Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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Enzalutamide
CAS:Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP).Formula:C21H16F4N4O2SPurity:100% - 99.7%Color and Shape:SolidMolecular weight:464.44Ref: TM-T6002
5mg48.00€10mg56.00€25mg74.00€50mg96.00€100mg154.00€200mg187.00€500mg274.00€1mL*10mM (DMSO)52.00€A-484954
CAS:A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.Formula:C13H15N5O3Purity:97.47%Color and Shape:SolidMolecular weight:289.29Ref: TM-TQ0137
1mg43.00€2mg56.00€5mg88.00€10mg144.00€25mg305.00€50mg543.00€100mg775.00€1mL*10mM (DMSO)103.00€Anti-LRRK2 Antibody (1C773)
Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.Color and Shape:Odour Liquid(R)-(-)-Gossypol acetic acid
CAS:(R)-(-)-Gossypol acetic acid binds Bcl-2, Bcl-xL, Mcl-1 (Ki: 0.32, 0.48, 0.18 μM); no BIR3/BID inhibition. Phase 2.Formula:C30H30O8·C2H4O2Purity:96.73% - 99.5%Color and Shape:SolidMolecular weight:578.61Ref: TM-T6396
1g1,359.00€2mg39.00€5mg57.00€10mg87.00€25mg170.00€50mg283.00€100mg464.00€500mg1,008.00€Niacin
CAS:Niacin is a water-soluble B vitamin with antihyperlipidemic effects, found in food and converted to niacinamide for coenzyme activity.Formula:C6H5NO2Purity:100% - 99.68%Color and Shape:White Solid PowderMolecular weight:123.11CA-5f
CAS:CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.Formula:C24H24N2O3Purity:99.69%Color and Shape:SolidMolecular weight:388.46Glaucocalyxin B
CAS:Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).Formula:C22H30O5Purity:99.13% - 99.13%Color and Shape:SolidMolecular weight:374.47Hesperidin
CAS:Hesperidin (Cirantin), a citrus-fruit flavanone glycoside, boasts antioxidant, anti-inflammatory, anti-carcinogenic, and cardiovascular benefits.Formula:C28H34O15Purity:97.74% - 97.75%Color and Shape:Fine Brownish Powder Solid PowderMolecular weight:610.56Ridaforolimus
CAS:Ridaforolimus (AP23573) 是亲脂性大环内酯类抗生素雷帕霉素的小分子非前药类似物,具有潜在的抗肿瘤活性。它是一种有效和选择性的 mTOR 抑制剂,在 HT-1080 细胞中抑制 S6 磷酸化的 IC50值为 0.2 nM。Formula:C53H84NO14PPurity:90.00% - 98.55%Color and Shape:Off-White SolidMolecular weight:990.21Danshensu
CAS:Danshensu (Dan shen suan A) is an active ingredient of Salvia miltiorrhiza with wide cardiovascular benefit.Formula:C9H10O5Purity:98.4% - 99.74%Color and Shape:SolidMolecular weight:198.17Fulvestrant
CAS:Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30.Formula:C32H47F5O3SPurity:100% - 99.87%Color and Shape:White PowderMolecular weight:606.77SB 242235
CAS:SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.Formula:C19H20FN5OPurity:99.13% - 99.68%Color and Shape:SolidMolecular weight:353.39FAAH-IN-2
CAS:FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent inhibitor of FAAH(fatty acid amide hydrolase).Formula:C15H11ClFN3O2Purity:99.18%Color and Shape:Tan SolidMolecular weight:319.72Schaftoside
CAS:Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.Formula:C26H28O14Purity:100% - 99.32%Color and Shape:SolidMolecular weight:564.49Ref: TM-T3898
1mg42.00€5mg85.00€10mg111.00€25mg210.00€50mg311.00€100mg467.00€200mg653.00€1mL*10mM (DMSO)95.00€Fluvastatin sodium
CAS:Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterolFormula:C24H25FNNaO4Purity:98.54% - 99.46%Color and Shape:Light Yellow Solid PowderMolecular weight:433.45Myricetin
CAS:Myricetin (Cannabiscetin) is a natural flavonoid and MEK1 inhibitor. Myricetin has hypoglycemic and antioxidant activities. Cost-effective and quality-assured.Formula:C15H10O8Purity:97.92% - 99.85%Color and Shape:Yellow Needles From Dilute Alcohol SolidMolecular weight:318.24Alisol A
CAS:Alisol A: induces autophagy, anti-cancer, inhibits HepG2, MDA-MB-231, MCF-7 cells.Formula:C30H50O5Purity:99.77% - 99.94%Color and Shape:SolidMolecular weight:490.71SD 0006
CAS:SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.Formula:C20H20ClN5O2Purity:98.32%Color and Shape:SolidMolecular weight:397.86Ref: TM-T7276
2mg38.00€5mg58.00€10mg90.00€25mg145.00€50mg226.00€100mg338.00€200mg472.00€1mL*10mM (DMSO)65.00€Sertaconazole
CAS:Sertaconazole is a broad-spectrum antifungal.Formula:C20H15Cl3N2OSPurity:95.00%Color and Shape:SolidMolecular weight:437.77Ref: TM-T50005
5mg58.00€10mg82.00€25mg126.00€50mg182.00€100mg273.00€200mg409.00€1mL*10mM (DMSO)84.00€Liensinine
CAS:1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.Formula:C37H42N2O6Purity:98.92% - 99.93%Color and Shape:White-Like PowderMolecular weight:610.74Mycro 3
CAS:Mycro 3 is potent and selective for c-Myc in whole cell assays.Formula:C24H17ClF2N6O4Purity:97.87% - 99.51%Color and Shape:SolidMolecular weight:526.88Ref: TM-T4367
1mg49.00€5mg99.00€10mg168.00€25mg335.00€50mg477.00€100mg662.00€200mg892.00€1mL*10mM (DMSO)116.00€PD168393
CAS:PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Formula:C17H13BrN4OPurity:99.13% - 99.7%Color and Shape:SolidMolecular weight:369.22Ref: TM-T6932
1mg39.00€2mg49.00€5mg66.00€10mg89.00€25mg155.00€50mg222.00€100mg310.00€1mL*10mM (DMSO)56.00€AC-73
CAS:AC-73, an oral CD147 inhibitor, blocks ERK1/2/STAT3/MMP-2 pathway, reducing liver cancer progression and leukemia cell growth.Formula:C21H21NO2Purity:98.95%Color and Shape:SolidMolecular weight:319.4Ref: TM-T14091
1mg49.00€5mg97.00€10mg173.00€25mg305.00€50mg513.00€100mg909.00€500mg1,825.00€1mL*10mM (DMSO)108.00€EN6
CAS:EN6, a small molecule, activates autophagy by modifying ATP6V1A, inhibiting mTORC1 and enhancing lysosomal function to clear TDP-43 aggregates.Formula:C19H14F2N4O2Purity:95.16% - 97.04%Color and Shape:SolidMolecular weight:368.34Ref: TM-T11191
1mg47.00€5mg88.00€10mg137.00€25mg205.00€50mg264.00€100mg400.00€500mg909.00€1mL*10mM (DMSO)70.00€Dilmapimod
CAS:Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.Formula:C23H19F3N4O3Purity:97.53%Color and Shape:SolidMolecular weight:456.421-Monomyristin
CAS:1-Monomyristin (2,3-Dihydroxypropyl tetradecanoate) , a 1-monoglyceride of myristic acid, has antibacterial activity against several Gram-positive bacterialFormula:C17H34O4Purity:99.58%Color and Shape:SolidMolecular weight:302.45IITZ-01
CAS:IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)Formula:C26H23FN8OPurity:99.31%Color and Shape:SolidMolecular weight:482.51Schisandrin B
CAS:Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart.Formula:C23H28O6Purity:100% - 99.84%Color and Shape:SolidMolecular weight:400.46Ref: TM-T2925
1mg42.00€5mg88.00€10mg127.00€25mg230.00€50mg414.00€100mg600.00€500mg1,254.00€1mL*10mM (DMSO)94.00€GNE-9605
CAS:GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).Formula:C17H20ClF4N7OPurity:98.55% - 98.75%Color and Shape:SolidMolecular weight:449.83β-Lapachone
CAS:β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.Formula:C15H14O3Purity:99.64% - 99.85%Color and Shape:SolidMolecular weight:242.27Ref: TM-T6407
5mg48.00€10mg60.00€25mg97.00€50mg185.00€100mg305.00€200mg460.00€500mg753.00€1mL*10mM (DMSO)63.00€Isotretinoin
CAS:Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promoteFormula:C20H28O2Purity:98.06% - 99.61%Color and Shape:Reddish-Orange Plates From Isopropyl Alcohol (Ntp 1992)Molecular weight:300.44Dihydromyricetin
CAS:Dihydromyricetin, a flavonoid from Ampelopsis, is an antioxidant that blocks dihydropyrimidinase (IC50: 48 μM) and activates autophagy via mTOR inhibition.Formula:C15H12O8Purity:96.68% - 98.13%Color and Shape:SolidMolecular weight:320.25Neflamapimod
CAS:Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.Formula:C19H9Cl2F2N3OSPurity:99.02% - ≥95%Color and Shape:SolidMolecular weight:436.26Cabazitaxel
CAS:Cabazitaxel (XRP6258) is a taxane used for castration-resistant metastatic prostate cancer post-docetaxel failure.Formula:C45H57NO14Purity:98% - 99.93%Color and Shape:SolidMolecular weight:835.93LY2562175
CAS:LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).Formula:C28H27Cl2N3O4Purity:99.16% - 99.78%Color and Shape:SolidMolecular weight:540.44Ref: TM-T15806
1mg104.00€5mg227.00€10mg369.00€25mg740.00€50mg1,169.00€100mg1,568.00€200mg2,118.00€1mL*10mM (DMSO)269.00€Tizoxanide
CAS:Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.Formula:C10H7N3O4SPurity:98.89% - 99.28%Color and Shape:SolidMolecular weight:265.25Ambroxol
CAS:Ambroxol treats respiratory diseases by thinning mucus. Active in Mucosolvan, it enhances mucus clearance and protects lungs.Formula:C13H18Br2N2OPurity:99.72%Color and Shape:SolidMolecular weight:378.1Gimeracil
CAS:Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.Formula:C5H4ClNO2Purity:99.80%Color and Shape:SolidMolecular weight:145.54Bortezomib
CAS:Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.Formula:C19H25BN4O4Purity:100% - 99.97%Color and Shape:Yellow SolidMolecular weight:384.24Ref: TM-T2399
5mg52.00€10mg64.00€25mg80.00€50mg96.00€100mg144.00€200mg225.00€500mg373.00€1mL*10mM (DMSO)52.00€Pogostone
CAS:Pogostone: anti-bacterial/fungal, blocks T-cells, modulates cytokines, protects against gastric ulcers, boosts antioxidants/PGE2/NP-SH.Formula:C12H16O4Purity:98.46% - 99.03%Color and Shape:SolidMolecular weight:224.25Rosuvastatin calcium
CAS:Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemicFormula:(C22H27FN3O6S)CaPurity:98.85% - 99.68%Color and Shape:White To Off-White Crystalline SolidMolecular weight:1001.14SKF-96365 hydrochloride
CAS:SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal YFormula:C22H27ClN2O3Purity:99.48% - 99.85%Color and Shape:SolidMolecular weight:402.91Ref: TM-T2170
5mg57.00€10mg86.00€25mg138.00€50mg243.00€100mg470.00€200mg717.00€500mg1,111.00€1mL*10mM (DMSO)63.00€Hydroxychloroquine
CAS:HCQ, an anti-malarial, may induce cancer cell death and is being explored for COVID-19.Formula:C18H26ClN3OPurity:99.79%Color and Shape:SolidMolecular weight:335.87Cilostazol
CAS:Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.Formula:C20H27N5O2Purity:99.58% - 99.90%Color and Shape:Off-White SolidMolecular weight:369.46Gambogic Acid
CAS:Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases.Formula:C38H44O8Purity:97.16% - 98.67%Color and Shape:SolidMolecular weight:628.75Ref: TM-T6185
2mg39.00€5mg55.00€10mg77.00€25mg111.00€50mg160.00€100mg227.00€500mg560.00€1mL*10mM (DMSO)88.00€Sofalcone
CAS:Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.Formula:C27H30O6Purity:97.55%Color and Shape:SolidMolecular weight:450.52SB 202190
CAS:SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably.Formula:C20H14FN3OPurity:98% - 99.84%Color and Shape:Pale YellowMolecular weight:331.34Diazoxide
CAS:Diazoxide (Proglycem) is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies.Formula:C8H7ClN2O2SPurity:99% - 99.83%Color and Shape:SolidMolecular weight:230.67Nitazoxanide
CAS:Nitazoxanide (NSC-697855) is a synthetic benzamide antiprotozoal; it disrupts pyruvate electron transfer reactions.Formula:C12H9N3O5SPurity:97.20% - 99.53%Color and Shape:SolidMolecular weight:307.28Ref: TM-T1546
1g750.00€5mg35.00€10mg51.00€25mg90.00€50mg139.00€100mg207.00€200mg311.00€500mg520.00€1mL*10mM (DMSO)55.00€Belinostat
CAS:Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.Formula:C15H14N2O4SPurity:100% - 99.75%Color and Shape:SolidMolecular weight:318.35Ref: TM-T8517
5mg48.00€10mg69.00€25mg97.00€50mg144.00€100mg207.00€200mg306.00€500mg518.00€1mL*10mM (DMSO)63.00€
