mTOR
mTOR inhibitors are compounds that inhibit the activity of Mammalian Target of Rapamycin (mTOR), a central regulator of cell growth, proliferation, metabolism, and survival. The mTOR pathway is frequently altered in cancer and other diseases, making mTOR a critical target for therapeutic intervention. Inhibitors of mTOR are widely used in research related to cancer, aging, and metabolic disorders. At CymitQuimica, we offer a variety of mTOR inhibitors to support your research in signal transduction, oncology, and therapeutic development.
Products of "mTOR"
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Torkinib
CAS:Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).Formula:C16H16N6OPurity:99.11%Color and Shape:SolidMolecular weight:308.34Ref: TM-T2414
5mg57.00€10mg74.00€25mg96.00€50mg136.00€100mg227.00€200mg338.00€500mg560.00€1mL*10mM (DMSO)63.00€3BDO
CAS:3BDO is a new mTOR activator. 3BDO inhibits autophagy.Formula:C18H17NO5Purity:96.00%Color and Shape:SolidMolecular weight:327.33Ref: TM-T14033
2mg47.00€5mg69.00€10mg97.00€25mg208.00€50mg331.00€100mg520.00€200mg777.00€500mg1,188.00€1mL*10mM (DMSO)74.00€ETP-45658
CAS:ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).Formula:C16H17N5O2Purity:99.13%Color and Shape:SolidMolecular weight:311.34Ref: TM-T25399
1mg52.00€5mg111.00€10mg175.00€25mg316.00€50mg512.00€100mg747.00€1mL*10mM (DMSO)124.00€MKC-1
CAS:MKC-1 (Ro-31-7453) is an oral bisindolylmaleimide inhibitor that disrupts tubulin polymerization, potentially halting cancer cell division.Formula:C22H16N4O4Purity:98.38% - 99.46%Color and Shape:SolidMolecular weight:400.39Ref: TM-T9831
1mg57.00€5mg125.00€10mg177.00€25mg309.00€50mg445.00€100mg622.00€500mgTo inquire1mL*10mM (DMSO)134.00€KU-0063794
CAS:KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.Formula:C25H31N5O4Purity:100% - 98.35%Color and Shape:SolidMolecular weight:465.54PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Formula:C19H16N4O3Purity:96.59% - 99.3%Color and Shape:SolidMolecular weight:348.36VS-5584
CAS:VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.Formula:C17H22N8OPurity:97.82% - 99.54%Color and Shape:SolidMolecular weight:354.41DIM-C-pPhOH
CAS:CDIM8 (DIM-C-pPhOH) opposes NR4A1, halts TGF-β breast cancer migration, induces ROS/ER stress, and mimics Nur77 RNAi in pancreatic cancer.Formula:C23H18N2OPurity:98.61%Color and Shape:SolidMolecular weight:338.4Ref: TM-T4400
2mg44.00€5mg65.00€10mg84.00€25mg153.00€50mg227.00€100mg376.00€200mg495.00€1mL*10mM (DMSO)59.00€Bimiralisib
CAS:Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Formula:C17H20F3N7O2Purity:97.58% - 98.92%Color and Shape:SolidMolecular weight:411.38PI3K/mTOR Inhibitor-2
CAS:Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.Formula:C20H13ClF2N4O4SPurity:96.16%Color and Shape:SolidMolecular weight:478.86Ref: TM-T12459
1mg58.00€5mg145.00€10mg226.00€25mg378.00€50mg540.00€100mg730.00€200mg938.00€1mL*10mM (DMSO)153.00€Dihydromyricetin
CAS:Dihydromyricetin, a flavonoid from Ampelopsis, is an antioxidant that blocks dihydropyrimidinase (IC50: 48 μM) and activates autophagy via mTOR inhibition.Formula:C15H12O8Purity:96.68% - 98.13%Color and Shape:SolidMolecular weight:320.25WAY-600
CAS:WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308).Formula:C28H30N8OPurity:99.63%Color and Shape:SolidMolecular weight:494.59Ref: TM-T6730
1mg38.00€2mg64.00€5mg97.00€10mg140.00€25mg245.00€50mg363.00€100mg507.00€500mgTo inquire1mL*10mM (DMSO)111.00€mTORC1-IN-1
mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseasesPurity:98%Color and Shape:Odour SolidmTOR inhibitor-12
mTOR inhibitor-12 (Compound 11), a selective, brain-penetrant mTOR inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to centralFormula:C19H24N6O2SPurity:98%Color and Shape:SolidMolecular weight:400.5D-α-Hydroxyglutaric acid disodium
CAS:D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.Formula:C5H6Na2O5Purity:98%Color and Shape:SolidMolecular weight:192.08Torin 1
CAS:Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.Formula:C35H28F3N5O2Purity:98.3% - 99.38%Color and Shape:SolidMolecular weight:607.62ElteN378
CAS:ElteN378: potently inhibits FKBP12 (Ki=0.5 nM), low weight, similar affinity to Rapamycin.Formula:C23H26N2O3Purity:98.09%Color and Shape:SolidMolecular weight:378.46Ref: TM-T9950
1mg170.00€5mg376.00€10mg557.00€25mg895.00€50mg1,216.00€100mg1,691.00€200mg2,262.00€1mL*10mM (DMSO)329.00€AZD 3147
CAS:AZD 3147 inhibits mTORC1 (40.7 nM), mTORC2 (5.75 nM), and PI3Kα/β/δ/γ (912/5495/9333/6310 nM IC50s).Formula:C24H31N5O4S2Purity:98.34%Color and Shape:SolidMolecular weight:517.66Ref: TM-T36200
1mg97.00€5mg210.00€10mg338.00€25mg582.00€50mg777.00€100mg1,074.00€1mL*10mM (DMSO)273.00€Zotarolimus
CAS:Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).Formula:C52H79N5O12Purity:95% - ≥98%Color and Shape:SolidMolecular weight:966.21Ref: TM-T6033
1mg66.00€2mg96.00€5mg144.00€10mg225.00€25mg393.00€50mg565.00€100mg818.00€1mL*10mM (DMSO)239.00€mTOR inhibitor-2
CAS:mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).Formula:C23H21N7OPurity:98%Color and Shape:SolidMolecular weight:411.46Torin 2
CAS:Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.Formula:C24H15F3N4OPurity:98.31% - 99.32%Color and Shape:SolidMolecular weight:432.4GNE-477
CAS:GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.Formula:C21H28N8O3S2Purity:98.88% - 99.55%Color and Shape:SolidMolecular weight:504.63Polyphyllin I
CAS:Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Formula:C44H70O16Purity:98% - 99.5%Color and Shape:SolidMolecular weight:855.02PQR620
CAS:PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.Formula:C21H25F2N7O2Purity:97.61%Color and Shape:SolidMolecular weight:445.47Ref: TM-T5472
1mg64.00€5mg150.00€10mg210.00€25mg354.00€50mg505.00€100mg677.00€200mg914.00€1mL*10mM (DMSO)145.00€Apitolisib
CAS:Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).Formula:C23H30N8O3SPurity:98.28% - 99.52%Color and Shape:SolidMolecular weight:498.6WYE-132
CAS:WYE-125132: potent mTOR inhibitor, IC50 0.19 nM, selective over PI3Ks/hSMG1/ATR.Formula:C27H33N7O4Purity:99.16%Color and Shape:SolidMolecular weight:519.6Thioridazine hydrochloride
CAS:Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4Formula:C21H27ClN2S2Purity:99.55% - 99.55%Color and Shape:White To Off-White SolidMolecular weight:407.04NV-5138
CAS:NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.Cost-effective and quality-assured.Formula:C7H13F2NO2Purity:98% - ≥98%Color and Shape:SolidMolecular weight:181.18OSI-027
CAS:OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.Formula:C21H22N6O3Purity:97.42%Color and Shape:SolidMolecular weight:406.44Ref: TM-T6319
1mg42.00€2mg52.00€5mg86.00€10mg138.00€25mg248.00€50mg389.00€100mg567.00€1mL*10mM (DMSO)88.00€Onatasertib
CAS:Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity.Formula:C21H27N5O3Purity:99.14% - 99.91%Color and Shape:SolidMolecular weight:397.47MHY-1685
CAS:MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.Formula:C11H8N2O4Purity:98.44%Color and Shape:SolidMolecular weight:232.194-FPBUA
CAS:4-FPBUA, a semi-synthetic analog of lichen acid, enhances the functionality of cell-based blood-brain barriers (BBB) and increases the transport of β-amyloid (Aβ) in monolayer cells. Additionally, it acts as an inhibitor of mTOR, enhancing cellular autophagy (Autophagy) which can reverse BBB disruption in vivo, making it relevant for research in Alzheimer's disease.Formula:C31H23FO7Color and Shape:SolidMolecular weight:526.51mTOR inhibitor-11
CAS:mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6.Formula:C21H26N6O2Purity:98%Color and Shape:SolidMolecular weight:394.47GDC-0349
CAS:GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.Formula:C24H32N6O3Purity:96.00% - 98.98%Color and Shape:SolidMolecular weight:452.55Ref: TM-T6510
2mg39.00€5mg66.00€10mg107.00€25mg215.00€50mg324.00€100mg462.00€500mgTo inquire1mL*10mM (DMSO)70.00€mTOR inhibitor-1
CAS:C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.Formula:C16H15BrN2O3Purity:99.43%Color and Shape:SolidMolecular weight:363.21Anti-Phospho-MTOR (Ser2481) Antibody (4R8)
Anti-Phospho-MTOR (Ser2481) Antibody (4R8) is an antibody targeting Phospho-MTOR (Ser2481). Anti-Phospho-MTOR (Ser2481) Antibody (4R8) can be used in ELISA, WB, IF.Color and Shape:Odour LiquidEverolimus
CAS:Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.Formula:C53H83NO14Purity:97.76% - 99.52%Color and Shape:Off-White To Light Yellow PowdMolecular weight:958.22Ref: TM-T1784
5mg44.00€10mg55.00€25mg82.00€50mg96.00€100mg120.00€200mg177.00€500mg298.00€1mL*10mM (DMSO)55.00€L-Leucine
CAS:L-Leucine is an essential amino acid vital for protein synthesis, metabolism, muscle and bone repair, blood sugar control, and wound healing.Formula:C6H13NO2Purity:100%Color and Shape:White Solid CrystallineMolecular weight:131.17Temsirolimus
CAS:Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.Formula:C56H87NO16Purity:100% - 99.64%Color and Shape:White Crystalline PowderMolecular weight:1030.29Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Formula:C19H24O5Purity:96.66%Color and Shape:SolidMolecular weight:332.39MTI-31
CAS:MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, >5,000-fold selectivity, and an IC50 of 39 nM.Formula:C26H30N6O3Purity:99.76%Color and Shape:SolidMolecular weight:474.55Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Formula:C9H6O4Purity:97.47% - 99.8%Color and Shape:SolidMolecular weight:178.14TMBIM6 antagonist-1
CAS:TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitorFormula:C15H12N2O3Purity:99.26%Color and Shape:SolidMolecular weight:268.27Ref: TM-T8649
1mg93.00€2mg120.00€5mg187.00€10mg315.00€25mg567.00€50mg810.00€100mg1,111.00€500mg2,232.00€1mL*10mM (DMSO)202.00€Rapamycin
CAS:Rapamycin, a macrolide from Streptomyces hygroscopicus, inhibits mTOR (IC50: 0.1 nM) and promotes autophagy with immunosuppressive effects.Formula:C51H79NO13Purity:97.08% - 99.03%Color and Shape:Yellow SolidMolecular weight:914.17Ref: TM-T1537
1g283.00€10mg35.00€25mg48.00€50mg52.00€100mg69.00€200mg106.00€500mg188.00€1mL*10mM (DMSO)50.00€CC214-1
CAS:CC214-1 is an mTOR inhibitor that inhibits protein translation, induces autophagy, and is an in vitro tool compound for exploring the biology of mTOR kinases.Formula:C20H21N7O2Purity:97.87%Color and Shape:SolidMolecular weight:391.43WYE-354
CAS:WYE-354 is a selective mTOR inhibitor (IC50=5 nM), targeting mTORC1/C2 over PI3Kα (>100x) and PI3Kγ (>500x), sparing P-AKT(T308).Formula:C24H29N7O5Purity:97.86% - 99.61%Color and Shape:SolidMolecular weight:495.53Gedatolisib
CAS:Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signalingFormula:C32H41N9O4Purity:98% - 99.48%Color and Shape:SolidMolecular weight:615.73Omipalisib
CAS:Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Formula:C25H17F2N5O3SPurity:98% - 99.8%Color and Shape:SolidMolecular weight:505.5FT-1518
CAS:FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research.Formula:C20H26N8OPurity:98.34% - 98.80%Color and Shape:SolidMolecular weight:394.47CC-115
CAS:CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).Formula:C16H16N8OPurity:86.79% - 99.22%Color and Shape:SolidMolecular weight:336.35
