PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
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Products of "PI3K/Akt/mTOR Signaling"
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Mobocertinib
CAS:Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agentFormula:C32H39N7O4Purity:98.66% - 99.47%Color and Shape:SolidMolecular weight:585.7Saracatinib
CAS:Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.Formula:C27H32ClN5O5Purity:98% - 99.63%Color and Shape:SolidMolecular weight:542.03N,N-Didesethyl Sunitinib
CAS:N,N-Didesethyl Sunitinib Hydrochloride is a potent AMPK inhibitor with IC50 of 393 nM and 141 nM for AMPKα1 and AMPK2,respectively.Formula:C18H19FN4O2Purity:97.1%Color and Shape:SoildMolecular weight:342.37Parsaclisib hydrochloride
CAS:Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity.Formula:C20H23Cl2FN6O2Purity:98%Color and Shape:SolidMolecular weight:469.34GSK3-IN-4
CAS:GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.Formula:C18H20N4OPurity:97.1%Color and Shape:SoildMolecular weight:308.38Ref: TM-T64366
1mg77.00€5mg158.00€10mg225.00€25mg338.00€50mg472.00€100mg645.00€200mg868.00€1mL*10mM (DMSO)153.00€EGFR-IN-83
EGFR-IN-83 (Compound 9), an EGFR inhibitor with an IC50 of 2.53 nM, exhibits antiproliferative effects on MCF-7 and MDA-MB-231 cell lines, with respective IC50Formula:C22H17F3N4OPurity:98%Color and Shape:SolidMolecular weight:410.39O-Desmethyl gefitinib
CAS:O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.Formula:C21H22ClFN4O3Purity:97.17%Color and Shape:SolidMolecular weight:432.88Ref: TM-T16369
1mg56.00€5mg111.00€10mg170.00€25mg343.00€50mg547.00€100mg783.00€1mL*10mM (DMSO)120.00€SJF 1521
CAS:SJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.Formula:C57H61ClFN7O9SPurity:99.20%Color and Shape:SolidMolecular weight:1074.65Befotertinib
CAS:Befotertinib (D-0316) is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cell lung cancer.Formula:C29H32F3N7O2Purity:99.40%Color and Shape:SolidMolecular weight:567.61Ref: TM-T39275
1mg88.00€5mg187.00€10mg298.00€25mg525.00€50mg747.00€100mg1,026.00€1mL*10mM (DMSO)235.00€LTURM34
CAS:LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM.Formula:C24H18N2O3SPurity:99.34%Color and Shape:SolidMolecular weight:414.48Ref: TM-T15789
5mg46.00€10mg74.00€25mg145.00€50mg245.00€100mg364.00€200mg532.00€1mL*10mM (DMSO)49.00€MOMIPP
CAS:MOMIPP: PIKfyve inhibitor, spurs macropinocytosis, crosses blood-brain barrier, curbs glioblastoma growth.Formula:C18H16N2O2Purity:99.66%Color and Shape:SolidMolecular weight:292.33Ref: TM-T33467
1mg114.00€5mg160.00€10mg250.00€25mg455.00€50mg628.00€100mg944.00€1mL*10mM (DMSO)245.00€SRX3207
CAS:SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.Formula:C29H29N7O3SPurity:99.85%Color and Shape:SolidMolecular weight:555.65HER2-IN-21
CAS:HER2-IN-21 (compound 657994) is an inhibitor of the human epidermal growth factor receptor 2 (HER2) with an IC50 value of 3.85 μM.Formula:C20H18N4O3SColor and Shape:SolidMolecular weight:394.447GSK-3β inhibitor 20
CAS:GSK-3β inhibitor20 (compound 3A) is an effective inhibitor of GSK-3β, exhibiting an IC50 value of 74.4 nM.Formula:C22H21N5O2SColor and Shape:SolidMolecular weight:419.50SB 415286
CAS:SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.Formula:C16H10ClN3O5Purity:99.55%Color and Shape:SolidMolecular weight:359.72CHIR-98014
CAS:CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.Formula:C20H17Cl2N9O2Purity:97.25% - 99.41%Color and Shape:SolidMolecular weight:486.31GSK-3β inhibitor 12
CAS:GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3βFormula:C14H13N3OSPurity:98.42%Color and Shape:SolidMolecular weight:271.34AZD8186
CAS:AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).Formula:C24H25F2N3O4Purity:99.89% - 99.91%Color and Shape:SolidMolecular weight:457.47Ref: TM-T6773
2mg46.00€5mg66.00€10mg99.00€25mg168.00€50mg304.00€100mg505.00€500mg1,121.00€1mL*10mM (DMSO)72.00€K 00546
CAS:K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).Formula:C15H13F2N7O2S2Purity:99.12%Color and Shape:SolidMolecular weight:425.44GSK-3β inhibitor 2
CAS:GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50Formula:C14H14N4O3SPurity:95.69%Color and Shape:SolidMolecular weight:318.35Duvelisib (R enantiomer) hydrochloride
Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor.Formula:C22H18Cl2N6OPurity:99.76% - 99.87%Color and Shape:SoildMolecular weight:453.32Ref: TM-T11129L
1mg313.00€5mg758.00€10mg1,035.00€25mg1,568.00€50mg2,118.00€100mg2,783.00€1mL*10mM (DMSO)945.00€WZ4003
CAS:WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.Formula:C25H29ClN6O3Purity:100% - 99.65%Color and Shape:SolidMolecular weight:496.99Ref: TM-T6291
5mg50.00€10mg77.00€25mg117.00€50mg170.00€100mg255.00€200mg378.00€500mg622.00€1mL*10mM (DMSO)52.00€Theliatinib
CAS:Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).Formula:C25H26N6O2Purity:99.67%Color and Shape:SolidMolecular weight:442.51MK8722
CAS:MK8722 is an effective and systemic activator of pan-AMPK.Formula:C24H20ClN3O4Purity:98.08% - 99.88%Color and Shape:SolidMolecular weight:449.89Ref: TM-T16099
1mg37.00€2mg52.00€5mg79.00€10mg119.00€25mg226.00€50mg419.00€100mg617.00€1mL*10mM (DMSO)87.00€Autophinib
CAS:Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay andFormula:C14H11ClN6O3Purity:99.25% - 99.41%Color and Shape:SolidMolecular weight:346.73Safingol hydrochloride
CAS:Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a PKC-specific inhibitor that inhibits PKC and PI3k and induces cancer cell death.Formula:C18H40ClNO2Purity:99.31% - 99.71%Color and Shape:SoildMolecular weight:337.969Anti-EGFR Monoclonal Antibody
Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: HumanPurity:> 95% as determined by SDS-PAGE.Color and Shape:LiquidMolecular weight:150 kDaEGFRVIII Protein, Human, Recombinant (His & Avi)
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Color and Shape:Lyophilized PowderMolecular weight:41.6 kDa (predicted). Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-Bis PAGE result.YH32367
YH32367 (ABL105) is a bispecific antibody targeting HER2 and 4-1BB. It induces the secretion of IFN-γ, resulting in the death of tumor cells when co-cultured with hPBMC and HER2-expressing tumor cells. YH32367 demonstrates notable antitumor activity.Color and Shape:Odour LiquidDMNB
CAS:DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor, an enzyme involved in the NHEJ pathway of DSB repair in human cells.Formula:C9H9NO5Purity:97.87%Color and Shape:Yellow SolidMolecular weight:211.17mTOR inhibitor-3
CAS:mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.Formula:C25H30N8O2Purity:98.29% - 99%Color and Shape:SolidMolecular weight:474.56Ref: TM-T12123
1mg60.00€5mg127.00€10mg180.00€25mg306.00€50mg464.00€100mg655.00€500mg1,359.00€1mL*10mM (DMSO)135.00€Naquotinib mesylate
CAS:Naquotinib mesylate (ASP8273 (mesylate)) is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFRFormula:C31H46N8O6SPurity:98%Color and Shape:SolidMolecular weight:658.813F8
CAS:3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used inFormula:C15H14N2O4Purity:98.05% - 98.49%Color and Shape:SolidMolecular weight:286.28ARRY-380 (analog )
CAS:ARRY-380 analog (HER2-Inhibitor-1) is a potent and selective HER2 inhibitor.Formula:C29H27N7O4SPurity:98.22%Color and Shape:SolidMolecular weight:569.63Ref: TM-T2518
1mg35.00€2mg49.00€5mg74.00€10mg110.00€25mg180.00€50mg266.00€100mgTo inquire1mL*10mM (DMSO)96.00€PI3Kδ-IN-18
Se15, a selective PI3Kδ inhibitor, exhibits potency with an IC50 value of less than 0.1nM and is utilized in autoimmune research [1].Purity:98%Color and Shape:Odour SolidUmbralisib hydrochloride
CAS:Umbralisib hydrochloride: PI3Kδ inhibitor; IC50=22.2 nM, EC50=24.3 nM; active vs CK1ε, EC50=6.0 μM.Formula:C31H25ClF3N5O3Purity:98%Color and Shape:SolidMolecular weight:608.01Icotinib
CAS:Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.Formula:C22H21N3O4Purity:100%Color and Shape:SolidMolecular weight:391.42Ref: TM-T6153
1mg48.00€2mg64.00€5mg96.00€10mg155.00€25mg283.00€50mg527.00€100mg712.00€1mL*10mM (DMSO)97.00€WH-4-025
CAS:WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.Formula:C39H38F3N7O5Purity:99.41%Color and Shape:SolidMolecular weight:741.76Ref: TM-T9219
1mg40.00€2mg52.00€5mg88.00€10mg137.00€25mg264.00€50mg419.00€100mg617.00€1mL*10mM (DMSO)87.00€GSK3-IN-9
CAS:GSK3-IN-9 (0713) is a selective inhibitor of glycogen synthase kinase 3 (GSK3). It holds potential for research into fragile X syndrome, attention deficit hyperactivity disorder (ADHD), childhood epilepsy, intellectual disabilities, diabetes, acute myeloid leukemia (AML), autism, and mental disorders.Formula:C18H20N4OColor and Shape:SolidMolecular weight:308.378Cloperastine fendizoate
CAS:Cloperastine fendizoate (Hustazol) inhibits the hERG K+ currents in a concentration-dependent manner (IC50: 27 nM).Formula:C40H38ClNO5Purity:99.85%Color and Shape:SolidMolecular weight:648.19Sapanisertib
CAS:Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.Formula:C15H15N7OPurity:100% - 99.67%Color and Shape:SolidMolecular weight:309.33Ref: TM-T1838
1mg40.00€2mg51.00€5mg85.00€10mg96.00€25mg160.00€50mg235.00€100mg350.00€500mg838.00€1mL*10mM (DMSO)88.00€GNE-490
CAS:GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.Formula:C18H22N6O2SPurity:99.77%Color and Shape:SolidMolecular weight:386.47Ref: TM-T22339
1mg85.00€2mg115.00€5mg188.00€10mg321.00€25mg509.00€50mg702.00€100mg932.00€200mg1,283.00€1mL*10mM (DMSO)205.00€AMPK-α1β1γ1 activator 1
CAS:AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1Formula:C25H24ClNO9Purity:98%Color and Shape:SolidMolecular weight:517.91Avitinib
CAS:Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor,Formula:C26H26FN7O2Purity:100%Color and Shape:SolidMolecular weight:487.53DMH-25
CAS:DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.Formula:C15H8Br3NO3Purity:99.26%Color and Shape:SolidMolecular weight:489.94Ref: TM-T8569
1mg88.00€5mg170.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)212.00€Dehydroglyasperin D
CAS:Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29Formula:C22H24O5Purity:98%Color and Shape:SolidMolecular weight:368.42EGFR-IN-130
EGFR-IN-130 (compound 14b) is an EGFR inhibitor and an inducer of apoptosis (apoptoosis). It effectively kills HeLa cancer cells by inducing apoptosis.Formula:C27H25N3O6SColor and Shape:SolidMolecular weight:519.57EGFR/CSC-IN-1
CAS:EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potentialFormula:C54H54Cl2FN7O7S2Purity:98%Color and Shape:SolidMolecular weight:1067.08AS-605240
CAS:AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).Formula:C12H7N3O2SPurity:97% - 99.91%Color and Shape:SolidMolecular weight:257.27EGFR-IN-138
EGFR-IN-138 (compound 19) is a potent inhibitor of EGFR, with IC50 values of 37, 2.6, and 1.9 nM for the wild-type, L858R, and T790M EGFR, respectively.Formula:C42H37N7O5Color and Shape:SolidMolecular weight:719.79
