PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
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Products of "PI3K/Akt/mTOR Signaling"
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CHMFL-PI3KD-317
CAS:CHMFL-PI3KD-317: potent PI3Kδ inhibitor, IC50=6 nM, orally active, >10x selective vs. PI3K isoforms, anti-cancer.Formula:C21H24ClN5O3S2Purity:97.8%Color and Shape:SolidMolecular weight:494.03Ref: TM-T10804
1mg92.00€5mg216.00€10mg329.00€25mg593.00€50mg893.00€100mg1,216.00€1mL*10mM (DMSO)235.00€5-Iodo-indirubin-3'-monoxime
CAS:5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50sFormula:C16H10IN3O2Color and Shape:SolidMolecular weight:403.17EGFR-IN-127
EGFR-IN-127 is an ATP-competitive inhibitor targeting EGFR, with IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds potential for the study of non-small cell lung cancer (NSCLC).Color and Shape:Odour SolidPI4KIIIbeta-IN-10
CAS:PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).Formula:C22H25N3O5S2Purity:99.76%Color and Shape:SolidMolecular weight:475.58Ref: TM-T12468
1mg80.00€5mg164.00€10mg255.00€25mg420.00€50mg562.00€100mg792.00€200mg1,064.00€1mL*10mM (DMSO)167.00€BI-4020
CAS:BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase.Formula:C30H38N8O2Purity:100.00% - 98.44%Color and Shape:SolidMolecular weight:542.68Ref: TM-T10534
1mg170.00€5mg398.00€10mg568.00€25mg848.00€50mg1,130.00€100mg1,510.00€200mg2,062.00€1mL*10mM (DMSO)472.00€Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Formula:C13H14N6OPurity:98.01% - 99.36%Color and Shape:SolidMolecular weight:270.29Ref: TM-T7014
1mg38.00€2mg49.00€5mg79.00€10mg124.00€25mg240.00€50mg384.00€100mg560.00€1mL*10mM (DMSO)79.00€CGP77675
CAS:CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates andFormula:C26H29N5O2Purity:98.23%Color and Shape:SolidMolecular weight:443.54Dalmitamig
Dalmitamig is a humanized IgG4κ antibody targeting EGFR/CD28, with HumanIgG4(S228P) kappa as its corresponding isotype control.Color and Shape:Odour LiquidEGFR/CDK2-IN-3
EGFR/CDK2-IN-3 (compound 4b) serves as a dual inhibitor targeting both EGFR and CDK-2, exhibiting IC50 values of 71.7 nM and 113.7 nM, respectively.Formula:C30H20N6OSPurity:98%Color and Shape:SolidMolecular weight:512.58YM-53601 free base
CAS:YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.Formula:C21H21FN2OPurity:98%Color and Shape:SolidMolecular weight:336.4CH5132799
CAS:CH5132799 has been used in trials studying the treatment of Solid Tumors.Formula:C15H19N7O3SPurity:98.81% - 99.87%Color and Shape:SolidMolecular weight:377.42Ref: TM-T2619
1mg64.00€2mg96.00€5mg144.00€10mg227.00€25mg420.00€50mg622.00€100mg885.00€500mg1,786.00€GSK-3 Inhibitor 5
CAS:4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.Formula:C9H6BrNOPurity:99.58%Color and Shape:Off-White To Light Yellow Crystalline PowderMolecular weight:224.05Rilematovir
CAS:Rilematovir (JNJ-678) inhibits fusion protein, has antiviral properties, low toxicity, and targets RSV treatment.Formula:C21H20ClF3N4O3SPurity:99.82%Color and Shape:SolidMolecular weight:500.92EGFR-IN-133
CAS:EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC50 values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.Formula:C27H29F2N7O3Color and Shape:SolidMolecular weight:537.56P-2281
CAS:P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cellFormula:C9H8ClN3OPurity:99.95%Color and Shape:SolidMolecular weight:209.63Khellin
CAS:Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.Formula:C14H12O5Purity:99.85% - 99.95%Color and Shape:Light Yellow CrystallineMolecular weight:260.24TWS119
CAS:TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiationFormula:C18H14N4O2Purity:98.02% - 99.13%Color and Shape:SolidMolecular weight:318.331-Azakenpaullone
CAS:1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.Formula:C15H10BrN3OPurity:99.6%Color and Shape:Tan SolidMolecular weight:328.16Ref: TM-T6358
1mg79.00€2mg99.00€5mg188.00€10mg311.00€25mg560.00€50mg800.00€100mg1,093.00€500mg2,175.00€1mL*10mM (DMSO)187.00€MHY1485
CAS:MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.Formula:C17H21N7O4Purity:100% - 99.6%Color and Shape:SolidMolecular weight:387.39Depatuxizumab
CAS:Depatuxizumab, a brain-penetrant, humanized anti-EGFR monoclonal antibody, selectively inhibits the growth of mutant EGFRvIII and wild-type EGFR xenograftPurity:98%Color and Shape:LiquidAnti-EGFR Antibody (3B845)
Anti-EGFR Antibody (3B845) is an antibody targeting EGFR. Anti-EGFR Antibody (3B845) can be used in ELISA, WB, IHC.Color and Shape:Odour LiquidPetosemtamab (FUT8-KO)
Petosemtamab (FUT8-KO) is a variant of Petosemtamab with the fucosyltransferase 8 gene (FUT8) knocked out. Petosemtamab is a monoclonal antibody (mAb) targeting EGFR (with a Kd of 0.22 nM) and LGR5 (with a Kd of 0.86 nM). This antibody disrupts EGFR signaling and causes receptor degradation in LGR5+ cancer cells. It is applicable in research on solid tumors such as head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer (CRC).Color and Shape:Odour LiquidMELK-8a hydrochloride
CAS:MELK-8a hydrochloride is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK, IC50 = 2 nM).Formula:C25H33ClN6OPurity:99.87%Color and Shape:SolidMolecular weight:469.02Ref: TM-T11996
2mg35.00€5mg52.00€10mg85.00€25mg156.00€50mg239.00€100mg353.00€200mg492.00€1mL*10mM (DMSO)55.00€Allitinib tosylate
CAS:Allitinib tosylate (AST-1306) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, respectively.Formula:C31H26ClFN4O5SPurity:98.46% - 98.68%Color and Shape:SolidMolecular weight:621.08Kaempferol 3-neohesperidoside
CAS:Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside), a flavonoid compound, demonstrates an insulinomimetic effect on the rat soleus muscle.Formula:C27H30O15Purity:98.34%Color and Shape:SolidMolecular weight:594.52Ref: TM-TN1819
1mg62.00€5mg127.00€10mg187.00€25mg315.00€50mg472.00€100mg658.00€1mL*10mM (DMSO)166.00€PI3Kδ-IN-12
PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4Formula:C20H15Cl2N5O3Purity:98%Color and Shape:SolidMolecular weight:444.27ML753286
CAS:ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.Formula:C20H25N3O3Purity:98%Color and Shape:SolidMolecular weight:355.43PI3K-IN-38
CAS:PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.Formula:C20H24N6O2Purity:99.74%Color and Shape:SolidMolecular weight:380.44Rheb inhibitor NR1
CAS:Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor that promotes phosphorylation of S473pAKT.Formula:C25H19BrCl2N2O3SPurity:99.72%Color and Shape:SolidMolecular weight:578.3Ref: TM-T16741
1mg92.00€5mg188.00€10mg311.00€25mg628.00€50mg945.00€100mg1,596.00€1mL*10mM (DMSO)47.00€GSK3a-IN-38
CAS:GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a.Formula:C18H20N4OPurity:99.75%Color and Shape:SoildMolecular weight:308.38Cisapride hydrate
CAS:Cisapride acts directly as a selective agonist of serotonin 5-HT4 receptor with IC50 value of 0.483 μM. And It also acts indirectly as a parasympathomimetic.Formula:C23H31ClFN3O5Purity:98%Color and Shape:SolidMolecular weight:483.96Naquotinib
CAS:Naquotinib (ASP8273) (ASP8273) is an orally available, mutant-selective and irreversible EGFR inhibitor; (IC50s: 8-33 nM and 230 nM toward EGFR mutants and EGFRFormula:C30H42N8O3Purity:97.49%Color and Shape:SolidMolecular weight:562.71EGFR/CDK2-IN-4
EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor targeting EGFR and CDK-2, demonstrating IC50 values of 89.6 nM for EGFR and 165.4 nM for CDK-2.Formula:C24H16N6OS2Purity:98%Color and Shape:SolidMolecular weight:468.55Acalisib
CAS:Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.Formula:C21H16FN7OPurity:98.99% - ≥95%Color and Shape:SolidMolecular weight:401.4HG-9-91-01
CAS:HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 andFormula:C32H37N7O3Purity:96.86% - 99.64%Color and Shape:SolidMolecular weight:567.68Ref: TM-T4599
1mg84.00€2mg96.00€5mg160.00€10mg274.00€25mg459.00€50mg658.00€100mg939.00€1mL*10mM (DMSO)187.00€H-9 dihydrochloride
CAS:H-9 dihydrochloride: Strong PKA inhibitor, curbs 5-HT response and EGF signaling, affects pharyngeal function.Formula:C11H15Cl2N3O2SPurity:96.57%Color and Shape:SolidMolecular weight:324.23AZD-8835
CAS:AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).Formula:C22H31N9O3Purity:98.22% - 98.49%Color and Shape:SolidMolecular weight:469.544-Chloro-2'-bromoacetophenone
CAS:4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).Formula:C8H6BrClOPurity:99.56%Color and Shape:White To Beige SolidMolecular weight:233.49FD2056
CAS:FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.Formula:C23H17ClN6O2SPurity:98%Color and Shape:SolidMolecular weight:476.94MSC2360844
CAS:MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).Formula:C26H27FN4O5SPurity:100% - 99.32%Color and Shape:SolidMolecular weight:526.58Ref: TM-T12115
1mg52.00€5mg116.00€10mg182.00€25mg354.00€50mg568.00€100mg900.00€200mg1,206.00€1mL*10mM (DMSO)135.00€ASP4132
CAS:ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.Formula:C46H51F3N6O8S2Purity:98.34%Color and Shape:SolidMolecular weight:937.06Ref: TM-T8432
1mg67.00€2mg96.00€5mg131.00€10mg197.00€25mg358.00€50mg535.00€100mg753.00€1mL*10mM (DMSO)205.00€ABC1183
CAS:ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.Formula:C18H14N4OSPurity:98.53%Color and Shape:SolidMolecular weight:334.39PH14
PH14, a dual PI3K/HDAC inhibitor, demonstrates potent inhibition with IC50 values of 20.3 nM for PI3Kα and 24.5 nM for HDAC3.Purity:98%Color and Shape:Odour SolidAntiproliferative agent-34
CAS:Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.Formula:C27H27N7O5Purity:98%Color and Shape:SolidMolecular weight:529.55YKL-06-062
CAS:YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor that inhibits SIK1, SIK2 and SIK3 with IC50s of 2.12 nM, 1.40 nM and 2.86 nM.Formula:C31H39N7OPurity:99.95%Color and Shape:SolidMolecular weight:525.69S6K1-IN-DG2
CAS:S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.Formula:C16H17BrN6OPurity:99.25%Color and Shape:SolidMolecular weight:389.25ARN-3236
CAS:ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nMFormula:C19H16N2O2SPurity:99.57% - 99.7%Color and Shape:SolidMolecular weight:336.41Ref: TM-T5993
1mg60.00€2mg86.00€5mg124.00€10mg182.00€25mg343.00€50mg427.00€100mg658.00€200mg938.00€500mg1,388.00€1mL*10mM (DMSO)150.00€PI3K/VEGFR2-IN-1
CAS:PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting both PI3K and VEGFR2 with IC50 values of 2.21 μM for PI3K and 68 μM for VEGFR2, respectively.Formula:C17H14ClN3OSPurity:98%Color and Shape:SolidMolecular weight:343.83KU-57788
CAS:NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).Formula:C25H19NO3SPurity:100% - 99.87%Color and Shape:SolidMolecular weight:413.49PQR530
CAS:PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.Formula:C18H23F2N7O2Purity:99.50%Color and Shape:SolidMolecular weight:407.42
