Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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AS1842856
CAS:AS1842856 is a Foxo1 inhibitor that blocks the transcriptional activity of Foxo1. AS1842856 has autophagy inhibitory activity. Cost-effective and quality-assured.Formula:C18H22FN3O3Purity:100% - 99.56%Color and Shape:SolidMolecular weight:347.38SP-8356
CAS:SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.Formula:C18H20O4Purity:98.24%Color and Shape:SolidMolecular weight:300.35Ref: TM-T12981
1mg70.00€5mg156.00€10mg238.00€25mg449.00€50mg610.00€100mg815.00€200mg1,103.00€1mL*10mM (DMSO)170.00€Megestrol acetate
CAS:Megestrol acetate (BDH1298) is an oral progestogen with anti-androgenic properties, used for endometrial and breast cancer, anorexia, and cachexia.Formula:C24H32O4Purity:99.46%Color and Shape:Crystalline SolidMolecular weight:384.51GANT 61
CAS:GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2.Formula:C27H35N5Purity:100% - ≥95%Color and Shape:SolidMolecular weight:429.6TTNPB
CAS:TTNPB (Ro 13-7410,AGN-191183), a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM),Formula:C24H28O2Purity:99.55%Color and Shape:White SolidMolecular weight:348.48Ref: TM-T1288
2mg39.00€5mg57.00€10mg87.00€25mg162.00€50mg306.00€100mg464.00€500mg1,008.00€1mL*10mM (DMSO)59.00€Valproic acid sodium salt
CAS:Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.Formula:C8H15NaO2Purity:99% - 99.78%Color and Shape:White PowderMolecular weight:166.2Dinoprost tromethamine salt
CAS:Dinoprost tromethamine salt (PGF2α THAM) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.Formula:C24H45NO8Purity:99.73%Color and Shape:Natural Form Crystals SolidMolecular weight:475.62BIX-01294 trihydrochloride
CAS:BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.Formula:C28H38N6O2·3HClPurity:99.41% - 99.95%Color and Shape:SolidMolecular weight:600.02Ref: TM-T1959
1mg44.00€2mg55.00€5mg71.00€10mg107.00€25mg192.00€50mg274.00€100mg492.00€500mg1,103.00€1mL*10mM (DMSO)139.00€Salicylic acid
CAS:Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.Formula:C7H6O3Purity:98.04% - 98.83%Color and Shape:White Solid PowderMolecular weight:138.12CFTR corrector 2
CAS:CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.Formula:C27H23FN4O4Purity:99.66%Color and Shape:SolidMolecular weight:486.49Ref: TM-T5312
2mg39.00€5mg58.00€10mg85.00€25mg156.00€50mg226.00€100mg335.00€200mg469.00€1mL*10mM (DMSO)63.00€LRRK2-IN-7
CAS:LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, >1000x selectivity vs kinases/channels/CYPs.Formula:C24H26N6OPurity:99.26%Color and Shape:SolidMolecular weight:414.5BX795
CAS:BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.Formula:C23H26IN7O2SPurity:98% - 99.57%Color and Shape:SolidMolecular weight:591.47Ref: TM-T1830
5mg59.00€10mg97.00€25mg210.00€50mg343.00€100mg513.00€200mg740.00€500mg1,121.00€1mL*10mM (DMSO)88.00€Apocynin
CAS:Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM).Formula:C9H10O3Purity:99.71% - 99.98%Color and Shape:Yellowish To Brown PowderMolecular weight:166.17Trametinib
CAS:Trametinib (GSK1120212), an ATP-noncompetitive MEK 1/2 inhibitor (IC50: 0.7/0.9 nM), weakly inhibits >180 kinases.Formula:C26H23FIN5O4Purity:98% - 99.88%Color and Shape:SolidMolecular weight:615.39GSK2578215A
CAS:GSK2578215A is a potent and selective LRRK2 kinase inhibitor.Formula:C24H18FN3O2Purity:97.93% - 99.94%Color and Shape:SolidMolecular weight:399.42Indomethacin farnesil
CAS:Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug.Formula:C34H40ClNO4Purity:99.84%Color and Shape:SolidMolecular weight:562.14Clarithromycin
CAS:Clarithromycin (A-56268), a macrolide antibiotic, inhibits Cytochrome P450 3A4 and P-Glycoprotein.Formula:C38H69NO13Purity:99.89% - 99.89%Color and Shape:White To Off-White Crystalline PowderMolecular weight:747.95Dioscin
CAS:Dioscin (Collettiside III) is a saponin with antitumor activities.Formula:C45H72O16Purity:98.35% - 99.85%Color and Shape:SolidMolecular weight:869.04Torin 1
CAS:Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.Formula:C35H28F3N5O2Purity:98.3% - 99.38%Color and Shape:SolidMolecular weight:607.62AT9283
CAS:AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Formula:C19H23N7O2Purity:99.83% - 99.98%Color and Shape:SolidMolecular weight:381.43Ref: TM-T3068
1mg47.00€2mg60.00€5mg95.00€10mg170.00€25mg299.00€50mg499.00€100mg723.00€1mL*10mM (DMSO)97.00€LC3B recruiter 2
CAS:LC3B recruiter 2 (34R) is an LC3B recruiting agent incorporated into the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), with a direct binding affinity for LC3B. It connects via a linker to the CDK9 inhibitor SNS-032, creating an ATTEC capable of targeting and degrading the CDK9 and Cyclin T1 complex, while also inhibiting them. Consequently, LC3B recruiter 2 exerts its function through an LC3B-dependent autophagy-lysosome pathway, interfering with the cancer cell cycle progression, thereby demonstrating antitumor activity.Formula:C10H9ClN2O2Color and Shape:SolidMolecular weight:224.644Pifithrin-μ
CAS:Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.Formula:C8H7NO2SPurity:99.33% - 99.79%Color and Shape:SolidMolecular weight:181.21Flavopiridol hydrochloride
CAS:Flavopiridol hydrochloride (MDL 107826A), an inhibitor of cyclin-dependent kinase, is a synthetic N-methylpiperidinyl chlorophenyl flavone compound.Formula:C21H21Cl2NO5Purity:98.87% - 99.88%Color and Shape:SolidMolecular weight:438.3Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Formula:C51H82O21Purity:99.51% - 99.63%Color and Shape:SolidMolecular weight:1031.18Pexmetinib
CAS:Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor.Cost-effective and quality-assured.Formula:C31H33FN6O3Purity:98.41% - 99.66%Color and Shape:SolidMolecular weight:556.63Ref: TM-T6934
1mg47.00€5mg97.00€10mg139.00€25mg271.00€50mg435.00€100mg567.00€200mg810.00€1mL*10mM (DMSO)118.00€Nur77 modulator 1
CAS:Nur77 modulator 1: binds at 3.58 μM, boosts expression, alters location, triggers ER stress/autophagy, induces apoptosis, and fights hepatoma.Formula:C28H25N5O2SPurity:98.11%Color and Shape:SolidMolecular weight:495.6Ref: TM-T40130
1mg96.00€5mg227.00€10mg376.00€25mg620.00€50mg847.00€100mg1,169.00€1mL*10mM (DMSO)245.00€Aspirin
CAS:Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Formula:C9H8O4Purity:99.78% - 99.91%Color and Shape:White Solid CrystallineMolecular weight:180.16Degrasyn
CAS:Degrasyn (WP1130) inhibits DUBs (USP5, UCH-L1, USP9x, USP14, UCH37) and Bcr/Abl without affecting the 20S proteasome.Formula:C19H18BrN3OPurity:98.32% - 99.98%Color and Shape:SolidMolecular weight:384.27Ref: TM-T6300
2mg44.00€5mg64.00€10mg97.00€25mg198.00€50mg340.00€100mg532.00€200mg747.00€1mL*10mM (DMSO)69.00€Bilobalide
CAS:Bilobalide ((-)-Bilobalide), a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.Formula:C15H18O8Purity:98.27% - 99.91%Color and Shape:White SolidMolecular weight:326.3Bigelovin
CAS:Bigelovin: RXRα agonist, inhibits mTOR via ROS, induces apoptosis/autophagy, anti-tumor sesquiterpene from Inula sp.Formula:C17H20O5Purity:99.72% - 99.72%Color and Shape:SolidMolecular weight:304.34Ref: TM-TN6735
1mg92.00€5mg216.00€10mg283.00€25mg490.00€50mg700.00€100mg938.00€1mL*10mM (DMSO)215.00€Br-DAPI
CAS:IST5-002 (N6-Benzyladenosine-5'-phosphate) is a Stat5a/b inhibitor with anticancer activity and is used in cancer research.Formula:C16H14BrN5Purity:100%Color and Shape:SolidMolecular weight:356.22Apigenin
CAS:Apigenin (NSC 83244) is an aromatic oil extracted from the flowers or leaves of the daisy-like plants.Formula:C15H10O5Purity:97.95% - 99.66%Color and Shape:Yellow Needles From Aqueous Pyridine SolidMolecular weight:270.24Divalproex Sodium
CAS:Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted byFormula:C8H16O2·C8H15O2·NaPurity:99.84%Color and Shape:A White Powder With A Characteristic OdorMolecular weight:310.41Ref: TM-T6474
10mg39.00€25mg55.00€50mg79.00€100mg116.00€200mg188.00€500mg335.00€1mL*10mM (DMSO)55.00€Torin 2
CAS:Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.Formula:C24H15F3N4OPurity:98.31% - 99.32%Color and Shape:SolidMolecular weight:432.4Ginkgetin
CAS:Ginkgetin: antiviral, antifungal, anti-inflammatory; COX-2 reducer; STAT3 inhibitor; pro-apoptotic in cancer; neuroprotective in Parkinson's.Formula:C32H22O10Purity:98.91% - 99.94%Color and Shape:SolidMolecular weight:566.51Ref: TM-T4S2126
1mg58.00€5mg118.00€10mg172.00€25mg278.00€50mg411.00€100mg607.00€200mg847.00€1mL*10mM (DMSO)153.00€Maprotiline hydrochloride
CAS:Maprotiline hydrochloride (Psymion) is a tetracyclic antidepressant akin to tricyclics with similar side effects.Formula:C20H24ClNPurity:99.68% - 99.84%Color and Shape:White PowderMolecular weight:313.864Hydroxyurea
CAS:Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.Formula:CH4N2O2Purity:99.85% - 99.92%Color and Shape:SolidMolecular weight:76.05Carbamazepine
CAS:Carbamazepine: a tricyclic with anticonvulsant and analgesic effects, treats trigeminal neuralgia.Formula:C15H12N2OPurity:99.79% - 99.88%Color and Shape:SolidMolecular weight:236.27Saquinavir mesylate
CAS:Saquinavir mesylate (Ro 31-8959/003) is an Inhibitor of HIV Proteaseused in antiretroviral therapyFormula:C39H54N6O8SPurity:99.19%Color and Shape:White Or Pale Yellow PowderMolecular weight:766.9Imatinib
CAS:Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kitFormula:C29H31N7OPurity:100% - 99.94%Color and Shape:Off White PowderMolecular weight:493.6Polyphyllin I
CAS:Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Formula:C44H70O16Purity:98% - 99.5%Color and Shape:SolidMolecular weight:855.02Troglitazone
CAS:Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.Formula:C24H27NO5SPurity:98% - 99.62%Color and Shape:Yellow SolidMolecular weight:441.54Ref: TM-T3170
2mg42.00€5mg62.00€10mg88.00€25mg172.00€50mg305.00€100mg558.00€500mg1,169.00€1mL*10mM (DMSO)85.00€Liensinine diperchlorate
CAS:Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus.Formula:C37H44Cl2N2O14Purity:99.8% - ≥95%Color and Shape:SolidMolecular weight:811.67Tripterin
CAS:Tripterin (Celastrol) is an proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with antioxidant and anti-inflammatory effects.Formula:C29H38O4Purity:98.56% - 99.8%Color and Shape:Red Crystalline PowderMolecular weight:450.61LYN-1604 dihydrochloride
CAS:LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.Formula:C33H45Cl4N3O2Purity:98.95% - 99.80%Color and Shape:SolidMolecular weight:657.54Ref: TM-T8808L
1mg35.00€5mg78.00€10mg117.00€25mg212.00€50mg316.00€100mg447.00€200mg628.00€1mL*10mM (DMSO)101.00€BIA 10-2474
CAS:BIA 10-2474 is a long-acting reversible inhibitor of FAAH that increases levels of the neurotransmitter anandamide in the nervous system.Formula:C16H20N4O2Purity:99.27%Color and Shape:SolidMolecular weight:300.36Xylitol
CAS:Xylitol (Ribitol) is a five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group.Formula:C5H12O5Purity:99.89% - 99.96%Color and Shape:White Solid PowderMolecular weight:152.15Ivacaftor
CAS:Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,Formula:C24H28N2O3Purity:99% - 99.98%Color and Shape:SolidMolecular weight:392.49Ref: TM-T2588
1mg38.00€5mg81.00€10mg127.00€25mg205.00€50mg304.00€100mg455.00€500mg998.00€1mL*10mM (DMSO)88.00€MDK-6983
CAS:MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.Formula:C22H18Cl2N2O3Purity:97.55%Color and Shape:SolidMolecular weight:429.3Ref: TM-T28001
1mg115.00€5mg249.00€10mg368.00€25mg562.00€50mg787.00€100mg1,054.00€500mgTo inquire1mL*10mM (DMSO)284.00€Dorsomorphin dihydrochloride
CAS:Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity onFormula:C24H25N5O·2HClPurity:97.74% - 99.89%Color and Shape:SolidMolecular weight:472.41Ref: TM-T6146
2mg35.00€5mg51.00€10mg70.00€25mg135.00€50mg235.00€100mg424.00€500mg938.00€1mL*10mM (DMSO)57.00€
