Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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VISTA-IN-2
CAS:VISTA-IN-2 (Compound 1) is a V-domain Ig suppressor of T-cell activation (VISTA) inhibitor that promotes the degradation of VISTA in cells via autophagy,Formula:C23H23N3OPurity:98%Color and Shape:SolidMolecular weight:357.45Reversine
CAS:Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Formula:C21H27N7OPurity:98% - 99.75%Color and Shape:SolidMolecular weight:393.49Ref: TM-T1825
1mg38.00€2mg49.00€5mg70.00€10mg88.00€25mg164.00€50mg224.00€100mg393.00€1mL*10mM (DMSO)70.00€TA-01
CAS:TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.Formula:C20H12F3N3Purity:98.77% - 99.94%Color and Shape:SolidMolecular weight:351.32Ref: TM-T4645
2mg35.00€5mg52.00€10mg85.00€25mg156.00€50mg235.00€100mg329.00€200mg464.00€1mL*10mM (DMSO)71.00€10074-G5
CAS:10074-G5 is an inhibitor of c-Myc-Max dimerization.Formula:C18H12N4O3Purity:97.22% - 99.67%Color and Shape:SolidMolecular weight:332.31Ref: TM-T3686
2mg42.00€5mg63.00€10mg88.00€25mg142.00€50mg225.00€100mg396.00€200mg565.00€500mg900.00€1mL*10mM (DMSO)69.00€Temozolomide
CAS:Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity.Formula:C6H6N6O2Purity:98% - 99.87%Color and Shape:Off-White To Light-Pink Crystalline SolidMolecular weight:194.15Ref: TM-T1178
1g236.00€10mg49.00€25mg74.00€50mg89.00€100mg96.00€200mg127.00€500mg166.00€1mL*10mM (DMSO)59.00€Neferine
CAS:Neferine: anti-tumor, enhances DOX efficacy, prevents diabetic vasculopathy; mediates via CYP3A4, GSH depletion, blocks ROS/Akt/NF-κB.Formula:C38H44N2O6Purity:98.81% - 99.18%Color and Shape:SolidMolecular weight:624.77Metyrapone
CAS:Metyrapone (NSC-25265) blocks steroid 11β-monooxygenase, used to diagnose Cushing's syndrome.Formula:C14H14N2OPurity:99.03% - ≥95%Color and Shape:Crystals From Ether & Pentane SolidMolecular weight:226.27Afzelin
CAS:Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-Formula:C21H20O10Purity:98.92% - 99.38%Color and Shape:SolidMolecular weight:432.38DCC-3116
CAS:DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.Formula:C26H36F3N7O2Purity:98.80%Color and Shape:SoildMolecular weight:535.61Autocamtide-2-related inhibitory peptide
CAS:Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.Formula:C64H116N22O19Purity:100%Color and Shape:SolidMolecular weight:1497.74Nitroxoline
CAS:Nitroxoline (5-nitroquinolin-8-ol) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found inFormula:C9H6N2O3Purity:97.74% - ≥98%Color and Shape:SolidMolecular weight:190.16Sertaconazole nitrate
CAS:Sertaconazole nitrate, a broad-spectrum topical antifungal, treats skin and mucosal infections.Formula:C20H15Cl3N2OS·HNO3Purity:98.66%Color and Shape:SolidMolecular weight:500.78Silmitasertib
CAS:Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).Formula:C19H12ClN3O2Purity:98% - 99.90%Color and Shape:SolidMolecular weight:349.77Ref: TM-T2259
1mg40.00€2mg51.00€5mg85.00€10mg125.00€25mg207.00€50mg329.00€100mg520.00€500mg1,111.00€1mL*10mM (DMSO)93.00€Necrostatin-1
CAS:Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity.Formula:C13H13N3OSPurity:100% - 99.81%Color and Shape:SolidMolecular weight:259.33Ref: TM-T1847
5mg35.00€10mg49.00€25mg82.00€50mg113.00€100mg170.00€200mg250.00€500mg419.00€1mL*10mM (DMSO)52.00€Scutellarein
CAS:Scutellarein (6-Hydroxyapigenin) reduces inflammatory responses by inhibiting Src kinase activity.Formula:C15H10O6Purity:98.02% - 99.63%Color and Shape:SolidMolecular weight:286.24LY2183240
CAS:LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM).Formula:C17H17N5OPurity:99.26%Color and Shape:SolidMolecular weight:307.35PF-543
CAS:PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.Formula:C27H31NO4SPurity:99.02%Color and Shape:SolidMolecular weight:465.6Ref: TM-T6085
1mg50.00€5mg106.00€10mg156.00€25mg251.00€50mg374.00€100mg557.00€200mg903.00€1mL*10mM (DMSO)124.00€Lumacaftor
CAS:Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.Formula:C24H18F2N2O5Purity:99.48% - 99.68%Color and Shape:SolidMolecular weight:452.41D4476
CAS:D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).Formula:C23H18N4O3Purity:99.02% - 99.96%Color and Shape:SolidMolecular weight:398.41Ref: TM-T2449
1mg43.00€2mg55.00€5mg78.00€10mg95.00€25mg159.00€50mg226.00€100mg408.00€200mg597.00€500mg938.00€1mL*10mM (DMSO)86.00€Pennogenin 3-O-β-chacotrioside
CAS:Pennogenin 3-O-beta-chacotrioside from Paris polyphylla fights colorectal cancer, boosting autophagy proteins LC3 and Beclin-1.Formula:C45H72O17Purity:99.69% - 99.77%Color and Shape:SolidMolecular weight:885.043PO
CAS:3PO inhibits PFKFB3 (IC50: 22.9 µM) and cancer cell growth (IC50: 1.4-24 µM), reducing glucose uptake and key cellular metabolites.Formula:C13H10N2OPurity:97.76% - 99.67%Color and Shape:SolidMolecular weight:210.23Ref: TM-T22223
5mg57.00€10mg81.00€25mg127.00€50mg188.00€100mg340.00€200mg507.00€500mg807.00€1mL*10mM (DMSO)64.00€Emodin
CAS:Emodin, a plant-derived anthraquinone, inhibits Y cell growth via various signaling pathways.Formula:C15H10O5Purity:94.4% - 98.9%Color and Shape:Physical Description Orange Needles Or Powder (Ntp 1992)Molecular weight:270.24Cucurbitacin B
CAS:Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Formula:C32H46O8Purity:97.10% - 99.33%Color and Shape:SolidMolecular weight:558.7EIPA
CAS:EIPA (L593754) is a TRPP3 channel inhibitor and an inhibitor of Na+/H+ exchange (NHE). EIPA inhibits megacytosis, promotes autophagy. Cost-effective and quality-assured.Formula:C11H18ClN7OPurity:96.62% - 98.52%Color and Shape:Off-White To Yellow SolidMolecular weight:299.76Schisandrol B
CAS:Schisandrol B fights neuroinflammation, liver/renal damage, and reduces cell growth via multiple signaling pathways.Formula:C23H28O7Purity:99.14% - 99.32%Color and Shape:SolidMolecular weight:416.46Ref: TM-T6S1917
5mg71.00€10mg96.00€25mg202.00€50mg303.00€100mg452.00€500mg1,035.00€1mL*10mM (DMSO)79.00€Mdivi-1
CAS:Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM).Formula:C15H10Cl2N2O2SPurity:96.57% - 99.6%Color and Shape:SolidMolecular weight:353.22Ref: TM-T1907
5mg47.00€10mg56.00€25mg90.00€50mg153.00€100mg227.00€200mg338.00€500mg558.00€1mL*10mM (DMSO)50.00€Turofexorate Isopropyl
CAS:Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nMFormula:C25H24F2N2O3Purity:99.33% - 99.73%Color and Shape:SolidMolecular weight:438.47ROC-325
CAS:ROC-325: orally active autophagy inhibitor with anticancer effects, induces kidney cancer cell death; selective action.Formula:C28H27ClN4OSPurity:99.26%Color and Shape:SolidMolecular weight:503.06Ref: TM-T16777
1mg35.00€2mg47.00€5mg64.00€10mg97.00€25mg188.00€50mg311.00€100mg449.00€500mgTo inquireOlaparib
CAS:View and buy Olaparib from TargetMol.Olaparib is a small molecule inhibitor of PARP1/PARP2.Cited in 10 publications.Formula:C24H23FN4O3Purity:100% - 99.90%Color and Shape:SolidMolecular weight:434.46Autophagy-IN-6
Autophagy-IN-6 (compound 1u) is an inhibitor of lysosomal autophagy that induces the accumulation of the LC3-II protein. Additionally, it exhibits antiproliferative activity.Formula:C28H43N3O3Color and Shape:SolidMolecular weight:469.66MRT68921
CAS:MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.Formula:C25H34N6OPurity:99.23%Color and Shape:SolidMolecular weight:434.58Trimetazidine dihydrochloride
CAS:Trimetazidine, an anti-ischemic agent, enhances myocardial glucose use, inhibits fat metabolism, and helps with angina.Formula:C14H24Cl2N2O3Purity:99.58%Color and Shape:Crystalline SolidMolecular weight:339.258Dexamethasone acetate
CAS:Dexamethasone acetate (NSC 39471) is a potent anti-inflammatory steroid, blocks NF-kB, and lacks salt-retention.Formula:C24H31FO6Purity:99.22% - 99.65%Color and Shape:White Or Almost White Crystalline PowderMolecular weight:434.5Bardoxolone Methyl
CAS:Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-Formula:C32H43NO4Purity:97.81% - 99.09%Color and Shape:SolidMolecular weight:505.69Ref: TM-T6165
10mg47.00€25mg65.00€50mg88.00€100mg119.00€200mg187.00€500mg424.00€1mL*10mM (DMSO)50.00€FIPI
CAS:FIPI, a halopemide derivative, strongly blocks PLD1 and PLD2 (IC50s: 25 nM, 20 nM) and hinders PLD-mediated cell activity.Formula:C23H24FN5O2Purity:98.01% - 99.08%Color and Shape:SolidMolecular weight:421.47Etoposide
CAS:Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM).Formula:C29H32O13Purity:99.19% - 99.94%Color and Shape:Crystals From Methanol SolidMolecular weight:588.56Diosgenin glucoside
CAS:Diosgenin glucoside (Trillin) and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosisFormula:C33H52O8Purity:97.17% - 99.44%Color and Shape:SolidMolecular weight:576.76Leonurine
CAS:Leonurine (SCM-198) is an alkaloid that has been found in H. leonuri and with anti-oxidative and anti-inflammatory.Formula:C14H21N3O5Purity:98.55%Color and Shape:White Crystalline PowderMolecular weight:311.33Pentoxifylline
CAS:Pentoxifylline (PTX) stimulates cytokines, inhibits phosphodiesterase, enhances blood flow, and increases cell flexibility.Formula:C13H18N4O3Purity:99.26% - 99.96%Color and Shape:SolidMolecular weight:278.31UM-164
CAS:UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.Formula:C30H31F3N8O3SPurity:98.72% - 99.52%Color and Shape:SolidMolecular weight:640.68CCT128930
CAS:'CCT128930, potent Akt2 inhibitor (IC50=6 nM), 28x more selective over PKA.'Formula:C18H20ClN5Purity:99.07% - 99.18%Color and Shape:SolidMolecular weight:341.84Ref: TM-T6303
2mg42.00€5mg65.00€10mg94.00€25mg170.00€50mg273.00€100mg409.00€200mg652.00€1mL*10mM (DMSO)71.00€Icariin
CAS:Icariin (Ieariline) is a flavonol glycoside that inhibits PDE5 and PDE4 activity and is a PPARα activator. Cost-effective and quality-assured.Formula:C33H40O15Purity:97.82% - 98.49%Color and Shape:SolidMolecular weight:676.66Irinotecan Hydrochloride
CAS:Irinotecan HCl, a camptothecin derivative prodrug, becomes active metabolite SN-38, inhibiting topoisomerase I to trigger apoptosis.Formula:C33H39ClN4O6Purity:98% - 99.94%Color and Shape:Yellow Crystalline PowderMolecular weight:623.14Ref: TM-T0486L
10mg35.00€25mg52.00€50mg69.00€100mg95.00€200mg136.00€500mg268.00€1mL*10mM (DMSO)74.00€Nicardipine hydrochloride
CAS:Nicardipine hydrochloride is a potent calcium channel blocker used to dilate cerebral and coronary vessels.Formula:C26H30ClN3O6Purity:99.58% - 99.89%Color and Shape:Yellow SolidMolecular weight:515.99Verteporfin
CAS:Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions.Formula:C41H42N4O8Purity:95.37% - 99.82%Color and Shape:Dark Green To Black SolidMolecular weight:718.79Ref: TM-T3112
1mg40.00€2mg51.00€5mg85.00€10mg115.00€25mg225.00€50mg365.00€100mg462.00€1mL*10mM (DMSO)120.00€BL-918
CAS:BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM.Formula:C23H15F8N3OSPurity:99.11% - 99.40%Color and Shape:SolidMolecular weight:533.44Ref: TM-T8322
1mg49.00€2mg70.00€5mg104.00€10mg156.00€25mg284.00€50mg455.00€100mg747.00€500mg1,501.00€1mL*10mM (DMSO)127.00€4E1rcat
CAS:4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.Formula:C28H18N2O6Purity:99.36%Color and Shape:SolidMolecular weight:478.45Atezolizumab
CAS:Atezolizumab is an antibody inhibitor, a humanized monoclonal antibody, IgG1, which targets PD-L1. Atezolizumab has antitumor effect. Cost-effective and quality-assured.Purity:95.10% - 99.3% （SEC-HPLC）Color and Shape:LiquidMolecular weight:145 kDaTamibarotene
CAS:Tamibarotene (Amnolake) is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplasticFormula:C22H25NO3Purity:97.22% - 98.2%Color and Shape:Crystalline SolidMolecular weight:351.44Ref: TM-T6694
1g369.00€10mg47.00€25mg64.00€50mg79.00€100mg97.00€200mg153.00€500mg249.00€1mL*10mM (DMSO)47.00€PF-06454589
CAS:PF-06454589 is a potent inhibitor of LRRK2.Formula:C14H16N6OPurity:99.06%Color and Shape:SolidMolecular weight:284.32Ref: TM-T7729
2mg35.00€5mg50.00€10mg80.00€25mg135.00€50mg197.00€100mg306.00€200mg442.00€1mL*10mM (DMSO)55.00€
