Endothelin Receptor
Endothelin receptors are GPCRs that mediate the effects of endothelins, potent vasoconstrictor peptides that play a significant role in vascular tone regulation, blood pressure control, and cell proliferation. Endothelin receptor antagonists are used in the treatment of conditions such as pulmonary arterial hypertension and heart failure. These receptors are also important targets in research on cardiovascular diseases and cancer. At CymitQuimica, we offer a selection of high-quality endothelin receptor modulators to support your research in cardiovascular biology, oncology, and vascular physiology.
Products of "Endothelin Receptor"
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Found 31 products on this category.
Sulfisoxazole
CAS:Sulfisoxazole: a short-acting antibacterial targeting gram-positive/negative bacteria and inhibits breast cancer exosome by affecting endothelin receptor A.Formula:C11H13N3O3SPurity:99.87% - 99.98%Color and Shape:White To Cream PowderMolecular weight:267.3Aprocitentan
CAS:Aprocitentan (ACT-132577) is ETA and ETB antagonist .Formula:C16H14Br2N6O4SPurity:99.17%Color and Shape:SolidMolecular weight:546.19Ref: TM-T7817
1mg58.00€5mg116.00€10mg170.00€25mg311.00€50mg439.00€100mg655.00€200mg887.00€1mL*10mM (DMSO)142.00€Bosentan
CAS:Bosentan is a competitive endothelin receptor antagonist, used for treating pulmonary arterial hypertension.Formula:C27H29N5O6SPurity:99.8% - 99.84%Color and Shape:Pale Yellow To Off-White SolidMolecular weight:551.614Ref: TM-T6264
10mg38.00€25mg56.00€50mg81.00€100mg127.00€200mg207.00€500mg310.00€1mL*10mM (DMSO)88.00€Nebentan potassium
CAS:Nebentan potassium (YM598) is an ETA receptor antagonist that inhibits pulmonary arterial hypertension and is used in the study of neurologic diseases.Formula:C24H20KN5O5SPurity:98.92%Color and Shape:SolidMolecular weight:529.61Ref: TM-T36008
1mg92.00€2mg120.00€5mg188.00€10mg311.00€25mg550.00€50mg882.00€100mg1,198.00€500mg2,403.00€1mL*10mM (DMSO)226.00€Atrasentan
CAS:Atrasentan (ABT-627) is an endothelin receptor antagonist that can inhibit the activity of ETA.Cost-effective and quality-assured.Formula:C29H38N2O6Purity:97.65% - 99.08%Color and Shape:SolidMolecular weight:510.62Ambrisentan
CAS:Ambrisentan, an endothelin antagonist for PAH, has a low risk of liver enzyme elevation, not linked to acute liver injury.Formula:C22H22N2O4Purity:99.65% - 99.86%Color and Shape:SolidMolecular weight:378.42SB-209670
CAS:SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.Formula:C29H28O9Purity:97.39% - 99.24%Color and Shape:SolidMolecular weight:520.53Ref: TM-T34541
1mg333.00€5mg787.00€10mg1,074.00€25mg1,510.00€50mg1,882.00€100mg2,375.00€500mg4,655.00€1mL*10mM (DMSO)797.00€Darusentan
CAS:Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteriesFormula:C22H22N2O6Purity:98.72%Color and Shape:SolidMolecular weight:410.43Ref: TM-T5458
1mg49.00€2mg69.00€5mg103.00€10mg170.00€25mg305.00€50mg505.00€100mg730.00€1mL*10mM (DMSO)106.00€BMS 182874
CAS:BMS 182874: Oral ETA antagonist, IC50=0.150 μM, Ki=0.055 μM, lowers hypertension in rats.Formula:C17H19N3O3SPurity:98.38%Color and Shape:SolidMolecular weight:345.42BQ-123
CAS:BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.Formula:C31H42N6O7Purity:99.22% - ≥95%Color and Shape:SolidMolecular weight:610.7Ref: TM-T6792
1mg88.00€5mg202.00€10mg329.00€25mg548.00€50mg782.00€100mg1,035.00€1mL*10mM (DMSO)274.00€IRL 2500
CAS:IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.Formula:C36H35N3O4Purity:98.29%Color and Shape:White Crystalline SolidMolecular weight:573.68Macitentan
CAS:Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).Formula:C19H20Br2N6O4SPurity:100% - 99.88%Color and Shape:SolidMolecular weight:588.27Aminaftone
CAS:Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis.Formula:C18H15NO4Purity:96.31% - 99.39%Color and Shape:SolidMolecular weight:309.32Sitaxsentan
CAS:Sitaxsentan (TBC-11251), a selective ETA receptor antagonist, prevents vasoconstriction by blocking endothelin.Formula:C18H15ClN2O6S2Purity:97.99% - 99.34%Color and Shape:SolidMolecular weight:454.9Sitaxsentan sodium
CAS:Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.Formula:C18H14ClN2O6S2·NaPurity:98.39% - ≥95%Color and Shape:SolidMolecular weight:476.89Ro 46-2005
CAS:Ro 46-2005: Synthetic non-peptide, blocks 125I-ET-1 at ETA receptors on human vascular cells (IC50: 220 nM).Formula:C23H27N3O6SPurity:98.02% - 98.8%Color and Shape:SolidMolecular weight:473.54Patecibart
CAS:Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).Purity:98%Color and Shape:LiquidClazosentan
CAS:Clazosentan (Ro 61-1790) is a selective ET_A receptor antagonist that inhibits ET-1 vasoconstriction and prevents cerebral vasospasm.Formula:C25H23N9O6SPurity:95.39% - 99.43%Color and Shape:SolidMolecular weight:577.57Ref: TM-T64084
1mg79.00€5mg178.00€10mg279.00€25mg628.00€50mg1,017.00€100mg1,311.00€200mg1,768.00€1mL*10mM (DMSO)230.00€Atrasentan hydrochloride
CAS:Atrasentan hydrochloride (ABT-627 hydrochloride) is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).Formula:C29H39ClN2O6Purity:98.64%Color and Shape:SolidMolecular weight:547.08Edonentan
CAS:Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.Formula:C28H32N4O5SPurity:98.78% - 99%Color and Shape:SolidMolecular weight:536.64Sulfatroxazole
CAS:Sulfatroxazole (Isosulfafurazole) (compound 12) is a selective antagonist of the ETA receptor with an IC50 of 0.26 μM.Formula:C11H13N3O3SColor and Shape:SolidMolecular weight:267.3Sparsentan
CAS:Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM,Formula:C32H40N4O5SPurity:97.94% - 98.75%Color and Shape:SolidMolecular weight:592.75Ref: TM-T5355
2mg39.00€5mg58.00€10mg94.00€25mg170.00€50mg259.00€100mg380.00€200mg540.00€1mL*10mM (DMSO)77.00€Bosentan (hydrate)
CAS:Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.Formula:C27H29N5O6S·H2OPurity:99.31% - 99.86%Color and Shape:White PowderMolecular weight:569.63Myriceric acid C
CAS:Myriceric acid C has cytotoxic activity against human lung carcinoma and breast carcinoma.Formula:C48H60O10Purity:98%Color and Shape:SolidMolecular weight:796.98BMS 182874 hydrochloride
CAS:BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.Formula:C17H20ClN3O3SPurity:97.01%Color and Shape:SolidMolecular weight:381.88Ref: TM-T21790
1mg81.00€2mg97.00€5mg148.00€10mg215.00€25mg361.00€50mg505.00€100mg702.00€200mg947.00€1mL*10mM (DMSO)155.00€BQ-788
CAS:BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.Formula:C34H51N5O7Purity:98.67%Color and Shape:SolidMolecular weight:641.8Ref: TM-T10595
1mg137.00€2mg188.00€5mg329.00€10mg472.00€25mg753.00€50mg1,017.00€100mg1,378.00€500mg2,737.00€1mL*10mM (DMSO)360.00€RO 46-8443
CAS:RO 46-8443: First non-peptide ETB receptor antagonist, >2000-fold ETB selectivity in binding and function.Formula:C31H35N3O8SPurity:98.77% - 99.77%Color and Shape:SolidMolecular weight:609.69Zibotentan
CAS:Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.Formula:C19H16N6O4SPurity:97.00% - 99.34%Color and Shape:SolidMolecular weight:424.43Avosentan
CAS:Avosentan(Ro 67-0565; SPP-301) is a potent endothelin receptor (ETA) antagonist.Cost-effective and quality-assured.Formula:C23H21N5O5SPurity:98.25% - 99.47%Color and Shape:SolidMolecular weight:479.51BQ-3020 ammonium
BQ-3020 ammonium, a selective endothelin receptor (ET B receptor) agonist, demonstrates inhibition of [125 I] ET-1 binding to ET B receptors with an IC50 of 0.2Formula:C96H140N20O25S·xNH3Purity:98%Color and Shape:SolidMolecular weight:2006.32 (free base)Enrasentan
CAS:Enrasentan (sb-217242) is a mixed antagonist of ET(A) and ET(B) receptors that reduces blood pressure and protects myocardial function.Formula:C29H30O8Purity:97.90% - 97.96%Color and Shape:SolidMolecular weight:506.54
