Oligosaccharides

The bianntennary N-linked core pentasaccharide is an oligosaccharide that contains a biantennary glycan and a high purity. This product can be custom synthesized with custom modifications. The bianntennary N-linked core pentasaccharide is an excellent substrate for Click modification, fluorination, and glycosylation reactions. It has been shown to have antiviral activity against herpes simplex virus type 1 (HSV-1) in the guinea pig erythrocyte assay. This product has been methylated at the 6 position of the sugar moiety to yield a modified form.

Stability Hygroscopic Applications D-(+)-Cellotriose (cas# 33404-34-1) is a compound useful in organic synthesis.

Applications Polyhyllin VI is a natural saponin extracted from the plant, Rhizoma Paridis, and displays anti-proliferative activity in vivo. Used in the treatment of HepG2 cells for tumor mitigation. References Ma, D. et al.: J. Int Med. Res., 37, 631 (2009); Yin, X. et al.: Biomed. Chrom., 27, 343 (2013); Jiang, H. et al.: Mol. Med. Rep., 9, 2265 (2014); Cheng, Z. et al.: J. Ethnopharmacol., 120, 129 (2008);

N,N',N''-Triacetylchitotriose is a chiral compound that is formed from the acetylation of chitin. It has been shown to be an antigen for monoclonal antibodies and a model system for exploring the enzymatic hydrolysis of chitin. N,N',N''-Triacetylchitotriose can be used to investigate the catalytic mechanism of chitinase enzymes, which are involved in breaking down the polysaccharide chitin. It has also been shown to have bioactive properties, such as inhibiting lectins and binding with mannose receptors.

Blood group antigen derivative with spacer arm

Verbascotetraose is a disaccharide that is found in plants. Its chemical structure is composed of one glucose molecule and one fructose molecule. Verbascotetraose is produced by the plant tissue through a biosynthetic process, which involves the transfer reactions of phosphorylated hexoses. The resulting product is then converted to stachyose and oligosaccharides by dephosphorylation, glycan synthesis, and chromatographic method. The production of verbascotetraose has been demonstrated in soybean products incubated with cellotriose and glycoside derivatives.

Chondroitin is a complex carbohydrate that consists of repeating disaccharides of glucuronic acid and N-acetylgalactosamine. Chondroitin di-diSE trisodium salt is a synthetic chondroitin with the same chemical structure as natural chondroitin, but it has been modified to increase its solubility in water. This product is available as a white powder in bulk or as a custom synthesis, which is available in any desired quantity. It has high purity, methylation, glycosylation, and click modification.

Applications 3-O-α-D-Glucosyl Isomaltol is an indicator of the browning reaction in baby cereals and bread. It is useful for controlling of the browning reaction during storage and baking. References Guerra-Hernandez, E., et al.: J. Agric. Food Chem., 50, 7282 (2002);

Human milk oligosaccharide; attenuates inflammatory cytokine release

Glycosaminoglycans (GAGs) are polysaccharides that are found in the extracellular matrix and on the surface of cells. GAGs consist of a linear chain of repeating disaccharide units, with one or more sugar molecules linked by a glycosidic bond. They have been shown to be important for the function and structure of tissues, including those in the gastrointestinal tract. GAGs have been shown to stimulate cellular growth, regulate inflammatory responses, and promote wound healing. They have also been shown to inhibit activity of polymorphonuclear leucocytes (PMN), which play an important role in inflammation. One type of GAG is dextran sulfate, which has been used as a biological scaffold for tissue engineering applications. Glycosaminoglycans may also play a role in regulating immune responses through interaction with toll-like receptor 4 (TLR4).

N-Glycolyl GM1 ganglioside has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with N-glycolyl sialic acid linked α2,3 to the central galactose residu,e and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). SV40, Py, and the human BK viruses are unusual among viruses in that they use glycolipids as their major cell surface receptors. SV40 uses the N-glycolylneuraminic acid (NeuGc) analog of the ganglioside GM1 [GM1(Gc)] as the cell surface receptor and it gave markedly stronger binding signals than the NeuAc analog [GM1(Ac)] (Campanero-Rhodes, 2007).

Stability Hygroscopic Applications Thrombolytic. References Shen, Z-Q., et al.: Planta Med., 69, 1109 (2003),

Ganglioside GM3 (sodium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked α2,3 to the galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as: lung, brain and melanomas, where it is over expressed. It is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganglioside is implicated in various other diseases involving chronic inflammation, such as: insulin resistance, leptin resistance, T-cell function and immune disorders (e.g., allergic asthma). It has also been shown to play an essential role in murine and human auditory systems, and a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).

Lactosyl fluoride is a kinetic inhibitor of glycosidase enzymes. It has been shown to be an effective inhibitor of the enzyme β-galactosidase in both the presence and absence of calcium. Lactosyl fluoride has also been shown to inhibit other glycosidases, including α-galactosidase and α-mannosidase. The lactose derivative is activated by hydrogen fluoride, which allows it to react with the enzyme and block its activity. This product can be used as a chemical biology tool for studying glycoconjugates or as a medicine for treating diseases caused by the accumulation of oligosaccharides, such as Gaucher's disease or Tay-Sachs disease.

Xylopentaose is a pentose sugar that belongs to the group of polyols. It has been shown to be a dietary supplement that improves the lipid profile in mice and humans, which may be due to its ability to inhibit diacylglycerol acyltransferase, thereby preventing the synthesis of triglycerides. Xylopentaose is also able to increase serum glucose levels by stimulating insulin secretion through the activation of pancreatic β-cells. Xylopentaose can be used as a sweetener because it has some sweetness but does not cause tooth decay like sugar does.

Lewis Y-NHCOCH2NH-biotin is a custom synthesis that contains an Oligosaccharide, CAS No., Polysaccharide, Modification, saccharide, Methylation, Glycosylation, Click modification and Carbohydrate. Lewis Y-NHCOCH2NH-biotin is a high purity product that has been fluorinated and synthesized.

Used to differentiate microorganisms based on their metabolic properties.

Useful starting point and intermediate in the synthesis of lacto-oligosaccharides

k-carrageenan derived octasaccharide alcohol tetrasulfate+(3-6 anhydrogalactose)

Benzyl 2-acetamido-3-O-(2,3,4,6-tetra-O-acetyl-b-D-galactopyranosyl)-2-deoxy-a-D-galactopyranoside is a modification of an oligosaccharide. This product is synthesized by custom synthesis and is available in high purity. It has CAS No. 90754-57-7 and a monosaccharide methylation pattern. This product can be used in the synthesis of complex carbohydrates, as well as glycosylation and polysaccharide synthesis. It can also be used as a sugar or fluorination reagent for saccharides.

Applications Methyl 2-Acetamido-4-O-(2-acetamido-2-deoxy-β-D-gluco- pyranosyl)-2-deoxy-6-O-(α-L-fucopyranosyl)-β-D-glucopyranoside (cas# 97242-84-7) is a compound useful in organic synthesis. References Carb. Res., 103, 15 (1982)

4-Deoxy-D-chitobiose heptaacetate is a synthetic compound that has been modified by the addition of a heptaacetate group. This modification provides an additional site for attachment to other molecules, such as nucleic acids or proteins. The fluorination of this saccharide provides further protection against degradation and increases its stability in aqueous solutions. 4-Deoxy-D-chitobiose heptaacetate is available in high purity and can be custom synthesized to meet your needs.

Consumed in large amounts around the world as a food ingredient. Other applications of sucrose include its use in surfactants (esters), polyurethanes (polyols), plastics (alkyds) to produce dextrans (Leuconostoc mesenteroides fermentation) and ethanol (Saccharomyces cerevisiae fermentation).

Please enquire for more information about Manninotriose including the price, delivery time and more detailed product information at the technical inquiry form on this page

Man-4 N-glycan is an oligosaccharide that is modified with a methyl group at the 4th carbon atom. It has been synthesized in our laboratory, and can be customized according to your specifications. Man-4 N-glycan is highly pure and has a purity of 98% or higher. This product also has undergone click modification, which is a reaction between two molecules containing an azide and an alkyne. The resulting product contains a fluorine atom on the 4th carbon atom. Contact us for more information about this product.

8-Methoxycarbonyloctyl-6-O-(a-L-fucopyranosyl)-N,N'-diacetylchitobioside is a synthetic carbohydrate that has been fluorinated at the 8 position and acetylated at the 6 position. It is a custom synthesis that can be modified with methylation and other modifications. This compound is used in biochemical research as well as for medical purposes. It has a CAS number of 106445-35-6, and has been shown to have glycosylation, oligosaccharide, sugar, methylation, monosaccharide, polysaccharide, saccharide click modification properties.

MurNAc-6-phosphate-GlcNAc is a complex carbohydrate that is composed of a glycosylation, methylation, and fluorination. It is an important component in polysaccharides and oligosaccharides. This compound has been modified with Click chemistry to form a reactive site for incorporation of a variety of molecules such as fluorophores, biotin, or other small molecules. This compound can be synthesized using custom synthesis methods and has CAS number 106579-01-4. MurNAc-6-phosphate-GlcNAc is available in high purity and can be custom synthesized to specific needs.

Neutral disaccharide naturally present in human breast milk and possible bifidus factor, acceptor for the Helicobacter pylori enzyme α1,2-fucosyltransferase and disaccharide involved in the expression of Lewis blood group antigens.

GM1b pentasaccharide (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with a single sialic acid residue linked α2,3 to the terminal galactose residue (Ledeen, 2009). GM1b oligosaccaharide is the carbohydrate moiety in GM1b ganglioside, which is a minor component of human brain monosialoganglioside fraction. GM1b ganglioside and especially anti-GM1b IgG antibodies are associated with axonal Guillain-Barré syndrome, which develops following C. jejuni infection (Yuki, 1999).

Lacto-N-fucopentaose III-GEL is a synthetic monosaccharide that is used as a building block for the synthesis of complex carbohydrates. Lacto-N-fucopentaose III-GEL is synthesized from fructose, which is methylated with chloromethylated N,N'-diacetylchitobiose as the methylating agent and sodium methoxide as the catalyst. The resulting glycoconjugate is then treated with hydrofluoric acid to introduce fluorine atoms into the carbohydrate backbone. Lacto-N-fucopentaose III-GEL has been modified by Click chemistry to incorporate an azide moiety at the nonreducing end. This modification allows for Oligosaccharide or Polysaccharide coupling reactions to take place between Lacto-N-fucopentaose III-GEL and other saccharides in order to produce gly

Hyaluronate biotin (HB) is a modified form of hyaluronic acid. It is produced by the methylation and glycosylation of hyaluronic acid and it has an average molecular weight of 1000 kDa. HB is used in tissue engineering, cell culture, and as a contrast agent for magnetic resonance imaging. The modification of hyaluronate with biotin allows for the visualization of HB using immunofluorescence microscopy. Hyaluronate biotin is a synthetic product that can be custom-synthesized to customer specifications, such as purity level, oligosaccharide content, and monosaccharide content.

Lacto-N-difucohexaose I-BSA is a high purity, custom synthesis sugar that is fluorinated, glycosylated, and methylated. It has been modified to be an oligosaccharide or monosaccharide with saccharides. Lacto-N-difucohexaose I-BSA is a complex carbohydrate that is made up of several different sugars. This product can be used for many purposes such as Click modification and Fluorination.

Benzyl 4- O- b- D- glucuronyl-b- D- xylopyranoside is a synthetic derivative of benzyl 4- O- b- D- glucuronylxylose. It has been shown to be a good substrate for glycosylation, click modification and fluorination. This product has been custom synthesized for the synthesis of complex carbohydrate, which is an oligosaccharide. It is also used in methylation reactions.

Sialylated tetrasaccharide found in human milk.Possible health benefits for the neonate, by supporting resistance to pathogens, gut maturation, immune function, and cognitive development.

6,1',6'-Tri-O-tertbutyldiphenylsilyl-sucrose is a high purity, custom synthesis chemical. It is an oligosaccharide and complex carbohydrate that is a Click modification of sucrose. This chemical has been fluorinated, glycosylated, and methylated.

3'-Sialyl-N-acetyllactosamine-BSA is an oligosaccharide that is a component of the glycosylation pathway. It is synthesized from 3'-sialyllactose and N-acetylglucosamine. This compound can be modified with fluorine, methylation, or click chemistry to yield novel derivatives for use in research.

Applications Isoorientin is a flavonoid compound that can be isolated from the passion flower, and several other species of plants. Isoorientin has also shown to exert antioxidant, anti-nociceptive, anti-inflammatory and gastroprotective activities in several studies. References Alves, S.F., et al.: J. Pharma. Rsch., 4, 4621 (2011); Ma, X., et al.: J. Agri. Food. Chem., 60, 10844 (2012); Joubert, E., et al.: J. Agri. Food. Chem., 60, 9171 (2012);

Monosialyl, monofucosyllacto-N-neohexaose is a synthetic oligosaccharide. It has a molecular weight of 1205. The compound has been modified with a click modification and fluorination, and has been shown to be stable in the presence of acid, base, and heat. The compound is also high purity and can be synthesized on request. Monosialyl, monofucosyllacto-N-neohexaose is an example of a complex carbohydrate that contains both a sugar and polysaccharide component. The sugar component is composed of one monosaccharide: sialic acid. The polysaccharide component consists of six disaccharides: two lactose molecules linked with one glucose molecule each. Monosialyl, monofucosyllacto-N-neohexaose is used as an artificial sweetener in food products such as cookies or cakes

Methyl 3-O-(2,3,4,6-tetra-O-acetyl-a-D-mannopyranosyl)-a-D-mannopyranoside is a synthetic glycosylation product of methyl 3,4,6-triacetate and a mannose. It is an Oligosaccharide with the molecular formula (C12H25O14)n. Methyl 3-O-(2,3,4,6-tetra-O-acetyl-a-D-mannopyranosyl)-a-D -mannopyranoside is a white crystalline powder that can be used in the synthesis of complex carbohydrates. It has been shown to react with fluorine to produce a monofluorinated product and methylated products. This compound can be custom synthesized and modified for specific applications. Methyl 3 - O - ( 2 , 3 , 4 , 6 -

Cellobiitol is produced by the borohydride reduction of cellobiose.  Few publications discuss the chemistry of cellobiitol but applications in the food and pharmaceutical industries have been published.

Hybrid N-glycans are glycan structures that contain both a high mannose and complex type oligosaccharide. Hybrid N-glycans are expressed on the surface of mammalian cells, and they can be found in human serum. Hybrid N-glycans have been shown to activate caspase 3 and induce apoptosis in some mouse models. They also have biological functions such as growth factor binding or antibody binding. Hybrid N-glycans may be involved in the activation of the immune system or in the development of cancerous tumors.

Gala1-3Galb1-3GlcNAc-HSA is a synthetic glycosylation product of Galactose, Glucose and Galactosamine with Hexose. It is a complex carbohydrate that can be used to modify proteins with the sugar group. The sugar group is synthesized by the Click modification of a monosaccharide and then methylated. The sugar group is attached to HSA via an N-acetylhexosamine linker. This product has been shown to have high purity and can be used in many applications such as fluorination, methylation, click modification, or complex carbohydrate research.

GD2 (shown as sodium salt) has a core trisaccharide structure (GalNAc-b-1,4-Gal-b-1,4-Glc) with its two sialic acids linked b-2,3/b-2,8 to the inner galactose residue and ceramide linked to position 1 on the reducing terminal glucose residue. GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 is overexpressed in a number of tumors, including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, it has been found in low concentrations on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state), and tumor-initiating capabilities.  It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).

Man-8D1D2 N-glycan is a synthetic glycan that is used as a monosaccharide or polysaccharide. This product is produced through the modification of the natural Man-8D1D2 glycan by the addition of fluorine atoms and methyl groups to the sugar, making it a useful reagent for chemical synthesis. The purity of this product is high and its CAS number is 56612-59-6.

3,2'-Di-O-acetyl-3',4'-O-carbonyl-6,6'-di-O-tert-butyldiphenylsilyl lactal is a custom synthesis of a fluorinated carbohydrate. It is a modification of an oligosaccharide and can be used in the synthesis of saccharides and polysaccharides. The CAS number for this compound is 163228-35-1. This compound has been modified with click chemistry to add methyl groups to the hydroxyl group on the sugar ring. This compound has been used as a monosaccharide or as a part of complex carbohydrates.

Please enquire for more information about Lactitol monohydrate including the price, delivery time and more detailed product information at the technical inquiry form on this page

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This is a synthetic, high purity and custom-synthesized carbohydrate. The chemical name is 1,2,3,6-Tetra-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-b-D-galactopyranosyl)-b-D-thioglucopyranose. It has been modified with the Click reaction to allow for chemical modification. This product is a complex carbohydrate that has been fluorinated to create an organic fluorine compound.

Please enquire for more information about 1-Deoxy-1-morpholino-D-fructose including the price, delivery time and more detailed product information at the technical inquiry form on this page

Human milk oligosaccharide; binds cholera toxin TcdA

4-Aminophenyl 2-O-(a-D-mannopyranosyl)-a-D-mannopyranoside is a fluorinated mannoside that is modified with methyl and glycosyl groups. It is used as a fluorescent probe for the detection of saccharides in organic solvents. The molecular weight of this compound is 687.

Stability Very Very Hygroscopic Applications Nicotinamide (N407750) analog. Nicotinamide riboside (β-NAR) is an intermediate in one biosynthetic pathway by which Nicotamide is converted into NAD (Nicotinamide Adenine Dinucleotide) References Friedlos, F., et al.: J. Biochem. Pharmacol., 44, 25 (1992), Ong, S., et al.: Biochemistry, 11210 (1992), Zhang, X., et al.: J. Biol. Chem., 278, 13503 (2003),

Lipid A monophosphoryl (MPL) is an adjuvant that stimulates the immune response to vaccines so that optimal protection can be achieved. MPL immunostimulant, a monophosphoryllipid A preparation derived from the lipopolysaccharide (LPS) of Salmonella minnesota R595. MPL is being considered as an adjuvant for a number of human vaccines, and experience to date has shown that it is safe, well tolerated, and able to provide a heightened immune response to coadministered antigens.

GA2-ganglioside is a ganglioside that is found in the membranes of cells. GA2-Ganglioside has been shown to inhibit the growth of tumors by binding to macrophages and T cells, which are two types of white blood cells. It has also been shown that GA2-Ganglioside can be used as a target for an antibody response against human HL-60 tumor cells. The antibody response induces cell lysis and reduces the size of the tumor. GA2-Ganglioside has also been shown to have anti-inflammatory properties, which may be due to its ability to bind to α subunits on bowel disease and infectious diseases, such as murine sarcoma virus, causing an antibody response that causes cell lysis and prevents replication of these viruses.

6'-a-Sialyl-N-acetyllactosamine-sp-biotin is a recombinant modified oligosaccharide. It is an Oligosaccharide that is synthesized by the methylation of 6'-sialyllactose with acetic anhydride and triethylamine in DMF. It has a molecular weight of 805.00 Da and a CAS number of 1038746-08-5. 6'-a-Sialyl-N-acetyllactosamine-sp-biotin may be used as a monomer for click chemistry, as well as for other applications in carbohydrate chemistry, such as the synthesis of polysaccharides and complex carbohydrates. This product has high purity and can be custom synthesized to order.

Benzyl 2-acetamido-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-b-D-galactopyranosyl)-a-D-glucopyranoside is a carbohydrate that belongs to the group of saccharides. It is a member of the class of oligosaccharides and has a CAS number of 60831-31-4. This compound is synthesized from benzyl 2,3,4,6 tetra acetyl b D galactopyranoside in which a sugar molecule has been added to the end of the chain. Benzyl 2 acetamido 2 deoxy 3 O (2,3,4,6 tetra O acetyl b D galactopyranosyl) a D glucopyranoside is also known as 2 alpha -D glucopyranose or α -D glucopyranose. This

Heparin breakdown product

Man-5 N-glycan is a glycan that is synthesized by the enzyme mannosyltransferase. This glycan contains five mannose residues, one galactose residue, and one N-acetylglucosamine residue. The Man-5 N-glycan is found in eukaryotes, which are organisms whose cells have nuclei and membrane bound organelles. It is often found on the surface of cells or in secretions such as mucus or saliva. Man-5 N-Glycans are involved in cell signaling and may play a role in bladder cancer development. They are also used to generate monoclonal antibodies for diagnostic purposes.

Gal[2346Ac]b(1-3)GlcNPhth[46Bzd]-b-MP is a custom synthesis of an oligosaccharide. It has been modified to include fluorination and click chemistry. The chemical name for this compound is Gal[2346Ac]b(1-3)GlcNPhth[46Bzd]-b-MP. This compound has a CAS number of 56971-00-0, which corresponds to the chemical name, Gal[2346Ac]b(1-3)GlcNPhth[46Bzd]-b-MP. The molecular weight of this compound is unknown. The purity of this compound is greater than 99%. This compound has a modification that consists of a monosaccharide and sugar.

a1,6-Mannobiose-BSA is a fluorinated monosaccharide that has been synthesized from mannose. It is a synthetic oligosaccharide that is used in glycosylation and polysaccharide modification. The compound has been modified with methyl groups and has undergone click chemistry to produce a reactive site on the sugar ring. This product has been synthesized using high purity reagents and has CAS No. 73978-99-2.