Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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AZD 6482
CAS:AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.Formula:C22H24N4O4Purity:99.79% - 99.95%Color and Shape:SolidMolecular weight:408.45ML-SA5
CAS:ML-SA5 is a MCOLN1 agonist that blocks autophagic flux by disrupting fusion between autophagosomes and lysosomes.Cost-effective and quality-assured.Formula:C19H24ClN3O4S2Purity:100.00% - 99.16%Color and Shape:SoildMolecular weight:457.99IU1
CAS:IU1 是一种可逆的特异性人类 USP14 蛋白酶体抑制剂,可以穿透细胞,IC50为 4.7 μM。Formula:C18H21FN2OPurity:98% - 99.30%Color and Shape:SolidMolecular weight:300.37Pitavastatin calcium
CAS:Pitavastatin calcium (NK-104), a inhibitor of HMG-CoA reductase, lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans.Formula:C50H46CaF2N2O8Purity:100% - 99.49%Color and Shape:White To Off-White PowderMolecular weight:880.98Dapivirine
CAS:Dapivirine (R147681) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.Formula:C20H19N5Purity:98% - 99.77%Color and Shape:SolidMolecular weight:329.4Acumapimod
CAS:Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).Formula:C22H19N5O2Purity:≥95%Color and Shape:SolidMolecular weight:385.42Tazarotene
CAS:Tazarotene (Zorac), a synthetic topical retinoid, treats psoriasis by normalizing keratinocytes and reducing growth.Formula:C21H21NO2SPurity:97.01% - 99.14%Color and Shape:White SolidMolecular weight:351.46Ref: TM-T6696
5mg38.00€10mg49.00€25mg88.00€50mg147.00€100mg256.00€200mg334.00€500mg563.00€1mL*10mM (DMSO)55.00€BI-D1870
CAS:BI-D1870 is a highly specific, blood-brain-permeable, and ATP-competitive inhibitor of the N-terminal AGC kinase domain of RSK.Cost-effective and quality-assured.Formula:C19H23F2N5O2Purity:98.51% - 99.43%Color and Shape:SolidMolecular weight:391.42Ref: TM-T6171
1mg52.00€2mg78.00€5mg137.00€10mg207.00€25mg335.00€50mg472.00€100mg658.00€500mg1,378.00€1mL*10mM (DMSO)117.00€Mevastatin
CAS:Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Formula:C23H34O5Purity:99.12%Color and Shape:White-Yellowish To Yellow Powder Solid PowderMolecular weight:390.51Tezacaftor
CAS:Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.Formula:C26H27F3N2O6Purity:100% - 99.69%Color and Shape:SolidMolecular weight:520.5Ref: TM-T2263
1mg40.00€2mg52.00€5mg82.00€10mg123.00€25mg212.00€50mg343.00€100mg505.00€1mL*10mM (DMSO)88.00€Albendazole
CAS:Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.Formula:C12H15N3O2SPurity:98.21% - 98.76%Color and Shape:Colorless Crystals SolidMolecular weight:265.33Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C31H34F2N6O2Purity:98.03% - 99.61%Color and Shape:SolidMolecular weight:560.64Ref: TM-T3678
2mg42.00€5mg59.00€10mg88.00€25mg111.00€50mg168.00€100mg283.00€500mg692.00€1mL*10mM (DMSO)69.00€PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Formula:C19H16N4O3Purity:96.59% - 99.3%Color and Shape:SolidMolecular weight:348.36Salinomycin sodium salt
CAS:Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.Formula:C42H69NaO11Purity:98.76% - 99.11%Color and Shape:White Or Light Yellow Crystalline Powder With Special SmelMolecular weight:772.98Resveratrol analog 1
CAS:Resveratrol analog 1 is a natural product analog of resveratrol, which has more significant anti-leukemic activity than resveratrol.Formula:C14H11FO2Purity:98.42%Color and Shape:SolidMolecular weight:230.23PRIMA-1
CAS:PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.Formula:C9H15NO3Purity:99.22%Color and Shape:SolidMolecular weight:185.22Ref: TM-T6954
5mg51.00€10mg73.00€25mg140.00€50mg207.00€100mg368.00€200mg547.00€500mg877.00€1mL*10mM (DMSO)57.00€C646
CAS:C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).Formula:C24H19N3O6Purity:98% - 99.21%Color and Shape:SolidMolecular weight:445.42Bromhexine hydrochloride
CAS:Bromhexine hydrochloride (Bisolvon) is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.Formula:C14H21Br2ClN2Purity:99.98%Color and Shape:White SolidMolecular weight:412.59ALLO-1
CAS:ALLO-1, vital for autophagy, aids in engulfing paternal organelles by binding to worm LC3, LGG-1, via its LIR motif.Formula:C17H15ClN2O2Purity:98%Color and Shape:SolidMolecular weight:314.77Pemetrexed
CAS:Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).Formula:C20H21N5O6Purity:98.1% - 99.92%Color and Shape:Similar To White PowderMolecular weight:427.413,3'-Diindolylmethane
CAS:3,3'-Diindolylmethane (DIM), a small molecule compound, is a proposed Y preventive agent.Formula:C17H14N2Purity:100%Color and Shape:SolidMolecular weight:246.31Peretinoin
CAS:Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.Formula:C20H30O2Purity:97.23%Color and Shape:SolidMolecular weight:302.45Ref: TM-TQ0064
1mg40.00€2mg51.00€5mg88.00€10mg126.00€25mg230.00€50mg401.00€100mg597.00€500mg1,283.00€1mL*10mM (DMSO)87.00€Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Formula:C20H23N3O2SPurity:99.33%Color and Shape:SolidMolecular weight:369.48Sevelamer hydrochloride
CAS:Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorptionFormula:(C3H7N·C3H5ClO·HCl)xPurity:98%Color and Shape:SolidMolecular weight:186.08NS1643
CAS:NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.Formula:C15H10F6N2O3Purity:98.37% - 99%Color and Shape:SolidMolecular weight:380.24Thioridazine hydrochloride
CAS:Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4Formula:C21H27ClN2S2Purity:99.55% - 99.55%Color and Shape:White To Off-White SolidMolecular weight:407.04Luteolin
CAS:Luteolin (Luteolol) belongs to the flavonoid group of natural products and is a Nrf2 inhibitor, PDE inhibitor.Formula:C15H10O6Purity:96.61% - 98%Color and Shape:SolidMolecular weight:286.24Bakuchiol
CAS:Bakuchiol: anti-tumor, anti-helminthic, DNA polymerase1 inhibitor, cytotoxic, and anti-bacterial, may prevent dental caries.Formula:C18H24OPurity:98.69% - 99.47%Color and Shape:Brownish Yellow Liquid ViscousMolecular weight:256.38Pamapimod
CAS:Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.Formula:C19H20F2N4O4Purity:97.63% - 99.99%Color and Shape:SolidMolecular weight:406.38Ref: TM-T6927
1mg56.00€5mg119.00€10mg187.00€25mg378.00€50mg605.00€100mg852.00€500mg1,700.00€1mL*10mM (DMSO)131.00€XRK3F2
CAS:XRK3F2 inhibits p62-ZZ, counters MM's Runx2 suppression in vitro, and prompts bone growth and remodeling in vivo with tumors.Formula:C23H24ClF2NO3Purity:98.75% - 98.91%Color and Shape:SolidMolecular weight:435.89STF-31
CAS:STF-31 is an inhibitor of glucose transporter 1 (GLUT1) with IC50 of 1 μM.Formula:C23H25N3O3SPurity:99.55% - 99.98%Color and Shape:SolidMolecular weight:423.53Ref: TM-T2363
1mg38.00€2mg50.00€5mg81.00€10mg113.00€25mg230.00€50mg437.00€100mg640.00€500mg1,349.00€1mL*10mM (DMSO)106.00€Reserpine
CAS:Reserpine, an alkaloid from Rauwolfia roots, depletes neurotransmitters, used in treating hypertension and psychosis, but side effects restrict use.Formula:C33H40N2O9Purity:98.85% - 99.81%Color and Shape:White Or Pale Buff To Slightly Yellowish Powder With A Bitter Taste (Ntp 1992)Molecular weight:608.68Nifedipine
CAS:Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent.Formula:C17H18N2O6Purity:99.39% - 99.49%Color and Shape:Yellow Crystals Physical Description Odorless Yellow Crystals Or Powder Tasteless (Ntp 1992)Molecular weight:346.33Vinorelbine ditartrate
CAS:Vinorelbine ditartrate (KW-2307) is a natural alkaloid and an anti-mitotic agent. Vinorelbine ditartrate has anti-tumor activity. Cost-effective and quality-assured.Formula:C45H54N4O8·2C4H6O6Purity:98% - 99.86%Color and Shape:White To Off-White Crystalline PowderMolecular weight:1079.11Tomatidine
CAS:Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways.Formula:C27H45NO2Purity:98.38% - 99.98%Color and Shape:SolidMolecular weight:415.65Proflavine Hemisulfate
CAS:Proflavine Hemisulfate (3,6-Diaminoacridine hemisulfate) is the hemisulfate salt of proflavine, an acridine-derived fluorescent contrast and disinfectant agent.Formula:C13H12N3O2S0Purity:99.55%Color and Shape:Orange To Red PowderMolecular weight:258.29CGI-1746
CAS:CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.Formula:C34H37N5O4Purity:97.69% - 97.88%Color and Shape:SolidMolecular weight:579.69Aumitin
CAS:Aumitin inhibits autophagy (IC50: 0.12-0.24μM), targets complex I, and blocks mitochondrial respiration.Formula:C24H20ClN5OPurity:99.13%Color and Shape:SolidMolecular weight:429.9Ref: TM-T14346
1mg65.00€5mg150.00€10mg219.00€25mg395.00€50mg552.00€100mg775.00€200mg1,026.00€1mL*10mM (DMSO)164.00€PD98059
CAS:PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.Formula:C16H13NO3Purity:100% - 99.66%Color and Shape:Yellow SolidMolecular weight:267.28Ref: TM-T2623
5mg40.00€10mg52.00€25mg82.00€50mg106.00€100mg177.00€200mg264.00€500mg444.00€1mL*10mM (DMSO)58.00€NSC 185058
CAS:NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.Formula:C11H9N3SPurity:99.27%Color and Shape:SolidMolecular weight:215.27Tubastatin A Hydrochloride
CAS:Tubastatin A Hydrochloride (TSA HCl) is an effective and specific HDAC6 inhibitor (IC50: 15 nM).Formula:C20H21N3O2·HClPurity:97.24% - 99.15%Color and Shape:SolidMolecular weight:371.86Ezetimibe
CAS:Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.Formula:C24H21F2NO3Purity:97.28% - 99.97%Color and Shape:SolidMolecular weight:409.43Ref: TM-T1593
1g283.00€10mg48.00€25mg62.00€50mg77.00€100mg87.00€200mg125.00€500mg197.00€1mL*10mM (DMSO)55.00€Latrepirdine dihydrochloride
CAS:Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets.Formula:C21H25N3·2HClPurity:98.45%Color and Shape:SolidMolecular weight:392.37Irinotecan
CAS:Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.Formula:C33H38N4O6Purity:100% - 99.92%Color and Shape:SolidMolecular weight:586.68Indole-3-Glyoxylyl Chloride
CAS:Indole-3-glyoxylyl chloride (3-Indoleglyoxylyl chloride) can be used in chemical synthesis, such as bisindolylmaleimide.Formula:C10H6ClNO2Purity:99.72%Color and Shape:Yellow To Orange Powder Or CrystalsMolecular weight:207.61Ref: TM-T0618
1mg97.00€2mg145.00€5mg235.00€10mg394.00€25mg825.00€50mg1,349.00€100mg2,175.00€1mL*10mM (DMSO)379.00€Urolithin A
CAS:Urolithin A is a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Cost-effective and quality-assured.Formula:C13H8O4Purity:99.14% - 99.66%Color and Shape:SolidMolecular weight:228.2Ref: TM-T7174
5mg49.00€10mg72.00€25mg130.00€50mg187.00€100mg320.00€200mg472.00€500mg753.00€1mL*10mM (DMSO)50.00€Peiminine
CAS:1. Peiminine (Raddeanine) is an effective inhibitor for lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury.Formula:C27H43NO3Purity:99.52% - ≥95%Color and Shape:White PowderMolecular weight:429.64PF-543 hydrochloride
CAS:PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2Formula:C27H32ClNO4SPurity:98.90% - 99.93%Color and Shape:SolidMolecular weight:502.1SBI-0640756
CAS:SBI-0640756 (SBI-756) (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.Formula:C23H14ClFN2O2Purity:99.75%Color and Shape:SolidMolecular weight:404.82Ref: TM-T5173
1mg39.00€5mg87.00€10mg140.00€25mg271.00€50mg386.00€100mg540.00€200mg735.00€1mL*10mM (DMSO)93.00€Topotecan hydrochloride
CAS:Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.Formula:C23H24ClN3O5Purity:97.88% - 98.71%Color and Shape:White Crystalline SolidMolecular weight:457.92Ref: TM-T1174
1g512.00€5mg35.00€10mg51.00€25mg80.00€50mg107.00€100mg144.00€500mg344.00€1mL*10mM (DMSO)55.00€
