Polycyclic Compounds

Please enquire for more information about 2-Chloro-3-amino-4-(2-methylpropylamino)quinoline including the price, delivery time and more detailed product information at the technical inquiry form on this page

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2-Ethylindole is a nanotube antibiotic with potent cytotoxic properties. It is synthesized by the reaction of dialkylamine and indole in the presence of nitrogen gas. The nitrogen atoms in 2-ethylindole are thought to be responsible for its inhibitory properties, as they bind to DNA and prevent the transcription of tumor necrosis factor-α (TNF-α) mRNA. Its cytotoxic potency has been demonstrated in human cervical carcinoma cells and other cancers. 2-Ethylindole also inhibits energy metabolism and structural analysis, which may be due to its aromatic hydrocarbon ring system. This compound has been shown to have oral bioavailability and can be administered in a cream form for topical application on skin cancer.

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Applications 4,7-Dichloro-2-phenyl-1H-isoindole-1,3(2H)-dione is an intermediate in the synthesis of phthalic compounds, phthalazines, and quinones with antimicrobial activity. References Marriott, G. J., et al.: J. Chem. Soc., 134 (1939); Katayama, H., et al.: Tetrahedron., 63, 6642 (2007);

Tetrindole mesylate is a non-steroidal anti-inflammatory drug that has been found to have selective action on the mammalian cells. It is a potent inhibitor of DNA methylation and histone methylation, which are important epigenetic regulators in cancer. Tetrindole mesylate has also been shown to inhibit growth factor receptor binding and receptor activation, as well as the growth of prostate cancer cells. This drug may also be useful for treating bone cancer, as it has been shown to inhibit radiation-induced osteoporosis and reduce the risk of radiation-induced cancers.

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