Autophagy

Cysteamine hydrochloride (Thioethanolamine Hydrochloride) is an agent for the treatment of nephropathic cystinosis and an antioxidant.

AICAR (Acadesine) 是一种AMPK 激活剂,引起ZMP积累,模拟AMP对AMPK和AMPKK的刺激作用,常用于糖尿病,心脑血管疾病以及肿瘤相关研究。

DL-Selenomethionine (SeMet) is a selenium analog of methionine, substituting sulfur with selenium, and can replace methionine in proteins.

UNC0638 inhibits G9a and GLP lysine methyltransferases with IC50 <15 nM and 19 nM, respectively, showing high selectivity.

Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.

Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an orally HMG-CoA reductase inhibitor that lowers cholesterol. Cost-effective and quality-assured.

Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FKBP to form a complex.

Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae, and used orally for various fungal and parasitic infections.

(1E,6E)-Bis(demethoxy)curcumin (Curcumin III) is a natural demethoxy derivative of curcumin,with anti-inflammatory and anti-cancer activities.

ABT-737 is a BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w. ABT-737 exhibits antitumor activity and anti-aging activity. Cost-effective and quality-assured.

D-CopA3 is an inhibitor of MDM2 and an activator of the p53 signaling pathway. It exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO with IC50 values of 15-18 μM and induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of the cell cycle inhibitor protein p21Cip1/Waf1, enhances mucosal barrier function, and reduces infiltration of inflammatory mediators. It shows anti-inflammatory properties in mouse models of acute enteritis induced by C. difficile toxin A and chronic colitis induced by DSS. Additionally, D-CopA3 demonstrates antitumor activity in a mouse HCT-116 xenograft model.

6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties.

Nocodazole: synthetic microtubule polymerization blocker, also impedes Abl with low IC50; binds to beta-tubulin.

Penfluridol (TLP-607) is a highly potent antipsychotic.

Scriptaid (GCK1026) is an inhibitor of HDAC, and has a greater effect on acetylated H4 than H3.

Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer.

Sitagliptin phosphate (MK-0431 phosphate) is a dipeptidyl peptidase-4 (DPP4) inhibitor.

Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.

Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood.

Dimethyl fumarate (DMF) is an orally Nrf2 activator. Dimethyl fumarate has antimicrobial and anti-inflammatory activities. Cost-effective and quality-assured.

Letrozole (CGS 20267) is an Aromatase Inhibitor. The mechanism of action of letrozole is as an Aromatase Inhibitor.

MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).

Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells.

3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition.

SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.

Corosolic acid inhibits angiogenesis, suppresses FAK, fights various cancers, induces apoptosis, and degrades β-catenin.

OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.

Gavilimomab(ABX-CBL) is a murine-derived IgM monoclonal antibody against CD147 antigen used in immunosuppressive treatments for glucocorticoid-resistant GVHD).

STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively.

PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.

p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.

Cisatracurium besylate (51W89) is a nondepolarizing skeletal muscle relaxant for intravenous administration.

4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).

Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.

IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.

AICAR phosphate (Acadesine phosphate) is an AMPK activator, an inhibitor of autophagy, YAP and mitophagy, and inhibits iNOS production.

Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.

Prazosin HCl, a synthetic antiadrenergic, treats hypertension, heart failure, and more by relaxing blood vessels with an unclear mechanism.

Berbamine is a natural product extracted from Phellodendron amurense.

Ganoderic acid A fights tumors, suppresses gene regulators, induces cancer cell death, and enhances cisplatin efficacy.

Levosimendan (OR1259) is a calcium sensitizer for acute heart failure, enhancing cardiac contractility without raising calcium levels.

LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1.

PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.

CaMKII-IN-1 is a potent and highly selective inhibitor of CaMKII (IC50 = 63 nM).

Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.

Pyriproxyfen (S-31183) is an insecticide that acts as a biomimetic of juvenile hormone.

Naproxen ((S)-Naproxen) is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic

ABT-751 (E7010) has been investigated for the treatment of Lung Cancer, Non-Small Cell Lung Cancer, and Non-Small-Cell Lung Cancer.

Gartanin enhances androgen receptor degradation and has neuroprotective effects by boosting HO-1, AMPK, SIRT1, and PGC-1α pathways.

Cinobufagin (Cinobufagine) is a selective Na+/K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain.