Antibacterial

WCK-5153 是 β-Lactamase 的增强剂和 PBP2 的抑制剂,对铜绿假单胞菌具有抗菌活性。 WCK-5153 可用于治疗由高度耐药的革兰氏阴性病原体引起的严重感染的研究。

Ethoxzolamide (L-643786) is a carbonic anhydrase inhibitor.

Imidazolidinyl urea (Imidurea) is an antimicrobial preservative used in cosmetics.

Applications Labelled analogue of Tildipirosin, a novel 16-membered-ring macrolide used in veterinary medicine. Tildipirosin treat bacterial pathogens including Mannheimia haemolytica and Pasteurella multocida that cause respiratory tract infections in cattle and swine. References Rose, M. et al.: J. Vet. Pharmacol. Ther., (2012); Anderson, N.M. et al.: Antimicrob. Agents. Chemother., (2012);

Amiprilose is an Immunopotentiator.

L-161240: antimicrobial, targets lipid A synthesis, IC50 30 nM, MIC 1-3 μg/mL vs. E. coli.

Elubiol, a broad-spectrum antifungal, hinders fungal ergosterol synthesis for treating oily skin and dandruff.

Sarafloxacin (A56620) has antibacterial activities against Gram-positive and Gram-negative bacteria.

Applications (Z)-7-(((2R)-2-Carboxy-2-((4-oxopentan-2-yl)amino)ethyl)thio)-2-((S)-2,2-dimethylcyclopropanecarboxamido)hept-2-enoic Acid is an impurity of Cilastatin (C441100), prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Antibacterial adjunct. References Finlay, K.R., et al.: Invest. Ophthalmol. Visual Sci., 24, 1147 (1983), Norrby, S.R., et al.: Antimicrob. Agents Chemother., 23, 300 (1983), Washburn, D.E., et al.: J. Antimicrob. Chemother., 12, 39 (1983),

Isoconazole nitrate (Fazol) (Travogen) is an azole antifungal reagent.

Cefaclor monohydrate (Cefaclorum) is a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity.

Amoxicillin inactivates bacterial cell wall proteins, disrupting peptidoglycan cross-linking, which weakens walls and causes cell lysis.

Nacubactam (OP0595 free acid) is a potent inhibitor of non-β-lactam-β-lactamase with activity against class A and class C β-lactamases.

Cefixime is a broad-spectrum third-gen cephalosporin antibiotic, stable against beta-lactamases and more effective on gram-negative bacteria.

Macozinone (PBTZ169) inhibits decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1), more efficiently than BTZ043.

Carvacrol methyl ether is derived from plant volatile oil and exhibits antibacterial activity.

Applications An antibacterial. A broad spectrum, orally absorbed third generation cephalosporin, ester prodrug of the active free acid metabolite, Cefpodoxime. References Fujimoto, K., et al.: J. Antibiot., 40, 370 (1987), Utsui, Y., et al.: Antimicrob. Agents Chemother., 31, 1085 (1987),

Antibacterial agent 18 is a multi-armed AIE molecule with antibacterial activity, inhibiting the growth of both Gram-positive and Gram-negative bacteria.

Chlorobutanol (Chlortran) is a chemical preservative, sedative hypnotic and weak local anaesthetic.

Captan (Aacaptan) is a phthalimide fungicide that disrupts oocyte development.

Applications (-)-Actinonin is a bioactive peptide and antibiotic that is a potent inhibitor of aminopeptidase M and leucine aminopeptidase. Actinonin has observed to be an inhibitor of peptide deformylase, meprin A, and thermolysin. Actinonin also inhibits tumor cell invasion and matrix degradation along with displayed antitumor activity in vitro and in vivo as well as acting as an apoptotic inducer. References Umezawa, H., et al.: J. Antibiot., 38, 1629 (1985), Escobar-Alvarez, S., et al.: J. Mol. Biol., 387, 1211 (2009), Berg, A., et al.: Biochem., 48, 1584 (2009), Kuehlmann, U., et al.: Life Sci., 84, 1 (2009),

A7132 is an antibacterial agent and possesses broad and potent antibacterial activity.

Phthalylsulfathiazole (N4-Phthalylsulfathiazole) is a broad spectrum antimicrobial agent, used in the treatment of dysentery, colitis, and gastroenteritis.

DuP-721: broad-spectrum, oral antibiotic targeting various bacteria, including M. tuberculosis.

Xanthorrhizol is a natural product isolated from Curcuma xanthorrhiza Roxb. Xanthorrhizol is a potential antibacterial agent.

Tigemonam is a monobactam, a novel orally administered monobactam that protects against gram-negative aerobic bacterial pathogens. Cost-effective and quality-assured.

Rifamycin sodium (Rifamycin sodium salt) salt is an antibiotic that inhibits bacterial DNA-dependent RNA polymerase.

Vinclozolin (Ornalin) is a fungicide with anti-androgenic activity, commonly used in agriculture.

HPi1: oral Helicobacter pylori antimicrobial, IC50 0.24μM, MIC 0.08-0.16μg/mL, inactive against gut commensals.

(E)-hexadec-11-en-1-ol is a pheromone of the spotted stem borer Chilo partellus and is a long-chain fatty acid found in the volatile oil of Daphne genkwa.

Antifungal agent 6 shows antifungal activity.

Thymol, a monoterpene phenol in essential oils from Lamiaceae and others, has antioxidant and antimicrobial properties.

Isepamicin sulfate (sch21420), an aminoglycoside, targets 30S ribosomal unit, effective against type I 6-acetyltransferase strains.

Ampicillin Sodium, a broad-spectrum aminopenicillin derivative, inhibits bacterial growth by blocking cell wall peptidoglycan synthesis.

2-Hydroxy-1-methoxyanthraquinone is a natural product isolated from Morinda lucida Benth. (Rubiaceae) with antimicrobial activity.Cost-effective and quality-assured.

WCK-4234 sodium inhibits β-lactamase A, C, D & OXA carbapenemases, useful against MDR infections.

Valnemulin hydrochloride (Valnemulin HCl), a broad-spectrum bacteriostatic agent, inhibits protein synthesis in bacteria by binding to the peptidyl transferase.

Ceftibuten dihydrate (Sch-39720 dihydrate) is the dihydrate form of ceftibuten, and is a third-generation cephalosporin with antibacterial activity.

Ceftiofur sodium (Naxcel), an antibiotic of the cephalosporin type (third generation), is used as veterinary medicine.

Azidamfenicol inhibits ribosomal peptidyltransferase with a Ki of 22 µM. Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic.

Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strains

Tilmicosin phosphate, a macrolide antibiotic, is used to treat cattle for pathogens that cause Bovine Respiratory Disease.

Terminolic acid, a triterpenoid from Combretum racemosum, inhibits IL-1β/IL-6 and boosts IL-4, with moderate antibacterial effects.

Delpazolid (LCB01-0371) is an oxazolidinone that's effective against Gram-positive bacteria and more active than linezolid in systemic infections.

Benzoylacetone (AI3 10572) exhibits antibacterial activity.

Sulfamethazine (Sulfadimidine) is a sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.

Cetalkonium chloride, an ammonium preservative with anti-inflammatory properties, aids in aphthous ulcer research.

JPD447, a derivative of MAC-0547630, represents a new class of UppS inhibitors designed to enhance the efficacy of β-lactam antibiotics.

Q203 (Telacebec) is a novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB and inhibits M. tuberculosis H37Rv (MIC50: 2.7 nM).

Stability Hygroscopic, Moisture Sensitive Applications Triclosan O-Sulfate is a metabolite of the bacteriostat, Triclosan (T774250). References Wu, J. et al.: Sepu, 27, 724 (2009);

LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex. LolCDE-IN-1 shows antibacterial activity.

Ethacridine lactate (Acrinol) is a poly(ADP-ribose) glycohydrolase (PARG) inhibitor.

Doripenem monohydrate (S 4661 monohydrate) is a broad-spectrum injectable antibiotic, used for Gram-positive, Gram-negative and anaerobic pathogens.

Psoralenoside: a compound from Psoralea fruit; has estrogenic, osteoblastic, antitumor, and antibacterial properties.

N-Acetyltyramine, a QSI from strain M3-10, inhibits violacein in C. violaceum and virulence in P. aeruginosa.

Potassium guaiacolsulfonate hemihydrate (Potassium guaiacolsulfonate) is an aromatic sulfonic acid used in medicine as an expectorant.

Sarafloxacin hydrochloride (A-56620 (hydrochloride)), a quinolone antibiotic drug, is a hydrochloride salt form of sarafloxacin.

Homoembelin (2,5-dihydroxy-3-nonyl-1,4-benzoquinone) is a pigment from E.

Benzyldodecyldimethylammonium chloride dihydrate: a QAC biocide against MRSA, MDR P. aeruginosa.

Furaltadone hydrochloride (Furaltadone HCl) is an antibacterial and shows distinct curative effect in the treatment of coccidiosis.

Dermabond (2-Octyl cyanoacrylate) is a tissue adhesive commonly used for wound or surgical incision closure, with antibacterial properties.

Stability Very Hygroscopic Applications Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit. Antibacterial.Antibiotic complex consists of three closely related components, gentamicins C1, C2, C1a, and also gentamicin A which differs from the other members of the complex but is similar to Kanamycin C.Gentamicin C1: R1=R2=CH3Gentamicin C2: R1=CH3; R2=HGentamicin C1A: R1=R2=H References Holt, H.A., et al.: J. Antimicrob. Chemother., 34, 747 (1994), Wilschanski, M., et al.: Am. J. Respir. Crit. Care Med., 161, 860 (2000),

KKL-35 is an inhibitor of trans-translation (IC50: 0.9 μM) with broad-spectrum antibiotic activity.

Relebactam (MK-7655) is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases.

Applications Clindamycin is a semi-synthetic antibiotic. Antibacterial. References Birkenmeyer, R.D., et al.: J. Med. Chem., 13, 616 (1970); Oesterling, et al.: J. Pharm. Sci., 59, 63 (1970); Gray, J.E., et al.: Toxicol. Appl. Pharmacol., 21, 516 (1972); Brown, L.W., et al.: Anal. Profiles Drug Subs., 10, 75 (1981);

Diiodohydroxyquinoline (Iodoquinol), a topical therapeutic agent, has satisfactory antibacterial properties.

Stability Temperature Sensitive Applications Amoxicilloic Acid Dimer is an impurity of Amoxicillin (A634528), a semi-synthetic antibiotic related to Penicillin. References Brogden, R.N., et al.: Drugs, 18, 169 (1979);Bird, A.E., et al.: Anal. Profiles Drug Subs. Excip., 23, 1 (1994)

Ceftiofur hydrochloride (U-67279A) is a stable, broad-spectrum 3rd-gen cephalosporin with antibacterial properties.

Propargylcholine, an alkyne-modified choline, blocks Dgc-catalyzed demethylation in P. aeruginosa.

Applications Protected Kanamycin A (K137500). Antibiotic complex produced by Streptomyces kanamyceticus Okami & Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congeners. Antibacterial. References Ito, et al.: J. Antibiot., 17, 189 (1964), Toda, S., et al.: J. Antibiot., 30, 1002 (1977), Claes, P.J., et al.: Anal. Profiles Drug. Subs., 6, 259 (1977),