Antibacterial

Cefuroxime axetil (Zinnat) is a second generation oral cephalosporin antibiotic.

Azithromycin (CP 62993) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.

4-Hydroxyquinoline, aka 4-Quinolinol, is a quinoline with antimicrobial properties, inhibiting gut bacteria, and scavenges photogenerated oxygen species.

Applications Sisomicin is an Antibacterial. Gentamicin-like aminoglycoside antibiotic; has broad spectrum antibiotic activity. References Weinstein, M.J., et al.: J. Antibiot., 23, 551 (1970), Sculier, J.P., et al.: J. Antimicrob. Chemother., 9, 63 (1982), Noone, P., et al.: Drugs, 27, 548 (1984),

BM212 is an antimycobacterial compound.It inhibits the growth of laboratory and clinical isolate M. tuberculosis strains.

Quorum Sensing-IN-3 (QS-IN-1) inhibits bacterial community sensing, which can inhibit information exchange between bacteria and inhibit biofilm formation.

Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.

Stability Hygroscopic Applications Clindamycin-13C,D3 is the labeled analog of Clindamycin (C580000, HCl salt), a semi-synthetic antibiotic prepared from Lincomycin. Antibacterial. References Birkenmeyer, R.D., et al.: J. Med. Chem., 13, 616 (1970); Oesterling, et al.: J. Pharm. Sci., 59, 63 (1970); Gray, J.E., et al.: Toxicol. Appl. Pharmacol., 21, 516 (1972); Brown, L.W., et al.: Anal. Profiles Drug Subs., 10, 75 (1981)

Salicyl-AMS is an inhibitor of mycobacterium auxin biosynthesis that inhibits the growth of mycobacterium in the presence of iron deficiency in vitro.

MAC-545496 is a glycopeptide-resistance-associated protein R (GraR) inhibitor, is an antivirulence agent.

Applications Macrolactone antibiotic. Antibacterial; growth promotant. This compound is a contaminant of emerging concern (CECs). References Crooy, P., et al.: J. Antibiot., 25, 371 (1972), Allington, D., et al.: Clin. Therap., 23, 24 (2001), Eeman, M., et al.: Langmuir, 22, 11337 (2006),

Nanchangmycin, a polyether antibiotic similar to dianemycin, effectively combats diverse nematodes and insects, not mammals/plants.

Zapnometinib (ATR-002) is a MEK inhibitor.

Cephalothin is a beta-lactam antibiotic, inhibits class C β-lactamase AmpC (Ki: 0.32 μM).

Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals.

Diflucortolone valerate (Diflucortolone 21-valerate) is a corticosteroid esterified with valeric acid. It helps to reduce itching, redness, and swelling.

Ginkgolic Acid (C13:0) (6-Tridecylsalicylic acid): 0exhibits the highest α-glucosidase inhibitory activity.

Bisdionin C blocks GH18 chitinase: IC50-0.2 μM for A. fumigatus, 8.3 μM for HCHT, 3.4 μM for AMCase.

Merafloxacin (CI 934) is a fluoroquinolone antibacterial, which was also identified as a 1 PRF inhibitor of SARS-CoV-2.

Tiamulin fumarate (Thiamutilin fumarate) is an antibiotic with antimicrobial activity that inhibits protein synthesis and is used in the study of pneumocystitis

Bixafen is a succinate dehydrogenase inhibitor with hepatotoxicity, pancreotoxicity, and fungicidal activity, used for controlling crop diseases.

Antibacterial agent 27 has potent anti-Candida activity.

Stability Hygroscopic Applications A nitrofuran labelled antibiotic with low resistance potential that is rapidly metabolized by mammals. Active against both Gram-positive and Gram-negative bacteria. Nitrofurantoin is also a prooxidant that is cytotoxic due to the generation of intracellular H2O2. Antibacterial.Environmental contaminants; Food contaminants; Heat processing contaminants References Cadwallader, D.E., et al.: Anal. Profiles Drug Subs., 5, 345 (1976), Rogers, R.G., et al.: Am. J. Obstr. Gynecol., 191, 182 (2004),

Applications Danofloxacin is a broad spectrum fluoroquinolone antibacterial compound. References Golet, E., et al.: Anal. Chem., 73, 3632 (2001); Golet, E., et al.: Environ. Sci. Technol., 36, 3645 (2002); Huet, A., et al.: J. Agric. Food Chem., 54, 2822 (2006);

Temocillin disodium (BRL 17421 disodium) is a carbapenem antibiotic with antimicrobial activity and can be used to study urinary tract infections.

Applications Norfloxacin-d5 is deuterium labeled Norfloxacin (N681000), a synthetic fluoroquinolone and an antibacterial agent. Norfloxacin can be used to treat urinary tract infections. References Koga, H., et al.: J. Med. Chem., 23, 1358 (1980), Hirai, K., et al.: Antimicrob. Agents Chemother., 19, 188 (1981), Holmes, B., et al.: Drugs, 30, 482 (1985),

Impurity Cefazolin EP Impurity A Applications 7-Amino-3-[(5-methyl-1,3,4-thiadiazol-2-ylthio)methyl]-3-cephem-4-carboxylic Acid (Cefazolin EP Impurity A) is a substrate used in the assessment of immobilized PGA orientation and in the synthesis of beta lactam antibiotics. References Serra, I. et al.: Anal. Bioanal. Chem., 405, 745 (2013); Terreni, M. et al.: App. Microbiol. Biotech., 77, 579 (2007); Kurochkina, V. et al.: Biocat. Biotransform., 20, 35 (2002)

Kasugamycin (Ksg) HCl hydrate blocks translation initiation in canonical mRNAs, not leaderless ones, by competing with initiator tRNA.

Cefpirome sulfate (HR-810 sulfate) is a fourth generation cephalosporin antibiotic.

Applications CP 1282 is the tautomer of the antibiotic Cefotetan (C242970) with similar degradation rates. References Koshiro, A. et al.: Chem. Pharm. Bull., 37, 1864 (1989); Naber, K. et al.: Zeitsch. Antmickrob. Antineoplast. Chemother., 2, 161 (1984);

Thiacetazone (Diazam) is a thiosemicarbazone that thioacetazone treatment of pulmonary tuberculosis

Carbadox, an antibacterial for swine dysentery and growth promotion, is banned in the UK due to carcinogen and mutagen risks.

Lalistat 1 inhibits LAL (IC50=68 nM) and H. influenzae IgA1 protease; useful in Niemann-Pick C research.

Monocaprylin (Sefsol 318) is a monoglyceride of caprylic acid with an excellent antibacterial activity.

Trofosfamide is a derivative of oxazaphosphorine with antineoplastic potency.

Meropenem trihydrate (SM 7338 trihydrate) with broad-spectrum antibacterial activity,is a carbapenem antibiotic.

Stability Air Sensitive Applications 4-(2-Aminoethyl)morpholine is used as a reagent in the synthesis of novel quinoxaline-5-carboxamide derivatives which have antibacterial activity. Also used as a reagent in the synthesis of pyrazol-4-ylpyrimidine derivatives as potential ROS1 kinase inhibitors. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Srinivas, K., et al.: J. Appl. Chem., 3, 1432 (2014); Abdelazem, A.Z., et al.: Eur. J. Med. Chem., 90, 195 (2015)

Applications Sulfamethazine is an antibacterial.This compound is a contaminant of emerging concern (CECs). References Papostephanou, M., et al.: Anal. Profiles Drug Subs., 7, 401 (1978),

Sulfabenzamide (N-Sulfanilylbenzamide) is a sulfonamide antibacterial agent used alone or with sulfathiazole and sulfacetamide as a topical, intravaginal

Tulathromycin A (CP 472295) is a macrolide antibiotic.

Tricyclazole (Tricyclazol) is a pentaketide-derived melanin biosynthesis inhibitor.

Azlocillin sodium, an acylampicillin, is a broad-spectrum antibiotics

Nifursol is a livestock feed additive and antiobiotic used to prevent the growth of histomonas.

Applications Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic). References Brewer, G.A., et al.: Anal. Profiles Drug Subs., 6, 183 (1977), Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979)

2,2'-Dihydroxy chalcone inhibits β-glucuronidase (IC50=1.6 μM) and lysozyme (IC50=1.4 μM), and fights E. coli, S. fowleri, S. albicans, S. aureus.

Dermaseptin acetate, a frog-skin peptide, has strong antimicrobial properties effective in micromolar ranges.

Stability Light Sensitive Applications Coenzyme Q10 is a cofactor that is part of the electron transport chain (3). It is also a free radical scavenger in lipid and mitochondrial membranes (3). Coenzyme Q10 has antibacterial and antioxidative properties and used to prevent and treat cancer (1,2). This compound is a neuroprotective product. References (1) Trumpower, B.L.: J Bioenerg Biomembr (1981) 13,1 (2) Inatsu, S. et al.: Antimicrob. Agents Chemother. (2006) 50, 2237 (3) Matthews, R. T., et al.: Proc Natl Acad Sci U S A. (1998) 95:8892-7.

Stability Light Sensitive Applications Antibiotic substance produced by Streptomyces spp. Antiamebic; antibacterial; antirickettsial. References Weiss, et al.: Antibiot. Chemother., 7, 374 (1957), Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971),

Dichlorophen (DDM) is a nontoxic laxative vermicide of chlorinated phenol compound.

Bedaquiline, a diarylquinoline antibiotic, targets ATP synthase in Mycobacterium tuberculosis.

N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)pyrazine-2-carboxamide inhibits RecBCD and AddAB enzyme families.

Sulfisoxazole acetyl (Gantrisin) is an agent with antibacterial activity.

Cymal-6 (Cyclohexyl-hexyl-β-D-maltoside) is a TEM-1 β-lactamase inhibitor and a glycoside surfactant.

Applications Antibiotic substance isolated from a Streptomyces ardus fermentation broth. Antibacterial; antineoplastic. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Tannock, I., et al.: Clin. Cancer Res., 8, 878 (2002), Cummings, J., et al.: Br. J. Cancer, 92, 532 (2005), Ivascu, A., et al.: J. Biomol. Screen, 11, 922 (2006),

Applications Labelled Sulbactam (S699185). A semi-synthetic β-lactamase inhibitor. It is used in combination with β-lactam antibiotics as antibacterial. References English, A.R., et al.: Antimicrob. Agents Chemother., 14, 414 (1978), Stromberg, B.V., Surg. Gynecol. Obstet., 162, 575 (1986), Mehtar, S., et al.: J. Antimicrob. Chemother., 17, 389 (1986), Campoli-Richards, D.M., et al.: Drugs, 33, 577 (1987),

Applications Antimicrobial.Environmental contaminants; Food contaminants; Heat processing contaminants References Yurchenco, J.A., et al.: Antimicrob. Chemother., 3, 1035 (1953), Sharma, C., et al.: J. Clin. Microbiol., 36, 756 (1998),

Nitrofural, a 20th-century antibiotic, fights various gram-positive/negative bacteria and urinary pathogens.

Cefodizime: a new, well-tolerated cephalosporin antibiotic with immunomodulatory properties for serious respiratory and urinary infections.

Stability Hygroscopic Applications A macrolide compound which is known to have antibacterial activity, and is useful in the therapy of bacterial infections in mammals. Antibiotic. References Broto, P., et al.: Eur. J. Med. Chem., 19, 71 (1984), Farrar, V., et al.: J. Med. Chem., 36, 3517 (1993), Clark, D., et al.: J. Pharm. Sci., 88, 807 (1999),

Applications Bis(2-ethylhexyl)maleate is a potential anti-inflammatory and antimicrobial agent, extracted from Urtica dioica L. (Urticaceae) leaves. Also used in the preparation of lubricants additives. References Dar, S. et al.: African. J. Biotech., 11, 12910 (2012); Ahmed, N. et al.: Pet. Sci. Tech., 26, 298 (2008);

Dicloxacillin Sodium (BRL1702 Sodium) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative bacteria.

Roseoflavin, a chemical analog of FMN and riboflavin that has antimicrobial activity, can directly bind to FMN riboswitch aptamers and downregulate the

Saccharin (O-Sulfobenzimide) is a flavoring agent and non-nutritive sweetener.

Nitrofurantoin, an antibiotic, targets bacteria for urinary infections by blocking DNA, RNA, and protein synthesis.

Applications Novel intermediate of Azithromycin that acts as antibiotic. References Krajacic, M.B., et al.: J. Antibiot., 58, 380 (2005),

CHIR-090 is a very potent and selective LpxC inhibitor with antibiotic activity.

Ceftobiprole (Ro 63-9141) is a β-lactam antibacterial agent that exhibits potent bactericidal activity by binding to PBPs.Cost-effective and quality-assured.

PA3552-IN-1: Antibiotic adjuvant, lowers PA3552 expression, resensitizes MDR P. aeruginosa to Polymyxin B.

Applications The isotopically labelled drug Sulfadiazine. Antibacterial. References Bohni, et al.: Chemotherapy, 14, 195 (1969), Carr, et al.: Antimicrob. Agents Chemother., 4, 585 (1973), Stober, H., et al.: Anal. Profiles Drug Subs., 11, 523 (1982),

Enmetazobactam (AAI101) is an extended-spectrum β-lactamase inhibitor for the treatment of multi-drug resistant gram-negative bacterial infections.

Propineb is used as a fungicide.

Triclocarban (Cutisan), an antimicrobial agent, is used in personal cleaning products.

Sulfanitran is a sulfonamide antibiotic used in the poultry industry.

Applications Succinic Acid was identified in essential oil from Saxifraga stolonifera and has antibacterial activity. References Zhang, Z.: Xibei Nongye Xuebao, 25, 1536 (2016)

Lexithromycin is an erythromycin A derivative. It has antibacterial activity.