OX Receptor
Orexin receptors (OX1 and OX2) are GPCRs that bind to orexins, neuropeptides involved in regulating wakefulness, appetite, and energy homeostasis. Dysregulation of orexin signaling is linked to sleep disorders such as narcolepsy, as well as metabolic conditions like obesity. Orexin receptor modulators are being investigated for their therapeutic potential in treating sleep disorders, anxiety, and addiction. At CymitQuimica, we offer a range of high-quality orexin receptor modulators to support your research in sleep biology, metabolism, and neuropharmacology.
Products of "OX Receptor"
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Filorexant
CAS:Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).Formula:C24H25FN4O2Purity:98.88%Color and Shape:SolidMolecular weight:420.48IPSU
CAS:IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.Formula:C23H27N5O2Purity:97.05%Color and Shape:SolidMolecular weight:405.49Ref: TM-T5503
2mg51.00€5mg86.00€10mg97.00€25mg200.00€50mg299.00€100mg432.00€200mg662.00€1mL*10mM (DMSO)92.00€SB-408124
CAS:SB408124: Non-peptide, OX1 receptor antagonist, Ki 57 nM (whole cell) and 27 nM (membrane), 50x more selective than OX2.Formula:C19H18F2N4OPurity:98.14%Color and Shape:SolidMolecular weight:356.37MK-1064
CAS:MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).Formula:C24H20ClN5O3Purity:99.19% - 99.82%Color and Shape:SolidMolecular weight:461.9SB-674042
CAS:SB-674042 is a nonpeptide dual antagonist of the appetite peptides OX1 and OX2 receptors.SB-674042 is used in the treatment of depression.Formula:C24H21FN4O2SPurity:99.9%Color and Shape:SolidMolecular weight:448.51EMPA
CAS:EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nMFormula:C23H26N4O4SPurity:99.11%Color and Shape:SolidMolecular weight:454.54Ref: TM-T11186
1mg51.00€5mg105.00€10mg157.00€25mg278.00€50mg416.00€100mg625.00€200mg873.00€1mL*10mM (DMSO)116.00€DORA-22
CAS:DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memoryFormula:C23H22F2N4O2Purity:97.67%Color and Shape:SolidMolecular weight:424.44Ref: TM-T5500
1mg131.00€2mg188.00€5mg284.00€10mg430.00€25mg710.00€50mg998.00€100mg1,349.00€1mL*10mM (DMSO)331.00€RTIOXA-43
CAS:RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.Formula:C37H37N5O5SPurity:99.17%Color and Shape:SolidMolecular weight:663.79Ref: TM-T87345
1mg221.00€5mg545.00€10mg879.00€25mg1,696.00€50mg2,725.00€100mg3,686.00€1mL*10mM (DMSO)795.00€Seltorexant
CAS:Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.Formula:C21H22FN7OPurity:100% - 99.86%Color and Shape:SolidMolecular weight:407.44Ref: TM-T12877L
1mg37.00€2mg52.00€5mg79.00€10mg103.00€25mg153.00€50mg274.00€100mg378.00€500mg868.00€1mL*10mM (DMSO)87.00€Suntinorexton
CAS:Suntinorexton (TAK 861) is an orexin type 2 receptor (OX2R) agonist used in the study of neurologic disorders.Formula:C23H28F2N2O4SPurity:100%Color and Shape:SolidMolecular weight:466.54Ref: TM-T39807
1mg204.00€5mg503.00€10mg727.00€25mg1,074.00€50mg1,448.00€100mg1,892.00€200mg2,539.00€1mL*10mM (DMSO)526.00€Almorexant
CAS:Almorexant (ACT 078573), a strong dual orexin receptor antagonist, has Ki of 1.3 nM for OX1 and 0.17 nM for OX2.Formula:C29H31F3N2O3Purity:97.75% - 98.02%Color and Shape:SolidMolecular weight:512.56TCS-OX2-29
CAS:TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.Formula:C23H31N3O3Purity:99.81%Color and Shape:SolidMolecular weight:397.51Ref: TM-T4965
1mg35.00€5mg70.00€10mg96.00€25mg156.00€50mg215.00€100mg303.00€200mg449.00€1mL*10mM (DMSO)77.00€MK-3697
CAS:MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).Formula:C23H21N5O3SPurity:97.69% - 98.15%Color and Shape:SolidMolecular weight:447.51Ref: TM-T1913
1mg52.00€2mg69.00€5mg96.00€10mg119.00€25mg210.00€50mg350.00€100mg505.00€1mL*10mM (DMSO)105.00€TCS 1102
CAS:TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).Formula:C27H26N4O2SPurity:99.35% - 99.52%Color and Shape:SolidMolecular weight:470.59YNT-185
CAS:YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R,Formula:C33H37N5O5SPurity:98.6%Color and Shape:SolidMolecular weight:615.74PF3274167
CAS:PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.Formula:C19H19ClFN5O3Purity:99.67% - 99.88%Color and Shape:SolidMolecular weight:419.84ACT-462206
CAS:ACT-462206 is a Orexin 1/Orexin 2 receptor antagonist.ACT-462206 is highly potent and can be used to study sleep and anxiety.Formula:C20H24N2O4SPurity:99.45%Color and Shape:SolidMolecular weight:388.48Ref: TM-T26559
1mg44.00€5mg93.00€10mg137.00€25mg279.00€50mg445.00€100mg707.00€500mg1,415.00€1mL*10mM (DMSO)93.00€Orexin 2 Receptor Agonist
CAS:Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.Formula:C32H34N4O5SPurity:98.26% - 99.43%Color and Shape:SolidMolecular weight:586.7Ref: TM-T3177
2mg42.00€5mg64.00€10mg80.00€25mg137.00€50mg233.00€100mg340.00€200mg472.00€1mL*10mM (DMSO)81.00€SB-649868
CAS:SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).Formula:C26H24FN3O3SPurity:99.53%Color and Shape:SolidMolecular weight:477.55Ref: TM-T5498
1mg37.00€5mg111.00€10mg187.00€25mg399.00€50mg645.00€100mg1,035.00€200mg1,388.00€1mL*10mM (DMSO)136.00€L-368,899 hydrochloride
CAS:L-368,899 hydrochloride is an OXTR antagonist that prevents oxytocin-induced antiabnormal pain and anti-nausea, and may be used in the study of depression.Formula:C26H43ClN4O5S2Purity:99.59%Color and Shape:SolidMolecular weight:591.23Ref: TM-T11794
2mg111.00€5mg156.00€10mg243.00€25mg462.00€50mg723.00€100mg1,017.00€1mL*10mM (DMSO)212.00€
