Antibacterial

Timcodar, also known as VX-853, is a multidrug resistance Inhibitor.

2',4'-Dihydroxy-6'-methoxyacetophenone is extracted from leguminous plants with antimicrobial activity and can be used in the synthesis of pyrone.

Rifampicin (Rifamycin AMP) is a broad-spectrum antibiotic with strong antibacterial effect against Mycobacterium tuberculosis. Cost effective and quality assured.

Besifloxacin Hydrochloride (BOL-303224-A) is a fourth-generation fluoroquinolone antibiotic.

MBX-4132, inhibit trans translation by binding to the bacterial ribosome,is a member of a chemical class called oxadiazoles.

JH-LPH-33 is a UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with antimicrobial activity for the study of bacterial infections.

Cefapirin sodium is the sodium salt of Cephapirin, an antimicrobial agent.

3,4-Dihydroxy-2-methoxyxanthone shows antibacterial, and hepatoprotective activities, it can prevent tert-butylhydroperoxide-induced lipid peroxidation and cell

Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.

Buramate is an antipsychotic and anticonvulsant.

Rosoxacin (Acrosoxacin) shows antibacterial activities against a broad spectrum of Gram-negative bacteria including Neisseria gonorrhoeae (MIC90 = 0.03mg/ml).

Polyquaternium-1: a mild eye-safe preservative that inhibits microbes in multi-dose ophthalmic meds.

Vaborbactam (RPX7009) is a β-lactamase inhibitor that is often used in conjunction with meropenem to study pneumonia and CRE infections.

Targocil inhibits WTA, stopping MSSA and MRSA growth (effective at 2μg/mL).

Cefoxitin sodium (Betacef) is a semisynthetic cephamycin antibiotic resistant to beta-lactamase.

Pyrazinamide (Pyrazinecarboxamide), an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide

Mezlocillin Sodium (Baycipen) is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive

(1R,2S)-Xeruborbactam disodium ((1R,2S)-QPX7728 disodium) is a boronic acid derivative with antibacterial activity, used in the study of bacterial infections.

Erythromycin thiocyanate, a macrolide from Streptomyces erythreus, binds 50S ribosomes, halting protein synthesis in bacteria.

Nilofabicin (CG-400549) is a potent inhibitor of enoyl-(acyl-carrier-protein) reductase fall(FabI) and can be used in studies about the treatment of complicated

Applications (2S,3S)-3-Amino-2-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl]amino]butanoic Acid is an impurity of Aztreonam (A965200), the first totally synthetic monocyclic β-lactam antibiotic. References Murugan, R., Narayanan, S.S.: Anal. Chem. Indian J., 8, 36 (2009); Sykes, R.B., et al.: Antimicrob. Agents Chemother., 21, 85 (1982); Florey, K., et al.: Anal. Profiles Drug Subs., 17, 1 (1988)

QPX7728 disodium (Xeruborbactam disodium) is a cyclic boronate inhibitor of many serine and metal-β-lactamases, exhibiting antibacterial activity.

Sulfaproxiline (Sulfaproxylin) is a synthetic antibacterial drug of sulfonamide.

Robenidine hydrochloride (Robenidine Hydrochoride) is an anticoccidial agent mainly used in poultry.

Florfenicol treats bovine respiratory disease and foot rot in cattle, and catfish enteric septicemia.

Cymen-ar-ol is a broad spectrum and highly effective bactericide that can contact mucous membrane.

VP-4604: potent anti-MRSA, inhibits S. aureus growth (MIC 4-8 μg/mL), >95% effective against MRSA.

Etzadroxil, a volatile ester, treats drug-resistant urinary infections.

Cassiaside B is a natural product with potent antibacterial activity.

Applications Fluorinated quinolone antibacterial.This compound is a contaminant of emerging concern (CECs). References Hoffken, G., et al.: Antimicrob. Ag. Chemother., 27, 375 (1985), Scully, B.E., et al.: Lancet, 1, 819 (1986)

Ethylparaben (Ethyl parahydroxybenzoate) is a Standardized Chemical Allergen.

Stability Hygroscopic Applications Pefloxacin derivative as antibacterial. Fluorinated quinolone antibacterial.This compound is a contaminant of emerging concern (CECs). References Koga, H., et al.: J. Med. Chem., 23, 1358 (1980), Hirai, K., et al.: Antimicrob. Agents Chemother., 19, 188 (1981), Holmes, B., et al.: Drugs, 30, 482 (1985),

Stability Hygroscopic Applications Bafilomycin B1 is an inhibitor of vacuolar-ATPase enzymes in fungi. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Stability Light Sensitive Applications Methyl Stearidonate can be isolated from diatom Navicula delognei and has antibacterial activity against Staphylococcus aureus, S. epidermidis, Salmonella typhimurium, and Proteus vulgaris. References Findlay, J.A., Patil, A.D.: J. Nat. Prod., 47, 815 (1984)

Avibactam (NXL-104) free acid is a covalent and reversible inhibitor of non-β-lactam β-lactamase (IC50s: 8 nM and 5 nM for β-lactamase TEM-1 and CTX-M-15).

Iclaprim (AR-100) is a novel specific bacterial Dihydrofolate inhibitor. It can inhibit the growth of S. aureus (MIC90: 0.06 μg/mL).

N-(Ketocaproyl)-DL-homoserine lactone is a quorum sensing (QS) autoinducer. N-(Ketocaproyl)-DL-homoserine lactone also is a natural and active ligand of LuxR.

Tebipenem Pivoxil (Orapenem) , an orally activity carbapenem antibiotic, is utilized in treating otolaryngologic and respiratory infections.

Hexahydrofarnesyl acetone (Phytone) is a sesquiterpene with antibacterial and anti-inflammatory activity and studied for pain relief.

Zidebactam (WCK-5107) is an effective β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 inhibitor (IC50: 0.26 μg/mL).

Applications Linear Daptomycin Hydrochloride Salt is the hydrochloride salt of L466470, which is the open-conformation of Daptomycin (D193350), cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial. Daptomycin Impurity References Allen, N.E., et al.: Antimicrob. Agents Chemother., 31, 1093 (1987), Tully, F.P., et al.: Expert Opin. Invest. Drugs, 8, 1223 (1999),

β-Lactamase-IN-1 (4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one) is a β-Lactamase inhibitor and targets the infection of Neisseria

JFD01307SC is a glutamine synthetase inhibitor and an anti-tuberculosis agent, mimicking L-Glutamate.

Applications Sulfachloropyridazine is an antibacterial compound.This compound is a contaminant of emerging concern (CECs). References Wammer, K.: Environ. Toxicol. Chem. 25, 1480 (2006);

MtUng-IN-1 acts as an inhibitor of Mycobacterium uracil DNA glycosylase (MtUng).MtUng-IN-1 is indicated for use in cancer and infectious disease research.

Chlorhexidine is a biguanide antiseptic targeting bacteria, damaging cell membranes and causing cell death, more effective against gram-positive types.

Nitroxoline (5-nitroquinolin-8-ol) is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in

N-hexanoyl-L-Homoserine lactone (C6-HSL), a small diffusible signaling molecule, is involved in controlling gene expression and affecting cellular metabolism.

Impurity Fosfomycin EP Impurity A Stability Hygroscopic Applications P-[(1R,2R)-1,2-Dihydroxypropyl]-phosphonic Acid (Fosfomycin EP Impurity A) is a Fosfomycin (F727500) impurity. Fosfomycin is an antibiotic that exerts a broad spectrum of antibacterial activity. P-[(1R,2R)-1,2-Dihydroxypropyl]-phosphonic Acid is an intermediate in the synthesis of [2-[2-Amino-3-hydroxy-2-(hydroxymethyl)propoxy]-1-hydroxypropyl]phosphonic Acid (A611565), another Fosfomycin (F727500) impurity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References McGrath, J.W., et al.: Org. Biomolec. Chem., 7, 9 (1944); Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981);

I2906 has antimicrobial activity and inhibits Mycobacterium tuberculosis.

Applications Labelled analogue of Neomycin, an aminoglycoside antibiotic found in many topical medications. Neomycin has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia.

Cephalothin sodium, a first-gen cephalosporin antibiotic, disrupts bacterial cell walls by inactivating penicillin-binding proteins, leading to cell lysis.

Tiadinil, a plant activator of systemic acquired resistance, boosts the production of herbivore-induced plant volatiles.

Ochromycinone (STA 21) is a selective STAT3 inhibitor.

Cefmetazole sodium: semisynthetic cephamycin, broad-spectrum, effective against infections, no severe side effects.

Stability Hygroscopic Applications Isotope labelled Aztreonam (A965200), the first totally synthetic monocyclic β-lactam antibiotic. References Sykes, R.B., et al.: Antimicrob. Agents Chemother., 21, 85 (1982), Florey, K., et al.: Anal. Profiles Drug Subs., 17, 1 (1988),

Applications Di-TFA Salt of 2,6-Diamino-2,3,6-trideoxy-D-ribo-Hexose is a degradent of Tobramycin (T524000) a single factor antibiotic comprising about 10% of nebramycin, the aminoglycosidic antibiotic complex produced by Streptomyces tenebrarius. Antibacterial. References Koch, K.F., et al.: Antimicrob. Agents Chemother., 309 (1970), Welles, J.S., et al.: Toxicol. Appl. Pharmacol., 22, 332 (1972), Dash, A.K., et al.: Anal. Profiles Drug Subs. Excip., 24, 579 (1996),

QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species( SmcR with an EC50 of 208.9 nM).

β-Chloro-L-alanine (L-β-Chloroalanine), a bacteriostatic amino acid analog, inhibits a number of enzymes, including threonine deaminase and alanine racemase.

Isoeugenol (4-Propenylguaiacol), an essential oil constituent of nutmeg, clove, and cinnamon, shows antimicrobial activity.

Ceftazidime (GR20263) is a beta-lactam, cephalosporin antibiotic with bactericidal activity.

Applications Salinomycin is an ionophore antibiotic used in farming for the prevention of coccidiodomycosis in poultry and to alter gut flora in order to improve nutrient absorption in ruminants. An anticoccidial agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Porter, C., et al.: Poult Sci., 34, 995 (1955), Hancock, R., et al.: Lancet, 349, 418 (1997), Ogita, A., et al.: Toxicology, 215, 205 (2005), Usuki, Y., et al.: Bioorg. Med. Chem. Lett., 16, 1553 (2006), Ogita, A., et al.: J. Antibiot., 60, 511 (2007),

Mitonafide (NSC-300288) suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.

Oral 3rd-gen cephalosporin antibiotic; treats ear, throat, sinus infections; active vs. Gram+ & Gram- bacteria; Cefpodoxime proxetil is a prodrug.

Diazolidinyl urea (Germall II) is a formaldehyde-releasing preservative used in cosmetics and personal-care products,

SQ609 is a dipiperidine-based drug candidate with notable in vitro anti-tuberculosis effects in mouse macrophages.

Applications Taurultam is a compound that inhibits cell proliferation and cell adhesion in angiogenesis. Taurultam exhibits bacteriocidal effects on Escherichia coli and is also a degradation product of Taurolidine (T009050). References Jones, D., et al.: Lett. Appl. Micro., 14, 5 (1992); Kirsch, L. & Sinn, Y.: Pharm. Dev. Tech., 2, 345 (1997); Mšhler, T., et al.: Cancer Therapy, 6, 623 (2008)

Cefuroxime Sodium: a second-gen cephalosporin antibiotic resistant to beta-lactamase, halts bacterial wall synthesis, causing cell lysis.

Antibacterial agent 131 is a compound with antibacterial properties.

Omadacycline (Amadacycline), a new tetracycline antibiotic, can inhibit the 30s subunit of bacterial ribosome.

Faropenem daloxate (Faropenem medoxil) is useful for penem and antibiotics.

c-Met-IN-15 exhibits antibacterial activity.

Lanopepden mesylate (GSK 1322322 mesylate) is a peptide desmethylase inhibitor with antimicrobial activity and is used in the study of pneumonia.

Impurity Fosfomycin EP-Impurity A Applications P-[(1R,2R)-1,2-Dihydroxypropyl]-phosphonic Acid is a Fosfomycin (F727500) impurity. Fosfomycin is an antibiotic that exerts a broad spectrum of antibacterial activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References McGrath, J.W., et al.: Org. Biomolec. Chem., 7, 9 (1944); Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981);

Diniconazole is a fungicide that inhibits ABA catabolism and competes with Arabidopsis ABA 8'-hydroxylase, CYP707A3.