PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
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Products of "PI3K/Akt/mTOR Signaling"
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EGFRVIII Protein, Human, Recombinant (His & Avi), PE-Labeled
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification.Color and Shape:Lyophilized PowderMolecular weight:41.6 kDa (predicted)EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated
EGFR vIII Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag.Color and Shape:Lyophilized PowderMolecular weight:60-90 KDa (reducing condition)BI-4732
CAS:DL-Homocystine is a mutagen secreted by F. nucleatum.Formula:C32H36N10O2Purity:98.88%Color and Shape:SolidMolecular weight:592.69Olmutinib
CAS:Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase InhibitorFormula:C26H26N6O2SPurity:99.14%Color and Shape:SolidMolecular weight:486.59Ref: TM-T8460
2mg35.00€5mg57.00€10mg93.00€25mg131.00€50mg185.00€100mg283.00€200mg464.00€1mL*10mM (DMSO)63.00€Pilaralisib
CAS:Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K).Formula:C25H25ClN6O4SPurity:98.24% - 99.61%Color and Shape:SolidMolecular weight:541.02GLPG3312
CAS:GLPG3312 is a selective and potent pan-SIK inhibitor with the advantage of oral activity, for SIK1, SIK2 and SIK3, anti-inflammatory and immunomodulatory .Formula:C23H21F2N5O3Purity:98.53%Color and Shape:SolidMolecular weight:453.44Osimertinib dimesylate
CAS:Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M).Formula:C30H41N7O8S2Purity:98%Color and Shape:SolidMolecular weight:691.82Seletalisib
CAS:Seletalisib (UCB5857) (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).Formula:C23H14ClF3N6OPurity:99.81%Color and Shape:SolidMolecular weight:482.85Ref: TM-TQ0044
1mg57.00€2mg81.00€5mg120.00€10mg188.00€25mg329.00€50mg472.00€100mg660.00€1mL*10mM (DMSO)126.00€AG 555
CAS:AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.Formula:C19H18N2O3Purity:100% - 99.51%Color and Shape:SolidMolecular weight:322.364-PivO-NMT chloride
CAS:4-PivO-NMT chloride is an indole derivative-based regulator of the AMPK signaling pathway. It modulates neurogenesis or neurite outgrowth by influencing AMPK activity and holds potential for research in neurological disorders, pain, and inflammation.Formula:C16H23ClN2O2Color and Shape:SolidMolecular weight:310.82TBB
CAS:TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).Formula:C6HBr4N3Purity:98.51% - 99.45%Color and Shape:Off-White SolidMolecular weight:434.71GSK 3 Inhibitor IX
CAS:GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex.Formula:C16H10BrN3O2Purity:98% - 99.72%Color and Shape:SolidMolecular weight:356.17Ref: TM-T1917
1mg44.00€2mg55.00€5mg82.00€10mg101.00€25mg229.00€50mg411.00€100mg610.00€500mg1,301.00€1mL*10mM (DMSO)90.00€PI3Kα-IN-14
PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting inPurity:98%Color and Shape:Odour SolidDesmethyl-VS-5584
CAS:Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.Formula:C16H20N8OPurity:100%Color and Shape:SolidMolecular weight:340.38Chamigrenal
CAS:β-Chamigrenal: Anti-inflammatory, inhibits NO and PGE2 in macrophages, PAF antagonist (IC50=1.2x10^-4 M), weakly cytotoxic to MCF-7 (IC50=30.50 uM).Formula:C15H22OPurity:99.31%Color and Shape:SolidMolecular weight:218.33Sonolisib
CAS:Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)).Formula:C29H35NO8Purity:98%Color and Shape:SolidMolecular weight:525.59(S)-Afatinib
CAS:(S)-Afatinib (BIBW2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for EGFRwt, L858R, L858R/T790M, HER2, and HER4, respectively.Formula:C24H25ClFN5O3Purity:100% - 99.96%Color and Shape:Off-White SolidMolecular weight:485.94Neratinib
CAS:Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.Formula:C30H29ClN6O3Purity:100% - 98.55%Color and Shape:SolidMolecular weight:557.04Tyrphostin A9
CAS:Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitorFormula:C18H22N2OPurity:98.21% - 99.87%Color and Shape:Yellow SolidMolecular weight:282.38AV-412 free base
CAS:AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2).Formula:C27H28ClFN6OColor and Shape:SolidMolecular weight:507Amivantamab (FUT8-KO)
Amivantamab (FUT8-KO) is a humanized dual-specificity antibody targeting EGFR-MET, exhibiting immunotherapeutic anticancer activity. This compound inhibits ligand binding, enhances the internalization and degradation of receptor-antibody complexes, and stimulates macrophage-mediated phagocytosis and natural killer cell cytotoxicity, both of which are Fc-dependent.Formula:C13H12O4Color and Shape:LiquidMolecular weight:232.23Cromolyn sodium
CAS:Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.Formula:C23H14Na2O11Purity:98.25% - 99.95%Color and Shape:Colorless Crystals From Ethanol + Ether White Crystalline PowderMolecular weight:512.33EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled
EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag.Color and Shape:Lyophilized PowderMolecular weight:71.5 kDa (predicted). Due to glycosylation, the protein migrates to 90-115 kDa based on Tris-Bis PAGE result.Cyanoacetohydrazide
CAS:Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.Formula:C3H5N3OPurity:99.78%Color and Shape:Stout Prisms From Alcohol Slightly Brown PowderMolecular weight:99.09Nemiralisib
CAS:Nemiralisib (GSK-2269557) is an oral PI3Kδ inhibitor (pKi 9.9) for treating respiratory diseases like COPD.Formula:C26H28N6OPurity:99.91%Color and Shape:SolidMolecular weight:440.54PIK-75
CAS:PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).Formula:C16H14BrN5O4SPurity:100% - 99.88%Color and Shape:SolidMolecular weight:452.28CHMFL-EGFR-202
CAS:CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase (IC50s: 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases).Formula:C25H24ClN7O2Purity:99.19%Color and Shape:SolidMolecular weight:489.96Ref: TM-T10802
1mg115.00€2mg172.00€5mg255.00€10mg375.00€25mg562.00€50mg787.00€100mg1,074.00€1mL*10mM (DMSO)305.00€PI3Kdelta inhibitor 1
CAS:PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.Formula:C27H38N6O5SPurity:98%Color and Shape:SolidMolecular weight:558.69GS-9901
CAS:GS-9901 is a selective, orally active and potent PI3Kδ inhibitor (IC50: 1 nM) for the study of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.Formula:C22H17ClFN9OPurity:99.12% - 99.14%Color and Shape:SolidMolecular weight:477.88mTORC1-IN-1
mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseasesPurity:98%Color and Shape:Odour SolidAnti-EGFR Monoclonal Antibody-AF555
Anti-EGFR Monoclonal Antibody-AF555 is a Biotin-conjugated rabbit antibody targeting EGFR. Anti-EGFR Monoclonal Antibody-AF555 can be used in FACS.Purity:> 95% as determined by SDS-PAGE.Color and Shape:LiquidMolecular weight:150 kDaCinrebafusp alfa
CAS:Cinrebafusp alfa (PRS 343) is an anticalin-based bispecific drug with high affinity for both CD137/HER2, displaying dissociation constants (Kd) of 0.3 nM toPurity:98%Color and Shape:LiquidWHI-P180
CAS:WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.Formula:C16H15N3O3Purity:99.21%Color and Shape:SolidMolecular weight:297.31ARUK2001607
ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.Formula:C14H13N3O2S2Purity:99.86%Color and Shape:SoildMolecular weight:319.40PT-1
CAS:PT-1 is an AMPKα1 activator that dose-dependently activates AMPK α1394, α1335, and α2398 and enhances AMPK phosphorylation.Formula:C23H16ClN3O6SPurity:99.62%Color and Shape:SolidMolecular weight:497.91Almonertinib
CAS:Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.Formula:C30H35N7O2Purity:99.99%Color and Shape:SolidMolecular weight:525.64Ref: TM-T5462
1mg89.00€5mg197.00€10mg311.00€25mg525.00€50mg757.00€100mg1,035.00€500mg2,110.00€1mL*10mM (DMSO)249.00€Torin 1
CAS:Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.Formula:C35H28F3N5O2Purity:98.3% - 99.38%Color and Shape:SolidMolecular weight:607.62ElteN378
CAS:ElteN378: potently inhibits FKBP12 (Ki=0.5 nM), low weight, similar affinity to Rapamycin.Formula:C23H26N2O3Purity:98.09%Color and Shape:SolidMolecular weight:378.46Ref: TM-T9950
1mg170.00€5mg376.00€10mg557.00€25mg895.00€50mg1,216.00€100mg1,691.00€200mg2,262.00€1mL*10mM (DMSO)329.00€4-Epidoxycycline
CAS:4-Epidoxycycline is a hepatic metabolite of the antibiotic doxycycline and lacks antibiotic properties in mice. In both in vitro assays and in vivo mouse models, 4-Epidoxycycline regulates HER2 gene expression similarly to doxycycline and exhibits comparable efficacy in tumor tissues, achieving over 95% tumor regression rates.Formula:C22H24N2O8Color and Shape:SolidMolecular weight:444.44E-4031
CAS:E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)Formula:C21H29Cl2N3O3SPurity:99.31% - 99.87%Color and Shape:SolidMolecular weight:474.44Panitumumab
CAS:Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).Purity:95% - 99%Color and Shape:LiquidMolecular weight:147 kDaTAS0728
CAS:TAS0728 is a HER2 inhibitor, with antitumor activityFormula:C26H32N8O3Purity:97.78%Color and Shape:SolidMolecular weight:504.58Ref: TM-T7819
1mg50.00€5mg111.00€10mg170.00€25mg321.00€50mg512.00€100mg695.00€200mg937.00€1mL*10mM (DMSO)117.00€FIIN-3
CAS:FIIN-3 is an irreversible inhibitor of FGFR.Formula:C34H36Cl2N8O4Purity:97.63% - 98.92%Color and Shape:SolidMolecular weight:691.61mTOR inhibitor-2
CAS:mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).Formula:C23H21N7OPurity:98%Color and Shape:SolidMolecular weight:411.46Neolinine
CAS:Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity.Formula:C23H37NO6Purity:98%Color and Shape:SolidMolecular weight:423.55Umbralisib R-enantiomer
CAS:Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.Formula:C31H24F3N5O3Purity:95.61%Color and Shape:SolidMolecular weight:571.55Ref: TM-T13140
1mg187.00€5mg455.00€10mg655.00€25mg1,169.00€50mg1,510.00€100mg1,882.00€1mL*10mM (DMSO)560.00€HTH-01-015
CAS:HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).Formula:C26H28N8OPurity:98.1% - 99.08%Color and Shape:SolidMolecular weight:468.55Brigatinib
CAS:Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.Formula:C29H39ClN7O2PPurity:100% - 99.93%Color and Shape:SolidMolecular weight:584.09PIK-294
CAS:PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).Formula:C28H23N7O2Purity:100% - 99%Color and Shape:SolidMolecular weight:489.53Epitinib succinate
CAS:Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer.Formula:C28H32N6O6Purity:97.43% - 99.47%Color and Shape:SolidMolecular weight:548.59Ref: TM-T35914
1mg75.00€2mg97.00€5mg170.00€10mg271.00€25mg449.00€50mg615.00€100mg843.00€500mg1,691.00€
