Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Products of "Autophagy"
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20-DEOXYINGENOL
CAS:20-DEOXYINGENOL is a natual product.Formula:C20H28O4Purity:99.98% - ≥95%Color and Shape:SolidMolecular weight:332.43Ulipristal acetate
CAS:Ulipristal acetate (CDB-2914) is an oral selective progesterone modulator used for emergency contraception and suppressing uterine growths.Formula:C30H37NO4Purity:98.83% - 99.94%Color and Shape:SolidMolecular weight:475.62SB 216763
CAS:SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Formula:C19H12Cl2N2O2Purity:99.13% - 99.61%Color and Shape:SolidMolecular weight:371.22Ref: TM-T3077
2mg39.00€5mg52.00€10mg79.00€25mg131.00€50mg197.00€100mg334.00€500mg803.00€1mL*10mM (DMSO)52.00€SHP2-IN-35
SHP2-IN-35 (Compound 3f) functions as an inhibitor of SHP2. It exhibits antiproliferative activity in cancer cell lines RKO, SW480, and CT26, with IC50 values of 5.72 μM, 3.71 μM, and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the expression of cell cycle-related genes, and induces mitochondrial autophagy (autophagy). Within the tumor microenvironment (TME), SHP2-IN-35 suppresses the expression of certain cytokines and chemokines, thereby modulating tumor progression.Formula:C34H32FeO6Color and Shape:SolidMolecular weight:592.46Norepinephrine
CAS:Norepinephrine (Levophed) can stimulate apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway.Formula:C8H11NO3Purity:98.56% - 99.84%Color and Shape:Colorless Micr°Crystals SolidMolecular weight:169.18PAC-1
CAS:PAC-1 (Procaspase activating compound 1) has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer and Thoracic Cancers.Formula:C23H28N4O2Purity:96.78% - 99.77%Color and Shape:SolidMolecular weight:392.49Momelotinib
CAS:Momelotinib (LM-1149), an oral JAK1/2 inhibitor with IC50s 11/18 nM, blocks ATP binding, disrupting JAK-STAT pathway and reducing tumor growth.Formula:C23H22N6O2Purity:97.47% - 99.56%Color and Shape:SolidMolecular weight:414.46Ref: TM-T1849
1mg38.00€2mg49.00€5mg81.00€10mg95.00€25mg166.00€50mg259.00€100mg406.00€200mg625.00€1mL*10mM (DMSO)88.00€AGN 193109
CAS:AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).Formula:C28H24O2Purity:98.81% - 99.89%Color and Shape:SolidMolecular weight:392.49Ginsenoside Rb1
CAS:Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.Formula:C54H92O23Purity:99.12% - 99.76%Color and Shape:SolidMolecular weight:1109.29Rasagiline Mesylate
CAS:Rasagiline Mesylate (AGN1135) is a novel MAO-B inhibitor, which can treat idiopathic Parkinson's disease.Formula:C13H17NO3SPurity:99.33%Color and Shape:White PowderMolecular weight:267.34Cucurbitacin E
CAS:Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.Formula:C32H44O8Purity:98.88% - 99.19%Color and Shape:SolidMolecular weight:556.69Ref: TM-T5S1467
1mg59.00€5mg115.00€10mg177.00€25mg300.00€50mg445.00€100mg643.00€1mL*10mM (DMSO)140.00€Nutlin-3a
CAS:Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction. Nutlin-3a has antitumor activity. Cost-effective and quality-assured.Formula:C30H30Cl2N4O4Purity:95.62% - 99.71%Color and Shape:SolidMolecular weight:581.49Ref: TM-T6023
1mg49.00€2mg70.00€5mg96.00€10mg164.00€25mg268.00€50mg398.00€100mg587.00€1mL*10mM (DMSO)135.00€Valinomycin
CAS:Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes ParkinFormula:C54H90N6O18Purity:100%Color and Shape:White SolidMolecular weight:1111.32Sophocarpine monohydrate
CAS:Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.Formula:C15H22N2OPurity:99.55%Color and Shape:SolidMolecular weight:246.35AM580
CAS:AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )Formula:C22H25NO3Purity:98% - 99.89%Color and Shape:SolidMolecular weight:351.44Ref: TM-T5854
2mg39.00€5mg57.00€10mg87.00€25mg164.00€50mg316.00€100mg469.00€500mg1,064.00€1mL*10mM (DMSO)64.00€LYN-1604
CAS:LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.Formula:C33H43Cl2N3O2Purity:98%Color and Shape:SolidMolecular weight:584.62Stavudine
CAS:Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.Formula:C10H12N2O4Purity:100% - 99.74%Color and Shape:White PowderMolecular weight:224.213-Methyladenine
CAS:3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).Formula:C6H7N5Purity:98.02% - 99.51%Color and Shape:SolidMolecular weight:149.15Typhaneoside
CAS:Typhaneoside (Aervitrin) is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Shaofu Zhuyu decoction.Formula:C34H42O20Purity:98.92% - 99.95%Color and Shape:SolidMolecular weight:770.69Glycycoumarin
CAS:Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.Formula:C21H20O6Purity:97.64% - 99.78%Color and Shape:SolidMolecular weight:368.38Ref: TM-TN1702
1mg42.00€5mg81.00€10mg122.00€25mg235.00€50mg348.00€100mg515.00€200mg743.00€1mL*10mM (DMSO)89.00€
