolidMolecular weight:428.43Ketanserin
CAS:Ketanserin: quinazoline derivative, 5-HT2 receptor antagonist, may lower blood pressure and inhibit blood clots.Formula:C22H22FN3O3Purity:99.19% - 99.73%Color and Shape:SolidMolecular weight:395.43Mifepristone
CAS:Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.Formula:C29H35NO2Purity:98.9% - ≥95%Color and Shape:Pale Yellow SolidMolecular weight:429.59Cisplatin
CAS:Cisplatin (CDDP) is a DNA cross-linking agent.Formula:Cl2H6N2PtPurity:97.13% - 99.63%Color and Shape:Orange-Yellow To Deep Yellow Solid Or PowderMolecular weight:300.04Bicalutamide
CAS:Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting theFormula:C18H14F4N2O4SPurity:98% - 99.87%Color and Shape:Off-White Crystalline SolidMolecular weight:430.37Carvedilol phosphate hemihydrate
CAS:Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent.Formula:C24H26N2O4·5H2O·H3O4PPurity:99.24%Color and Shape:SolidMolecular weight:513.49Crustecdysone
CAS:Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.Formula:C27H44O7Purity:96.31% - 99.06%Color and Shape:Canary Yellow Fine PowderMolecular weight:480.63SP600125
CAS:SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitiveFormula:C14H8N2OPurity:97.63% - 99.58%Color and Shape:SolidMolecular weight:220.2320-DEOXYINGENOL
CAS:20-DEOXYINGENOL is a natual product.Formula:C20H28O4Purity:99.98% - ≥95%Color and Shape:SolidMolecular weight:332.43Ulipristal acetate
CAS:Ulipristal acetate (CDB-2914) is an oral selective progesterone modulator used for emergency contraception and suppressing uterine growths.Formula:C30H37NO4Purity:98.83% - 99.94%Color and Shape:SolidMolecular weight:475.62SB 216763
CAS:SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Formula:C19H12Cl2N2O2Purity:99.13% - 99.61%Color and Shape:SolidMolecular weight:371.22Ref: TM-T3077
2mg39.00€5mg52.00€10mg79.00€25mg131.00€50mg197.00€100mg334.00€500mg803.00€1mL*10mM (DMSO)52.00€SHP2-IN-35
SHP2-IN-35 (Compound 3f) functions as an inhibitor of SHP2. It exhibits antiproliferative activity in cancer cell lines RKO, SW480, and CT26, with IC50 values of 5.72 μM, 3.71 μM, and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the expression of cell cycle-related genes, and induces mitochondrial autophagy (autophagy). Within the tumor microenvironment (TME), SHP2-IN-35 suppresses the expression of certain cytokines and chemokines, thereby modulating tumor progression.Formula:C34H32FeO6Color and Shape:SolidMolecular weight:592.46Norepinephrine
CAS:Norepinephrine (Levophed) can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway.Formula:C8H11NO3Purity:98.56% - 99.84%Color and Shape:Colorless Micr°Crystals SolidMolecular weight:169.18PAC-1
CAS:PAC-1 (Procaspase activating compound 1) has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer and Thoracic Cancers.Formula:C23H28N4O2Purity:96.78% - 99.77%Color and Shape:SolidMolecular weight:392.49Momelotinib
CAS:Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.Formula:C23H22N6O2Purity:97.47% - 99.56%Color and Shape:SolidMolecular weight:414.46Ref: TM-T1849
1mg38.00€2mg49.00€5mg81.00€10mg95.00€25mg166.00€50mg259.00€100mg406.00€200mg625.00€1mL*10mM (DMSO)88.00€AGN 193109
CAS:AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).Formula:C28H24O2Purity:98.81% - 99.89%Color and Shape:SolidMolecular weight:392.49Ginsenoside Rb1
CAS:Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.Formula:C54H92O23Purity:99.12% - 99.76%Color and Shape:SolidMolecular weight:1109.29Rasagiline Mesylate
CAS:Rasagiline Mesylate (AGN1135) is a novel MAO-B inhibitor, which can treat idiopathic Parkinson's disease.Formula:C13H17NO3SPurity:99.33%Color and Shape:White PowderMolecular weight:267.34
