Polycyclic Compounds

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Stability Hygroscopic Applications 3-Amino-3-azabicyclo[3,3,0]octane is used as a reactant in the synthesis of Gliclazide (G409875), a sulfonylurea hypoglycemic agent. Used as an antidiabetic. References Duhault, J., et al.: Arzneimittel-Forsch., 22, 1686 (1972); Holmes, B., et al.: Drugs, 27, 301 (1984)

7-[(2S,3R)-3-Amino-2-methyl-azetidin-1-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-quinoline-3-carboxylic acid (ABT) is a drug that binds to bacterial enzymes and inhibits their ability to synthesize proteins. ABT is a conjugate of fluoroquinolone and an amino acid. As the drug is degradable by hydrolysis, it has been shown to be less toxic in Sprague Dawley rats than other fluoroquinolones. This drug has been used in diagnostic tests as a ligand for affinity ligands, but has not been approved for human use. The drug also possesses functional groups that are important for binding to reconstituted enzymes.br>br>ABT's ester linkages are degradable by hydrolysis and can be

2-Quinolinethiol is a quinoline derivative that has been used as an inhibitor molecule in analytical chemistry. It crystallizes in the orthorhombic system and forms x-ray crystal structures. 2-Quinolinethiol has also been shown to inhibit carbostyril, hydrogen bond, and basic structure of x-ray crystal structures of zinc diethyldithiocarbamate. 2-Quinolinethiol has a redox potential of -0.10 V and can be used as a chelate ligand for metal ions such as silver ions.

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Lactone

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Please enquire for more information about 6-Methyl-2-phenylquinoline-4-carbonyl chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

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6-fluoroquinolin-8-ol is a fungicidal agent that belongs to the quinoline derivatives group. It inhibits the synthesis of dextrose and trichophyton mentagrophytes, which are important for the growth of fungi. 6-fluoroquinolin-8-ol has shown synergistic effects with 8-hydroxyquinoline and other quinoline derivatives. This drug has been shown to be cytotoxic and neuropathogenic in animal models, leading to an increased incidence of Parkinson's disease in mice following treatment with this compound. The cytotoxicity of 6-fluoroquinolin-8-ol may be due to its ability to cause oxidative damage by generating reactive oxygen species (ROS).

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5-Benzyloxyindole-2-carboxylic acid is a versatile compound that has been used as a building block for the synthesis of diverse chemical compounds. It has been shown to be useful in the synthesis of natural products and pharmaceuticals, such as anticancer drugs, antibiotics, and analgesics. 5-Benzyloxyindole-2-carboxylic acid is also used as an intermediate in the production of other chemical compounds. It has a CAS number of 6640-09-1 and is classified as a research chemical.

6-Bromoquinoline- 4-carbaldehyde is an analog of quinoline derivatives that inhibits tumor growth. It has been shown to have anti-cancer properties in u87mg cells and xenograft models, with tumor growth inhibition and regression observed. 6-Bromoquinoline-4-carbaldehyde selectively targets kinases involved in cell proliferation, such as epidermal growth factor receptor (EGFR), platelet derived growth factor receptor (PDGFR), and human epidermal growth factor receptor 2 (HER2). The introduction of a bromine atom into the quinoline ring was found to be important for its activity, while optimization of the structure led to increased potency. The plasma concentration of 6-bromoquinoline-4-carbaldehyde was found to be high enough for it to reach therapeutic levels after oral administration, making it suitable for use as an anti-cancer agent.

7-Methyl-1H-indazole is a diazonium salt that belongs to the class of imidazoline. It has a safety profile and has been shown to lower blood pressure in animal models. 7-Methyl-1H-indazole is used as an intermediate in catalytic asymmetric synthesis of indazoles, benzoxazoles, and other heterocyclic compounds. 7-Methyl-1H-indazole also acts as a ligand for calcitonin receptors and can be used intranasally for the treatment of nasal congestion.

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Paliperidone is a drug substance that belongs to the group of anticoagulants. It is an acidic compound with a chemical formula of C14H14Cl2N2O. Paliperidone inhibits the formation of blood clots by blocking the action of thrombocytes and fibrinogen, which are proteins essential for coagulation. Paliperidone has been shown to be effective in treating schizophrenia, schizoaffective disorder, and bipolar disorder in humans. Impurities in paliperidone include alcohols, benzene, chlorides, morpholine, and acetonitrile. The drug product contains 2-chloroethyl groups that are necessary for its activity.

Please enquire for more information about Ethyl 5-(2-furyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Lactone

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7-Fluoroisatin is a crystalline compound that can exist as two different polymorphs. The metastable form of 7-fluoroisatin has been shown to have low energy vibrations and hydrogen bonding interactions, which are responsible for the intermolecular hydrogen bonding. 7-Fluoroisatin also has a tautomeric form that exists as a hydrochloride salt, which is not stable in the solid state. The protonated form of 7-fluoroisatin has been shown to be an excellent hydrogen bond acceptor, with the ability to stabilize long range interactions.

6,7,8-Trimethoxycoumarin is a methoxylated coumarin compound, which is a derivative of the natural product coumarin. It is primarily sourced from certain plant species where methoxylation occurs naturally as part of plant secondary metabolism. The compound exhibits interesting properties due to its structural modifications, particularly in its potential interactions with biological molecules. The mode of action of 6,7,8-Trimethoxycoumarin generally involves modulating enzyme activity or interacting with various cellular pathways, although specific mechanisms can vary depending on the biological context. For instance, some methoxylated coumarins have been reported to inhibit enzymes involved in metabolic pathways or to show antioxidant activity due to their ability to scavenge free radicals. The uses and applications of 6,7,8-Trimethoxycoumarin are mainly centered around research into its biological activity. Studies often explore its potential as an agent in pharmacological settings, particularly in fields such as oncology, where coumarins are known for their cytotoxic properties, or in investigating antimicrobial effects. Researchers also focus on its potential role as a chemical probe for elucidating biological processes or as a precursor in synthetic chemistry for the development of more complex bioactive compounds.

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Applications Indole derivative with anticancer activity. References Lavrenov, S. et al.: Bioorgan. Med. Chem. 18, 6905 (2010)

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(S,S,S)-2-Azabicyclo[3.3.0]octane-3-carboxylic acid benzyl ester hydrochloride is a research chemical that can be used as a reaction component or reagent in organic synthesis. This compound is also useful in the construction of complex compounds and fine chemicals with applications including drug discovery, pharmaceuticals, agrochemicals, and polymer chemistry.

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2-Methyl-8-nitroquinoline (2MNQ) is a leukotriene receptor antagonist that prevents the binding of leukotrienes to their receptors, thereby inhibiting their effects. 2MNQ has been shown to be effective in treating virulent infections, such as MRSA and Pseudomonas aeruginosa. 2MNQ can be used in a dry weight assay for measuring the inhibition of leukotriene receptors. The interaction of 2MNQ with leukotriene receptors is specific, which makes it important for elucidating the mechanism of action. A homogeneous assay using biphenyl as a substrate for 2MNQ is also available for measuring its inhibitory activity on leukotriene receptors. 2MNQ binds to flavins and hydrochloric acid in an inorganic manner and has a redox potential that is low enough to allow efficient reaction with hydrogen peroxide or an organic base.

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2-Azaspiro[4.5]decane is an organic compound that has been synthesized by the cyclization of allylamine and isobutyraldehyde. It can be modified with chlorine to form 2-chloroazaspiro[4.5]decane, which has been used as a pharmaceutical preparation and as a reagent in organic chemistry. The stereochemical configuration of 2-azaspiro[4.5]decane is the same as that of benzene, but it lacks a hydrogen atom on the ring and contains two hydroxyl groups instead. This molecule can be used to study immunity and efficient methods for pharmaceutical preparation. 2-Azaspiro[4.5]decane is labile, so it should be stored at low temperature or under inert gas to avoid oxidation reactions or other chemical reactions with air or water molecules.

Applications Indole-3-pyruvic Acid is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmental changes. References Kong, W., et al.: Plant Cell Physiol, 56, 715-726 (2015)

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6-Methylcoumarin (Toncarine) (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity.

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(3R)-10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4benzoxazine-6carboxylic acid (NUCLOZIDE) is a metallocene that is used as an organic polymerization catalyst. It has been shown to have anti-depressant properties in mice and humans by acting on the brain's serotonin receptors. NUCLOZIDE also inhibits the production of dopamine in the brain and may be able to reduce symptoms of Parkinson's disease.

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