Polycyclic Compounds

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7-Bromo-4-chloroquinoline-3-carbonitrile (7BCQ) is a drug that has been shown to have potent cytotoxic activity against colon tumor cells. 7BCQ is an alkylating agent that inhibits the enzymatic activity of DNA topoisomerase II and protein tyrosine kinases. The methoxy group in 7BCQ binds to the DNA backbone, which prevents the formation of new strands of DNA. This drug also induces apoptosis by binding to cellular nucleophiles, such as ethenyl and ethynyl groups. Optimization of this molecule has led to the discovery of a n-oxide form that exhibits greater potency than other forms.

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4,4' -Bis(N,N-dimethylamino)-2,2' -bipyridine (DMAB) is a ligand that is used in electrochemical studies. It has been shown to have ancillary properties, which means that it does not interact directly with the substrate but modifies its environment. DMAB can form a complex with the proton at the electrode surface and x-ray crystal structures have been obtained for this interaction. These structures demonstrate that DMAB binds to the tetrazole ring of pyridine and stabilizes the molecule by increasing its redox potentials.

5-Fluoroindole-2-carboxylic acid is a new substance that has been found to be an inhibitor of the influenza virus. It prevents the virus from replicating by inhibiting the synthesis of viral proteins and nucleic acids. 5-Fluoroindole-2-carboxylic acid can be prepared by dispersive solid phase extraction of a mixture of fluoroindole, fumaric acid, and potassium hydroxide in water. The compound has also been shown to potentiate the effects of carbamazepine on caspases and enhance mass spectrometric analysis for gaseous hydrochloric acid. 5-Fluoroindole-2-carboxylic acid produces antinociceptive effects in animals.

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6-n-Propoxypurine (6-PP) is an intermediate in the purine biosynthetic pathway. It is a methylated adenosine analog that inhibits protein synthesis by inhibiting the enzyme ribonucleotide reductase and blocking the conversion of ribonucleotides to nucleotides. 6-PP also has autophagic activity, which may be due to its ability to decrease ATP levels. 6-PP is found in both cellular and extracellular environments, where it is converted into 6-dimethylaminopurine (6-DAP), a cytokinin with erythropoietic effects. 6-DAP can be methylated to produce 6-mercaptopurine riboside, a drug used for the treatment of some forms of cancer.

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Please enquire for more information about 2-(2-Isopropoxyphenyl)quinoline-4-carbonyl chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Please enquire for more information about 2,2,4-Trimethyl-1,2-dihydroquinolin-6-yl phenylacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page

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5-Methoxysuberenone is a chemical constituent of the root bark of Toddalia asiatica (L.) Lam. (T. aculeata Pers.), Rutaceae.

Please enquire for more information about 1-Isoquinolineacetic acid,ethylester including the price, delivery time and more detailed product information at the technical inquiry form on this page

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8-Methoxy-2-methylquinoline (8MMQ) is a quinoline derivative with two methoxy groups. It is synthesized from 2,5-dimethoxyaniline and 2,4,6-trimethylaniline. 8MMQ is used in diagnostic assays for the detection of staphylococcus. The enhancement effect of 8MMQ on the reactivity of fluorometric probes has been shown to be dependent on the electron donor properties of the multinuclear metal complex. The reaction products depend on the nature and concentration of proton donors and/or acceptors present in solution. 8MMQ reacts with ammonium nitrate to form a blue product that absorbs light at 540 nm. This reaction can be used as an analytical method for determining ammonium nitrate content in fertilizers.

5-Amino-2-pyridone (5AP) is a synthetic molecule that exhibits potent and selective activity against influenza virus neuraminidase. It binds to the protein in a hydrophobic pocket and protonates the active site, preventing it from functioning. The 5AP-inhibited neuraminidase has been shown to be active against influenza A and B viruses as well as avian H1N1 virus. 5AP has been optimized for use in animal models, with studies showing that it is effective for treatment of influenza when administered intranasally or by aerosol. 5AP also inhibits the replication of other RNA viruses, including Sindbis virus and vesicular stomatitis virus. 5AP was shown to inhibit the replication of human respiratory syncytial virus (HRSV) in cell culture by binding to its viral surface glycoprotein, sialic acid-binding immunoglobulin-like receptor 2 (SI

Quinoline-6-carboxylic acid (QCA) is an antibiotic that belongs to the group of quinolines. It has been shown to have antibacterial activity against gram-negative bacteria and is a substrate for reductase enzymes. QCA inhibits bacterial growth by binding to DNA gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. The reduction potential of QCA is -0.66 V vs. NHE at pH 7, which is similar to other quinolines but different from chloramphenicol (-0.87 V). QCA displays a higher affinity for DNA than chloramphenicol does, with values of 10 μM and 4 μM respectively. This antibiotic also has been shown to react with electrophiles such as oxygen or nitrite in the presence of ultraviolet radiation or single-crystal x-ray diffraction techniques, forming reaction products such as oxoquinoline derivatives and nitro

4,6-Dichloropyrido[3,2-d]pyrimidine is a hydroxamic acid with oncogenic properties. It has been shown to induce tumor growth in animal models and is believed to work by inhibiting the activation of signaling pathways that control cell proliferation. 4,6-Dichloropyrido[3,2-d]pyrimidine inhibits the activation of oncogenic signaling pathways by binding to phosphorylated serine/threonine residues in their kinase domains. This drug also has antiproliferative activity on prostate cancer cells in culture.

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Fraxinol is a natural lignan, which is a small class of polyphenols, derived from the inner bark of the Ash tree (Fraxinus species). Its primary action is believed to involve antioxidant and anti-inflammatory pathways, where it scavenages reactive oxygen species and modulates cytokine production. This activity suggests potential modulation of cellular oxidative stress responses, contributing to its therapeutic interest. The compound is being studied extensively for its potential medicinal applications. These include its use as a supplement in the management of inflammatory conditions and as an adjunct in therapies addressing oxidative stress-related diseases. Additionally, due to its bioactivity, Fraxinol is being explored in various experimental setups to elucidate its full pharmacological spectrum, particularly in relation to its impact on cellular signaling and gene expression modification pathways. These studies aim to uncover new insights into its possible application in clinical settings.

Please enquire for more information about 7-Chloro-2-(3,4-dimethylphenyl)-8-methylquinoline-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

5-Cyanoindole-3-carboxaldehyde is an aldehyde that is used in synthesis of β-unsaturated aldehydes. It is prepared by the reaction of 3-cyanoindole with formaldehyde. 5-Cyanoindole-3-carboxaldehyde has antibacterial activity against gram positive and gram negative bacteria. It also has a high yield and can be purified by filtration or by condensation with chlorobenzene. 5-Cyanoindole-3-carboxaldehyde can be activated by irradiation, which makes it useful for the production of pharmaceuticals.

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7-Methyl-2,3-dihydro-1H-indole is a versatile compound that has various applications in different industries. It is commonly used in the synthesis of pharmaceuticals, herbicides, and research chemicals. This compound can be synthesized through cyclocondensation reactions and exhibits unique properties due to its structure. In the pharmaceutical industry, 7-Methyl-2,3-dihydro-1H-indole is used as a building block for the synthesis of several drugs. Its ability to form hydrogen bonds and its reactivity with different functional groups make it an essential component in drug development. Additionally, this compound has shown potential in the treatment of neurological disorders such as epilepsy, as it can act as a precursor for gabapentin synthesis. The agricultural industry also benefits from 7-Methyl-2,3-dihydro-1H-indole. It serves as a key intermediate in the production of herbicides that effectively control weeds and unwanted vegetation. The compound's selective action

Please enquire for more information about 7,7-Dimethyl-5-oxo-4-phenyl-1,4,5,6,7,8-hexahydroquinoline-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Applications Isoquinoline-5-sulfonic Acid (cas# 27655-40-9) is a compound useful in organic synthesis. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

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2-Methylindole is a reactive molecule that can undergo electrophilic substitution at the 2-position. It reacts with a variety of nitrogen nucleophiles, acylating them at the 2-position. These reactions are catalyzed by enzymes such as carbonyl reductase and methyl ketone reductase. The reaction mechanism is not yet fully understood, but it has been proposed that it proceeds through an acylation reaction between two molecules of 2-methylindole to form a linear product. The regiospecificity of this reaction has been demonstrated in vivo using a model system.

Phellopterin: partial central benzodiazepine receptor agonist, cytotoxic at 40-400 μM on RAW264.7 cells, inhibits VCAM-1, affects monocyte adhesion.

Nodakenin, a coumarin isolated from the roots of Angelica biserrata (Shan et Yuan) Yuan etShan, possesses neuroprotective, antiaggregatory, antibacterial, and memory

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1-Acetyl-3-indolecarboxaldehyde is a ligand that binds to the cannabinoid receptor 1 (CB1). It has been shown to bind to the CB1 receptor with high affinity and selectivity. In addition, it has been demonstrated to inhibit the proliferation of human breast cancer cells in vitro. The compound is used as a fluorescent probe for cb1 receptor binding. Data obtained from molecular modelling studies have suggested that the hydroxyl group might be involved in binding to the CB1 receptor. 1-Acetyl-3-indolecarboxaldehyde also binds carotenoids, which are molecules responsible for giving plants and other photosynthetic organisms their coloration. This compound can be found in many different plants, such as carrots and bananas, where it acts as an antioxidant.

Please enquire for more information about 2-(4-Chlorophenyl)-6,8-dimethylquinoline-4-carbonyl chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

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2-(4-Aminophenyl)quinoline-4-carboxylic acid is a copolymer with the structure of an amide. It is synthesized by chemical methods and has been used as a substrate for spectroscopy experiments. Copolymers of 2-(4-aminophenyl)quinoline-4-carboxylic acid have been shown to be active in the synthesis of polyisatin, which can be used in the manufacture of polyurethane.

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6-Hydrazinopurine is an anti-hepatitis drug that is a prodrug for 6-chloropurine. Its mechanism of action is not fully understood, but it has been shown to bind to the virus receptor and inhibit the replication of the virus. It also competitively inhibits amines in biochemical assays. This property may be due to its hydroxyl group, which can form a hydrogen bond with the amino group of amines. It has been shown to be active against prostate carcinoma cells. 6-Hydrazinopurine has been shown to inhibit the growth of cancer cells by inducing apoptosis and decreasing cell proliferation.

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Applications Used for synthesis of Rho kinase inhibitors. References Biggadike, K., et al.: J. Med. Chem., 50, 6519 (2007), Cheng, Y., et al.: Bioorg. Med. Chem., 16, 4617 (2008),