Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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Deguelin
CAS:Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.Formula:C23H22O6Purity:96.39% - 99.29%Color and Shape:SolidMolecular weight:394.42Idarubicin hydrochloride
CAS:Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Formula:C26H27NO9·HClPurity:100% - 99.93%Color and Shape:SolidMolecular weight:533.95Ancitabine hydrochloride
CAS:Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity.Formula:C9H12ClN3O4Purity:99.02% - 99.37%Color and Shape:White SolidMolecular weight:261.66SMER28
CAS:SMER28 triggers autophagy in cells without mTOR, blocking amyloid beta buildup.Formula:C11H10BrN3Purity:99.94% - 99.97%Color and Shape:SolidMolecular weight:264.12Ref: TM-T3155
5mg51.00€10mg73.00€25mg127.00€50mg235.00€100mg452.00€200mg660.00€500mg1,035.00€1mL*10mM (DMSO)51.00€Sapanisertib
CAS:Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.Formula:C15H15N7OPurity:100% - 99.67%Color and Shape:SolidMolecular weight:309.33Ref: TM-T1838
1mg40.00€2mg51.00€5mg85.00€10mg96.00€25mg160.00€50mg235.00€100mg350.00€500mg838.00€1mL*10mM (DMSO)88.00€DPN
CAS:DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) .Formula:C15H13NO2Purity:99.01%Color and Shape:Off-White SolidMolecular weight:239.27Memantine hydrochloride
CAS:Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects.Formula:C12H22ClNPurity:99.56% - 99.96%Color and Shape:Crystalline SolidMolecular weight:215.763Britannin
CAS:Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.Formula:C19H26O7Purity:98% - 98.53%Color and Shape:SolidMolecular weight:366.41Oxyphenisatin acetate
CAS:Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.Formula:C24H19NO5Purity:98% - 98.62%Color and Shape:SolidMolecular weight:401.41Baicalin
CAS:Baicalin (Baicalein 7-O-β-D-glucuronide) is a prolyl endopeptidase inhibitor isolated from scutellaria baicalensis, with antioxidant, anti-tumor, anti-HIVFormula:C21H18O11Purity:90.08% - 99.25%Color and Shape:Yellow PowderMolecular weight:446.36Hoechst 33342
CAS:Hoechst 33342: a benzimidazole dye, DNA stain for AT-rich regions, cell-permeable, quantifies DNA in live cells.Formula:C27H28N6OPurity:98.45% - 99.57%Color and Shape:Yellow-Green PowderMolecular weight:452.55Retinoic acid
CAS:Retinoic acid (Tretinoin) binds to and activates RARs, thereby inducing changes in gene expression that lead to inhibition of tumorigenesis.Formula:C20H28O2Purity:97.21% - 99.6%Color and Shape:Yellow-Orange PowderMolecular weight:300.44Crenolanib
CAS:Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).Formula:C26H29N5O2Purity:97.45% - 99.28%Color and Shape:SolidMolecular weight:443.54SBI-0206965
CAS:SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.Formula:C21H21BrN4O5Purity:99.13%Color and Shape:SolidMolecular weight:489.32DAPT
CAS:DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active.Formula:C23H26F2N2O4Purity:98.06% - 99.81%Color and Shape:White SolidMolecular weight:432.46Ref: TM-T6202
5mg58.00€10mg88.00€25mg165.00€50mg279.00€100mg414.00€200mg517.00€500mg835.00€1mL*10mM (DMSO)59.00€Omeprazole Sodium
CAS:Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion.Formula:C17H18N3NaO3SPurity:99.57%Color and Shape:Clear In WaterMolecular weight:367.4SR-3677
CAS:SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).Formula:C22H24N4O4Purity:98.46%Color and Shape:SolidMolecular weight:408.45H-89 dihydrochloride
CAS:H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).Formula:C20H20BrN3O2S·2HClPurity:100% - 99.40%Color and Shape:SolidMolecular weight:519.28Ref: TM-T6250
5mg39.00€10mg58.00€25mg106.00€50mg202.00€100mg344.00€200mg512.00€500mg815.00€1mL*10mM (DMSO)52.00€Meloxicam
CAS:Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug.Formula:C14H13N3O4S2Purity:97.09% - 99.60%Color and Shape:Light Yellow SolidMolecular weight:351.4Autogramin-2
CAS:Autogramin-2 (tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate) potently inhibits autophagy induced by eitherFormula:C21H27N3O4SPurity:96.25%Color and Shape:SolidMolecular weight:417.52AS-605240
CAS:AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).Formula:C12H7N3O2SPurity:97% - 99.91%Color and Shape:SolidMolecular weight:257.27PTC-209
CAS:PTC-209 is a potent and selective BMI-1 inhibitor.Formula:C17H13Br2N5OSPurity:99.43% - 99.60%Color and Shape:SolidMolecular weight:495.19Curcumin
CAS:Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity.Formula:C21H20O6Purity:95% - 98.98%Color and Shape:Orange-Yellow Crystal Powder; Gives Brownish-Red Color With Alkali; Light-Yellow Color With Acids Physical Description Orange-Yellow Needles (Ntp 1992)Molecular weight:368.3799JH-II-127
CAS:JH-II-127 is an oral LRRK2 inhibitor with IC50s: 6.6 nM (WT), 2.2 nM (G2019S), 47.7 nM (A2016T).Formula:C19H21ClN6O3Purity:98.32%Color and Shape:SolidMolecular weight:416.86Pantoprazole
CAS:Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal refluxFormula:C16H15F2N3O4SPurity:99.28% - 99.63%Color and Shape:Almost White SolidMolecular weight:383.37MAO-B-IN-26
CAS:MAO-B-IN-26 (Compound IC9) serves as both a MAO-B and acetylcholinesterase inhibitor.Formula:C17H12BrNOPurity:98%Color and Shape:SolidMolecular weight:326.19Tea polyphenol
CAS:Tea polyphenol, also called green tea extract, are a mixture of chemical compounds, such as flavanoids and tannins, found naturally in tea.Formula:C17H19N3OPurity:98%Color and Shape:Yelloish Green Free Flowing PowderMolecular weight:281.36Venetoclax
CAS:Venetoclax (ABT-199) is a selective inhibitor of Bcl-2 (Ki < 0.010 nM), binding over 3 orders of magnitude less avidly to Bcl-xL, and Bcl-W (Kis = 48/245 nM).Formula:C45H50ClN7O7SPurity:98% - 99.96%Color and Shape:SolidMolecular weight:868.44LY2109761
CAS:LY2109761: a TGF-β dual inhibitor, Ki=38 nM (TβRI) & 300 nM (TβRII), hinders Smad2 phosphorylation.Formula:C26H27N5O2Purity:97% - 99.83%Color and Shape:SolidMolecular weight:441.52Ref: TM-T2123
2mg47.00€5mg70.00€10mg111.00€25mg188.00€50mg335.00€100mg507.00€200mg730.00€1mL*10mM (DMSO)77.00€Regorafenib monohydrate
CAS:Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murineFormula:C21H17ClF4N4O4Purity:99.69%Color and Shape:SolidMolecular weight:500.83Ref: TM-T1792L
5mg35.00€10mg48.00€25mg69.00€50mg88.00€100mg140.00€200mg207.00€500mg348.00€1mL*10mM (DMSO)58.00€Thalidomide
CAS:Thalidomide, a glutamic acid derivative, has teratogenic and immunomodulatory effects.Formula:C13H10N2O4Purity:98.88% - 99.88%Color and Shape:White SolidMolecular weight:258.23Taxifolin
CAS:Taxifolin (Dihydroquercetin) is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.Formula:C15H12O7Purity:94.91% - 98.9%Color and Shape:Yellowish PowderMolecular weight:304.25Beclin1-ATG14L interaction inhibitor 1
CAS:Beclin1-ATG14L Interaction Inhibitor 1 (COM 19) is a selective inhibitor targeting the specific interaction between Beclin1 and ATG14L.Formula:C23H24N4O5SPurity:98%Color and Shape:SolidMolecular weight:468.53Matrine
CAS:Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.Formula:C15H24N2OPurity:100% - 97.16%Color and Shape:SolidMolecular weight:248.36SLW131
CAS:SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.Formula:C21H27N5O5SColor and Shape:SolidMolecular weight:461.535Alginic acid
CAS:Alginic acid, a polysaccharide from brown seaweed, has anti-anaphylactic and anti-inflammatory properties and is used in food industry.Formula:C14H22O13Purity:≥98%Color and Shape:SolidMolecular weight:398.317GSK-690693
CAS:GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.Formula:C21H27N7O3Purity:100% - 98.78%Color and Shape:SolidMolecular weight:425.48Brivanib
CAS:Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold againstFormula:C19H19FN4O3Purity:98.87%Color and Shape:SolidMolecular weight:370.38Ref: TM-T6036
1mg47.00€5mg88.00€10mg144.00€25mg259.00€50mg375.00€100mg560.00€200mg815.00€1mL*10mM (DMSO)97.00€SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Formula:C20H22F3N5OPurity:100% - 99.84%Color and Shape:SolidMolecular weight:405.42Carboplatin
CAS:Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor.Formula:C6H12N2O4PtPurity:98% - 99.72%Color and Shape:White Crystalline PowderMolecular weight:371.25Licochalcone A
CAS:Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.Formula:C21H22O4Purity:98.11% - 98.96%Color and Shape:White Crystalline PowderMolecular weight:338.4PD 169316
CAS:PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.Formula:C20H13FN4O2Purity:98.65%Color and Shape:SolidMolecular weight:360.34URB-597
CAS:URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.Formula:C20H22N2O3Purity:98.24%Color and Shape:SolidMolecular weight:338.4LRRK2-IN-10
CAS:LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2Formula:C20H15N5OPurity:98%Color and Shape:SolidMolecular weight:341.37LC3-mHTT-IN-AN1
CAS:LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B.Formula:C15H9Br2NO3Purity:97.26%Color and Shape:SolidMolecular weight:411.04Spautin-1
CAS:Spautin-1 is an autophagy inhibitor that can suppress the deubiquitination activity of ubiquitin-specific peptidase USP10 and USP13. Cost-effective and quality-assured.Formula:C15H11F2N3Purity:97.69% - 98.99%Color and Shape:SolidMolecular weight:271.26Nesolicaftor
CAS:Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.Formula:C18H18N4O4Purity:98.64%Color and Shape:SolidMolecular weight:354.36Ref: TM-T16681
1mg96.00€5mg215.00€10mg378.00€25mg650.00€50mg927.00€100mg1,254.00€1mL*10mM (DMSO)236.00€2-Methoxyestradiol
CAS:2-ME2, an estradiol derivative, hinders angiogenesis and tumor growth, causes cell apoptosis, and stops mitosis.Formula:C19H26O3Purity:98% - 99.95%Color and Shape:Off-White SolidMolecular weight:302.41Schisandrin
CAS:Schisandrin (Wuweizi alcohol-A) is a compound with anti-asthmatic, anti-cancer, and anti-inflammatory effects.Formula:C24H32O7Purity:98.97% - 99.32%Color and Shape:White PowderMolecular weight:432.51
