gsk-3
GSK-3 inhibitors are compounds that target Glycogen Synthase Kinase 3 (GSK-3), an enzyme involved in numerous cellular processes, including glycogen metabolism, gene transcription, and cell proliferation. GSK-3 is implicated in various diseases, such as diabetes, neurodegenerative disorders, and cancer. Inhibitors of GSK-3 are important tools for exploring these pathways and developing potential therapies. At CymitQuimica, we provide GSK-3 inhibitors to support your research in metabolic diseases, neurobiology, and oncology.
Products of "gsk-3"
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BRD0705
CAS:BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.Formula:C20H23N3OPurity:99.01%Color and Shape:SolidMolecular weight:321.42Ref: TM-T10606
1mg89.00€5mg183.00€10mg266.00€25mg395.00€50mg553.00€100mg742.00€1mL*10mM (DMSO)200.00€PIMPC
CAS:PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibitsFormula:C21H19N5OPurity:98%Color and Shape:SolidMolecular weight:357.41CCG 203769
CAS:CCG 203769 (Thiadiazolidinone (TDZD) deriv. 6) is a selective inhibitor of RGS4 with an IC50 of 17 nM for the RGS4-Gαo protein-protein interaction.Formula:C8H14N2O2SPurity:99.46%Color and Shape:SolidMolecular weight:202.27Ref: TM-T10705
1mg88.00€5mg187.00€10mg264.00€25mg469.00€50mg657.00€100mg944.00€500mg1,882.00€1mL*10mM (DMSO)207.00€DIF-3
CAS:DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.Formula:C13H17ClO4Purity:99.57%Color and Shape:SolidMolecular weight:272.72Ref: TM-T60485
1mg92.00€5mg235.00€10mg350.00€25mg588.00€50mg838.00€100mg1,130.00€500mg2,308.00€1mL*10mM (DMSO)215.00€TBB
CAS:TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).Formula:C6HBr4N3Purity:98.51% - 99.45%Color and Shape:Off-White SolidMolecular weight:434.71GSK-3β inhibitor 14
CAS:GSK-3β inhibitor 14 (1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-2-methyl-5-(phenylmethyl)-) is a weak GSK-3β inhibitor, IC50﹥ 100μM.Formula:C17H17NOSPurity:99.88%Color and Shape:SolidMolecular weight:283.39Tideglusib
CAS:Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities.Formula:C19H14N2O2SPurity:98.40% - 99.35%Color and Shape:SolidMolecular weight:334.39Ref: TM-T3067
10mg47.00€25mg77.00€50mg113.00€100mg187.00€200mg283.00€500mg490.00€1mL*10mM (DMSO)50.00€Cyanoacetohydrazide
CAS:Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.Formula:C3H5N3OPurity:99.78%Color and Shape:Stout Prisms From Alcohol Slightly Brown PowderMolecular weight:99.09MBM-55
CAS:MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM.Formula:C28H27FN6O2Purity:99.98%Color and Shape:SolidMolecular weight:498.55Ref: TM-T11960
1mg177.00€5mg298.00€10mg432.00€25mg662.00€50mg868.00€100mg1,169.00€500mg2,365.00€1mL*10mM (DMSO)325.00€Indirubin-3'-monoxime
CAS:Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/Formula:C16H11N3O2Purity:99.55%Color and Shape:Dark Red SolidMolecular weight:277.28Ref: TM-T5200
2mg38.00€5mg55.00€10mg88.00€25mg165.00€50mg246.00€100mg366.00€200mg538.00€1mL*10mM (DMSO)60.00€GSK3β-IN-2
CAS:GSK3β-IN-2 (Compound S01) is an inhibitor of GSK3β with an IC50 of 0.35 nM. It activates the Wnt/β-catenin signaling pathway, promoting neurogenesis and neurite outgrowth. GSK3β-IN-2 reduces tau protein phosphorylation induced by Aβ at the Ser396 site, thereby decreasing neurofibrillary tangles. Furthermore, GSK3β-IN-2 improves Alzheimer's disease symptoms in a zebrafish model.Formula:C25H18N4OColor and Shape:SolidMolecular weight:390.437GNF4877
CAS:GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.Formula:C25H27FN6O4Purity:98.63% - 99.40%Color and Shape:SolidMolecular weight:494.52CHIR-99021 HCl
CAS:CHIR-99021 HCl is a selective GSK-3α/β inhibitor (IC50: 10/6.7 nM), 500x selective over other kinases, boosts Wnt pathway, and enhances stem cell renewal.Formula:C22H19Cl3N8Purity:98.07% - 98.44%Color and Shape:SolidMolecular weight:501.8Ref: TM-T2310L
1mg35.00€2mg52.00€5mg77.00€10mg96.00€25mg163.00€50mg240.00€100mg465.00€200mg675.00€500mg1,026.00€1mL*10mM (DMSO)86.00€BIP-135
CAS:BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.Formula:C21H13BrN2O3Purity:99.77%Color and Shape:SolidMolecular weight:421.24Ref: TM-T14613
1mg34.00€5mg80.00€10mg116.00€25mg221.00€50mg329.00€100mg472.00€200mg652.00€1mL*10mM (DMSO)86.00€JNK3 inhibitor-9
JNK3inhibitor-9 (Compound 24a) is a potent, selective JNK3 inhibitor capable of crossing the blood-brain barrier (BBB), demonstrating an IC50 value of 12 nM. It effectively inhibits GSK3α/β, which is involved in Tau phosphorylation, with IC50 values of 14 nM and 35 nM, respectively. JNK3inhibitor-9 also reduces the phosphorylation of c-Jun and APP and protects neurons from Aβ1-42 toxicity.Formula:C25H27N7O2Molecular weight:457.528Bikinin
CAS:Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.Formula:C9H9BrN2O3Purity:100% - 99.86%Color and Shape:SolidMolecular weight:273.08Ref: TM-T1965
10mg47.00€25mg77.00€50mg119.00€100mg187.00€200mg279.00€500mg472.00€1mL*10mM (DMSO)34.00€7BIO
CAS:7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.Formula:C16H10BrN3O2Purity:99.77%Color and Shape:SolidMolecular weight:356.17Ref: TM-T22012
5mg46.00€10mg64.00€25mg116.00€50mg178.00€100mg284.00€200mg401.00€1mL*10mM (DMSO)52.00€GSK-3β inhibitor 10
CAS:GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.Formula:C12H12N2O3SPurity:98.34%Color and Shape:SolidMolecular weight:264.3Ref: TM-T9725
2mg39.00€5mg64.00€10mg94.00€25mg170.00€50mg261.00€100mg375.00€200mg525.00€1mL*10mM (DMSO)62.00€GS87
CAS:GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.Formula:C16H11N5O2SPurity:98.86%Color and Shape:SolidMolecular weight:337.36Ref: TM-T8605
1mg131.00€2mg188.00€5mg283.00€10mg430.00€25mg710.00€50mg998.00€100mg1,349.00€1mL*10mM (DMSO)298.00€KY19382
CAS:KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.Formula:C17H11Cl2N3O2Purity:98.06%Color and Shape:SolidMolecular weight:360.19Ref: TM-T9025
1mg99.00€5mg197.00€10mg350.00€25mg590.00€50mg840.00€100mg1,130.00€500mg2,308.00€1mL*10mM (DMSO)243.00€
