Polycyclic Compounds

Applications Tert-Butyl 4-(Aminomethyl)Indoline-1-Carboxylate (cas# 1086392-32-6) is a useful research chemical.

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7-Aminoquinoline is a nucleophilic compound that is involved in the catalysis of bond cleavage. It has been shown to react with organic molecules and produce an oxygenative interaction. 7-Aminoquinoline has been shown to produce anti-inflammatory properties by inhibiting prostaglandin synthesis, which occurs through the inhibition of cyclooxygenase activity.

(+/-)-Heraclenin is a naturally occurring coumarin, which is a class of organic compounds notable for diverse biological activities. This compound is primarily sourced from various plant species belonging to the family Apiaceae, such as Heracleum species. Coumarins like (+/-)-heraclenin are known for their ability to modify biological responses due to their chemical structure. The mode of action of (+/-)-heraclenin involves interacting with cellular pathways and enzymes, potentially influencing processes such as inflammation, oxidative stress, and microbial growth. Its molecular properties allow it to participate in chemical reactions that may inhibit or alter the function of specific biological systems. In scientific research, (+/-)-heraclenin is of interest for its potential uses in pharmacology and therapeutic development. Studies often explore its anti-inflammatory, antimicrobial, and antioxidant activities, providing insights into its utility in developing new medical treatments. Its role in modulating biochemical pathways invites further exploration in the realms of drug discovery and natural product chemistry.

8-Chloro-4-(2-Chloro-4-Fluorophenoxy)Quinoline is a selectable antibiotic that inhibits the synthesis of amino acids. It blocks the dehydrogenase enzyme, which catalyzes the conversion of 2-ketoglutarate to succinyl-CoA, an intermediate in the Krebs cycle and a precursor for amino acid biosynthesis. This leads to a build up of 2-ketoglutarate, which is toxic to cells. 8-Chloro-4-(2-Chloro-4-Fluorophenoxy)Quinoline has been shown to be effective against wild type strains and resistant mutants of filamentous fungi and can also be used as a model organism for studying other antifungal agents.

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6-Hydroxyindazole is a drug available for the treatment of Parkinson's disease. It has been shown to be neuroprotective and in animal studies it has been shown to reduce the levels of dopamine-β-hydroxylase and tyrosine hydroxylase in the brain. 6-Hydroxyindazole also protects against aluminium toxicity, which may be due to its ability to inhibit the formation of nitric oxide. This drug is used in dyestuffs as a reducing agent, but can also produce toxic effects by attacking metal ions such as copper and zinc.

Applications alpha-Furil Dioxime (cas# 23789-34-6) is a useful research chemical.

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5-Chloroindole-3-Carboxylic Acid is a ring system that is a dimer of two indole rings and one carboxyl group. It has the ability to form hydrogen bonds with itself, which allows it to stack together in an orderly manner. The carboxyl group on the 5-chloroindole-3-carboxylic acid molecule can form hydrogen bonds with water molecules due to its electronegativity. This property enables 5-chloroindole-3-carboxylic acid molecules to be soluble in water, which is why it is used for water treatment and as a corrosion inhibitor.

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Applications 4-Hydroxymethylbicyclo[2.2.2]octane-1-carboxylic Acid Isopropylamide is a useful synthetic intermediate.

8-Azahypoxanthine is a hydroxyl analog of hypoxanthine. It contains a nitrogen atom in place of the oxygen atom on the 2-position. 8-Azahypoxanthine has been shown to be an effective inhibitor of purine biosynthesis in yeast cells and can be used as a replacement for xanthine during the synthesis of adenosine triphosphate (ATP) from uracil. 8-Azahypoxanthine was found to have good detection sensitivity, with an estimated detection limit of 0.2 µM. The optimum pH for this compound is 7.8, which is similar to that of wild type strain and tissue culture media. Mutants resistant to 8-azahypoxanthine were generated by exposure to high concentrations (>100 mM) for long periods (>2 days). Mutant strains showed no detectable enzyme activity against orotic acid or glycosidic bond formation with erythromycin

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5-Amino-8-hydroxyquinoline dihydrochloride (5-AQDH) is an anticancer drug that inhibits the activity of survivin, a protein that is overexpressed in cancer cells. It has been shown to be effective in vivo against melanoma tumor growth. 5-AQDH binds to the unpaired cysteine residues of the survivin molecule and inhibits its function by binding to the active site, blocking access to ATP and preventing DNA synthesis. The efficacy of 5-AQDH has been confirmed in vitro by studying the effect on cell viability and DNA synthesis, as well as by measuring plasma mass spectrometry data from melanoma patients. This drug is currently being investigated for its potential use as an anticancer agent.

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Nodakenin ((+)-Marmesinin) is a compound with anti-allergic and anti-inflammatory activities.

4-Benzyloxyindole is a serotonin receptor binding agent. It has a macrocyclic structure that is composed of four benzyloxy groups and a nitrogen atom in the center. The 4-benzyloxyindole binds to the serotonin receptors, specifically to those that are G-protein coupled and mediate intracellular signaling cascades. 4-Benzyloxyindole has been shown to be an inhibitor of calcium channels and may be used for treatment of diseases such as hypertension, schizophrenia, depression, migraine headaches, and epilepsy.

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Lactone

Ethyl2-methylquinoline-4-carboxylate is a biomolecule that can be derived from the oxidation of ethyl malonate using aerobic conditions. This molecule reacts with amines to form enamines by activation with nucleophiles. Ethyl2-methylquinoline-4-carboxylate has been used as a carbon source in biomolecular chemistry and as an ester in the synthesis of heterocyclic compounds. It can also serve as a reactant for the synthesis of tautomeric forms.

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4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole is a phosphoinositide inhibitor that induces apoptosis in cancer cells. It targets the enzyme phosphatidylinositol 3-kinase (PI3K) and the downstream target of PI3K: phosphatidylinositol 3-phosphate (PI3P). The PI3P is a precursor for other lipids such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 4-phosphate (PIP). These lipids are involved in the regulation of cell proliferation and apoptosis. This compound has a significant inhibitory effect on cancer cell lines and inhibits cancer growth in an animal model.

4,6,7,8-Tetrahydro-2,5(1H,3H)-quinolinedione is a decaline derivative with a beta-blocking effect. It is synthesized from the reaction of carbostyril and acrylic acid in the presence of hydrocarbon solvent. 4,6,7,8-Tetrahydro-2,5(1H,3H)-quinolinedione can be used to produce β-blockers with different structures. Tetrahydro-2,5(1H,3H)-quinolinedione can also react with dehydrogenation agents to form new products.

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Quinoline-2,8-diol is a bacterial strain that can be used to remove fatty acids from wastewater. The recombinant cytochrome P450 in this strain can degrade fatty acids, which are carcinogenic and have been shown to cause hepatic steatosis. In addition, the quinoline-2,8-diol strain has shown an ability to inhibit xenograft tumor growth in mice by activating cytochrome P450 and inducing apoptosis. This bacterial strain also has the potential to produce xanthurenic acid from tyrosine. Xanthurenic acid is toxic and has been shown to inhibit polymerase chain reaction (PCR) amplification of DNA. Quinoline-2,8-diol may be used as a model for experimental studies of xanthurenic acid's effects on energy metabolism and DNA synthesis.

2-Amino-8-hydroxyquinoline is a molecule that has been shown to have optical properties. 2-Amino-8-hydroxyquinoline has also been shown to be reactive in vitro and inhibit the growth of cancer cells. It is thought that this inhibition may be due to its ability to bind to the active site of DNA polymerase, preventing DNA replication. 2-Amino-8-hydroxyquinoline has also been shown in vitro studies and vivo studies to have potent inhibition activity against human serum albumin (HSA). The molecules that are used as linkers to attach 2-amino 8 hydroxyquinoline to other molecules are thermodynamically stable. The isomers of 2 amino 8 hydroxyquinoline have also been studied by X-ray crystallography and nuclear magnetic resonance spectroscopy, which provides information about the structure of the molecule. Finally, 2 amino 8 hydroxyquinoline has been found to be an odorant

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3,5-Dinitro-2-pyridone is a nitrating agent that is used in the preparation of other chemicals. It is an organic chemical compound with the formula HN(NO)(ONO). 3,5-Dinitro-2-pyridone has a low activation energy and can be used to nitrate aromatic rings, such as phenols or amines. The nitro group can stabilize the resulting compound and prevent decomposition. This nitrating agent also has a catalytic effect on certain reactions because it can act as an oxidizing agent by abstracting hydrogen atoms from a molecule. 3,5-Dinitro-2-pyridone is activated by heat and cannot be stored at high temperatures for long periods of time without decomposing into other compounds.

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8-Hydroxyquinoline-2-carboxylic acid is a 3-hydroxyanthranilic acid derivative that is often used as a biomarker of urine. The 8OHQA can be synthesized from 3-hydroxyanthranilic acid by the action of xanthine oxidase and hydrogen peroxide, and it has been shown to be an inhibitor of protein synthesis. This inhibition may be due to its ability to form hydrogen bonds with the hydroxyl group on the ribose side chain and its ability to coordinate with metals. 8OHQA has been shown to have anti-inflammatory effects in bladder cancer cells, which may be due to its ability to inhibit prostaglandin synthesis.

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Ethyl 6,7-difluoro-1-methyl-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate is a precursor to the antibiotic prulifloxacin. The compound is synthesized from malonic acid and diethyl 2-(chlorocarbonyl)-5-fluoro-6,7-difluoro-1-(methyl)quinolinecarboxylate by cyclization and hydroxylation. The diethyl ester group is then deprotected to give prulifloxacin.

Applications 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester is used in the synthesis of antibacterials. References Phillips, O. et al.: Exp. Opin. Ther. Pat., 19, 529 (2009);

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Applications A 6-substituted 8-quinolinecarboxylic acid as antimicrobial and genotoxic agent. References Weyer, R., et al.: Arzneim.-Forsch., 24, 269 (1974),

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o-Phenanthroline monohydrochloride monohydrate is a ligand that is used in crystallography to study the crystal structure of metal ions. It has been shown to be an efficient catalyst for the ring-opening of chloroformates, and can also be used as an analytical reagent that is capable of detecting chlorine in organic compounds. The hydrate form of o-phenanthroline monohydrochloride has a molecular formula of C12H14ClN3O4·2H2O and a molecular weight of 392.7 g/mol.

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7-Bromoquinolin-4-ol is a cytotoxic alkaloid that belongs to the class of marine alkaloids. It was isolated from the marine sponge, Dendrilla membranosa. This compound has been shown to be cytotoxic in a mouse lymphoma cell line and may be useful for the treatment of lymphomas. 7-Bromoquinolin-4-ol has been synthesized and studied for its cytotoxicity against various mouse lymphoma cell lines. Spectroscopic studies revealed that this compound is brominated at the quinoline ring and it is also difficult to synthesize.

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1H-Indazole-3-carboxylic acid is an organic compound with a molecular formula of C9H6N2O2. It is a colorless solid, but appears yellow in solution. This compound has been shown to inhibit protein synthesis by binding to the apical site of the ribosome, preventing the peptide bond from forming between amino acids. It also inhibits carboxylate metabolism and cellular glycolysis by inhibiting ATP production. 1H-Indazole-3-carboxylic acid has been shown to be effective against cancer cells and can be used as a potential anti-cancer drug.

5-Methyl-3-p-isopropylphenylpyrazole is an organic compound that is used as a synthon in the synthesis of pyrazoles. It has been shown to bind to anions and hydrogen bonds, which may be due to its structure. 5-Methyl-3-p-isopropylphenylpyrazole has also been shown to interact with other molecules through cavity interactions, which are due to the placement of substituents on the pyrazole ring. This interaction can be analyzed by correlating the interaction energies with conformational changes in the framework.

5,6-Dimethyl-1,10-phenanthroline (DMPA) is a molecule with the chemical formula H2C8N4O2. It has been shown to have antioxidant and anticancer properties. DMPA binds to DNA to form an adduct that denatures the DNA. This prevents DNA from being transcribed into RNA, which prevents gene expression and cell division. The anticancer activity of DMPA may be due to its ability to increase oxidative dna damage in cancer cells, leading to apoptosis. DMPA has also been shown to bind redox potentials of metals such as copper, iron and nickel that are found in the environment or in cancer cells. This binding alters the electron transfer reactions involving these metals and leads to a change in the viscosity of the solution. The molecular modeling studies have shown that DMPA binds with nitrogen atoms in coordination geometry with oxygen atoms on two sites on one molecule (see Figure 1). This binding is characterized by

5-Fluoroindole-3-carboxaldehyde is a cell-based assay for the determination of the phytoalexin level in plants. It is also used as an analog to study the effect of nitroethane, chloride, aluminium and acid on plant cells. 5-Fluoroindole-3-carboxaldehyde has been shown to degranulate cells in a dose-dependent manner at a cellular level. This compound has been shown to enhance cancer cell proliferation by inhibiting apoptosis and degranulation. 5-Fluoroindole-3-carboxaldehyde can be used as an organic solvent in the lab because it does not react with other compounds or degrade into toxic substances.

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