GRK
G protein-coupled receptor kinases (GRKs) are a family of enzymes that phosphorylate activated GPCRs, leading to receptor desensitization and regulation of receptor signaling. GRKs play critical roles in controlling the intensity and duration of GPCR signaling, making them important in the regulation of various physiological processes, including cardiovascular function, immune response, and neurotransmission. GRK inhibitors and activators are studied for their potential therapeutic applications in heart failure, cancer, and neurological disorders. At CymitQuimica, we provide a range of high-quality GRK modulators to support your research in signal transduction, receptor regulation, and therapeutic development.
Products of "GRK"
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Found 10 products on this category.
GRK5-IN-2
CAS:GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor.Formula:C20H20N4O4Purity:99.61%Color and Shape:SolidMolecular weight:380.4Ref: TM-T9609
2mg35.00€5mg50.00€10mg80.00€25mg145.00€50mg226.00€100mg335.00€200mg469.00€1mL*10mM (DMSO)55.00€GRK2-IN-1 hydrochloride (2055990-90-2 free base)
GRKs-IN-1 hydrochloride has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).Formula:C24H26ClFN4O4Purity:98%Color and Shape:SolidMolecular weight:488.94CCG258208
CAS:GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).Formula:C24H25FN4O4Purity:98%Color and Shape:SolidMolecular weight:452.48CCG215022
CAS:CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.Formula:C26H22FN7O3Purity:97.63% - 99.69%Color and Shape:SolidMolecular weight:499.5Ref: TM-T3498
1mg96.00€2mg140.00€5mg235.00€10mg378.00€25mg630.00€50mg898.00€100mg1,216.00€500mg2,442.00€1mL*10mM (DMSO)259.00€GRK6-IN-1
CAS:GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.Formula:C22H23ClN6O2Purity:99.37%Color and Shape:SolidMolecular weight:438.91Ref: TM-T62518
1mg57.00€5mg120.00€10mg188.00€25mg432.00€50mg747.00€100mg1,216.00€1mL*10mM (DMSO)133.00€GSK299115A
CAS:GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively.Formula:C20H16Cl2N4O2Purity:98.99%Color and Shape:SolidMolecular weight:415.27Ref: TM-T27471
1mg319.00€5mg772.00€10mg1,074.00€25mg1,596.00€50mg2,147.00€100mg2,822.00€1mL*10mM (DMSO)945.00€GRK6-IN-2
CAS:GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.Formula:C21H21FN6Purity:98.94%Color and Shape:SolidMolecular weight:376.43Takeda103A
CAS:Takeda103A (CMPD103A) is the GRK2-dependent bovine tubulin oxidation effective inhibitor.Formula:C24H23F2N7OPurity:97.17%Color and Shape:SolidMolecular weight:463.48Ref: TM-T24850
1mg85.00€2mg105.00€5mg164.00€10mg258.00€25mg424.00€50mg562.00€100mg787.00€200mg1,035.00€1mL*10mM (DMSO)187.00€GSK270822A
CAS:GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.Formula:C24H20N4O2Purity:98.13% - 99.78%Color and Shape:SolidMolecular weight:396.44Ref: TM-T27467
1mg140.00€5mg331.00€10mg439.00€25mg667.00€50mg894.00€100mg1,198.00€200mg1,596.00€1mL*10mM (DMSO)340.00€1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID
CAS:1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID targets GRK2.Formula:C13H13NO5Purity:99.55%Color and Shape:SolidMolecular weight:263.25
![1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT8913.webp&w=3840&q=75)