PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
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Products of "PI3K/Akt/mTOR Signaling"
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EGFR/BRAFV600E-IN-3
EGFR/BRAFV600E-IN-3 is an inhibitor targeting EGFR, BRAFV600E, and EGFRT790M with IC50 values of 57 nM, 68 nM, and 9.70 nM, respectively.Formula:C25H18N4O3Purity:98%Color and Shape:SolidMolecular weight:422.44MTK458
CAS:MTK458 (EP-0035985) is a PINK1 activator with antidepressant activity for the study of Parkinson;s disease.Formula:C17H15F3N4Purity:98.36%Color and Shape:SolidMolecular weight:332.32Caxmotabart
Caxmotabart is a humanized IgG1κ antibody targeting ERBB2, with HumanIgG1kappa, Isotype Control as its corresponding isotype control.Color and Shape:Odour LiquidIHMT-PI3Kδ-372
CAS:IHMT-PI3Kδ-372 is a selective inhibitor of PI3Kδ with an IC50 of 14 nM and can be used in studies about chronic obstructive pulmonary disease.Formula:C26H23F2N7O2Purity:99.54%Color and Shape:SolidMolecular weight:503.5AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purity:98.6% - 99.39%Color and Shape:Yellow SolidMolecular weight:294.3PI3Kδ-IN-1
CAS:PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).Formula:C22H20F3N7O2Purity:99.3%Color and Shape:SolidMolecular weight:471.44BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Formula:C28H25F3N6O2Purity:100% - 98.40%Color and Shape:SolidMolecular weight:534.53Ref: TM-T6072L
1mg52.00€5mg114.00€10mg187.00€25mg411.00€50mg607.00€100mg847.00€1mL*10mM (DMSO)156.00€PI3Kγ inhibitor 1
CAS:PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.Formula:C32H26N8O2SPurity:98%Color and Shape:SolidMolecular weight:586.67LCH-7749944
CAS:LCH-7749944 suppresses human gastric cancer cell growth, induces apoptosis, and inhibits PAK4 with IC50 of 14.93 μM.Formula:C20H22N4O2Purity:99.48%Color and Shape:SolidMolecular weight:350.41Ref: TM-T11826
1mg49.00€5mg108.00€10mg164.00€25mg284.00€50mg424.00€100mg615.00€200mg830.00€1mL*10mM (DMSO)116.00€740 Y-P acetate
740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-Formula:C143H226N43O41PS3Purity:99.92%Color and Shape:SoildMolecular weight:3330.79SKLB 1028
CAS:SKLB 1028, an oral EGFR/FLT3/Abl inhibitor, excels in AML and CML with Abl mutations.Formula:C24H29N9Purity:99.71% - 99.85%Color and Shape:SolidMolecular weight:443.55Ref: TM-T34656
1mg56.00€5mg119.00€10mg187.00€25mg378.00€50mg560.00€100mg800.00€500mg1,644.00€1mL*10mM (DMSO)143.00€(E/Z)-CP-724714
CAS:(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].Formula:C27H27N5O3Purity:98%Color and Shape:SolidMolecular weight:469.54Methyl 2,5-dihydroxycinnamate
CAS:Methyl 2,5-dihydroxycinnamate is an EGF receptor-associated tyrosine kinases inhibitor.Formula:C10H10O4Purity:98.98%Color and Shape:CrystallineMolecular weight:194.18PF-06843195
CAS:PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .Formula:C20H25F3N8O4Purity:98.01%Color and Shape:SolidMolecular weight:498.46Matuzumab
CAS:Matuzumab (EMD 72000) is a humanized monoclonal antibody targeting EGFR that can be used to study non-small cell lung cancer.Purity:95%Color and Shape:LiquidMolecular weight:145.9 kDabpV(phen)
CAS:bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN).Formula:C12H8KN2O5VPurity:98%Color and Shape:SolidMolecular weight:350.24HG-14-10-04
CAS:HG-14-10-04 is a potent and specific ALK inhibitor.Formula:C29H34ClN7OPurity:100% - 99.75%Color and Shape:SolidMolecular weight:532.08EGFR Protein, Human, Recombinant (His & Avi)
EGFR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.Color and Shape:Lyophilized PowderMolecular weight:71.5 kDa (predicted). Due to glycosylation, the protein migrates to 85-110 kDa based on Tris-Bis PAGE result.mTOR inhibitor 9b
CAS:mTOR inhibitor 9b is an enzyme inhibitor of protein kinase mTOR he phosphatidylinositol 3-kinase PIK3CA with IC50s of 0.76 nm and 1.262 µM, respectively.mTORFormula:C21H23N5O2SPurity:99.53%Color and Shape:SoildMolecular weight:409.5PF-04979064
CAS:PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).Formula:C24H26N6O3Purity:98.04% - ≥98%Color and Shape:SolidMolecular weight:446.5CHIR-99021
CAS:View and buy CHIR-99021 from TargetMol.CHIR-99021 is a GSK-3α/β inhibitor.Cited in 10 publications.Formula:C22H18Cl2N8Purity:97.94% - ≥95%Color and Shape:SolidMolecular weight:465.34Ref: TM-T2310
2mg43.00€5mg64.00€10mg96.00€25mg160.00€50mg254.00€100mg404.00€200mg603.00€500mg938.00€1mL*10mM (DMSO)70.00€ZM323881 hydrochloride
CAS:ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.Formula:C22H19ClFN3O2Purity:100%Color and Shape:SolidMolecular weight:411.86KU-0060648
CAS:KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.Formula:C33H34N4O4SPurity:98.75%Color and Shape:SolidMolecular weight:582.71(Rac)-JBJ-04-125-02
CAS:(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.Formula:C29H26FN5O3SPurity:95.85%Color and Shape:SolidMolecular weight:543.61Ref: TM-T8872
1mg105.00€5mg216.00€10mg354.00€25mg597.00€50mg852.00€100mg1,159.00€1mL*10mM (DMSO)263.00€GSK3i XIII
CAS:GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.Formula:C18H19N5Purity:98.87%Color and Shape:SolidMolecular weight:305.38Ref: TM-T24111
1mg99.00€5mg195.00€10mg293.00€25mg494.00€50mg715.00€100mg1,008.00€500mg2,015.00€1mL*10mM (DMSO)216.00€AV-412
CAS:AV-412 (MP412) is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM).Formula:C41H44ClFN6O7S2Purity:99.85% - 99.92%Color and Shape:SolidMolecular weight:851.41Ref: TM-T10419
1mg44.00€2mg58.00€5mg95.00€10mg144.00€25mg254.00€50mg424.00€100mg613.00€1mL*10mM (DMSO)136.00€Ligustroside
CAS:Ligustroside mildly inhibits PGE2, has slight antioxidant and anti-inflammatory effects, and is moderately antiviral against parainfluenza 3.Formula:C25H32O12Purity:98%Color and Shape:SolidMolecular weight:524.51MAZ51
CAS:MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Formula:C21H18N2OPurity:98.53%Color and Shape:SolidMolecular weight:314.38D-69491 hydrochloride
CAS:D-69491 hydrochloride is an inhibitor of HER-2 tyrosine kinase activity, blocking the phosphorylation of HER-2 and inhibiting the proliferation of SKOV-3 cells. It exhibits antitumor activity.Formula:C25H26Cl2FN7O3Color and Shape:SolidMolecular weight:562.42IC-87114
CAS:IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).Formula:C22H19N7OPurity:100% - 97.97%Color and Shape:SolidMolecular weight:397.43Ref: TM-T2660
2mg39.00€5mg57.00€10mg90.00€25mg145.00€50mg240.00€100mg378.00€200mg552.00€1mL*10mM (DMSO)64.00€CHIR 98024
CAS:CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.Formula:C20H17Cl2N9O2Purity:96.74%Color and Shape:SolidMolecular weight:486.31Ref: TM-T3074
1mg44.00€2mg55.00€5mg96.00€10mg153.00€25mg298.00€50mg487.00€100mg705.00€1mL*10mM (DMSO)97.00€GLPG3970
CAS:GLPG3970, a pioneering inhibitor of SIK2/SIK3, is utilized in the investigation of inflammation and autoimmune diseases.Formula:C25H27F3N4O4Purity:100% - 99.63%Color and Shape:SolidMolecular weight:504.5Ref: TM-T73384
1mg66.00€5mg137.00€10mg188.00€25mg406.00€50mg607.00€100mg919.00€1mL*10mM (DMSO)156.00€PI3Kδ-IN-23
CAS:PI3Kδ-IN-23 (compound A11) is a potent inhibitor of PI3Kδ, with an IC50 of 0.27 nM. It binds to PI3Kδ through covalent interaction with Lys779 and plays a significant role in cancer research.Formula:C30H30N6O5Molecular weight:554.596Autogramin-1
CAS:Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.Formula:C23H27N5O5SPurity:97.22% - 98.76%Color and Shape:SolidMolecular weight:485.56EGFR-IN-129
EGFR-IN-129 (Compound 10b) is an effective, selective EGFR inhibitor with an IC50 of 51.2 nM and demonstrates broad-spectrum antiproliferative activity against the NCI tumor panel.Formula:C21H18N4O3SColor and Shape:SolidMolecular weight:406.46Petosemtamab
CAS:Petosemtamab (MCLA 158), a dual-action monoclonal antibody targets EGFR & LGR5, used in solid tumor research like HNSCC & CRC.Purity:> 95% - > 95%Color and Shape:LiquidMolecular weight:145.97 kDaRGX-202
CAS:RGX-202 (β-GPA) is an orally active inhibitor of the SLC6A8 transport protein. RGX-202 is a creatine analog that alters skeletal muscle energy expenditure.Formula:C4H9N3O2Purity:99.67% - 99.8%Color and Shape:SolidMolecular weight:131.13mTOR inhibitor 9f
CAS:mTOR inhibitor 9f is a selective mTOR inhibitor with IC50 of 1.25nM and 82nM for mTOR and PI3Kα, respectively.Formula:C25H23N5O2SPurity:98.39%Color and Shape:SoildMolecular weight:457.55ALKBH1-IN-3
ALKBH1-IN-3 is an effective inhibitor of the DNA N6-methyladenosine (6mA) demethylase ALKBH1. This compound enhances the abundance of 6mA in gastric cancer cell lines HGC27 and AGS, simultaneously inhibiting cell viability and upregulating the AMP-activated protein kinase (AMPK) signaling pathway. ALKBH1-IN-3 holds potential for use in cancer research, including studies on gastric cancer.Color and Shape:Odour SolidTyrphostin AG 112
CAS:Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.Formula:C13H8N4OPurity:97.01%Color and Shape:SolidMolecular weight:236.23Sevabertinib
CAS:Sevabertinib (BAY 2927088) is an EGFR tyrosine kinase inhibitor, with anticancer activity, used in research on non-small cell lung cancer.Formula:C24H25ClN4O5Purity:99.81%Color and Shape:SolidMolecular weight:484.93EGFR-IN-122
CAS:EGFR-IN-122 (compound Yfq07) serves as a potent inhibitor of EGFR. It effectively inhibits the proliferation of PC-9GR and HCC827GR cells.Formula:C19H20N4O3Color and Shape:SolidMolecular weight:352.39BIO-acetoxime
CAS:BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.Formula:C18H12BrN3O3Purity:97.28%Color and Shape:SolidMolecular weight:398.21Ref: TM-T6787
1mg35.00€2mg48.00€5mg70.00€10mg104.00€25mg187.00€50mg298.00€100mg464.00€1mL*10mM (DMSO)78.00€Allitinib
CAS:Allitinib (AST-1306) (AST-1306) has anti-cancer activity,and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]Formula:C24H18ClFN4O2Purity:99.10% - 99.28%Color and Shape:SolidMolecular weight:448.88Ref: TM-T14336
1mg52.00€5mg111.00€10mg175.00€25mg329.00€50mg494.00€100mg700.00€1mL*10mM (DMSO)135.00€Alflutinib mesylate
CAS:Alflutinib mesylate (AST2818 mesylate) ,is an irreversible tyrosine kinase inhibitor that selectively inhibits EGFR mutations, especially T790M.Formula:C29H35F3N8O5SPurity:97.94% - 99.81%Color and Shape:SolidMolecular weight:664.7PI3Kδ-IN-3
CAS:PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.Formula:C28H24N6O3Purity:98.43%Color and Shape:SolidMolecular weight:492.53EGFR-IN-86
EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cellFormula:C20H21N7O2SPurity:98%Color and Shape:SolidMolecular weight:423.49Becotatug
CAS:Becotatug (JMT-101) is an IgG1 antibody that targets EGFR and can be conjugated to Afatinib and Osimertinib, functioning as a synthetic antibody-drug conjugatePurity:98%Color and Shape:LiquidLapatinib
CAS:Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.Formula:C29H26ClFN4O4SPurity:99.00% - 99.81%Color and Shape:PowderMolecular weight:581.06IPI-3063
CAS:IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).Formula:C25H25N7O2Purity:99.08%Color and Shape:SolidMolecular weight:455.51Ref: TM-T15592
1mg47.00€2mg64.00€5mg104.00€10mg170.00€25mg340.00€50mg472.00€100mg645.00€1mL*10mM (DMSO)113.00€
