PKA
Protein kinase A (PKA) is a key enzyme in the GPCR signaling cascade, activated by cyclic AMP (cAMP) in response to various extracellular signals. PKA regulates a wide range of cellular processes, including metabolism, gene expression, and cell growth. Dysregulation of PKA activity is associated with various diseases, including cancer, metabolic disorders, and cardiovascular conditions. PKA modulators are valuable tools in research aimed at understanding GPCR signaling pathways and developing new therapeutic strategies. At CymitQuimica, we provide a selection of high-quality PKA modulators to support your research in signal transduction, cellular regulation, and disease mechanisms.
Products of "PKA"
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8-Bromo-cAMP sodium salt
CAS:8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. 8-Bromo-cAMP is an activator of cyclic AMP-dependent protein kinase.Formula:C10H10BrN5NaO6PPurity:98% - 99.94%Color and Shape:Off-White PowderMolecular weight:430.08KT5720
CAS:KT5720 is a cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (PKA) (Ki: 60 nM).Formula:C32H31N3O5Purity:98%Color and Shape:SolidMolecular weight:537.61H-89 dihydrochloride
CAS:H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).Formula:C20H20BrN3O2S·2HClPurity:100% - 99.40%Color and Shape:SolidMolecular weight:519.28Ref: TM-T6250
5mg39.00€10mg58.00€25mg106.00€50mg202.00€100mg344.00€200mg512.00€500mg815.00€1mL*10mM (DMSO)52.00€Protein kinase G inhibitor-1
CAS:Protein kinase G inhibitor-1 is a potent Protein kinase G inhibitor, IC50= 0.9 uM.Formula:C14H18N2O2SPurity:98.11%Color and Shape:SoildMolecular weight:278.37Ref: TM-T67755
1mg115.00€5mg255.00€10mg375.00€25mg562.00€50mg792.00€100mg1,064.00€200mg1,444.00€1mL*10mM (DMSO)235.00€H-89
CAS:H-89 is a PKA inhibitor, a candidate cardioprotectant, induces spatial learning impairment in rats, and can be used to study myocardial infarction.Formula:C20H20BrN3O2SPurity:98.06%Color and Shape:Off-White PowderMolecular weight:446.36Ref: TM-T11524
5mg40.00€10mg59.00€25mg114.00€50mg170.00€100mg254.00€500mg627.00€1mL*10mM (DMSO)44.00€Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formula:C14H18ClN3O2SPurity:100% - ≥95%Color and Shape:White SolidMolecular weight:327.83Aplithianines A
Aplithianines A effectively inhibits J-PKAcα with an IC50 value of 1 μM and displays higher potency against wild-type PKA, achieving an IC50 of 84 nM byPurity:98%Color and Shape:Odour SolidAT13148
CAS:AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.Formula:C17H16ClN3OPurity:98.04% - ≥95%Color and Shape:SolidMolecular weight:313.78CCG215022
CAS:CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.Formula:C26H22FN7O3Purity:97.63% - 99.69%Color and Shape:SolidMolecular weight:499.5Ref: TM-T3498
1mg96.00€2mg140.00€5mg235.00€10mg378.00€25mg630.00€50mg898.00€100mg1,216.00€500mg2,442.00€1mL*10mM (DMSO)259.00€HA-100
CAS:HA-100 is an inhibitor of protein kinaseFormula:C13H15N3O2SPurity:99.44%Color and Shape:Pale Yellow Crystalline SolidMolecular weight:277.34Rp-cAMPS triethylammonium salt
CAS:Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.Formula:C16H27N6O5PSPurity:98%Color and Shape:SolidMolecular weight:446.46Bucladesine sodium
CAS:Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties.Formula:C18H23N5NaO8PPurity:96.56% - 99.76%Color and Shape:White PowderMolecular weight:491.37AP-C2
CAS:AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.Formula:C18H16N4SPurity:100%Color and Shape:SoildMolecular weight:320.41A-3 hydrochloride
CAS:A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.Formula:C12H14Cl2N2O2SPurity:99.32%Color and Shape:SolidMolecular weight:321.22Ref: TM-T14069
1mg35.00€5mg66.00€10mg96.00€25mg170.00€50mg274.00€100mg439.00€500mg938.00€1mL*10mM (DMSO)90.00€Bilobetin
CAS:Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.Formula:C31H20O10Purity:97.74% - 99.73%Color and Shape:SolidMolecular weight:552.48Ref: TM-T4S2128
1mg47.00€2mg70.00€5mg144.00€10mg250.00€25mg424.00€50mg613.00€100mg843.00€1mL*10mM (DMSO)187.00€AT7867
CAS:AT7867 inhibits Akt1/2/3 & p70S6K/PKA (IC50: 32/17/47 nM & 85/20 nM), minimal effect beyond AGC kinases.Formula:C20H20ClN3Purity:99.63%Color and Shape:SolidMolecular weight:337.85Ref: TM-T6304
2mg44.00€5mg65.00€10mg86.00€25mg135.00€50mg210.00€100mg313.00€200mg452.00€1mL*10mM (DMSO)65.00€Gliotoxin
CAS:Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.Formula:C13H14N2O4S2Purity:98%Color and Shape:SolidMolecular weight:326.39PKG drug G1
CAS:PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.Formula:C13H11N3OSPurity:97.57% - 97.67%Color and Shape:SolidMolecular weight:257.31Ref: TM-T4661
2mg39.00€5mg56.00€10mg87.00€25mg156.00€50mg227.00€100mg344.00€500mg812.00€1mL*10mM (DMSO)62.00€Staurosporine
CAS:Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFormula:C28H26N4O3Purity:99.24% - 99.98%Color and Shape:Off-White PowderMolecular weight:466.53Ref: TM-T6680
1mg62.00€2mg87.00€5mg97.00€10mg145.00€25mg246.00€50mg401.00€100mg597.00€500mg1,283.00€1mL*10mM (DMSO)109.00€Metadoxine
CAS:Metadoxine (Metadoxil) is a neurotransmitter stimulant.Formula:C8H11NO3·C5H7NO3Purity:99.19%Color and Shape:Off-White PowderMolecular weight:298.29
