PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
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Products of "PI3K/Akt/mTOR Signaling"
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AS-604850
CAS:AS-604850: ATP-competitive PI3Kγ inhibitor, IC50 250 nM, 18x > PI3Kα, 80x > PI3Kδ/β.Formula:C11H5F2NO4SPurity:99.65%Color and Shape:SolidMolecular weight:285.22Osimertinib mesylate
CAS:Osimertinib mesylate (AZD-9291 mesylate) is an EGFR third-generation inhibitor. Osimertinib mesylate has antitumor activity. Cost-effective and quality-assured.Formula:C29H37N7O5SPurity:100% - 99.88%Color and Shape:SolidMolecular weight:595.71Anti-EGFR Monoclonal Antibody-Biotin
Antibody Type: Rabbit Monoclonal<br> Application: FACS<br> Application: HumanPurity:> 95% as determined by SDS-PAGE.Color and Shape:LiquidMolecular weight:150 kDaGNE-477
CAS:GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.Formula:C21H28N8O3S2Purity:98.88% - 99.55%Color and Shape:SolidMolecular weight:504.63MeBIO
CAS:MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.Formula:C17H12BrN3O2Purity:98.84%Color and Shape:SolidMolecular weight:370.2Ref: TM-T21966
1mg39.00€5mg74.00€10mg117.00€25mg220.00€50mg354.00€100mg520.00€500mg1,130.00€1mL*10mM (DMSO)86.00€(E)-AG 556
CAS:AG 556 is a selective inhibitor of EGFR and blocks LPS-induced TNF-α production.Formula:C20H20N2O3Purity:99.48%Color and Shape:Light Yellow PowderMolecular weight:336.38JNK3 inhibitor-9
JNK3inhibitor-9 (Compound 24a) is a potent, selective JNK3 inhibitor capable of crossing the blood-brain barrier (BBB), demonstrating an IC50 value of 12 nM. It effectively inhibits GSK3α/β, which is involved in Tau phosphorylation, with IC50 values of 14 nM and 35 nM, respectively. JNK3inhibitor-9 also reduces the phosphorylation of c-Jun and APP and protects neurons from Aβ1-42 toxicity.Formula:C25H27N7O2Molecular weight:457.528Zorifertinib
CAS:Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor.Formula:C22H23ClFN5O3Purity:98.20% - 99.36%Color and Shape:White To Off-White SolidMolecular weight:459.9T-00127_HEV1
CAS:T-00127_HEV1 is an inhibitor of phosphatidylinositol 4-kinase III beta(PI4KIIIβ, IC50 = 60 nM).Formula:C22H29N5O3Purity:99.71%Color and Shape:SolidMolecular weight:411.5Ref: TM-T16967
1mg56.00€5mg119.00€10mg187.00€25mg375.00€50mg560.00€100mg800.00€500mg1,644.00€1mL*10mM (DMSO)246.00€Laduviglusib trihydrochloride
CAS:Laduviglusib trihydrochloride, a GSK-3α/β inhibitor (IC50: 10/6.7 nM), activates Wnt/β-catenin signaling and induces autophagy.Formula:C22H20Cl5N8Purity:99.03%Color and Shape:SolidMolecular weight:573.71Ref: TM-T22657
1mg43.00€2mg57.00€5mg93.00€10mg136.00€25mg269.00€50mg510.00€100mg682.00€500mg1,415.00€1mL*10mM (DMSO)106.00€(S)-Sunvozertinib
CAS:(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.Formula:C29H35ClFN7O3Purity:99.64%Color and Shape:SolidMolecular weight:584.08SF2523
CAS:SF2523 is a highly selective and potent inhibitor.Formula:C19H17NO5SPurity:97.78% - 98.06%Color and Shape:SolidMolecular weight:371.41Ref: TM-T3986
1mg37.00€5mg79.00€10mg119.00€25mg274.00€50mg432.00€100mg638.00€500mg1,359.00€1mL*10mM (DMSO)87.00€PI3K-IN-46
CAS:PI3K-IN-46 is a specific inhibitor of PI3Kγ.Formula:C13H9N3OSPurity:97.51%Color and Shape:SoildMolecular weight:255.35-Bromoindole
CAS:5-bromoindole is a potential inhibitor of glycogen synthase kinase 3 (GSK-3)and an important pharmaceutical chemical intermediateFormula:C8H6BrNPurity:99.99%Color and Shape:White To Beige Crystalline PowderMolecular weight:196.04FD274
CAS:FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM,Formula:C22H14ClFN6O2SPurity:98%Color and Shape:SoildMolecular weight:480.9IC 86621
CAS:IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.Formula:C12H15NO3Purity:99.33%Color and Shape:SolidMolecular weight:221.25GSK3-IN-1
CAS:GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.Formula:C14H10ClN3OSPurity:99.66%Color and Shape:SolidMolecular weight:303.77Ref: TM-T9987
2mg44.00€5mg64.00€10mg105.00€25mg226.00€50mg335.00€100mg480.00€200mg652.00€1mL*10mM (DMSO)77.00€JND3229
CAS:JND3229 inhibits EGFRC797S; IC50: 5.8-30.5 nM; halts cell growth; effective in non-small cell lung cancer study.Formula:C33H41ClN8O2Purity:97.35%Color and Shape:SolidMolecular weight:617.18PI3K-IN-10
CAS:PI3K-IN-10 is a potent inhibitor of pan-PI3K .Formula:C23H19ClN6OPurity:98%Color and Shape:SolidMolecular weight:430.89AZD 6482
CAS:AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.Formula:C22H24N4O4Purity:99.79% - 99.95%Color and Shape:SolidMolecular weight:408.45Bikinin
CAS:Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.Formula:C9H9BrN2O3Purity:100% - 99.86%Color and Shape:SolidMolecular weight:273.08Ref: TM-T1965
10mg47.00€25mg77.00€50mg119.00€100mg187.00€200mg279.00€500mg472.00€1mL*10mM (DMSO)34.00€Mavelertinib
CAS:Mavelertinib (PF-06747775) is an EGFR tyrosine kinase (EGFR TKI) inhibitor that inhibits T790M/L858R and can be used to study tumours.Formula:C18H22FN9O2Purity:100%Color and Shape:SolidMolecular weight:415.42(3S)-GSK-F1
CAS:(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4-Kinase Alpha (PI4KIIIα), pIC50=8.3.Formula:C27H18F5N5O4SPurity:99.35%Color and Shape:SoildMolecular weight:603.52Ref: TM-T67837
1mg73.00€5mg140.00€10mg221.00€25mg393.00€50mg562.00€100mg883.00€1mL*10mM (DMSO)192.00€Isoprenaline hydrochloride
CAS:Isoprenaline hydrochloride (NCI-c55630) is a potent beta-adrenergic agonist with the peripheral vasodilator, bronchodilator, and cardiac stimulating properties.Formula:C11H18ClNO3Purity:98% - 99.25%Color and Shape:Turn Brownish-Pink Upon Prolonged Exposure To Air (Ntp 1992)Molecular weight:247.719Mutated EGFR-IN-3
CAS:Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.Formula:C31H29FN4O2Purity:98%Color and Shape:SolidMolecular weight:508.59EGFR-IN-9
CAS:EGFR-IN-9 is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M).Formula:C29H24N4O3Purity:99.46%Color and Shape:SolidMolecular weight:476.53AZD3458
CAS:AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).Formula:C20H23N3O4S2Color and Shape:SolidMolecular weight:433.54Mevastatin
CAS:Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Formula:C23H34O5Purity:99.12%Color and Shape:White-Yellowish To Yellow Powder Solid PowderMolecular weight:390.51EGFR-IN-126
CAS:EGFR-IN-126 (compound 9d) is an effective inhibitor of EGFR L858R/T790M/C797S, displaying an IC50 value of 0.005 μM. It exhibits antitumor activity both in vivo and in vitro.Formula:C28H28BrFN4O3Color and Shape:SolidMolecular weight:567.45ZLN 024 hydrochloride
CAS:ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).Formula:C13H14BrClN2OSPurity:99.86%Color and Shape:SolidMolecular weight:361.68Gefitinib-based PROTAC 3
CAS:Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).Formula:C47H57ClFN7O8SPurity:97.29% - 98.25%Color and Shape:SolidMolecular weight:934.51HKI-357
CAS:HKI-357 irreversibly inhibits EGFR/ERBB2 (IC50: 34/33 nM), blocks EGFR Y1068 autophosphorylation, and AKT/MAPK phosphorylation.Formula:C31H29ClFN5O3Purity:95.11%Color and Shape:SolidMolecular weight:574.05Ref: TM-T11569
1mg79.00€5mg153.00€10mg227.00€25mg462.00€50mg662.00€100mg938.00€1mL*10mM (DMSO)187.00€BRD0705
CAS:BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.Formula:C20H23N3OPurity:99.01%Color and Shape:SolidMolecular weight:321.42Ref: TM-T10606
1mg89.00€5mg183.00€10mg266.00€25mg395.00€50mg553.00€100mg742.00€1mL*10mM (DMSO)200.00€PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Formula:C19H16N4O3Purity:96.59% - 99.3%Color and Shape:SolidMolecular weight:348.36PD158780
CAS:PD 158780 blocks all ErbB receptors: EGFR, ErbB2-4, with IC50s: 8μM, 49-52 nM.Formula:C14H12BrN5Purity:98.81%Color and Shape:SolidMolecular weight:330.18EGFR/PI3Kα-IN-1
EGFR/PI3Kα-IN-1 (compound 30k), a dual EGFR/PI3Kα inhibitor, exhibits potent activity with IC 50 values of 3.6 nM (EGFRL858R/T790M) and 30 nM (PI3Kα). It effectively inhibits tumor cell proliferation and demonstrates significant anticancer activity.Formula:C50H49N11O5SColor and Shape:SolidMolecular weight:916.06PIK-inhibitors
CAS:PIK-inhibitors (MDK34597) is a pan PI3K inhibitors, an analog of PI-103.Formula:C19H17N5O2Purity:96.98%Color and Shape:SolidMolecular weight:347.37PI5P4Ks-IN-2
CAS:PI5P4Ks-IN-2 inhibits PI5P4K isoforms α, β, γ, γ+ with IC50 <4.3, <4.6, 6.2, 0.32 µM, respectively.Formula:C22H23N5Purity:99.09% - 99.21%Color and Shape:SoildMolecular weight:357.45Ref: TM-T72032
1mg160.00€5mg338.00€10mg502.00€25mg848.00€50mg1,111.00€100mg1,454.00€1mL*10mM (DMSO)369.00€RLY-2608
CAS:RLY-2608 is a variant PI3Kalpha inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.Formula:C29H14ClF5N6O2Purity:98.7% - 98.96%Color and Shape:SolidMolecular weight:608.91EGFR vIII Protein, Human, Recombinant (His)
EGFR vIII Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag.Color and Shape:Lyophilized PowderMolecular weight:61-75 Kda (reducing condition)Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formula:C14H22N2O·HCl·H2OPurity:99.95%Color and Shape:SolidMolecular weight:288.82Barecetamab
CAS:Barecetamab (ISU-104) is a humanized monoclonal antibody against tyrosine protein kinase ErbB3 with anticancer activity.Color and Shape:LiquidVS-5584
CAS:VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.Formula:C17H22N8OPurity:97.82% - 99.54%Color and Shape:SolidMolecular weight:354.41CAL-130
CAS:CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).Formula:C23H22N8OPurity:98%Color and Shape:SolidMolecular weight:426.47Lapatinib ditosylate monohydrate
CAS:Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.Formula:C29H26ClFN4O4S·2(C7H8O3S)·H2OPurity:98% - 99.41%Color and Shape:Colourless To Light-Yellow CrystalMolecular weight:943.47AMG319
CAS:AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.Formula:C21H16FN7Purity:98.57% - 98.9%Color and Shape:Crystalline SolidMolecular weight:385.4PI3Kγ inhibitor 2
CAS:PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).Formula:C20H18F3N5O3Purity:98%Color and Shape:SolidMolecular weight:433.38WHI-P154
CAS:WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.Formula:C16H14BrN3O3Purity:98% - 99.6%Color and Shape:SolidMolecular weight:376.2Sapitinib
CAS:Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib orFormula:C23H25ClFN5O3Purity:98.89% - 99.83%Color and Shape:SolidMolecular weight:473.93EGFR-IN-128
EGFR-IN-128 (compound 28) is a potent and selective molecule targeting wild-type EGFREx20Ins, demonstrating therapeutic efficacy across various human xenograft models and capable of penetrating the blood-brain barrier in preclinical species.Formula:C27H20N4OColor and Shape:SolidMolecular weight:416.47
