Antibacterial

Antimicrobial agent-14, a benzyl thiophene sulfonamide, has a 200 μM MIC against Campylobacter coli ATCC33559.

Applications Calcium Ascorbate Dihydrate is a salt of Ascorbic Acid (A786990), physiological antioxidant. Coenzyme for a number of hydroxylation reactions; required for collagen synthesis. Widely distributed in plants and animals. Inadequate intake results in deficiency syndromes such as scurvy. Used as antimicrobial and antioxidant in foodstuffs. References Al-Meshal, I.A., et al.: Anal. Profiles Drug Subs., 11, 45 (1982), Levine, M., et al.: N. Engl. J. Med., 314, 892 (1986), Prust, C., et al.: Nature Biotech., 23, 195 (2005),

AX20017 is a small-molecule protein kinase G (PknG) inhibitor(IC50 : 0.39 μM). It acts by blocking the proliferation of M. tuberculosis.

Penicillin G benzathine has anti-bacterial infectious activity and can be used to study early syphilis.

Stability Hygroscopic Applications N-Demethyl Lincomycin Hydrochloride is an impurity of Lincomycin (L466200), an antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial. References Mason, D.J., et al.: Antimicrob. Agents Chemother., 555 (1962); Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964); Muti, H.Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994)

TBA-354 is anti-tuberculous and active against Mycobacterium tuberculosis strain H37Rv.

Applications Antibacterial References Suzuki, T., et al.: Anal. Sci., 16, 343 (2000), Payne G., et al.: Brit. J. Clin. Pharmacol., 59, 244 (2005), Okuda J., et al.: Microbiol. immunol., 51, 467 (2007), Okumura R., et al.: Chemother., 55, 262 (2009),

Nourseothricin sulfate (Streptothricin sulfate) is a broad-spectrum antibiotic,and inhibits protein biosynthesis in prokaryotic cells and strongly inhibits the

Methylisothiazolinone (MI) is a powerful synthetic biocide and preservative within the group of isothiazolinones.

8-Hydroxyquinoline (8-Quinolinol) is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and pesticide properties.

Ornidazole (Tiberal) is a nitroimidazole antiprotozoal agent used in ameba and trichomonas infections.

Oxacillin (Oxabel) is an antibiotic of the penicillin class, which exerts bactericidal effects by inhibiting bacterial cell wall synthesis.

Tetrazole (1H-TETRAZOLE) is the bioisoster of carboxylic acid, possess considerable antibacterial property.

Oxacillin sodium monohydrate (Stapenor monohydrate) is an antibacterial agent and is a narrow spectrum beta-lactam antibiotic of the penicillin class.

Balofloxacin, a quinolone antibiotic, can inhibit the synthesis of bacterial DNA by interfering with the DNA gyrase.

Mycophenolic acid-d3 is a derivative that lowers GTP, affects RNA polymerase II transcription, changes polyadenylation, and counters cordyceps.

Tilmicosin (EL-870), a macrolide antibiotic, treats bovine and ovine respiratory diseases in animals.

Stability Hygroscopic Applications Antibiotic complex produced by Streptomyces kanamyceticus Okami & Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congeners. Antibacterial.A representative lot contains d4, d5, d6, d7, d8, and d9. References Ito, et al.: J. Antibiot., 17, 189 (1964), Toda, S., et al.: J. Antibiot., 30, 1002 (1977), Claes, P.J., et al.: Anal. Profiles Drug. Subs., 6, 259 (1977),

CRS400393: Anti-tuberculosis drug, MIC - M. abs.: 0.03μg/mL, M. avium: 2μg/mL, M. intracellulare: ≤0.12 μg/mL, M. tuberculosis: ≤0.12 μg/mL.

Stability Light Sensitive Applications Semisynthetic antibiotic. Antibacerial (tuberculostatic). References Furesz, et al.: Antibiot. Chemother., 16, 316 (1970), Gallo, G.G., et al.: Anal. Profiles Drug Subs., 5, 467 (1976),

BTZ043 is a DprE1 inhibitor with nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.

Clindamycin palmitate hydrochloride (Clindamycin palmitate HCl) is the hydrochloride salt of clindamycin and palmitate, a lincosamide antibiotic.

Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium (Rhein-8-glucoside calcium salt) salt) shows moderate bioactivity against human Protein Tyrosine

Cefcapene pivoxil hydrochloride hydrate is a pivalate ester prodrug form of cefcapene, a semi-synthetic third-generation cephalosporin with antibacterial effect

Applications Semi-synthetic macrolide antibiotic; related to Erythromycin A. Antibacterial. References Langtry, H.D., et al.: Drugs, 56, 273 (1998),

HA5 hinders S. mutans biofilm and dextran production, and reduces eDNA, with an IC50 of 6.42 μM, yet doesn't stop its growth.

Tolfenpyrad is an effective insecticide[1], used against pests that are resistant to existing insecticides such as organophosphates and carbamates.[2]

(3R,6R)-Vaborbactam ((3R,6R)-Vaborbactam (Iso-1360457-46-0)) is a cyclic boronic acid pharmacophore β-lactamase inhibitor.

Applications Polyquaternium 1 is an antimicrobial preservative used for rabbit ocular surface study on polyquad-preserved travoprost/timolol, benzalkonium chloride-preserved travoprost/timolol, and latanoprost/timolol in fixed combinations. References Pisella, P., et al.: Br. J. Ophthalmol., 86, 418 (2002), Robin, A., et al.: Am. J. Ophthalmol., 144, 533 (2007), Schmier, J., et al.: Curr. Med. Res. Opin., 23, 2867 (2007),

Polymyxin B Sulfate, a mix of B1 and B2 from Bacillus polymyxa, fights gram-negative infections but may harm nerves and kidneys.

Tazobactam (YTR-830H) is an antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.

Applications Used in the preparatiom of esters of 6-aminohexanoic acid as antibacterial agents. EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo xy peptidase, plasmin, and plasminogen activator. References Dolezal, P., et al.: Pharm. Res., 10, 1015 (1993), Vavrova, K., et al.: Curr. Med. Chem., 12, 2273 (2005), Holas, T., et al.: Bioorg. Med. Chem., 14, 7671 (2006),

Phthalylsulfacetamide (Tamid) is a sulfonamide antibiotic used for topical application to the skin and the conjunctiva.

Epetraborole hydrochloride (GSK2251052 hydrochloride) is a potent and selective leucyl-tRNA synthetase inhibitor.

Applications Sodium Acrylate is the acid form of Acrylic Acid (A191350); which is an antibacterial agent. References Kind, T., et al.: Anal. Biochem., 363, 185 (2007), Spratlin, J., et al.: Clin. Cancer Res., 15, 431 (2009),

Stability Not very stable in Aqueous Base Applications Labelled Paraformaldehyde is the polymerized form of formaldehyde, used in root canal sealers that provide antimicrobial activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Gomes, B. et al.: Braz. Dent. J., 15, 30 (2004); Myers, G. et al.: Appl. Microbiol., 11, 357 (1963);

Applications Sulfapyridine-d4 is the labeled analogue of Sulfapyridine (S699083), which is used in treatment of dermatitis herpetiformis; antibacterial. References Wien, R., et al.: J. Pharmacol. Exp. Ther., 84, 211 (1945); Stone, O.J., et al.: Med. Hypotheses, 31, 99 (1990); Elder, M.J., et al.: Br. J. Ophthalmol., 80, 549 (1996)

AU1235 is a Mycobacterium tuberculosis inhibitor.

Applications Daptomycin Impurity B1-1 is an impurity of Daptomycin (D193350), cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial. References Allen, N.E., et al.: Antimicrob. Agents Chemother., 31, 1093 (1987), Tully, F.P., et al.: Expert Opin. Invest. Drugs, 8, 1223 (1999),

Isoforsythiaside has antioxidant, and antibacterial activities.

Oxychlororaphine (phenazine-1-carboxamide) inhibits strongly the growth of Streptomyces sp. 441.

Benurestat (EU-2826) is a urease inhibitor.

Sorbicillin is a sorbic acid-like compound isolated from Penicillium, exhibiting anti-inflammatory activities, and induces apoptosis in HL-60 cells.

Eravacycline dihydrochloride (TP-434-046) is a potent and broad-spectrum antibacterial agent against six E. coli (MICs: 0.125-0.25 mg/L).

Cynaroside (Luteolin 7-O-Glucoside) is a flavone, a flavonoid-like chemical compound. It has an anti-oxidant effect, inhibiting lipid and protein oxidation.

Demeclocycline (Declostatin) is a tetracycline antibiotic from Streptomyces aureus that has antimicrobial activity and can be used to induce dysuria.

Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases.

Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.

Stability Unstable in Solution Applications Meropenem-d6 is the labeled analogue of Meropenem, a carbapenem antibiotic. Antibacterial. References Adams, M.D., et al.: J. Bacteriol., 190, 8053 (2008); Pattanaik, P., et al.: J. Biol. Chem., 284, 945 (2009); Mendes, R., et al.: J. Antimicrob. Chemother., 63, 55 (2009)

Oxacillin sodium salt (Oxabel) is an antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.

Cefazolin is a semi-synthetic cephalosporin that has a broad spectrum of antibacterial activity and inhibits the synthesis of bacterial cell walls.

Ronidazole (Ronidazol) is an antiprotozoal and antimicrobial agent used mainly in veterinary practice.

Doripenem is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens.

Flucloxacillin sodium (floxacillin sodium) is a highly active antibiotic against Gram-negative and Gram-positive bacteria.

Ceforanide: second-gen cephalosporin antibiotic that disrupts bacterial cell walls by halting peptidoglycan cross-linking.

Clotrimazole (FB 5097), an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol.

Clorophene (Clorofene) is an antimicrobial agent and can be used in personal care products.

Applications 5-Chloro-2-hydroxybenzophenone is a type of UV filter used in the protection of surfaces sensitive to radiation. Applied in sunscreens and camera lens filters. Potential antibacterial agent. References Li, M. et al.: Toxicolog. Env. Chem., 94, 566 (2012); Bi, C. et al.: Asian J. Chem., 23, 5477 (2011);

Applications Meropenem Trihydrate is a carbapenem antibiotic with wide spectrum of antibacterial. References Hickey, M.B., et al.: J. Pharma. Sci., 96, 1090 (2007); Condie, C.K., et al.: Am. J. Health. System. Pharma., 65, 454 (2008);

Antibacterial agent 26 is an antimicrobial compound that is a potent DHFR inhibitor (S. aureus DHFR Ki of 0.020 nM).

Clindamycin is a semisynthetic antibiotic that blocks bacterial protein synthesis by detaching peptidyl-tRNA from ribosomes.

Cefotaxime: 3rd-gen cephalosporin antibiotic, broad-spectrum, similar to ceftriaxone, sold as Claforan.

Cadazolid (ACT-179811) is an oxazolidinone-type antibiotic, with activity against gram-positive bacteria, including Clostridium difficile.

Sulfachloropyrazine sodium(Sulfachloropyrazine) is an antiprotozoal,with antibacterial and anticoccidial effects

Sulfaquinoxaline (Sulfabenzpyrazine) is an antiprotozoal agent.

Gamithromycin (ML-1709460) is a macrolide compound with antibacterial activity.

Quaternium 12, a bactericidal, virucidal, and fungicidal compound used in many products.

InhA-IN-3 (TU13) is a Mycobacterium tuberculosis InhA (enoyl ACP reductase) inhibitor for the study of Mycobacterium tuberculosis infection.

TCA1 (TCA 1) is a small molecule with activity against drug-resistant and persistent tuberculosis.

Applications Semi-synthetic antibiotic related to Penicillin. Antimicrobial. References Robinson, B., et al.: Biochem. Med. Metab. Biol., 48, 122 (1992), Lesnefsky, E., et al.: J. Biol. Chem., 279, 47961 (2004), Marroquin, L., et al.: Toxicol. Sci., 97, 539 (2007),

Pretomanid ((S)-PA 824) , a nitroimidazole, is used as an anti-tuberculosis drug for tuberculosis with MIC less than 2.8 μM.

Imipenem monohydrate (Imipenem) is a β lactam antibiotic. Imipenem monohydrate acts on the bacterial cell wall. Cost-effective and quality-assured.

Applications D-Tyrosine-d2 is deuterium labelled D-Tyrosine (T899970). D-Tyrosine, the stereoisomer to L-Tyrosine (T899975), is an amino acid used in various organic syntheses for antibiotics. It is used in the synthesis of (-)-anisomycin, as well as BATSI (boronic acid transition state inhibitors) which act on β-lactamases. It has also been studied as an inhibitor of microbial growth on surfaces, reducing microbial attachment to hydrophillic glass and hydrophobic polypropylene surfaces. References Li, Ji. et al.: Chin. Chem. Lett., 23, 647 (2012); Xu, H. et al.: Water Res., 45, 5796 (2011); Ke, W. et al.: Antimicrob. Agents Chemother., 55, 174 (2011)