Polycyclic Compounds

Please enquire for more information about Methyloxindole-4-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Isoquinoline-6-carboxylic acid is a compound that elutes in the chloride, ethyl acetate, and trifluoroacetic acid. It can be synthesized by reacting 3-methylisoquinoline with thionyl chloride, phosphorus oxychloride, or aluminum. The synthesis of isoquinoline-6-carboxylic acid begins by refluxing isobutene with sulfuric acid solution and aluminum. The reaction produces isobutyraldehyde and hydrogen chloride gas as byproducts. Isoquinoline-6-carboxylic acid can be purified using a silica gel column chromatography process.

Please enquire for more information about 1-Methyl-5-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2'-Butyl-1'-oxo-1',4'-dihydro-2'H-spiro[cyclopentane-1,3'-isoquinoline]-4'-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

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3-Methyloxindole is a bacterial strain that has been shown to inhibit protein synthesis and cause cell death in a model system of mice. 3-Methyloxindole inhibits the growth of bacteria by affecting the metabolic profiles of the cells, which are determined by the reactive intermediates. This compound is metabolized in the human liver and lung tissue to form oxindole, which has been shown to be less toxic than 3-methyloxindole. The effects of 3-methyloxindole on plants are similar to those seen with acyl halides, such as acetyl chloride, and may be due to hydrogen bond formation between this molecule and plant proteins.

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3-Cyano-7-ethoxycoumarin is a specialized fluorescent probe, which is a synthetic organic compound designed for use in biochemical assays. This compound is sourced from the broader family of coumarins, which are known for their versatile fluorescence properties. The mode of action of 3-Cyano-7-ethoxycoumarin involves its ability to exhibit strong fluorescent emission when excited by specific wavelengths of light, making it a valuable tool for monitoring biochemical reactions and interactions. 3-Cyano-7-ethoxycoumarin is primarily used in enzymatic assays, particularly those involving cytochrome P450 enzymes and other oxidoreductases. These assays can elucidate enzyme activity, inform on metabolic pathways, and contribute to drug discovery and development processes. Additionally, its application extends to studying receptor-ligand interactions and cell signaling pathways, providing insights into cellular mechanisms and interactions. The compound’s fluorescence characteristics make it ideal for high-throughput screening methods, allowing scientists to gather data efficiently across numerous samples.

Applications 4,4-Dimethyl-1,2,3,4-tetrahydroquinoline

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Ethyl-4-hydroxyquinoline-3-carbaldehyde is a synthetic drug that is used as a cross-coupling agent in organic synthesis. It is also used to produce antiretroviral therapies. The functional theory explains the reaction mechanism of this drug. In the nucleophilic addition step, ethyl-4-hydroxyquinoline-3-carbaldehyde attacks the electrophilic carbon atom of the alkyl halide and forms a carbon-carbon bond with it. Hydrogenation reduction is then performed to remove any electron density that may be present on the oxygen atoms. This process produces monoethyl and dimethyl ethers, which are later hydrolyzed to form ethyl esters and methylated quinolones.

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Lactone

3-Azaspiro[5.5]undecane is a drug that binds to the influenza virus and prevents it from binding to human cells, which results in inhibition of its replication. It has been shown to be effective against both seasonal and pandemic influenza strains. 3-Azaspiro[5.5]undecane can be used as an antiviral drug for prophylactic treatment or postexposure prophylaxis. 3-Azaspiro[5.5]undecane is a potent inhibitor of the influenza virus and has been shown to be a clinically useful agent for the prevention of flu infection in humans. The active compound, amantadine, inhibits viral replication by inhibiting viral uncoating, transcription, and translation, as well as blocking viral neuraminidase activity. Amantadine also blocks the release of newly synthesized viruses from infected cells by binding to lipid bilayers, preventing these viruses from attaching themselves to other cells in

Please enquire for more information about 7-Benzyloxy-1-(4-benzyloxy-3-ethoxycarbonyloxybenzyl)-6-methoxy-3,4-dihydroisoquinoline hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-(1,2,3,4-Tetrahydroisoquinolin-1-ylmethyl)-1H-isoindole-1,3(2H)-dione including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 6,8-Dimethyl-2-(2-thienyl)quinoline-4-carbonyl chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-(tert-Butyl)-5-nitro-1H-indole including the price, delivery time and more detailed product information at the technical inquiry form on this page

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5-Hydroxy-6-methoxyindole-carboxylic acid (5-HMICA) is a molecule that is found in the pericardium and urine of patients with cancer. 5-HMICA has been shown to suppress tumor growth and activate cell mediated cytotoxicity in vitro. It also induces T helper type 1 (Th1) immune responses, which are associated with the production of cytokines such as interferon gamma and tumor necrosis factor alpha. 5-HMICA has been shown to have anti-cancer properties by inducing tumor cell death through a number of mechanisms including modulation of antioxidant enzymes, suppression of DNA repair, inhibition of proliferation, and induction of apoptosis. 5-HMICA also suppresses suppressor genes involved in tumorigenesis and stimulates eumelanin synthesis for skin pigmentation.

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6-Bromo-5-chloro-1H-indazole is a chemical substance that is used in the manufacture of pharmaceuticals. It is a reagent for the synthesis of substituted anilines, which are used to synthesize new drugs. 6-Bromo-5-chloro-1H-indazole is also used as a dyeing agent for plastics and textiles. The compound has a molecular weight of 192.2 g/mol and it has the following physical properties: white crystalline solid, no odor, soluble in water, methanol, ethanol, acetone and chloroform. It can be stored at room temperature but should be kept away from light and moisture.

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Applications 3-Mercaptoindole (cas# 480-94-4) is a compound useful in organic synthesis. References Harris, R.L.N.: Tetrahedron Letters, 51, 4465 (1969)

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5-Chloro-7-iodo-8-hydroxyquinoline is a metal chelate that has been shown to have pharmacological effects in experimental animals. It has antioxidative properties and can protect against oxidative injury. 5-Chloro-7-iodo-8-hydroxyquinoline was found to be toxic in various animal models, including the neuronal death and mitochondrial membrane potential. This toxicity may be due to its ability to inhibit the activity of DNA polymerase and protein synthesis. The compound also showed significant cytotoxicity at low concentrations, but had no significant cytotoxicity at higher concentrations. 5-Chloro-7-iodo-8-hydroxyquinoline is similar in structure to clioquinol, which has been shown to have neurotoxic effects in humans.

N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide is a natural compound that has been shown to inhibit the enzyme secretase, which plays an important role in the development of cancer. The drug may also act as a signal pathway inhibitor by inhibiting the activity of phosphatidylinositol 3 kinase and protein kinase C (PKC). N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide also inhibits the production of glutamate, a neurotransmitter, by blocking calcium channels in neurons. This drug has been shown to increase bone mass and decrease bone resorption in rats with bone cancer. It is also effective against solid tumours such as breast, lung, and prostate cancers. N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide is structurally related to other drugs used for platinum based chemotherapy.

Please enquire for more information about Ethyl 5-(1,3-dimethyl-1H-pyrazol-4-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 8-Methoxy-4,4-dimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinoline-1-thione including the price, delivery time and more detailed product information at the technical inquiry form on this page

1,6-Dimethyl-1H-indole-3-carbaldehyde is a compound that can be used in the synthesis of many organic and pharmaceutical compounds. It is also an intermediate for the production of other chemicals. 1,6-Dimethyl-1H-indole-3-carboxylic acid has been shown to be useful as a building block in organic synthesis, due to its versatility and reactivity. The compound is also a reagent and can be used as part of research studies. This chemical has CAS number 202584-14-3.

6,7-Dimethoxyquinolin-4(1H)-one is a chemical compound with a sequence of C6H5COOCH3. It is used as an intermediate in the synthesis of cabozantinib, an antineoplastic drug. The chemical reaction of this compound with malonate and chlorination can be used to produce 6,7-dimethoxyquinolin-4(1H)-one in high yield. The bulk drug can be obtained by hydrogenating the product. 6,7-Dimethoxyquinolin-4(1H)-one is also hypotensive and has been shown to have anti-malarial properties when it reacts with veratrole. This compound is environmentally friendly because it does not react with ozone or chlorine dioxide.

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((2R,4S)-2-Benzyl-4-((quinolin-4-ylmethyl)amino)piperidin-1-yl)(3,5-dimethylphenyl)methanone is a potent and selective 5HT4 receptor agonist. It has been shown to have antidepressant properties in animal models of depression. ((2R,4S)-2-Benzyl-4-((quinolin-4-ylmethyl)amino)piperidin-1-yl)(3,5-dimethylphenyl)methanone has been shown to increase the release of dopamine in the brain. The effective dose for this drug is low, which may be due to its ability to stimulate dopaminergic activity at the postsynaptic level. ((2R,4S)-2-Benzyl-4-(quinolin(4)-ylethynylamino))piperidin(1)-y))(

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Applications 2-(pyridin-3-yl)pyrido[2,3-d]pyrimidine has been used in the preparation of divalent transition metal aminonicotinaldehyde chloride complexes, antimicrobial, antioxidant and antitumor activities, electrochemical and molecular docking with EGFR protein. References Konakanchi R., et al., Res. Chem. Intermed., 44, 27-53 (2018)

Laquinimod is an immunomodulator drug that inhibits the activity of the immune system. It binds to toll-like receptor 7, which is a protein on the surface of certain cells that responds to infection and inflammation. Laquinimod has been shown to inhibit neurodegeneration in vitro, which may be due to its ability to bind with neuronal death receptors and block the inflammatory response. Laquinimod also inhibits bowel disease by reducing inflammation and controlling immunity in the intestinal tract. Laquinimod has been shown to have long-term efficacy when administered at physiological levels. This drug is chemically stable, even after exposure to light.

6-Azaspiro[2.5]octane is a hexane derivative that has been investigated as a possible drug to treat diabetes. It is an amide and may be used as a spirocyclic heterocyclic ring. 6-Azaspiro[2.5]octane may have the ability to reduce blood glucose levels by inhibiting pancreatic lipase, which regulates the production of triglycerides and free fatty acids in the liver. In diabetic rats, 6-azaspiro[2.5]octane reduced blood glucose levels, suggesting that it could be used as a therapeutic agent for diabetes mellitus type 2.

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(2R)-1-[2-[(3-Hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)amino]acetyl]-2-pyrrolidinecarbonitrile is a drug that belongs to the class of DPP-IV inhibitors and is used for the treatment of type 2 diabetes mellitus. It has been shown to be effective in reducing postprandial blood glucose levels in patients with type 2 diabetes mellitus. The mechanism of action of this drug is not fully understood, but it may have an effect on insulin release from pancreatic beta cells and/or inhibition of gastric emptying or intestinal absorption of glucose. This drug has been shown to reduce tubulointerstitial injury in diabetic rats and can be used as a combination therapy for type 2 diabetes mellitus. There are no known clinically relevant interactions between (2R)-1-[2-[(3-Hydroxytricyclo

Please enquire for more information about 2-(3-Chloro-2-methylphenyl)-1,3-dioxoisoindoline-5-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

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5-Methyl-1H-indazole-4-boronic acid is a heteroaryl compound that is used as an intermediate in the synthesis of heteroaryl compounds. It has been shown to have proliferative effects on cells and is often used as a cell proliferation reagent for various proliferative disorders.

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