ATM/ATR
ATM (Ataxia Telangiectasia Mutated) and ATR (ATM and Rad3-related) are key kinases involved in the DNA damage response (DDR) that are activated in response to DNA double-strand breaks and replication stress. ATM/ATR inhibitors target these kinases, disrupting their ability to detect and repair DNA damage. This inhibition can lead to increased genomic instability and cell death, particularly in cancer cells that rely on robust DNA repair mechanisms for survival. ATM/ATR inhibitors are crucial tools in cancer research and therapy, especially in combination with DNA-damaging agents. At CymitQuimica, we provide a wide range of high-quality ATM/ATR inhibitors to support your research in DNA damage response, cancer biology, and therapeutic development.
Products of "ATM/ATR"
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Found 44 products on this category.
ATR-IN-21
CAS:ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].Formula:C23H27N7OPurity:98%Color and Shape:SolidMolecular weight:417.51AZD0156
CAS:AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.Formula:C26H31N5O3Purity:99.03% - 99.13%Color and Shape:SolidMolecular weight:461.56Schisandrin B
CAS:Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart.Formula:C23H28O6Purity:100% - 99.84%Color and Shape:SolidMolecular weight:400.46Ref: TM-T2925
1mg42.00€5mg88.00€10mg127.00€25mg230.00€50mg414.00€100mg600.00€500mg1,254.00€1mL*10mM (DMSO)94.00€Berzosertib
CAS:Berzosertib (VE-822) is an ATR inhibitor (Ki<0.2 nM) that also inhibits ATM (Ki=34 nM). Berzosertib has antitumor activity. Cost-effective and quality-assured.Formula:C24H25N5O3SPurity:100% - 99.7%Color and Shape:SolidMolecular weight:463.55Ref: TM-T2669
1mg35.00€5mg74.00€10mg92.00€25mg155.00€50mg225.00€100mg359.00€200mg525.00€500mg833.00€1mL*10mM (DMSO)77.00€ATR-IN-29
CAS:ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].Formula:C19H22N8OPurity:98%Color and Shape:SolidMolecular weight:378.43Elimusertib
CAS:Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy inFormula:C20H21N7OPurity:98.72% - 99.84%Color and Shape:SolidMolecular weight:375.43Ref: TM-T7318
1mg37.00€5mg79.00€10mg111.00€25mg216.00€50mg359.00€100mg562.00€500mg1,206.00€1mL*10mM (DMSO)87.00€PIK-93
CAS:PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.Formula:C14H16ClN3O4S2Purity:97.72%Color and Shape:SolidMolecular weight:389.88Camonsertib
CAS:Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.Formula:C21H26N6O3Purity:98.15% - 99.6%Color and Shape:SolidMolecular weight:410.47Ref: TM-T62083
1mg169.00€5mg416.00€10mg605.00€25mg944.00€50mg1,254.00€100mg1,730.00€1mL*10mM (DMSO)470.00€NU6027
CAS:NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-Formula:C11H17N5O2Purity:98.36%Color and Shape:SolidMolecular weight:251.29ATR kinase-IN-3
CAS:ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.Formula:C24H27F2N9O2Color and Shape:SolidMolecular weight:511.53Ceralasertib
CAS:Ceralasertib (AZD6738) is an ATR kinase inhibitor (IC50=1 nM) with selective and oral activity. Ceralasertib has antitumor activity. Cost effective and quality assured.Formula:C20H24N6O2SPurity:98% - 99.99%Color and Shape:SolidMolecular weight:412.51CP-466722
CAS:CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.Formula:C17H15N7O2Purity:99.14% - 99.85%Color and Shape:SolidMolecular weight:349.35GJ103 sodium salt
CAS:GJ103 sodium salt, a GJ072 analog, lowers surface tension, viscosity, and pH in aqueous solutions, aiding molecular movement.Formula:C16H13N4NaO3SPurity:99.70% - 99.91%Color and Shape:SolidMolecular weight:364.36azd1390
CAS:AZD1390: Potent ATM inhibitor (IC50: 0.78 nM), >10,000-fold selectivity vs. PIKK enzymes.Formula:C27H32FN5O2Purity:97.41% - 99.38%Color and Shape:SolidMolecular weight:477.57ATR kinase-IN-2
CAS:ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.Formula:C24H29F2N9O2Color and Shape:SolidMolecular weight:513.54(S)-WSD0628
CAS:(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.Formula:C23H23F2N5O2Color and Shape:SolidMolecular weight:439.458AZ20
CAS:AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.Formula:C21H24N4O3SPurity:100.00% - 98.02%Color and Shape:SolidMolecular weight:412.51KU-55933
CAS:KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.Formula:C21H17NO3S2Purity:100% - 99.80%Color and Shape:SolidMolecular weight:395.49CGK733
CAS:CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.Formula:C23H18Cl3FN4O3SPurity:98% - 99.7%Color and Shape:SolidMolecular weight:555.84Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).Formula:C30H23N5OPurity:97.64% - 99.85%Color and Shape:SolidMolecular weight:469.54ATM Inhibitor-11
CAS:ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.Formula:C27H33FN6O2Color and Shape:SolidMolecular weight:492.59ATM Inhibitor-1
CAS:ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.Formula:C27H36N6O3Purity:98%Color and Shape:SolidMolecular weight:492.61ATM Inhibitor-9
ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].Formula:C25H32N6O2Purity:98%Color and Shape:SolidMolecular weight:448.56KU 59403
CAS:KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).Formula:C29H32N4O4S2Purity:99.10%Color and Shape:SolidMolecular weight:564.72AZ31
CAS:AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,Formula:C24H28N4O3Purity:98.01%Color and Shape:SolidMolecular weight:420.5Wortmannin
CAS:Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.Formula:C23H24O8Purity:95.84% - 99.76%Color and Shape:White SolidMolecular weight:428.43A011
A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycleFormula:C27H28N6OPurity:98%Color and Shape:SolidMolecular weight:452.55Elimusertib hydrochloride(1876467-74-1 free base)
Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumorFormula:C20H22ClN7OPurity:99.03%Color and Shape:SolidMolecular weight:411.89Ref: TM-T10468
1mg37.00€5mg88.00€10mg120.00€25mg235.00€50mg349.00€100mg497.00€200mg683.00€1mL*10mM (DMSO)96.00€ATR-IN-22
CAS:ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM andFormula:C25H31N7OPurity:98%Color and Shape:SolidMolecular weight:445.56ATM Inhibitor-8
ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value ofFormula:C26H34N6O2Purity:98%Color and Shape:SolidMolecular weight:462.59ATR-IN-24
CAS:ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].Formula:C23H26N6O2Purity:98%Color and Shape:SolidMolecular weight:418.49ART0380
CAS:ART0380 is a potent, antitumor, selective, orally available, ATP-competitive ATR kinase inhibitor for the study of ataxia telangiectasia mutated (ATM) cancer.Formula:C18H24N6O2SPurity:100% - 99.76%Color and Shape:SolidMolecular weight:388.49Ref: TM-T85731
1mg70.00€5mg154.00€10mg210.00€25mg376.00€50mg533.00€100mg747.00€200mg1,017.00€1mL*10mM (DMSO)166.00€Gartisertib
CAS:Gartisertib (VX-803) is an ATR inhibitor with anti-tumor activity, inhibiting the anti-proliferative effects induced in ccRCC cells.Formula:C25H29F2N9O3Purity:99.52%Color and Shape:SolidMolecular weight:541.55Ref: TM-T10407
1mg134.00€5mg321.00€10mg537.00€25mg1,074.00€50mg1,491.00€100mg2,242.00€1mL*10mM (DMSO)383.00€KU-60019
CAS:KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).Formula:C30H33N3O5SPurity:97.15% - 98.05%Color and Shape:SolidMolecular weight:547.67VE-821
CAS:VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).Formula:C18H16N4O3SPurity:99.26% - 99.97%Color and Shape:SolidMolecular weight:368.41Lartesertib
CAS:Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancerFormula:C23H21FN6O3Purity:99.9%Color and Shape:SolidMolecular weight:448.45Ref: TM-T62684
1mg130.00€2mg187.00€5mg311.00€10mg533.00€25mg1,035.00€50mg1,730.00€100mg2,680.00€1mL*10mM (DMSO)344.00€ATR-IN-23
CAS:ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and inducesFormula:C20H22N6O3S2Purity:98%Color and Shape:SolidMolecular weight:458.56CA-M11
CA-M11 (compound CA-M11) is capable of entering the liver's bile salt transport system to release Mirin.Formula:C34H46N2O6SColor and Shape:SolidMolecular weight:610.80ETP-46464
CAS:ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).Formula:C30H22N4O2Purity:97.76%Color and Shape:SolidMolecular weight:470.52Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Formula:C23H26O7Purity:98.93%Color and Shape:SolidMolecular weight:414.45AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Formula:C18H20N8O2Purity:99.03% - 99.85%Color and Shape:SolidMolecular weight:380.4Ref: TM-T7122
1mg40.00€5mg88.00€10mg119.00€25mg187.00€50mg311.00€100mg472.00€200mg687.00€1mL*10mM (DMSO)87.00€(Z)-Mirin
CAS:(Z)-Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.Formula:C10H8N2O2SPurity:98.37% - 99.96%Color and Shape:SolidMolecular weight:220.25Ref: TM-T3134
5mg55.00€10mg87.00€25mg140.00€50mg226.00€100mg416.00€200mg542.00€500mg872.00€1mL*10mM (DMSO)55.00€AZ32
CAS:AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.Formula:C20H16N4OPurity:98.68% - 99.68%Color and Shape:SolidMolecular weight:328.37Ref: TM-T4443
1mg56.00€2mg81.00€5mg119.00€10mg187.00€25mg329.00€50mg515.00€100mg742.00€1mL*10mM (DMSO)131.00€KU60019
CAS:Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.Formula:C30H33N3O5SPurity:95.9% - 99%Color and Shape:SolidMolecular weight:547.67
