DUB
DUB inhibitors target deubiquitinases, enzymes that remove ubiquitin molecules from proteins, thereby regulating the stability, localization, and activity of proteins within the cell. Deubiquitinases play essential roles in various cellular processes, including cell cycle regulation, DNA repair, and immune responses. Dysregulation of DUB activity is linked to cancer, neurodegenerative disorders, and viral infections. Inhibitors of DUBs can modulate these processes, offering potential therapeutic approaches for these conditions. At CymitQuimica, we provide DUB inhibitors to support your research in protein homeostasis, cancer, and neurobiology.
Products of "DUB"
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C527
CAS:C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).Formula:C17H8FNO3Purity:97.22%Color and Shape:SolidMolecular weight:293.25IU1-248
CAS:IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].Formula:C20H23N3O2Purity:99.30%Color and Shape:SolidMolecular weight:337.42Ref: TM-T9375
1mg49.00€5mg104.00€10mg169.00€25mg334.00€50mg472.00€100mg658.00€200mg930.00€1mL*10mM (DMSO)115.00€GNE-6776
CAS:GNE-6776 is a selective USP7 inhibitor.Formula:C20H20N4O2Purity:96.59% - 98.2%Color and Shape:SolidMolecular weight:348.4Ref: TM-T4634
1mg81.00€5mg170.00€10mg273.00€25mg525.00€50mg753.00€100mg1,026.00€1mL*10mM (DMSO)187.00€USP15-IN-1
CAS:USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).Formula:C22H23N3O3Purity:99.35% - 99.81%Color and Shape:SolidMolecular weight:377.44SJB2-043
CAS:SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).Formula:C17H9NO3Purity:98.44%Color and Shape:SolidMolecular weight:275.26USP22-IN-1
CAS:USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Formula:C22H18N4Purity:98.2%Color and Shape:SolidMolecular weight:338.41VLX1570
CAS:VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.Formula:C23H17F2N3O6Purity:98.53% - 99.91%Color and Shape:SolidMolecular weight:469.39Ref: TM-T4067
1mg96.00€2mg155.00€5mg259.00€10mg406.00€25mg680.00€50mg938.00€100mg1,301.00€1mL*10mM (DMSO)265.00€IU1-47
CAS:IU1-47 是一种特异性 USP14抑制剂,IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5, IC50为 20 μM。Formula:C19H23ClN2OPurity:98.94%Color and Shape:SolidMolecular weight:330.85Ref: TM-T15604
1mg35.00€5mg74.00€10mg127.00€25mg263.00€50mg467.00€100mg785.00€200mg1,074.00€1mL*10mM (DMSO)81.00€USP8-IN-1
CAS:USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].Formula:C18H21N5O3SPurity:98.01%Color and Shape:SoildMolecular weight:387.46Ref: TM-T60146
1mg88.00€5mg187.00€10mg264.00€25mg464.00€50mg655.00€100mg944.00€1mL*10mM (DMSO)207.00€USP7-IN-1
CAS:USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Formula:C23H24ClN3O3Purity:98.70%Color and Shape:SolidMolecular weight:425.91Ref: TM-T13268
1mg97.00€5mg188.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€200mg1,130.00€1mL*10mM (DMSO)217.00€IMP-1710
CAS:IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Formula:C23H19N5OPurity:99.77%Color and Shape:SolidMolecular weight:381.43Wu-5
CAS:Wu-5 is a potent USP10 inhibitor that inhibits FLT3 and AMPK pathways, promoting the breakdown of FLT3-ITD and inducing apoptosis.Formula:C15H13NO7SPurity:99.29%Color and Shape:SoildMolecular weight:351.33OTUB2-IN-1
OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).Formula:C19H18N2O6S2Purity:98.19%Color and Shape:SolidMolecular weight:434.49USP1-IN-2
CAS:USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.Formula:C26H22F4N6OPurity:99.60% - 99.88%Color and Shape:SolidMolecular weight:510.486XL177A
CAS:XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.Formula:C48H57ClN8O5Purity:98.75%Color and Shape:SolidMolecular weight:861.47Ref: TM-T9122
1mg96.00€5mg187.00€10mg298.00€25mg507.00€50mg730.00€100mg1,026.00€1mL*10mM (DMSO)283.00€HBX 19818
CAS:HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).Formula:C25H28ClN3OPurity:98.76%Color and Shape:SolidMolecular weight:421.96Ref: TM-T15464
1mg38.00€5mg85.00€10mg117.00€25mg187.00€50mg266.00€100mg373.00€200mg530.00€1mL*10mM (DMSO)94.00€DUB-IN-2
CAS:Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.Formula:C15H9N5OPurity:98.96%Color and Shape:SolidMolecular weight:275.26Ref: TM-T11111
1mg79.00€5mg172.00€10mg259.00€25mg518.00€50mg758.00€100mg1,103.00€200mg1,483.00€1mL*10mM (DMSO)182.00€P 22077
CAS:P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.Formula:C12H7F2NO3S2Purity:97.9% - 99.58%Color and Shape:SolidMolecular weight:315.32USP28-IN-3
CAS:USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formula:C23H20Cl2N2O3SPurity:99.85%Color and Shape:SolidMolecular weight:475.39USP5-IN-1
USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.Formula:C19H20ClN3O5SPurity:99.53%Color and Shape:SoildMolecular weight:437.9FT827
CAS:FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.Formula:C27H28N6O5SPurity:98.76%Color and Shape:SolidMolecular weight:548.61HBX 41108
CAS:HBX 41108: non-competitive, reversible USP7 inhibitor; IC50: 424nM; blocks USP7-p53 deubiquitination; IC50: 0.8μM.Formula:C13H3ClN4OPurity:95.63%Color and Shape:SolidMolecular weight:266.64ML-323
CAS:ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.Formula:C23H24N6Purity:99.87% - 99.96%Color and Shape:SolidMolecular weight:384.48Ref: TM-T1757
1mg89.00€5mg207.00€10mg331.00€25mg512.00€50mg775.00€100mg1,140.00€1mL*10mM (DMSO)245.00€USP7-IN-3
CAS:USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).Formula:C29H31F3N6O3Purity:98%Color and Shape:SolidMolecular weight:568.59Vialinin A
CAS:Vialinin A, a p-terphenyl with antioxidant properties, inhibits TNF-α/USP4/5/SENP1, used in autoimmune/cancer research.Formula:C34H26O8Purity:99.89%Color and Shape:SolidMolecular weight:562.57USP7-797
CAS:USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.Formula:C27H28ClN3O3SPurity:96.18%Color and Shape:SolidMolecular weight:510.05USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Formula:C17H16N6O2SPurity:100% - 96.31%Color and Shape:SolidMolecular weight:368.41USP8-IN-2
CAS:USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.Formula:C19H20ClF3N4OSPurity:98.83%Color and Shape:SolidMolecular weight:444.9Ref: TM-T67876
1mg88.00€5mg210.00€10mg329.00€25mg548.00€50mg782.00€100mg1,035.00€1mL*10mM (DMSO)245.00€NSC632839
CAS:NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2Formula:C21H22ClNOPurity:99.74% - 99.87%Color and Shape:SolidMolecular weight:339.86USP7-IN-8
CAS:Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.Formula:C21H21N3O2Purity:99.31%Color and Shape:SolidMolecular weight:347.41Ref: TM-T9217
1mg48.00€5mg97.00€10mg156.00€25mg284.00€50mg411.00€100mg562.00€200mg743.00€1mL*10mM (DMSO)105.00€TCID
CAS:TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Formula:C9H2Cl4O2Purity:99.34%Color and Shape:SolidMolecular weight:283.92OTUB1/USP8-IN-1 HCl
OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemiaFormula:C22H17Cl2FN2O4Purity:99.90%Color and Shape:SolidMolecular weight:463.29DUB-IN-3
CAS:DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.Formula:C16H9N5OPurity:99.34%Color and Shape:SolidMolecular weight:287.28Ref: TM-T11112
1mg137.00€2mg188.00€5mg325.00€10mg465.00€25mg743.00€50mg1,035.00€100mg1,406.00€500mg2,802.00€1mL*10mM (DMSO)341.00€USP30 inhibitor 18
CAS:USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Formula:C26H28FN3O4SPurity:99.03%Color and Shape:SolidMolecular weight:497.58Ref: TM-T36682
1mg144.00€5mg298.00€10mg472.00€25mg753.00€50mg1,074.00€100mg1,444.00€500mg2,822.00€1mL*10mM (DMSO)325.00€P005091
CAS:P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.Formula:C12H7Cl2NO3S2Purity:99.53% - 99.87%Color and Shape:SolidMolecular weight:348.22DUB-IN-1
CAS:DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).Formula:C20H11N5OPurity:98.33% - 98.96%Color and Shape:SolidMolecular weight:337.33Ref: TM-T11110
1mg65.00€5mg116.00€10mg183.00€25mg353.00€50mg495.00€100mg652.00€200mg895.00€1mL*10mM (DMSO)128.00€MF-094
CAS:MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.Formula:C30H37N3O4SPurity:98.46%Color and Shape:SolidMolecular weight:535.7Ref: TM-T12024
1mg43.00€5mg87.00€10mg144.00€25mg283.00€50mg454.00€100mg655.00€500mg1,454.00€1mL*10mM (DMSO)120.00€I-138
CAS:I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Formula:C26H23F3N6OPurity:99.41%Color and Shape:SolidMolecular weight:492.5Ref: TM-T73560
1mg188.00€2mg255.00€5mg369.00€10mg597.00€25mg1,121.00€50mg1,700.00€100mg2,205.00€1mL*10mM (DMSO)425.00€EOAI3402143
CAS:EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis.Formula:C25H28Cl2N4O3Purity:98.09%Color and Shape:SolidMolecular weight:503.42Ref: TM-T11209
1mg66.00€5mg144.00€10mg227.00€25mg445.00€50mg717.00€100mg1,064.00€1mL*10mM (DMSO)160.00€STD1T
CAS:STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.Formula:C19H19N3O4S2Purity:98.77%Color and Shape:SolidMolecular weight:417.5OTUB1/USP8-IN-1
CAS:OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Formula:C22H16ClFN2O4Purity:98.59%Color and Shape:SoildMolecular weight:426.83USP7/USP47 inhibitor
CAS:USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,Formula:C18H11Cl2N3O3S3Purity:97.98% - 98.5%Color and Shape:SolidMolecular weight:484.4Ref: TM-T4338
1mg43.00€5mg92.00€10mg160.00€25mg329.00€50mg547.00€100mg905.00€500mg1,786.00€1mL*10mM (DMSO)99.00€FT671
CAS:FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).Formula:C24H23F4N7O3Purity:98%Color and Shape:SolidMolecular weight:533.48USP25/28 inhibitor AZ1
CAS:USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.Formula:C17H16BrF4NO2Purity:99.79% - 99.79%Color and Shape:SolidMolecular weight:422.21Ref: TM-T7685
1mg35.00€5mg70.00€10mg97.00€25mg210.00€50mg321.00€100mg472.00€500mg1,035.00€1mL*10mM (DMSO)78.00€SJB3-019A
CAS:SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFormula:C16H8N2O3Purity:99.75%Color and Shape:SolidMolecular weight:276.25Ref: TM-T12926
1mg94.00€2mg137.00€5mg224.00€10mg339.00€25mg560.00€50mg810.00€100mg1,121.00€500mg2,232.00€IU1
CAS:IU1 是一种可逆的特异性人类 USP14 蛋白酶体抑制剂,可以穿透细胞,IC50为 4.7 μM。Formula:C18H21FN2OPurity:98% - 99.30%Color and Shape:SolidMolecular weight:300.37LDN-91946
CAS:LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Formula:C15H10N2O4SPurity:92.78%Color and Shape:SolidMolecular weight:314.32GNE-6640
CAS:GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).Formula:C20H18N4OPurity:98.64%Color and Shape:SolidMolecular weight:330.38Ref: TM-T5461
1mg70.00€2mg92.00€5mg153.00€10mg250.00€25mg535.00€50mg772.00€100mg1,074.00€1mL*10mM (DMSO)166.00€GSK2643943A
CAS:GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Formula:C17H12FN3Purity:97.09%Color and Shape:SolidMolecular weight:277.3USP28-IN-4
CAS:USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formula:C22H18Cl2N2O3SPurity:98.48%Color and Shape:SolidMolecular weight:461.36
