Hedgehog/Smoothened
The Hedgehog/Smoothened signaling pathway is a crucial GPCR-related pathway involved in embryonic development, tissue regeneration, and stem cell maintenance. Smoothened (SMO) is a key transmembrane protein that transduces signals from the Hedgehog (Hh) ligands to activate downstream signaling cascades. Dysregulation of the Hedgehog/Smoothened pathway is implicated in various cancers and developmental disorders, making it a significant target for therapeutic intervention. At CymitQuimica, we offer a range of high-quality modulators for the Hedgehog/Smoothened pathway to support your research in developmental biology, oncology, and regenerative medicine.
Products of "Hedgehog/Smoothened"
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GANT 61
CAS:GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2.Formula:C27H35N5Purity:100% - ≥95%Color and Shape:SolidMolecular weight:429.6Ellagic acid
CAS:Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor. Ellagic acid is an antioxidant. Cost-effective and quality-assured.Formula:C14H6O8Purity:97.11% - 99.75%Color and Shape:Cream Colored Needles From Pyridine 1992)Molecular weight:302.19MRT-10
CAS:MRT-10 is a Smoothened (Smo) receptor antagonist.Formula:C24H23N3O5SPurity:99.47%Color and Shape:SolidMolecular weight:465.52Ref: TM-T23027
1mg47.00€2mg63.00€5mg96.00€10mg135.00€25mg265.00€50mg378.00€100mg530.00€200mg720.00€1mL*10mM (DMSO)87.00€Naftifine hydrochloride
CAS:Naftifine HCl: synthetic antifungal; inhibits squalene epoxidase, disrupting fungal cell sterol synthesis.Formula:C21H22ClNPurity:98.75% - 99.84%Color and Shape:SolidMolecular weight:323.86Jervine
CAS:Jervine inhibits Smoothened, blocking Hedgehog signaling and GLI1 transcription activation.Formula:C27H39NO3Purity:99.20% - 99.86%Color and Shape:Needles From Methanol + Water SolidMolecular weight:425.6Ref: TM-T3363
5mg70.00€10mg119.00€25mg259.00€50mg499.00€100mg715.00€500mg1,444.00€1mL*10mM (DMSO)74.00€AZD8542
CAS:AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.Formula:C25H24N4O2Purity:99.96%Color and Shape:SolidMolecular weight:412.48Taladegib
CAS:Taladegib (LY2940680), an oral Smo receptor antagonist, targets Hedgehog signaling for cancer treatment.Formula:C26H24F4N6OPurity:100% - 99.39%Color and Shape:SolidMolecular weight:512.5Vismodegib
CAS:Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).Formula:C19H14Cl2N2O3SPurity:98% - 99.99%Color and Shape:SolidMolecular weight:421.3GANT 58
CAS:GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).Formula:C24H16N4SPurity:99.53%Color and Shape:SolidMolecular weight:392.48Sonidegib
CAS:Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.Formula:C26H26F3N3O3Purity:98% - 99.97%Color and Shape:SolidMolecular weight:485.5GSA-10
CAS:GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.Formula:C26H30N2O5Purity:≥98%Color and Shape:SolidMolecular weight:450.53Purmorphamine
CAS:Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo.Formula:C31H32N6O2Purity:97.19% - 99.48%Color and Shape:Light Tan SolidMolecular weight:520.62JK184
CAS:JK184 is a potent Hedgehog (Hh) pathway inhibitor.Formula:C19H18N4OSPurity:99.09% - 99.89%Color and Shape:SolidMolecular weight:350.44TAK-441
CAS:TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.Formula:C28H31F3N4O6Purity:98.79%Color and Shape:SolidMolecular weight:576.56MRT-81
CAS:MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.Formula:C31H29N3O5SPurity:98.31%Color and Shape:SolidMolecular weight:555.64Ref: TM-T9532
1mg48.00€5mg97.00€10mg145.00€25mg255.00€50mg368.00€100mg505.00€200mg692.00€1mL*10mM (DMSO)116.00€
