Antibacterial

3-Hydroxy-C4-HSL is a bacterial community sensing (QS) inducer.

RPW-24 is a stimulator of host immune defenses, has antibacterial activity.

Obafluorin is a β-lactone antibiotic produced by fluorescent Pseudomonas ATCC 39502, with broad-spectrum antibacterial activity.

Sulfalene (SMP2), a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria.

Ertapenem sodium (MK-826) is a long-acting carbapenem antibiotic effective against a wide range of bacteria, including ESBL producers.

Applications rac Fosfomycin-13C3 Benzylamine Salt is an antibiotic. References Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981);

Ceftriaxone sodium hydrate is a broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.

Methyl quinoline-2-carboxylate (Methyl 2-quinolinecarboxylate) inhibits the binding of Mycobacterium tuberculosis.

Methenamine Hippurate is a component of Hiprex, with antibacterial activity.

MF 5137 is an effective antimicrobial agent.

Ethyl Orsellinate (Orsellinic acid ethyl ester) is a phenolic acid, extracted from lichens.

N2-Acetylaciclovir (Aciclovir EP Impurity F) is a derivative of the antiviral compound Aciclovir, which has selective T-cell immunotoxicity.

Lenampicillin hydrochloride is an orally active prodrug of Ampicillin. Lenampicillin hydrochloride is an effective beta-lactam antibacterial agent that inhibits bacterial penicillin-binding proteins. It is applied in the investigation of suppurative skin

MAC13243 HCl inhibits LolA chaperone, targeting Gram-negative bacteria as a specific antimicrobial agent.

Orbifloxacin (CP-104354) is a broad-spectrum fluoroquinolone antibiotic.

ML406 shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition(IC50 : 30 nM)

Impurity Clindamycin Phosphate EP Impurity E Stability Hygroscopic Applications Clindamycin Hydrochloride (Clindamycin Phosphate EP Impurity E) is a semi-synthetic antibiotic prepared from Lincomycin. Antibacterial. References Birkenmeyer, R.D., et al.: J. Med. Chem., 13, 616 (1970); Oesterling, et al.: J. Pharm. Sci., 59, 63 (1970); Gray, J.E., et al.: Toxicol. Appl. Pharmacol., 21, 516 (1972); Brown, L.W., et al.: Anal. Profiles Drug Subs., 10, 75 (1981);

Gepotidacin mesylate dihydrate (GSK2140944 mesylate dihydrate) is an antibiotic and an inhibitor of bacterial type II topoisomerase.

Antibacterial compound 1 is an antibacterial compound.

Nonacosane is a straight-chain alkane comprising of 29 carbon atoms. It has a role as a plant metabolite and a volatile oil component.

6-azathymine inhibits D-3-aminoisobutyrate-pyruvate aminotransferase; 6-azauracil competes with beta-alanine, uncompetitive with pyruvic acid, Ki ~8.9 mM.

Applications Tilmicosin-d3 is the labeled analogue of Tilmicosin (T440500), a macrolide antibiotic structurally related to tylosin. Antibacterial. References Debono, M., et al.: J. Antibiot., 42, 1253 (1989); Ose, E.E., et al.: Vet. Rec., 123, 367 (1988); Morck, D.W., et al.: J. Am. Vet. Med. Assoc., 202, 273 (1993)

Closantel (R-31520), a salicylanilide anthelmintic compound, shows different anthelmintic spectra and obvious toxicity in mammals.

Eravacycline (TP-434) is a potent and broad-spectrum antibacterial agent.

MUT056399 (Fab-001) is a highly potent inhibitor of the FabI enzyme of both S. aureus and E. coli (IC50s of 12 nM and 58 nM, respectively).

Applications Labelled Azithromycin, a semi-synthetic macrolide antibiotic; related to Erythromycin A. Antibacterial. References Langtry, H.D., et al.: Drugs, 56, 273 (1998),

Piperacillin (Pipercillin) is a semisynthetic penicillin with wide spectrum of antimicrobial activity(particularly pseudomonas strains)

KDOAM-25, a potent KDM5 inhibitor, enhances H3K4 methylation, hampers MM1S cell growth; IC50: 71 nM (5A), 19 nM (5B), 69 nM (5C/D).

Stability Hygroscopic Applications Holomycin is a member of the pyrrothine class of antibiotics and displays broad-spectrum antibacterial activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Oliva, B., et al.: Antimicrob. Agents Ch., 45, 532 (2001); Scharf, Daniel H., et al.: J. Microbiol. Biotechn., 24, 26 (2014); Zotchev, Sergey B.: J. Biol. Chem., 288, 14688 (2013); Kenig, M., et al.: J. Antib., 32, 549 (1979)

Prothionamide (1321-TH)is a thioamide derivative with antitubercular activity.

Mafenide Acetate is a sulfonamide-type medication inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.

Sultamicillin Tosylate (Unacim orale) is an oral form of the antibiotic combination (codrug or mutual prodrug) ampicillin/sulbactam.

3-Formyl rifamycin is a degradation product of Rifampicin, with antibacterial activity.

Applications Broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and gram-negative bacteria. Antibacterial; antirickettsial. References Bartz, et al.: J. Biol. Chem., et al.: 172, 445 (1948), Gottlieb, et al.: J. Bacteriol., 55, 409 (1948), Szulczewski, D., et al.: Anal. Profiles Drug Subs., 4, 47 (1975), Price, A., et al.: J. Antibiot., 43, 118 (1981), Shalit, I., et al.: Drugs, 28, 281 (1984),

N-Acetyl-Calicheamicin (N-Acetyl-γ-calicheamicin) is an antibiotic with high anti-tumor activity.

(CL227193) )binds to and inactivates penicillin-binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the

Cefotetan, a cephamycin antibiotic, fights various bacteria by disrupting cell wall synthesis.

Broxaldine (Brobenzoxaldine) is a small molecular drug with antiprotozoal activity.

Ciprofloxacin hydrochloride monohydrate (Bay-09867 hydrochloride monohydrate) is a fluoroquinolone antibiotic with potent antibacterial activity.

CPFX4158 is a mannose deriviative and an antibacterial agent that is potentially useful in transgenic humanized- CEACAM6 mouse.

Aureothricin: DTP antibiotic from Streptomyces, broad-spectrum, inhibits HUVEC adhesion to vitronectin.

Sarecycline hydrochloride is a narrow-spectrum tetracycline antibiotic with antimicrobial and anti-inflammatory activity.

Cefetamet pivoxil hydrochloride (Ro 15-8075) is a third generation cephalosporin antibiotic with oral activity.

Spiramycin, a Streptomyces-made macrolide antibiotic, targets gram-positive pathogens, N. gonorrhoeae, staph, and Toxoplasma gondii.

Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications.

Avibactam sodium hydrate (NXL-104 hydrate) is a β-lactamase inhibitor, inhibiting β-lactamases TEM-1 and CTX-M-15.

AN0128 (CRM-0005) is a boron-containing antibacterial agent with anti-inflammatory activity, inhibiting S. aureus, and used in dermatological research.