PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
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Products of "PI3K/Akt/mTOR Signaling"
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(R)-(-)-Rolipram
CAS:(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.Formula:C16H21NO3Purity:99.6%Color and Shape:SolidMolecular weight:275.34GDC0084
CAS:GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.Formula:C18H22N8O2Purity:99.16% - 99.76%Color and Shape:SolidMolecular weight:382.42G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Formula:C22H19F2NO3Purity:97.30%Color and Shape:SolidMolecular weight:383.39Ref: TM-T8742
1mg50.00€5mg97.00€10mg145.00€25mg259.00€50mg374.00€100mg523.00€200mg710.00€1mL*10mM (DMSO)105.00€ALSTERPAULLONE
CAS:Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing EffecFormula:C16H11N3O3Purity:99.39%Color and Shape:SolidMolecular weight:293.28Ref: TM-T7426
1mg58.00€5mg116.00€10mg183.00€25mg313.00€50mg449.00€100mg620.00€200mg835.00€1mL*10mM (DMSO)111.00€Avitinib maleate
CAS:Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.Formula:C30H30FN7O6Purity:98% - 99.74%Color and Shape:SolidMolecular weight:603.61EGFR-IN-136
EGFR-IN-136 (compound 21v) is a potent inhibitor of EGFR, demonstrating IC50 values of 20.2 nM, 1.2 nM, 2.3 nM, and 12.5 nM for EGFRWT, EGFRLR/TM, EGFR19D/TM/CS, and EGFRLR/TM/CS, respectively. It exhibits antiproliferative and antitumor activities and holds potential for research in non-small cell lung cancer (NSCLC).Formula:C30H36N7O4PMolecular weight:589.625DA-143
DA-143 is a selective inhibitor of DNA-PKcs (IC50: 2.5 nM), demonstrating disparate inhibitory effects on mTOR, PI3KΔ, and ATM, with IC50 values of 280 nM, 106 nM, and 6,594 nM, respectively. This compound effectively blocks the phosphorylation of DNA-PKcs substrates and enhances the sensitivity of cancer cells to doxorubicin.Color and Shape:Odour SolidCNX-2006
CAS:CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.Formula:C26H27F4N7O2Purity:98.85% - 99.16%Color and Shape:SolidMolecular weight:545.53Tilatamig
Tilatamig is a humanized antibody of the Ig(G1-κ, G1-λ2) type targeting EGFR/MET.Color and Shape:Odour LiquidMK-3903
CAS:MK-3903 is a potent and selective AMPK activator (EC50: 8 nM).Formula:C27H19ClN2O3Purity:98.54% - 98.63%Color and Shape:SolidMolecular weight:454.9Ref: TM-T5187
1mg35.00€5mg80.00€10mg120.00€25mg188.00€50mg354.00€100mg588.00€200mg833.00€1mL*10mM (DMSO)88.00€AS-041164
CAS:AS-041164: Oral PI3Kγ inhibitor, IC50 70 nM; weaker on PI3Kα/β/δ; anti-inflammatory.Formula:C11H7NO4SPurity:99.45%Color and Shape:SolidMolecular weight:249.24Selective PI3Kδ Inhibitor 1
CAS:Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).Formula:C23H20FN7OPurity:97.96%Color and Shape:SolidMolecular weight:429.45Anti-EGFR Monoclonal Antibody-AF647
Anti-EGFR Monoclonal Antibody-AF647 is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-AF647 can be used in FACS.Purity:> 95% as determined by SDS-PAGE.Color and Shape:LiquidMolecular weight:150 kDaBrivanib
CAS:Brivanib (BMS-540215) is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM, moderate potency against VEGFR-1 and FGFR-1, but >240-fold againstFormula:C19H19FN4O3Purity:98.87%Color and Shape:SolidMolecular weight:370.38Ref: TM-T6036
1mg47.00€5mg88.00€10mg144.00€25mg259.00€50mg375.00€100mg560.00€200mg815.00€1mL*10mM (DMSO)97.00€NRC-2694
CAS:NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.Formula:C24H26N4O3Purity:99.38%Color and Shape:SolidMolecular weight:418.49Ref: TM-T16343
1mg85.00€5mg160.00€10mg250.00€25mg424.00€50mg562.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)170.00€Neptinib
CAS:Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib effectively inhibits the EGFR kinase family, exhibiting IC 50 values of 0.24 nM for EGFR wt, 7.25 nM for EGFR L858R/T790M, 0.46 nM for EGFR L858R, and 1.79 nM for EGFR T790M.Formula:C22H23ClFN5O2Color and Shape:SolidMolecular weight:443.90SHR-A1201
SHR-A1201 is an antibody-drug conjugate (ADC) targeting HER2. This compound is composed of a humanized anti-HER2 antibody, the linker SMCC, and the cytotoxic payload Mertansine, which is a microtubule inhibitor. SHR-A1201 is utilized in research for HER2-positive breast cancer.Formula:C50H63ClF3N5O12Color and Shape:LiquidMolecular weight:1018.51EGFR-IN-84
EGFR-IN-84 (Compound 6g), an EGFR inhibitor with an IC50 of 24 nM, impedes the growth of A549 cells with an IC50 value of 1.537 μM and is utilized for lungFormula:C25H20N6O3S2Purity:98%Color and Shape:SolidMolecular weight:516.59MTX-241F
MTX-241F, a selective small molecule inhibitor, targets members of the EGFR and PI3 kinase families.Formula:C20H14ClFN6Purity:98%Color and Shape:SolidMolecular weight:392.82hAChE-IN-5
hAChE-IN-5 (compound 49) is a dual inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE), exhibiting inhibitory potency withPurity:98%Color and Shape:Odour SolidOlmutinib
CAS:Olmutinib is an oral mutant-specific EGFR inhibitor for cancer treatment with potential lower toxicity.Formula:C26H26N6O2SPurity:99.63%Color and Shape:SolidMolecular weight:486.59Ref: TM-T6918
2mg39.00€5mg57.00€10mg88.00€25mg137.00€50mg180.00€100mg283.00€200mg462.00€1mL*10mM (DMSO)59.00€VP3.15 dihydrobromide
CAS:VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Formula:C20H24Br2N4OSPurity:96.68% - ≥95%Color and Shape:SolidMolecular weight:528.3Ref: TM-T5956
2mg47.00€5mg70.00€10mg96.00€25mg216.00€50mg376.00€100mg560.00€500mg1,216.00€1mL*10mM (DMSO)81.00€AZD8931 diFuMaric acid
CAS:AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).Formula:C31H33ClFN5O11Purity:99.92%Color and Shape:SolidMolecular weight:706.1Ref: TM-T8751
1mg88.00€5mg172.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)255.00€NVP-BAG956
CAS:NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444 nM for PI3Kδ/PI3Kα/PI3Kγ/PI3Kβ).Formula:C28H21N5Purity:99.71% - 99.80%Color and Shape:SolidMolecular weight:427.5Ref: TM-TQ0313
1mg57.00€5mg120.00€10mg210.00€25mg424.00€50mg707.00€100mg1,293.00€200mg1,738.00€1mL*10mM (DMSO)133.00€Anti-Phospho-EGFR (Tyr1092) Antibody (9I899)
Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) is an antibody targeting Phospho-EGFR (Tyr1092). Anti-Phospho-EGFR (Tyr1092) Antibody (9I899) can be used in ELISA, WB.Color and Shape:Odour LiquidMubritinib
CAS:Mubritinib (TAK-165) (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM.Formula:C25H23F3N4O2Purity:98.61% - 99.87%Color and Shape:SolidMolecular weight:468.472′-Thioadenosine
CAS:2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM againstFormula:C10H13N5O3SPurity:98%Color and Shape:SolidMolecular weight:283.31MRT 67307 dihydrochloride
CAS:MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.Formula:C26H38Cl2N6O2Purity:98.43%Color and Shape:SoildMolecular weight:537.53Ceftriaxone Sodium
CAS:Ceftriaxone Sodium is a sporotaxin antibiotic that inhibits GSK3β and Aurora B. It is used in the study of sepsis and infective endocarditis.Formula:C18H17N8NaO7S3Color and Shape:SolidMolecular weight:576.562AEE788
CAS:AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.Formula:C27H32N6Purity:100% - 98.94%Color and Shape:SolidMolecular weight:440.58Ref: TM-T2116
2mg47.00€5mg70.00€10mg103.00€25mg188.00€50mg325.00€100mg490.00€500mg1,103.00€1mL*10mM (DMSO)77.00€Antitumor agent-116
Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis.Formula:C31H23BrN4O4SPurity:98%Color and Shape:SolidMolecular weight:627.51PD-161570
CAS:PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Formula:C26H35Cl2N7OPurity:99.23%Color and Shape:SolidMolecular weight:532.51Ref: TM-T23127
1mg35.00€5mg92.00€10mg149.00€25mg305.00€50mg492.00€100mg700.00€200mg938.00€1mL*10mM (DMSO)125.00€LY2090314
CAS:LY2090314, a potent GSK-3α/β blocker (IC50: 1.5/0.9 nM), could boost platinum chemo. Tested in leukemia and advanced cancers.Formula:C28H25FN6O3Purity:99.03% - 99.88%Color and Shape:SolidMolecular weight:512.53Ref: TM-T1755
1mg48.00€2mg63.00€5mg96.00€10mg153.00€25mg264.00€50mg432.00€100mg638.00€1mL*10mM (DMSO)107.00€DZD1516
CAS:DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in bothFormula:C28H27F2N7O3Purity:98%Color and Shape:SolidMolecular weight:547.56PI3K-IN-1
CAS:PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.Formula:C31H29N5O6SPurity:97.03% - 98%Color and Shape:SolidMolecular weight:599.66IM-12
CAS:IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.Formula:C22H20FN3O2Purity:100% - 99.71%Color and Shape:SolidMolecular weight:377.41Ref: TM-T2261
5mg52.00€10mg87.00€25mg155.00€50mg283.00€100mg469.00€500mg1,035.00€1mL*10mM (DMSO)58.00€Limertinib
CAS:Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.Formula:C29H32ClN7O2Purity:97.44%Color and Shape:SolidMolecular weight:546.06Ref: TM-T35897
1mg90.00€5mg187.00€10mg316.00€25mg637.00€50mg827.00€100mg1,169.00€200mg1,586.00€1mL*10mM (DMSO)250.00€Tuxobertinib
CAS:Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations. BDTX-189 exhibits anticancer activity.Formula:C29H29ClN6O4Purity:99.22%Color and Shape:SolidMolecular weight:561.03Ref: TM-T9072
2mg40.00€5mg60.00€10mg96.00€25mg188.00€50mg354.00€100mg525.00€200mg752.00€1mL*10mM (DMSO)74.00€EGFR-IN-149
CAS:EGFR-IN-149 (Compound 3-OH) is an EGFR inhibitor with an IC50 value of 0.42 nM.Formula:C16H15N3OSColor and Shape:SolidMolecular weight:297.375GSK251
CAS:GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.Formula:C29H37FN6O4SPurity:98.9%Color and Shape:SolidMolecular weight:584.71Erucic acid sodium
CAS:Erucic acid sodium, a monounsaturated fatty acid (MUFA) extracted from the seeds of rapeseed, readily crosses the blood-brain barrier (BBB). It normalizes the accumulation of long-chain fatty acids in the brain, enhances cognitive function, and effectively prevents dementia.Formula:C22H42NaO2Color and Shape:SolidMolecular weight:361.56EGFR-IN-76
CAS:EGFR-IN-76 is a potent EGFR inhibitor.Formula:C30H30ClFN6O2Purity:97.02% - 97.72%Color and Shape:SolidMolecular weight:561.05PI3Kδ-IN-15
CAS:CAL-101 (Idelalisib) is a selective inhibitor of p110δ; shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ.Formula:C21H16FN7OPurity:99.39%Color and Shape:SolidMolecular weight:401.4PF-06409577
CAS:PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).Formula:C19H16ClNO3Purity:95.17% - 98.16%Color and Shape:SolidMolecular weight:341.79Ref: TM-T4427
2mg46.00€5mg66.00€10mg105.00€25mg210.00€50mg381.00€100mg568.00€500mg1,225.00€1mL*10mM (DMSO)74.00€MBM-55S
CAS:MBM-55S, a Nek2 inhibitor with 1 nM IC50, induces cell cycle arrest and apoptosis, suppressing tumor growth.Formula:C36H39FN6O10Purity:98.38% - 98.73%Color and Shape:SolidMolecular weight:734.73Ref: TM-T11961
1mg185.00€2mg279.00€5mg426.00€10mg627.00€25mg938.00€50mg1,320.00€100mg1,786.00€500mg3,591.00€1mL*10mM (DMSO)630.00€ZL-2201
CAS:ZL-2201 is a potent inhibitor of DNA-PK, demonstrating an IC50 value of 1 nM.Formula:C20H25N9O5SPurity:98%Color and Shape:SolidMolecular weight:503.54Norcantharidin
CAS:Norcantharidin (Norcantharadine) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.Formula:C8H8O4Purity:99.29%Color and Shape:SolidMolecular weight:168.15Sunvozertinib
CAS:Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor, with inhibitory effects on EGFR, Her2.Cost-effective and quality-assured.Formula:C29H35ClFN7O3Purity:98.11% - 99.71%Color and Shape:SolidMolecular weight:584.08Ref: TM-T64124
1mg35.00€5mg64.00€10mg89.00€25mg131.00€50mg212.00€100mg373.00€500mg1,388.00€1mL*10mM (DMSO)159.00€U3-1565
U3-1565 (Anti-HB-EGF antibody) is an antibody targeting HB-EGF with potential anti-tumor activity, used in the study of advanced solid tumors.Color and Shape:LiquidMolecular weight:144.82 kDa (Predicted)WS6
CAS:WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Formula:C29H31F3N6O3Purity:97.23% - 99.83%Color and Shape:SolidMolecular weight:568.59
