Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
Sort by
Cucurbitacin E
CAS:Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.Formula:C32H44O8Purity:98.88% - 99.19%Color and Shape:SolidMolecular weight:556.69Ref: TM-T5S1467
1mg59.00€5mg115.00€10mg177.00€25mg300.00€50mg445.00€100mg643.00€1mL*10mM (DMSO)140.00€Nutlin-3a
CAS:Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction. Nutlin-3a has antitumor activity. Cost-effective and quality-assured.Formula:C30H30Cl2N4O4Purity:95.62% - 99.71%Color and Shape:SolidMolecular weight:581.49Ref: TM-T6023
1mg49.00€2mg70.00€5mg96.00€10mg164.00€25mg268.00€50mg398.00€100mg587.00€1mL*10mM (DMSO)135.00€Valinomycin
CAS:Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes ParkinFormula:C54H90N6O18Purity:100%Color and Shape:White SolidMolecular weight:1111.32Sophocarpine monohydrate
CAS:Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.Formula:C15H22N2OPurity:99.55%Color and Shape:SolidMolecular weight:246.35AM580
CAS:AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )Formula:C22H25NO3Purity:98% - 99.89%Color and Shape:SolidMolecular weight:351.44Ref: TM-T5854
2mg39.00€5mg57.00€10mg87.00€25mg164.00€50mg316.00€100mg469.00€500mg1,064.00€1mL*10mM (DMSO)64.00€LYN-1604
CAS:LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.Formula:C33H43Cl2N3O2Purity:98%Color and Shape:SolidMolecular weight:584.62Stavudine
CAS:Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.Formula:C10H12N2O4Purity:100% - 99.74%Color and Shape:White PowderMolecular weight:224.213-Methyladenine
CAS:3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).Formula:C6H7N5Purity:98.02% - 99.51%Color and Shape:SolidMolecular weight:149.15Typhaneoside
CAS:Typhaneoside (Aervitrin) is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Shaofu Zhuyu decoction.Formula:C34H42O20Purity:98.92% - 99.95%Color and Shape:SolidMolecular weight:770.69Glycycoumarin
CAS:Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.Formula:C21H20O6Purity:97.64% - 99.78%Color and Shape:SolidMolecular weight:368.38Ref: TM-TN1702
1mg42.00€5mg81.00€10mg122.00€25mg235.00€50mg348.00€100mg515.00€200mg743.00€1mL*10mM (DMSO)89.00€Telaglenastat
CAS:Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.Formula:C26H24F3N7O3SPurity:100% - 99.89%Color and Shape:SolidMolecular weight:571.57Ref: TM-T6797
1g1,130.00€2mg38.00€5mg51.00€10mg79.00€25mg126.00€50mg210.00€100mg350.00€500mg825.00€1mL*10mM (DMSO)65.00€Dantrolene sodium hemiheptahydrate
CAS:Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calciumFormula:C14H9N4NaO5·5H2OPurity:99.72%Color and Shape:Orange PowderMolecular weight:399.29Fangchinoline
CAS:Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.Formula:C37H40N2O6Purity:98.81% - 99.86%Color and Shape:SolidMolecular weight:608.72Bexarotene
CAS:Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).Formula:C24H28O2Purity:99% - 99.65%Color and Shape:White SolidMolecular weight:348.48Vemurafenib
CAS:Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently.Formula:C23H18ClF2N3O3SPurity:98% - 99.65%Color and Shape:SolidMolecular weight:489.92FKBP51F67V-selective antagonist Ligand2
CAS:FKBP51F67V-selective antagonist Ligand2 (example 3-3), a potent ligand, selectively binds to the FKBP51 F67V variant, with no affinity for wild-type FKBP51 orFormula:C43H56N2O10Purity:98%Color and Shape:SolidMolecular weight:760.91Tarenflurbil
CAS:Tarenflurbil, the R-enantiomer of flurbiprofen, lacks COX inhibition and was tested for Alzheimer's treatment.Formula:C15H13FO2Purity:100% - 98%Color and Shape:SolidMolecular weight:244.26NVP-AEW541
CAS:NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-basedFormula:C27H29N5OPurity:96.03% - 99.55%Color and Shape:SolidMolecular weight:439.55PHA-665752
CAS:PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs.Formula:C32H34Cl2N4O4SPurity:97.01% - 99.35%Color and Shape:SolidMolecular weight:641.61Oleanolic Acid
CAS:Oleanolic Acid (Caryophyllin) is a natural compound with anti-tumor activities, which are widely distributed in plants.Formula:C30H48O3Purity:98.4% - 98.51%Color and Shape:SolidMolecular weight:456.7GW406108X
CAS:GW406108X is a Kif15 and ULK1 inhibitor; IC50: 0.82 µM (ATPase), pIC50: 6.37; blocks autophagy.Formula:C20H11Cl2NO4Purity:98%Color and Shape:SolidMolecular weight:400.21AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purity:98.6% - 99.39%Color and Shape:Yellow SolidMolecular weight:294.3Brefeldin A
CAS:Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM).Formula:C16H24O4Purity:96.45% - 99.89%Color and Shape:White SolidMolecular weight:280.36Tolbutamide
CAS:Tolbutamide (HLS 831) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.Formula:C12H18N2O3SPurity:99.80% - 99.93%Color and Shape:White Crystalline PowderMolecular weight:270.35Pyrazinamide
CAS:Pyrazinamide (Pyrazinecarboxamide), an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amideFormula:C5H5N3OPurity:99.71% - 99.81%Color and Shape:Crystals Physical Description White Powder Sublimes From 318°F (Ntp 1992)Molecular weight:123.11Elaiophylin
CAS:Elaiophylin exhibits anti-Plasmodium falciparum and anti-Trypanosoma brucei activity; IC50: 0.36 μM & 0.45 μM, respectively.Formula:C54H88O18Purity:98%Color and Shape:SolidMolecular weight:1025.27BMS-582949 hydrochloride
CAS:The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).Formula:C22H27ClN6O2Purity:97.57% - 98.75%Color and Shape:SolidMolecular weight:442.95Ref: TM-T3462
1mg35.00€5mg71.00€10mg101.00€25mg170.00€50mg264.00€100mg393.00€200mg552.00€1mL*10mM (DMSO)78.00€Sanguinarine chloride
CAS:Sanguinarine chloride (Pseudochelerythrine chloride), a benzophenanthridine alkaloid, stimulates apoptosis by activating the production of reactive oxygenFormula:C20H14ClNO4Purity:98% - 99.41%Color and Shape:SolidMolecular weight:367.78Obatoclax Mesylate
CAS:Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, andFormula:C20H19N3O·CH4O3SPurity:99.67% - 99.88%Color and Shape:SolidMolecular weight:413.49Rosiglitazone hydrochloride
CAS:Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.Formula:C18H19N3O3S·HClPurity:99.63% - 99.79%Color and Shape:SolidMolecular weight:393.89Fludrocortisone acetate
CAS:Fludrocortisone acetate (9α-Fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, andFormula:C23H31FO6Purity:96.92% - 98.03%Color and Shape:Crystalline SolidMolecular weight:422.49(-)-Epicatechin gallate
CAS:(-)-Epicatechin gallate, a catechin isomer and strong antioxidant, affects membrane proteins and alters gA channel function in bilayers.Formula:C22H18O10Purity:96.65% - 99.72%Color and Shape:SolidMolecular weight:442.37ATG12-IN-1
CAS:ATG12-IN-1 (compound 4) acts as an autophagy inhibitor targeting the ATG12-ATG3 protein-protein interaction (IC50= 9 μM), suitable for research in cancer studies.Formula:C23H15ClN4O2Color and Shape:SolidMolecular weight:414.84BPO-27 racemate
CAS:BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.Formula:C26H18BrN3O6Purity:98.19%Color and Shape:SolidMolecular weight:548.34Ref: TM-T10591
1mg47.00€5mg117.00€10mg170.00€25mg280.00€50mg409.00€100mg565.00€200mg758.00€1mL*10mM (DMSO)135.00€Quercetin
CAS:Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1.Formula:C15H10O7Purity:96.29% - 98.05%Color and Shape:Sensitive To Exposure To Air And Light Insoluble In Water Alcoholic Solutions Taste Very Bitter (Ntp 1992)Molecular weight:302.24Cediranib
CAS:Cediranib (AZD2171) is a potent KDR tyrosine kinase inhibitor (IC50 < 1nM), also targets Flt1/4, PDGFRβ, c-Kit, and more selective for VEGFR.Formula:C25H27FN4O3Purity:97.21% - 99.94%Color and Shape:SolidMolecular weight:450.51Ref: TM-T2500
2mg42.00€5mg63.00€10mg92.00€25mg136.00€50mg177.00€100mg254.00€200mg462.00€500mg742.00€1mL*10mM (DMSO)69.00€Ursolic acid
CAS:Ursolic acid (Prunol) is a natural pentacyclic triterpene carboxylic acid. Ursolic acid has anti-tumor and anti-inflammatory effects. Cost-effective and quality-assured.Formula:C30H48O3Purity:99.66% - 99.79%Color and Shape:Platelets From Alcohol SolidMolecular weight:456.7LY294002
CAS:LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).Formula:C19H17NO3Purity:98% - 99.96%Color and Shape:Pale Yellow SolidMolecular weight:307.34Nobiletin
CAS:Nobiletin: a citrus-derived flavone with anti-inflammatory and anti-cancer properties; water-insoluble, very weak acid.Formula:C21H22O8Purity:98.78% - 99.76%Color and Shape:SolidMolecular weight:402.39Ref: TM-T2834
5mg57.00€10mg88.00€25mg124.00€50mg168.00€100mg265.00€200mg393.00€500mg653.00€1mL*10mM (DMSO)59.00€Sinomenine
CAS:Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.Formula:C19H23NO4Purity:99.02% - 99.89%Color and Shape:White PowderMolecular weight:329.39Sulfosuccinimidyl oleate
CAS:Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells.Formula:C22H37NO7SPurity:98%Color and Shape:SolidMolecular weight:459.6Tubastatin A
CAS:Tubastatin A: Selective HDAC6 inhibitor, IC50 of 15 nM, 1000x less effective on other isozymes except HDAC8.Formula:C20H21N3O2Purity:97.22% - 99.51%Color and Shape:SolidMolecular weight:335.4Ref: TM-T1966
10mg48.00€25mg64.00€50mg79.00€100mg111.00€200mg169.00€500mg274.00€1mL*10mM (DMSO)47.00€N-Benzylpalmitamide
CAS:N-Benzylpalmitamide (Macamide 1) inhibits fatty acid amide hydrolase (FAAH) in a time-dependent manner and could potentially offer a good alternative for theFormula:C23H39NOPurity:97.08% - 99.77%Color and Shape:SolidMolecular weight:345.56LG-100064
CAS:LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)Formula:C23H26O3Purity:98.65%Color and Shape:SolidMolecular weight:350.45Ref: TM-T11844
2mg47.00€5mg70.00€10mg97.00€25mg167.00€50mg249.00€100mg369.00€200mg545.00€1mL*10mM (DMSO)77.00€Icaritin
CAS:Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity.Formula:C21H20O6Purity:97.69% - 98.96%Color and Shape:SolidMolecular weight:368.38EAD1
CAS:EAD1 is a useful organic compound for research related to life sciences. The catalog number is T35329 and the CAS number is 1644388-26-0.Formula:C24H27Cl2N7Purity:98%Color and Shape:SolidMolecular weight:484.42R1487 Hydrochloride
CAS:R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.Formula:C19H19ClF2N4O3Purity:99.42%Color and Shape:SolidMolecular weight:424.834E2RCat
CAS:4E2RCat is an inhibitor of eIF4E-eIF4G interaction (IC50 = 13.5 μM) and is capable of blocking coronavirus replication as monitored by viral protein expressionFormula:C22H14ClNO4S2Purity:96.48%Color and Shape:SolidMolecular weight:455.93Onjisaponin B
CAS:Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-Formula:C75H112O35Purity:99.20% - 99.88%Color and Shape:SolidMolecular weight:1573.67Rilmenidine Phosphate
CAS:Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension.Formula:C10H19N2O5PPurity:99.87% - ≥95%Color and Shape:SolidMolecular weight:278.24Ref: TM-T6641
1mg40.00€5mg88.00€10mg137.00€25mg264.00€50mg418.00€100mg627.00€500mg1,301.00€1mL*10mM (DMSO)87.00€
