Antibacterial

Rufloxacin HCl (MF-934 HCl): a fluoroquinolone that inhibits topoisomerase and B-cell differentiation.

Pymetrozine (CGA 215944) is a Homoptera feeding inhibitor that effectively prevents transmission of the cauliflower mosaic caulimovirus by the aphid species

IMB-808 is an LXRα/β dual agonist that promotes ABCA1 expression and cholesterol efflux, used in atherosclerosis research.

Ftaxilide (Histanorm) has antibacterial property, used as antiseptic.

Amikacin hydrate (BAY 41-6551 hydrate) is an aminoglycoside antibiotic with bacteriostatic properties.

Biapenem (CLI 86815), a carbapenem antibiotic, has broad antibacterial effects, stable kidney enzyme resistance, and low neurotoxicity.

N-acetyl Dapsone is an anti-inflammatory and antimicrobial compound widely used in the treatment of leprosy, malaria, acne and various immune disorders.

Robinetin (3,3',4',5',7-Pentahydroxyflavone) has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with

Applications 9-(2,5-d|Dioxo-L-3-amino-1-pyrrolidineacetic acid)-10-deglycine Daptomycin is a stereoisomer of Daptomycin (D193350), cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial. References Allen, N.E., et al.: Antimicrob. Agents Chemother., 31, 1093 (1987), Tully, F.P., et al.: Expert Opin. Invest. Drugs, 8, 1223 (1999),

Stability Light Sensitive, Temperature Sensitive Applications Labelled Lymecycline. A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial. References Andrews, C., et al.: Pharm. Res., 17, 639 (2000), Votano, J., et al.: J. Med. Chem., 49, 7169 (2006), Davis, A., et al.: Curr. Opin. Chem. Biol., 8, 378 (2004),

Applications Ceftiofur Sodium is a cephalosporin based antibacterial compound. References Heinrich, K. et al: Food Addit. Contam. A., 30, 1733 (2013); Harlow, B. et al.: Veter. Microbiol., 166, 225 (2013);

Cefazolin sodium, a beta-lactam antibiotic, targets PBPs to disrupt bacterial cell wall synthesis, causing cell lysis.

Applications Labelled Isoniazid. Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic). References Brewer, G.A., et al.: Anal. Profiles Drug Subs., 6, 183 (1977), Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979)

Sulfamoxole (Sulfamoxol) is an antibacterial belonging to sulfonamide.

PNU-176798 is an agent with antimicrobial.

Walrycin B is a new-type antibacterial compound targeting the WalR response regulator.

Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches.

Applications Cefotiam Dihydrochloride-13C, 15N2 is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations. References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)

Cefoperazone (Medocef) inactivates PBPs, disrupting bacterial cell wall synthesis and division; inhibits rMrp2 [3H]E217βG uptake (IC50: 199 μM).

Difloxacin hydrochloride (Difloxacin HCl) is a fluoroquinolone antibiotic, is a broad-spectrum antibacterial drug.

TBT1 is a first-gen MsbA ATPase activator and LPS transport blocker in Acinetobacter, EC50 at 13 μM.

Impurity Cefalotin EP Impurity D Applications Deacetylcephalothin Lactone (Cefalotin EP Impurity D) is an impurity in the synthesis of Cefalonium (C236800), a first-generation cephalosporin antibiotic used as a long-acting intramammary cerate for infusion of dairy cows. References Endo, T.: Kach. Kokin. Kenk., 12, 8 (1991); Berry, E.A. et al.: J. Dairy Sci., 90, 760 (2007); Bradley, A.J. et al.: J. Dairy Sci., 93, 1566 (2010); Shibata, K., et al.: J. Antibiot., 50, 135 (1997);

Thiamphenicol (Dextrosulphenidol) is a methylsulfonyl analog of chloramphenicol. It is an antibiotic and immunosuppressive agent.

Sulfamethoxazole (STX 608), a sulfonamide antimicrobial, inhibits Cytochrome P450 2C9.

Stability Hygroscopic Applications Ribostamycin is a broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus. It is used in pharmacokinetic and nephrotoxicity studies. References Zhou, S., et al.: Clinical Pharmacokinetics, 22, 144 (1992); Kitasato, I., et al.: Drugs Under Experimental and Clinical Research, 15, 273 (1989)

Applications Antibacterial. References Bourguignon, G.J., et al.: Antimicrob. Agents Chemother., 4, 479 (1973), Grubb, P.E., et al.: Anal. Profiles Drug Subs., 8, 371 (1979), Wright, H.T., et al.: Science, 213, 455 (1981),

Myristoyl glutamic acid (N-Myristoyl-L-glutamic acid) is a myristoyl glutamic acid, a surfactant that can be added to evolved make-up with foaming and partial

(3R,4R)-A2-32-01 is the (R,R)-enantiomer of A2-32-01 and has potential antibacterial activity.

2,6-Dimethoxyquinone, slightly soluble and weakly basic, is found in Rauvolfia vomitoria, Tibouchina pulchra, and wheat.

Cefsulodin sodium (Sulcephalosporin) hydrate is a β lactam antibiotic.

Effusanin A: antibacterial, damages DNA, inhibits DU145 cells at 3.16 μM and LoVo cells at 3.02 μM.

Chalcone (Cinnamophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as

Contezolid (MRX-I) is an antibiotic with bactericidal activity and can be used to study tuberculosis.

Chloroxine (Capitrol) is a quinoline derivative with antibacterial activity. Topical administration of chloroxine diminishes mitotic activity in the epidermis.

Dihydrostreptomycin sulfate (Dihydrostreptomycin sesquisulfate) inhibits protein synthesis by binding to the 30S ribosomal subunit.

Stability Hygroscopic Applications Neomycin C Hexaacetate is an aminoglycoside antibiotic found in many topical medications. Neomycin has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia. References Umezawa, S., et al.: Bull. Chem. Soc. Jpm., 53, 3259 (1980); The Journal of antibiotics, NO. 2. 189 (1977);

Impurity Cefuroxime Sodium EP Impurity E Applications Desethyl Acetate (E)-Cefuroxime Axetil (Cefuroxime Sodium EP Impurity E) is a product from the photoisomerization of Cefuroxime Axetil (C248065), which is s widely used to treat respiratory tract infections. Antibacterial. References Fabre, H., et. al.: J. Pharm. Sci., 83, 553 (1994); Nguyen, N., et al.: Pharm. Res., 8, 893 (1991); Stoeckel, K., et al.: Antimicrob. Agents Chemother., 42, 2602 (1998); Scott, L., et al.: Drugs, 61, 1455 (2001); Bulitta, J. B., et al.: Antimicrob. Agents Chemother., 53, 3462 (2009)

WAY-329764 is an antibacterial agent.

4-Methylherniarin (7-Methoxy-4-methylcoumarin) is a coumarin derivative and fluorescent label, it displays good activity against B. subtilis.

Applications Vaborbactam is a non-β-lactam β-lactamase inhibitor. While not effective as an antibiotic by itself, it restores potency to existing antibiotics by inhibiting the beta-lactamase enzymes that would otherwise degrade them. When combined with an appropriate antibiotic it can be used for the treatment of gram-negative bacterial. References Hecker, S.J., et al.: Journal of Medicinal Chemistry, 58, 3682 (2015);

Applications Azithromycin-d5, is the labeled analogue Azithromycin (A927000), a semi-synthetic macrolide antibiotic; related to Erythromycin A. Antibacterial. References Langtry, H.D., et al.: Drugs, 56, 273 (1998),

Applications An antibacterial drug. Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.This compound is a contaminant of emerging concern (CECs). References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 467 (1973), Wormser, G.P., et al.: Drugs, 24, 459 (1982), Wharton, M., et al.: Ann. Intern. Med., 105, 37 (1986),

Applications (R)-(+)-Camphor is a terpenoid with a wide variety of use. (R)-(+)-Camphor has insecticidal activity and is also used as an antimicrobial agent. (R)-(+)-Camphor is used as a culinary flavouring agent in parts of asia. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Abdelgaleil, S.A.M. Appl. Entomol. Zool., 45, 425 (2010); Tabanca, N. et al.: J. Agric. Food. Chem., 49, 4300 (2001);

Irloxacin, a new quinolone, works best in acid pH, effectively targeting both gram-positive and negative bacteria.

Succinylsulfathiazole (Succinylsulphathiazole) is a sulfonamide. An ultra long-acting drug.

Applications Oleacein is one of the most abundant phenolic compounds of extra virgin olive oil and has antioxidant, anti-inflammatory, anti-proliferative, and antimicrobial activity. Oleacein may also be used as a potential antiatherosclerotic drug. References Naruszewicz, M., et al.: Curr. Pharm. Design, 21, 1205 (2015); Vougogiannopoulou, K., et al.: J. Nat. Prod., 77, 441 (2014); Sindona, G., et al.: Curr. Med. Chem., 19, 4006 (2012)

Piperlonguminine is an alkaloid amide isolated from the Piper species.

β-Glucuronidase-IN-1 is an E.

NITD-349 is an inhibitor of MmpL3. It shows highly potent anti-mycobacterial activity with MIC50 of 23 nM against virulent Mycobacterium tuberculosis H37Rv.

3-Hydroxy-C4-HSL is a bacterial community sensing (QS) inducer.

RPW-24 is a stimulator of host immune defenses, has antibacterial activity.

Obafluorin is a β-lactone antibiotic produced by fluorescent Pseudomonas ATCC 39502, with broad-spectrum antibacterial activity.

Sulfalene (SMP2), a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria.

Ertapenem sodium (MK-826) is a long-acting carbapenem antibiotic effective against a wide range of bacteria, including ESBL producers.

Applications rac Fosfomycin-13C3 Benzylamine Salt is an antibiotic. References Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981);

Ceftriaxone sodium hydrate is a broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.

Methyl quinoline-2-carboxylate (Methyl 2-quinolinecarboxylate) inhibits the binding of Mycobacterium tuberculosis.

Methenamine Hippurate is a component of Hiprex, with antibacterial activity.

MF 5137 is an effective antimicrobial agent.

Ethyl Orsellinate (Orsellinic acid ethyl ester) is a phenolic acid, extracted from lichens.

N2-Acetylaciclovir (Aciclovir EP Impurity F) is a derivative of the antiviral compound Aciclovir, which has selective T-cell immunotoxicity.

Lenampicillin hydrochloride is an orally active prodrug of Ampicillin. Lenampicillin hydrochloride is an effective beta-lactam antibacterial agent that inhibits bacterial penicillin-binding proteins. It is applied in the investigation of suppurative skin

MAC13243 HCl inhibits LolA chaperone, targeting Gram-negative bacteria as a specific antimicrobial agent.

Orbifloxacin (CP-104354) is a broad-spectrum fluoroquinolone antibiotic.

ML406 shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition(IC50 : 30 nM)

Impurity Clindamycin Phosphate EP Impurity E Stability Hygroscopic Applications Clindamycin Hydrochloride (Clindamycin Phosphate EP Impurity E) is a semi-synthetic antibiotic prepared from Lincomycin. Antibacterial. References Birkenmeyer, R.D., et al.: J. Med. Chem., 13, 616 (1970); Oesterling, et al.: J. Pharm. Sci., 59, 63 (1970); Gray, J.E., et al.: Toxicol. Appl. Pharmacol., 21, 516 (1972); Brown, L.W., et al.: Anal. Profiles Drug Subs., 10, 75 (1981);

Gepotidacin mesylate dihydrate (GSK2140944 mesylate dihydrate) is an antibiotic and an inhibitor of bacterial type II topoisomerase.

Antibacterial compound 1 is an antibacterial compound.

Nonacosane is a straight-chain alkane comprising of 29 carbon atoms. It has a role as a plant metabolite and a volatile oil component.

6-azathymine inhibits D-3-aminoisobutyrate-pyruvate aminotransferase; 6-azauracil competes with beta-alanine, uncompetitive with pyruvic acid, Ki ~8.9 mM.

Applications Tilmicosin-d3 is the labeled analogue of Tilmicosin (T440500), a macrolide antibiotic structurally related to tylosin. Antibacterial. References Debono, M., et al.: J. Antibiot., 42, 1253 (1989); Ose, E.E., et al.: Vet. Rec., 123, 367 (1988); Morck, D.W., et al.: J. Am. Vet. Med. Assoc., 202, 273 (1993)

Closantel (R-31520), a salicylanilide anthelmintic compound, shows different anthelmintic spectra and obvious toxicity in mammals.

Eravacycline (TP-434) is a potent and broad-spectrum antibacterial agent.

MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli (IC50s of 12 nM and 58 nM, respectively).

Applications Labelled Azithromycin, a semi-synthetic macrolide antibiotic; related to Erythromycin A. Antibacterial. References Langtry, H.D., et al.: Drugs, 56, 273 (1998),

Piperacillin (Pipercillin) is a semisynthetic penicillin with wide spectrum of antimicrobial activity(particularly pseudomonas strains)

KDOAM-25, a potent KDM5 inhibitor, enhances H3K4 methylation, hampers MM1S cell growth; IC50: 71 nM (5A), 19 nM (5B), 69 nM (5C/D).

Stability Hygroscopic Applications Holomycin is a member of the pyrrothine class of antibiotics and displays broad-spectrum antibacterial activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Oliva, B., et al.: Antimicrob. Agents Ch., 45, 532 (2001); Scharf, Daniel H., et al.: J. Microbiol. Biotechn., 24, 26 (2014); Zotchev, Sergey B.: J. Biol. Chem., 288, 14688 (2013); Kenig, M., et al.: J. Antib., 32, 549 (1979)