PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
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Products of "PI3K/Akt/mTOR Signaling"
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Duvelisib (R enantiomer)
CAS:Duvelisib R enantiomer (IPI-145 R enantiomer) is an enantiomer of Duvelisib with lower activity. Duvelisib is a PI3K inhibitor.Formula:C22H17ClN6OPurity:98%Color and Shape:SolidMolecular weight:416.86YU238259
CAS:YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.Formula:C22H22ClN3O4SPurity:99.12% - 99.43%Color and Shape:SolidMolecular weight:459.95Ref: TM-T4339
1mg48.00€2mg63.00€5mg87.00€10mg153.00€25mg305.00€50mg543.00€100mg780.00€500mg1,605.00€1mL*10mM (DMSO)87.00€Pred17
Pred17 is an effective EGFR inhibitor with potential applications in lung cancer research.Formula:C27H22BN3OColor and Shape:SolidMolecular weight:415.29JR-AB2-011
CAS:JR-AB2-011: selective mTORC2 inhibitor, IC50 = 0.36μM, blocks Rictor-mTOR, Ki = 0.19μM, cytotoxic in glioblastoma.Formula:C17H14Cl2FN3OSPurity:98.87%Color and Shape:SolidMolecular weight:398.28Ref: TM-T11728
1mg95.00€5mg202.00€10mg344.00€25mg630.00€50mg945.00€100mg1,264.00€1mL*10mM (DMSO)224.00€OTSSP167
CAS:OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.Formula:C25H28Cl2N4O2Purity:98.22% - 99.47%Color and Shape:SolidMolecular weight:487.42Ref: TM-T1759
1mg40.00€2mg51.00€5mg88.00€10mg119.00€25mg187.00€50mg283.00€100mg432.00€500mg938.00€1mL*10mM (DMSO)96.00€Icotinib Hydrochloride
CAS:Icotinib Hydrochloride, an oral EGFR inhibitor (BPI-2009H), may halt cancer growth by blocking EGFR signaling.Formula:C22H22ClN3O4Purity:99.77%Color and Shape:SolidMolecular weight:427.88TAS6417
CAS:Zipalertinib (TAS6417, CLN-081) is a novel, highly potent, orally active covalent EGFR tyrosine kinase inhibitor.Cost-effective and quality-assured.Formula:C23H20N6OPurity:99.71%Color and Shape:SolidMolecular weight:396.44Ref: TM-T16996
1mg87.00€2mg124.00€5mg188.00€10mg311.00€25mg630.00€50mg1,008.00€100mg1,549.00€500mg3,117.00€1mL*10mM (DMSO)215.00€ALK/EGFR-IN-1
CAS:ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation.Formula:C27H34ClN7O3SPurity:98%Color and Shape:SolidMolecular weight:572.12R547
CAS:R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.Formula:C18H21F2N5O4SPurity:90% - 99.84%Color and Shape:SolidMolecular weight:441.45Ref: TM-T6312
1mg49.00€2mg72.00€5mg107.00€10mg156.00€25mg283.00€50mg542.00€100mg778.00€500mg1,605.00€1mL*10mM (DMSO)127.00€SYR127063
CAS:SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.Formula:C23H20ClF3N4O3Purity:98.57%Color and Shape:SolidMolecular weight:492.88PDK1-IN-RS2
CAS:PDK1-IN-RS2, a PIFtide mimic, selectively inhibits PDK1, blocking S6K1 activation (Kd: 9 μM).Formula:C15H9ClN2O2S3Purity:98%Color and Shape:SolidMolecular weight:380.89KI8751
CAS:KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.Formula:C24H18F3N3O4Purity:99.22% - 99.9%Color and Shape:SolidMolecular weight:469.41Ref: TM-T2446
2mg37.00€5mg52.00€10mg86.00€25mg156.00€50mg294.00€100mg472.00€200mg670.00€1mL*10mM (DMSO)56.00€EGFR-IN-11
CAS:EGFR-IN-11 selectively blocks EGFR-tyrosine kinase and promotes apoptosis; targets EGFRL858R/T790M/C797S, IC50=18 nM; halts cell cycle at G0/G1.Formula:C29H35N9O2SPurity:99.37%Color and Shape:SolidMolecular weight:573.71Ref: TM-T11158
1mg51.00€5mg116.00€10mg192.00€25mg304.00€50mg420.00€100mg560.00€1mL*10mM (DMSO)147.00€BRD0209
CAS:BRD0209 is a highly selective and potent GSK3 inhibitor.Formula:C22H25N3OPurity:99.75%Color and Shape:SolidMolecular weight:347.45Lapatinib Ditosylate
CAS:Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).Formula:C29H26ClFN4O4S·2C7H8O3SPurity:99.41%Color and Shape:Yellow SolidMolecular weight:925.46CP-380736
CAS:CP-380736 (PF-00520893) inhibits EGFR, a kinase key in cancer-signaling pathways like MAPK, JNK, and Akt.Formula:C14H18N2O5Purity:99.68%Color and Shape:White To Off-White SolidMolecular weight:294.3Lifirafenib
CAS:Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinantFormula:C25H17F3N4O3Purity:98% - 98.25%Color and Shape:SolidMolecular weight:478.42Ref: TM-T22272
1mg35.00€5mg69.00€10mg97.00€25mg190.00€50mgTo inquire100mgTo inquire1mL*10mM (DMSO)89.00€PD-089828
CAS:PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).Formula:C18H18Cl2N6OPurity:96.78%Color and Shape:SolidMolecular weight:405.28Mutant EGFR inhibitor
CAS:Selective, potent inhibitor for mutated EGFR: L858R, Exon19 deletion, T790M resistance mutants.Formula:C27H30ClN7O2Purity:96.21% - 98%Color and Shape:SolidMolecular weight:520.03Ref: TM-T2705
1mg37.00€2mg52.00€5mg80.00€10mg97.00€25mg168.00€50mg264.00€100mg379.00€500mgTo inquire1mL*10mM (DMSO)104.00€CZ415
CAS:CZ415 is a potent and highly selective mTOR inhibitor.Formula:C22H29N5O4SPurity:97.54% - 98.36%Color and Shape:SolidMolecular weight:459.56Ref: TM-T3514
1mg42.00€2mg51.00€5mg74.00€10mg110.00€25mg224.00€50mg338.00€100mg472.00€200mg652.00€1mL*10mM (DMSO)75.00€TGX-115
CAS:TGX-115 inhibits PI 3-K p110β (IC50=0.13μM) & p110δ (IC50=0.63μM), treats various cardiovascular diseases.Formula:C20H20N2O3Purity:99.2%Color and Shape:SolidMolecular weight:336.38Ref: TM-T24873
1mg200.00€5mg472.00€10mg645.00€25mg905.00€50mg1,121.00€100mg1,425.00€200mg1,863.00€1mL*10mM (DMSO)389.00€Samotolisib
CAS:Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.Formula:C23H26N4O3Purity:98.41% - 99.69%Color and Shape:SolidMolecular weight:406.48AMPK activator 13
AMPK Activator 13 is a potent activator of the AMPK pathway, effectively inhibiting mitotic clonal expansion in 3T3-L1 cells and enhancing mitochondrial oxygenPurity:98%Color and Shape:Odour SolidDNA-PK-IN-15
CAS:DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.Formula:C23H23N9OColor and Shape:SolidMolecular weight:441.49Tarloxotinib bromide
CAS:Tarloxotinib bromide (TH-4000) is an irreversible inhibitor of EGFR/HER2.Formula:C24H24Br2ClN9O3Purity:97.15%Color and Shape:SolidMolecular weight:681.77Ref: TM-T13088
1mg140.00€5mg283.00€10mg432.00€25mg707.00€50mg938.00€100mg1,311.00€1mL*10mM (DMSO)437.00€Tyrosine kinase-IN-7
CAS:Tyrosine kinase-IN-7 is a potent inhibitor of the tyrosine kinase EGFR, inhibiting EGFR(WT) and EGFR(T790M) and showing anti-cancer and anti-tumor activity.Formula:C16H15N3OSPurity:99.93%Color and Shape:SolidMolecular weight:297.38HL271
CAS:HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.Formula:C13H17ClF3N5OPurity:98%Color and Shape:SolidMolecular weight:351.76Vacuolin-1
CAS:Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane.Formula:C26H24IN7OPurity:97.20% - 98.45%Color and Shape:SolidMolecular weight:577.42Os30
Os30 is a potent fourth-generation EGFR inhibitor, specifically targeting the EGFRC797S-TK mutation with IC50 values of 18 nM for EGFRDel19/T790M/C797S TK andPurity:98%Color and Shape:Odour SolidTrastuzumab
CAS:Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.Purity:98% - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%Color and Shape:LiquidMolecular weight:Approximately 145.53 kDaTCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Formula:C27H25F3N4O4Purity:≥98%Color and Shape:SolidMolecular weight:526.51(Rac)-BRD0705
CAS:(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is an effective and selective inhibitor of GSK3α.Formula:C20H23N3OPurity:99.67%Color and Shape:SolidMolecular weight:321.42Ref: TM-T12664
1mg96.00€5mg212.00€10mg316.00€25mg510.00€50mg695.00€100mg940.00€1mL*10mM (DMSO)155.00€GSK2636771
CAS:GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, andFormula:C22H22F3N3O3Purity:98.58% - ≥95%Color and Shape:SolidMolecular weight:433.42Ref: TM-T2073
1mg43.00€2mg57.00€5mg88.00€10mg150.00€25mg254.00€50mg359.00€100mg547.00€1mL*10mM (DMSO)88.00€Modotuximab
CAS:Modotuximab (DS 1024) is a humanized antibody targeting EGFR with antitumor activity that accelerates the internalization and degradation of EGFR.Purity:95% - 95%Color and Shape:LiquidEGFRVIII Protein, Human, Recombinant (His & Avi), FITC-Labeled
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Color and Shape:Lyophilized PowderMolecular weight:41.6 kDa (predicted). Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-Bis PAGE result.SB 216763
CAS:SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Formula:C19H12Cl2N2O2Purity:99.13% - 99.61%Color and Shape:SolidMolecular weight:371.22Ref: TM-T3077
2mg39.00€5mg52.00€10mg79.00€25mg131.00€50mg197.00€100mg334.00€500mg803.00€1mL*10mM (DMSO)52.00€GSK2292767 FA
GSK2292767 FA: potent PI3Kδ inhibitor, pIC50=10.1, 500x selectivity, for respiratory research.Formula:C25H30N6O7SPurity:99.21%Color and Shape:SoildMolecular weight:558.61PI3Kδ-IN-17
CAS:PI3Kδ-IN-17 (Compound S5) is a potent PI3K δ inhibitor, exhibiting an IC50 value of 2.82 nM and demonstrates significant efficacy in suppressing theFormula:C23H24F3N7O2Purity:98%Color and Shape:SolidMolecular weight:487.48PD153035 hydrochloride
CAS:PD153035 hydrochloride (ZM 252868) is a effective and selective inhibitor of EGFR; few influence against FGFR, PGDFR, InsR, CSF-1, and Src.Formula:C16H15BrClN3O2Purity:99.39% - ≥95%Color and Shape:SolidMolecular weight:396.67GSK3-IN-2
CAS:GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.Formula:C17H19N3OSPurity:98.8%Color and Shape:SolidMolecular weight:313.42DS-7423
CAS:DS-7423: a dual PI3K/mTOR inhibitor; IC50s-PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.Formula:C22H27F3N10O2Purity:99.68%Color and Shape:SolidMolecular weight:520.51Ref: TM-T36083
1mg127.00€5mg283.00€10mg432.00€25mg707.00€50mg938.00€100mg1,378.00€1mL*10mM (DMSO)321.00€Cbz-B3A
CAS:Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.Formula:C35H58N6O9Purity:98.63%Color and Shape:SolidMolecular weight:706.87AZ7550 hydrochloride
CAS:AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formula:C27H32ClN7O2Purity:97.07%Color and Shape:SolidMolecular weight:522.04AMPK activator 4
CAS:Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.Formula:C24H21ClN2O3Purity:100% - 99.75%Color and Shape:SolidMolecular weight:420.89Ref: TM-T62238
1mg90.00€5mg183.00€10mg354.00€25mg595.00€50mg847.00€100mg1,159.00€500mg2,308.00€1mL*10mM (DMSO)215.00€BEBT-908
CAS:BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).Formula:C23H25N9O3SPurity:98.96%Color and Shape:SolidMolecular weight:507.57Ref: TM-T16529
1mg120.00€2mg167.00€5mg250.00€10mg378.00€25mg630.00€50mg898.00€100mg1,216.00€500mg2,442.00€1mL*10mM (DMSO)279.00€EGFRVIII Protein, Human, Recombinant (His & Avi), Biotinylated
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Color and Shape:Lyophilized PowderMolecular weight:41.6 kDa (predicted). Due to glycosylation, the protein migrates to 60-78 kDa based on Tris-Bis PAGE result.M77976
CAS:M77976 inhibits PDK4 with an IC50 of 648 μM, targeting obesity and diabetes research.Formula:C17H16N2O3Purity:99.80%Color and Shape:SolidMolecular weight:296.32Serclutamab
CAS:Serclutamab, a humanized chimeric monoclonal antibody of the IgG1-κ isotype, selectively targets the epidermal growth factor receptor (EGFR).Purity:98%Color and Shape:LiquidPS10
CAS:PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2 and significantly increases the activity of the pyruvate dehydrogenase complex.Formula:C14H13NO6SPurity:99.01%Color and Shape:SolidMolecular weight:323.32Anti-Phospho-EGFR (Tyr1068) Antibody (3Q245)
Anti-Phospho-EGFR (Tyr1068) Antibody (3Q245) is an antibody targeting Phospho-EGFR (Tyr1068). Anti-Phospho-EGFR (Tyr1068) Antibody (3Q245) can be used in ELISA, WB.Color and Shape:Odour Liquid
