PDK
PDK (Pyruvate Dehydrogenase Kinase) inhibitors target the PDK enzyme, which regulates the activity of the pyruvate dehydrogenase complex (PDC) and plays a role in metabolic control and apoptosis. By inhibiting PDK, these compounds shift cellular metabolism from glycolysis towards oxidative phosphorylation, which can induce apoptosis in cancer cells that rely on aerobic glycolysis (Warburg effect) for survival. PDK inhibitors are valuable in cancer metabolism research and therapeutic development. At CymitQuimica, we provide high-quality PDK inhibitors to support your research in cancer metabolism, apoptosis, and cellular bioenergetics.
Products of "PDK"
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Found 11 products on this category.
RS1-PDK1 inhibitor
CAS:RS1-PDK1 inhibitor (RS 1) is a selective inhibitor of the protein kinase PDK1 that can be used to treat and prevent disease or disorders.Formula:C15H9ClN2O2S3Purity:98%Color and Shape:SolidMolecular weight:380.89PS47
CAS:PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1.Formula:C17H15ClO2Purity:99.09%Color and Shape:SolidMolecular weight:286.75Ref: TM-T24677
5mg46.00€10mg65.00€25mg123.00€50mg187.00€100mg309.00€200mg435.00€1mL*10mM (DMSO)65.00€Osu03012
CAS:Osu03012 (AR-12): oral celecoxib-derived PDK1 inhibitor with anticancer potential.Formula:C26H19F3N4OPurity:97.95% - 99.22%Color and Shape:SolidMolecular weight:460.45Ref: TM-T2466
2mg37.00€5mg51.00€10mg87.00€25mg143.00€50mg264.00€100mg349.00€200mg454.00€500mg742.00€1mL*10mM (DMSO)51.00€PDK1-IN-RS2
CAS:PDK1-IN-RS2, a PIFtide mimic, selectively inhibits PDK1, blocking S6K1 activation (Kd: 9 μM).Formula:C15H9ClN2O2S3Purity:98%Color and Shape:SolidMolecular weight:380.89M77976
CAS:M77976 inhibits PDK4 with an IC50 of 648 μM, targeting obesity and diabetes research.Formula:C17H16N2O3Purity:99.80%Color and Shape:SolidMolecular weight:296.32PS10
CAS:PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2 and significantly increases the activity of the pyruvate dehydrogenase complex.Formula:C14H13NO6SPurity:99.01%Color and Shape:SolidMolecular weight:323.32MP7
CAS:MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).Formula:C28H22F2N4O4Purity:99.45% - 99.84%Color and Shape:SolidMolecular weight:516.5PS 48
CAS:PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).Formula:C17H15ClO2Purity:98.37% - ≥95%Color and Shape:SolidMolecular weight:286.75GSK2334470
CAS:GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.Formula:C25H34N8OPurity:99.04% - 99.87%Color and Shape:SolidMolecular weight:462.596-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
CAS:6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a PDK1 inhibitor with anticancer and antiproliferative activity that can be used to studyFormula:C9H6BrN3OPurity:98.81%Color and Shape:SolidMolecular weight:252.07PS210
CAS:PS210 selectively activates PDK1 (Kd: 3 μM), doesn't affect PDK1 downstream kinases. Prodrug PS423 inhibits PDK1-mediated S6K phosphorylation.Formula:C19H15F3O5Purity:99.78%Color and Shape:SolidMolecular weight:380.31Ref: TM-T16670
1mg37.00€2mg52.00€5mg74.00€10mg107.00€25mg197.00€50mg350.00€100mg522.00€1mL*10mM (DMSO)85.00€
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