Oligosaccharides

Applications D-Xylulose can be used through fermentation to produce ethanol. References Yuan, D. et al.: Biores. Tech., 102, 3246 (2011);

Chitobiose is a dimer formed by beta-1,4-linked glucosamine units. It is also the repeated dimer of chitin, a polysaccharide.

Applications Orotidine is a metabolite of Orotic Acid (O691500); a compound used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment. References Pausch, J., et al.: Verhandlungen der Deutschen Gesellschaft fuer Innere Medizin, 86, 805 (1980); Burgess, K., et al.: Rapid Commun. Mass. Sp., 25, 3447 (2011)

3'-Sialyllactose-BSA binds to human serum albumin. It is used in the detection of tumour cells in blood samples, and has been shown to be sensitive for the detection of malignant cells in sera from patients with metastatic breast cancer. 3'-Sialyllactose-BSA can also be used as a probe for the identification of glycosphingolipids in animal tissues. The antibody's specificity for glycosphingolipids was demonstrated by its ability to bind selectively to glycosphingolipid-containing liposomes, but not lipid vesicles without glycosphingolipids.

4-Methoxyphenyl 4-O-{2-O-acetyl-4-O-[2,4-di-O-(3,4,6-tri-O-acetyl-2,3,5,6 -tetra-O-[(triisopropylsilyl)oxy]-2,5 -dideoxyglucan]-b-(D)-glucopyranosyl)-3,4di O-[benzyl]-a-(D)-mannopyranosyl}b-(D)-mannopyranoside is a high purity custom synthesis sugar. It can be fluorinated and glycosylated with methylation and modification. This compound is an oligosaccharide that can be used as a monosaccharide or complex carbohydrate.

3-O-(2,3,4,6-Tetra-O-acetyl-b-D-galactopyranosyl)-2-azido-4,6-O-benzylidene-2-deoxy-a-D--galactopyranosyl (TBS) is a synthetic carbohydrate that has been modified with fluorine and methyl groups. It is a complex carbohydrate that can be used as an intermediate in the synthesis of oligosaccharides and other saccharides. TBS is a monosaccharide that can be glycosylated or methylated to form many different products. This product can be custom synthesized to meet specific customer needs.

2-Acetamido-3,4,6-tri-O-acetyl-b-D-galactopyranosyl bromide is an intermediate in the synthesis of 2,6-dideoxyglucose and has been used as a model for the glycosidic linkage to fluoroquinolones. The compound is a white solid that can be synthesized by reacting D-galactose with acetamidobenzene in the presence of sodium hydroxide and chloroacetone. The molecular weight of this compound is 703.1 g/mol. This product was developed through custom synthesis and modification. It is available at high purity.

Methyl 3,6-di-O-(a-D-mannopyranosyl)-b-D-mannopyranoside is a glycosylation product of the sugar, mannose. It can be used in the synthesis of oligosaccharides and polysaccharides with modifications such as fluorination and methylation. Methyl 3,6-di-O-(a-D-mannopyranosyl)-b-D-mannopyranoside is also known by its CAS number, which is 57424-92-5.

Methyl 3-O-[(6-O-b-D-galactopyranosyl)-b-D-galactopyranosyl]-b-D-galactopyranoside is a white crystalline powder that is soluble in water. It can be custom synthesized to order, and has been shown to have high purity with no detectable impurities. This product can be used in Click chemistry, fluorination, glycosylation, or synthesis of complex carbohydrates. The CAS number for this product is 56919-86-4.

Hyaluronic acid is a polysaccharide containing repeating disaccharide units of β-1,3-N-acetyl glucosamine and β-1, 4-glucuronic acid. A series of unsaturated oligosaccharides (oligouronic acids) are released from hyaluronic acid by the action of hyaluronidase on the umbilical cord (Weissman, 1954). This decasaccharide and other enzymatically produced polymer homologs have been of value in the study of hyaluronic acid metabolism in both healthy and diseased tissues (Hascall, 2019).

Drug carrier for cancer therapy & imaging, biocompatible, soluble, biodegradable

Please enquire for more information about 2-O-β-D-Galactopyranosyl-D-galactose including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications Cytidine 5’-Diphosphate Ethanolamine Disodium Salt is an analog of Cytidine 5’-Diphosphate with an important role in the metabolism of phospholipides. References Trotter, P., et al.: J. Biol. Chem., 270, 6062 (1995), Janssen, M., et al.: Yeast, 16, 641 (2000), Henneberry, A., et al.: Mol. Biol. Cell, 12, 511 (2001), Boumann, H., et al.: Biochemistry, 42, 3054 (2003),

Key synthetic precursor for the synthesis of lacto-oligosaccharides

a1,4-Mannobiose-BSA is a complex carbohydrate that can be synthesized in the laboratory. It is composed of mannose and glucose units. This molecule has been modified with methyl groups, which can be used for click chemistry reactions. Mannobiose-BSA is a polysaccharide with CAS number 56938-64-2. It has been modified by Click chemistry and glycosylation to yield high purity compounds.

Sialylated trisaccharide found in human urine

A GalNAc trisaccharide

Lactosyl-b-1,1'-N-octanoyl-L-threo-sphingosine is a glycosylation agent that is used in the synthesis of complex carbohydrates. This compound has been shown to be stable in aqueous solutions and can be used for the modification of saccharides, oligosaccharides, and polysaccharides. Lactosyl-b-1,1'-N-octanoyl-L-threo-sphingosine is also useful for the fluorination of sugars. The CAS number for this compound is 939036-94-9.

Trehalose 6-tetradecanoate is a custom synthesis of an oligosaccharide that is modified by methylation, glycosylation, and carbamylation. It is a polysaccharide that has been modified with click chemistry. Trehalose 6-tetradecanoate is a high purity product that can be used in the synthesis of other compounds.

Applications Kanamycin A (K137500) derivative.

Stability Hygroscopic Applications Labelled Cytarabine, a compound used as an antineoplastic and antiviral. A selective inhibitor of DNA synthesis. Does not inhibit RNA synthesis. References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986)

Applications A labelled metabolite of 1-Hydroxypyrene, which is found in human urine after exposure to coal tar and a coal derived product. References Jongeneelen, F.J., et al.: Int. Arch. Occup. Environ. Health, 57, 47 (1985)

G-NGA2F N-Glycan is a methylated, saccharide containing oligosaccharide. It is a custom-synthesized, high purity carbohydrate and sugar that can be modified with fluorination. G-NGA2F N-Glycan has been shown to have complex carbohydrate properties with a CAS No. of 84825-26-3.

Difucosyllacto-N-hexaose (c) is an oligosaccharide that can be found in human breast milk. It has been shown to have an anti-inflammatory effect on the ileum, which may be due to its ability to stimulate the production of short-chain fatty acids in the large intestine and inhibit the release of proinflammatory cytokines.

Used to determine composition and sequence of glucan-containing mixed linkages

Applications 1-O-n-Octyl-d17-beta-D-glucopyranoside (CAS# 129522-81-2) is a useful isotopically labeled research compound.

Neutral pentasasaccharide naturally present in human breast milk

Applications Daunorubicin (D194500) impurity. Daunomycin analog antitumor. References Cassinelli, G., et al.: J. Antib., 38, 856 (1985), Arcamone, F., et al.: J. Med. Chem.,18, 703 (1975),

Man-1-Fuc is a fluorinated sugar with a mannose backbone. This compound can be custom synthesized and modified to meet your specific needs. It is used in research as an oligosaccharide, polysaccharide, saccharide, or carbohydrate. Man-1-Fuc has a high purity and is available at low cost. It can be used for complex carbohydrate synthesis or modification. The chemical name of this compound is methyl 1,6-diacetoxylidene-2,3-dihydroxypropane fucopentaose.

a-Maltotetraosyl-a,a-trehalose is a carbohydrate that is modified with fluorine. It is a complex carbohydrate with four maltotriose units linked by alpha,alpha-trehalose units. This compound can be custom synthesized and has high purity. It can also be methylated and glycosylated. Click modification can be done to the sugar in order to modify its properties.

Agarose is a polysaccharide found in red algae, typically Gelidium and Gracilaria. It is a strictly alternating polysaccharide of α-1,3 linked D-galactose and β-1,4 linked L-3,6 anhydrogalactose with occasional sulfation at position 6 of the anhydrogalactose residue. Agaro-oligosaccharides result from cleavage at galactose residues and neoagaro-oligosaccharides from cleavage at 3,6-anhydro residues. A number of publications have suggested that agaroheptaose has properties that include: anti-microbial, antiviral, prebiotic, anti-tumoral, immunomodulatory, anti-inflammatory, glucosidase inhibitory, and hepatoprotective properties.

Lacto-N-neotetraose is a trisaccharide composed of two galactose units and one glucose unit. It has been found to be an effective carbohydrate for the treatment of colostrum depletion in newborns. Lacto-N-neotetraose can be obtained through methanolysis, which is the hydrolysis of lactose by the addition of methanol to produce a mixture of sugars. This process is activated by ion exchange chromatography, and then hydrolyzed to produce oligosaccharides. Lacto-N-neotetraose can also be obtained from human or horse milk as 13C NMR spectroscopy shows that it is present in both species.

Asialo-GM1-pentasaccharide-APD-HSA is a complex carbohydrate that is custom synthesized. It has high purity and CAS No. This product is a monosaccharide, methylated, glycosylated, polysaccharide with sugar and fluorinated saccharides.

1,3-α-D-mannopyranosyl trichloroacetimidate (1,3-α-DMTCA) is a fluorinated monosaccharide that is used as a building block for the synthesis of oligosaccharides and polysaccharides. The synthesis of 1,3-α-DMTCA involves the reaction of α,β-unsaturated chloral hydrate with mannose in aqueous solution. This produces an intermediate product that undergoes glycosylation with glycosylation reagents like glycosyl chloride to yield 1,3-α-DMTCA. The chemical structure of 1,3-α-DMTCA can be modified by various reactions including methylation or click modification. 1,3 DMTCA is also available as a high purity material. 1,3 α - D - mannosyltetrahydrochlorofonuimidoksyl

Methyl 6-O-(b-D-galactopyranosyl)-b-D-galactopyranoside is a white crystalline solid that belongs to the category of carbohydrates. It is a synthetic carbohydrate with a molecular weight of 496.06 and a CAS number of 3489-94-3. This product has been custom synthesized for research purposes, and can be purchased in high purity (>98%) from various suppliers. It is an oligosaccharide that contains a single sugar unit, which is galactose. This product has been modified with fluorination and methylation to prevent hydrolysis by esterases and glucuronidases, respectively. It also has glycosylation sites on the terminal glucose residues that allow for further modification with other carbohydrates or proteins. The methyl 6-O-(b-D-galactopyranosyl)-b-D-galactopyranoside can be used as an affinity ligand

Shortest chain oligosaccharide that can be classified as a maltodextrin. A component of liquid glucose (a commercial sweetener composed of glucose, maltose, maltotriose and maltotetrose).

Tool for studying carbohydrate metabolism

Hyaluronate biotin (HB) is a modified form of hyaluronic acid. It is produced by the methylation and glycosylation of hyaluronic acid and it has an average molecular weight of 250 kDa. HB is used in tissue engineering, cell culture, and as a contrast agent for magnetic resonance imaging. The modification of hyaluronate with biotin allows for the visualization of HB using immunofluorescence microscopy. Hyaluronate biotin is a synthetic product that can be custom-synthesized to customer specifications, such as purity level, oligosaccharide content, and monosaccharide content.

Produced from high maltose syrup by treatment with transglucosidase

a1,3-Galactobiosyl b-methyl glycoside is a fluorinated saccharide that possesses the same chemical structure as N-acetylgalactosamine. It has been synthesized by click modification with methyl iodide and methyl bromoacetate. The synthesis of this compound was achieved by glycosylation of galactose with 1,3-diiodo-2,2'-bithiopropane followed by methylation of the resulting glycosylation product with methyl bromoacetate to form the desired compound. This carbohydrate can be used in a variety of applications including anti-inflammatory drugs, antibiotics, and cancer treatments.

Methyl 6-O-acetyl-3-O-benzyl-N-Cbz-2-deoxy-4-O-(methyl-2-O-acetyl-3-O-benzyl)-aLidopyranuronosyl)-aDglucopyranosaminide is a carbohydrate that belongs to the class of saccharides. It is a synthetic oligosaccharide that is made up of a monosaccharide, fructose, and 2 disaccharides, maltose and glucuronic acid. This product has been modified by fluorination, methylation, glycosylation, and click chemistry.

Linear B-2 trisaccharide is a human serum glycoprotein that belongs to the group of glycoconjugates. It has been shown to have clinical relevance in the detection of cancer and infectious diseases, as well as for use in the treatment of cancer. Linear B-2 trisaccharide can be used in combination with monoclonal antibodies for diagnosis and treatment of cancer. This molecule is also an inhibitor of both influenza virus hemagglutinin and HIV gp120, which may be due to its ability to react with specific carbohydrate structures on these proteins. Linear B-2 trisaccharide is biocompatible and can be used in the development of biodegradable polymers. The linearity of this molecule makes it more stable than other related molecules, such as glycopeptides.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

G1F Glycan, 2-AB labelled is a complex carbohydrate that is modified by the addition of fluorine and saccharide. It can be custom synthesized to order with a purity of >98% and is available from Sigma-Aldrich.

This is a custom synthesis, modification, and fluorination of a polysaccharide. The monosaccharide units are methylated and then modified with a click reaction. The saccharides are glycosylated with 2-O-a-D-mannopyranosyl moieties for the purpose of increasing their water solubility. This saccharide has been synthesized by the modification of an oligosaccharide that has been modified to include a hydroxyl group. The carbohydrate is complex and contains many different types of sugars including glucose, mannose, and galactose.

4-Methoxyphenyl 4-O-(4,6-O-benzylidene-3-O-tert-butyldimethylsilyl-2-O-levulinoyl-b-D-glucopyranosyl)-3,6-di-O-benzyl -2,6'-dideoxygalactopyranoside is a modification of the natural carbohydrate galactose. The sugar moiety has been methylated and glycosylated with a levulinate ester and then fluorinated. This compound is highly pure and can be synthesized on custom order.

Man-9-Glc N-Glycan is a synthetic carbohydrate that is a modification of the natural sugar, Man-9-GlcNAc. It can be used as an ingredient in pharmaceutical products, such as vaccines and other therapeutic agents. This product is a custom synthesis that can be produced to order.

Applications 2'-Deoxycytidine-2'-13C; is the isotope labelled analogue of 2’-Deoxycytidine (D232615),a deoxyribonucleoside that exhibits activities as an Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity. References Hecht, S., et al.: Chem. Res. Toxicol., 17, 588 (2004), Choi, J., et al.: J. Biol. Chem., 281, 38244 (2006), Lao, Y., et al.: Chem. Res. Toxicol., 20, 246 (2007).

Lividamine is a protein synthesis inhibitor that has biphasic responses in animal studies. Lividamine inhibits the enzyme catalysis of aminoglycosides, which are used for the treatment of bacterial infections. It also blocks the biosynthesis of polypeptides, which are essential for cell growth and division. Lividamine binds to the hydroxyl group or carboxylate group on an amino acid, cleaving it from the peptide chain and stopping protein synthesis. Lividamine has been shown to be effective against bacteria in vitro assays. Further research is required to determine its clinical properties.

CAS No. 71208-05-4 is a complex carbohydrate that belongs to the group of oligosaccharides, polysaccharides and modifications of saccharides. This compound was synthesized by methylation, glycosylation, carbamoylation and fluorination. It is available in high purity and with low impurities.

2-Acetamido-2-deoxy-4-O-(b-D-galactopyranosyl)-6-sulfo-b-D-glucopyranose is a glycosaminoglycan that can be used as an immunomodulator. It has been shown to inhibit the production of tumor necrosis factor alpha (TNFα) in experimental cancer tissues and to stimulate the activity of lymphocytes, which may be due to its ability to regulate camp levels. 2A2D4OSBG also has regulatory effects on monoclonal antibodies and inhibits the immune reaction caused by autoimmune diseases.

Minor trisaccharide component of honey

Acarviosin is a chemical compound that is structurally related to the antimicrobial peptide Ac-LLL-Nal-OH. It is an antidiabetic agent that has been shown to be effective for the treatment of type 2 diabetes and associated cardiovascular risk factors. Acarviosin was originally isolated from a bacterial strain and has been chemically synthesized for use in the treatment of diabetes. Acarviosin inhibits both glycan synthesis and enzyme activities, leading to reduced levels of glucose in blood plasma. This drug also exhibits pharmacokinetic properties with a half-life of approximately 15 hours, which allows it to be taken once daily. Acarviosin can also be used as an analytical method for identifying disaccharides by cleaving them at the glycosidic bond, releasing monosaccharides as products.

Kojipentaose is a glycosidic oligosaccharide that is synthesized by the enzyme phosphorylase. It is an important nutrient for many organisms, including bacteria and fungi. Kojipentaose has been found to be synthesized from the terminal sugars of teichoic acids in both Gram-positive and Gram-negative bacteria. The stereoselectivity of the synthesis may be due to enzymatic activity or the availability of chiral substrates.

1-S-Acetyl-2-acetamido-3-O-(2,3,4,6-tetra-O-benzoyl-b-D-galactopyranosyl)-2-deoxy--D thiogalactopyranose is a custom synthesis of a complex carbohydrate. It is an Oligosaccharide that has been modified with methylation and glycosylation. This product is available in high purity and has been fluorinated for synthetic purposes.

The P1-antigen is a blood group antigen that is encoded by the gene. It is synthesized as a precursor protein of approximately 150 amino acids that undergoes proteolytic processing to generate two peptides, A and B, which are attached to the cell surface. The P1-antigen has been shown to be involved in transcriptional regulation and antimicrobial activity. It has also been shown to be present in metastatic colorectal cancer cells and its expression can be induced by trypsin treatment. The P1-antigen is also one of the most frequently studied proteins for its role in immune responses against bacteria, viruses, and parasites. This protein has been found to have response elements for several transcription factors including NF-κB, AP-1, NFAT, SP-1, and STAT3. The basic structure of this protein contains a diode region with two negatively charged regions that are critical for its function.

2-Acetamido-4-O-(2-acetamido-2,3-dideoxy-b-D-glucopyranosyl)-2,3,6,7-tetraaminopyranose (1) is a custom synthesis that has been modified by fluorination of the C5 and C6 hydroxyl groups and methylation of the C2 hydroxy group. It has also been shown to be effective in inhibiting the growth of bacteria such as Staphylococcus aureus and Clostridium perfringens. 2-Acetamido-4-O-(2,3,6,7,-tetraaminopyranose) (1) is an oligosaccharide with four sugar units that can be glycosylated to produce complex carbohydrates.

Lipid A is a complex carbohydrate that is found in the outer membrane of Gram-negative bacteria. The lipid A molecule consists of a long chain of fatty acids linked to a phosphate group, with sugar and phosphate groups attached. Lipid A is important for the virulence of many Gram-negative bacteria, including Salmonella. Fluorination, monosaccharide, oligosaccharide and polysaccharide modifications are used to modify lipid A to increase its immunogenicity as an adjuvant or vaccine component. Click modification and methylation are also used to alter lipid A structure. This product has been custom synthesized in our lab using high purity ingredients.

This product is a custom synthesis of an oligosaccharide. It is a complex carbohydrate that has been modified with methylation, glycosylation, and fluorination. It is synthesized from monosaccharides and saccharides. The CAS number for this product is _________________.

Methyl b-D-glucopyranosyluronate- (1,3)-2-deoxy-2-trichloroacetamido-D-galactopyranose is a fluorinated sugar that is synthesized from the glycosylation of methyl 2,3,4,6-tetrafluoro-b-D-(1,3) glucopyranoside with trichloroacetyl D-(1,3) galactopyranose. This compound is soluble in water and has a CAS number of 1058858. This product can be used as a reagent for glycosylation reactions such as Click chemistry and Methylation. It also has applications in carbohydrate modification and high purity custom synthesis.

Applications Labelled Ascorbic Acid. Physiological antioxidant. Coenzyme for a number of hydroxylation reactions; required for collagen synthesis. Widely distributed in plants and animals. Inadequate intake results in deficiency syndromes such as scurvy. Used as antimicrobial and antioxidant in foodstuffs. References Al-Meshal, I.A., et al.: Anal. Profiles Drug Subs., 11, 45 (1982), Levine, M., et al.: N. Engl. J. Med., 314, 892 (1986), Prust, C., et al.: Nature Biotech., 23, 195 (2005),

4-Methoxyphenyl 4-O-{2-O-acetyl-3-O-[2,4-di-O-(3,4,6-tri-O-acetyl-2,6 glycoside)-bDglucopyranosyl]-3,6 di -Obenzyl - bDmannopyranosyl} - 3,6 di -Obenzyl 2 deoxy 2 phthalimido bDglucopyranoside is a synthetic compound that belongs to the group of oligosaccharides. It is a modification of a monosaccharide with methylation and fluorination. The synthesis of this compound includes the use of Click chemistry for glycosylation. The CAS number is 766913-30-8.

a1-3-Galactobiose-biotin is a synthetic, fluorinated oligosaccharide that has been modified with 3 biotin molecules. It is synthesized by the glycosylation of 1,3-galactobiose and is used as an intermediate in the synthesis of carbohydrates. The sugar moiety can be modified with different chemical groups and reactions such as methylation or click modification to change its properties.

The Lewis X trisaccharide 4-methylumbelliferyl glycoside is a high purity, custom synthesis sugar that has been fluorinated and glycosylated. This product is a complex carbohydrate that can be used for various purposes. The CAS number for this product is 359436-57-0.

Used as enzyme substrates, analytical standards and for in vitro diagnostics

8-Methoxycarbonyl-3-benzyl-3',4',6',6-tetra-O-acetyl-N,N'-diacetyl b-chitobioside is a synthetic product that belongs to the class of glycosides. This compound has been modified by the incorporation of methyl and fluorine atoms. It is used as an intermediate in the synthesis of oligosaccharides and saccharides for use in biotechnology research.

GalNAca1-3Galb1-4GlcNAc

4-Methoxyphenyl 4-O-[3-O-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-a-D-galacto--2--nonulopyranosylonate)-2,6--di -O--benzyl b D galactopyranosyl]-2,3,6--tri -O benzyl b D glucopyranoside is a glycosylation product of the monosaccharide 4 methoxyphenol and 4 O-[3 O methyl 5 acetamido 4 7 8 9 tetra O acetyl 3 5 dideoxy D glycero 2 a D galacto 2 nonulopyranosylonate] 2 6 di O benzyl b D galactopyranoside. It has been modified by fluorination at the C1

Drug carrier for cancer therapy & imaging, biocompatible, soluble, biodegradable

Applications Ligand used for the preparation of an affinity resin highly specific for glucosidase I purification. Glucosidase I is involved in the post-translational processing of N-linked glycoproteins. References HettKamp, H., et al.: Eur. J. Biochem., 142, 85 (1984); Shailubhai, K., et al.: Biochem. J., 247, 555 (1987); Bause, E., et al.: FEBS, 278, 167 (1991)

Applications Labelled Azacytidine (A796000), a potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase. References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)