Polycyclic Compounds

Please enquire for more information about 1-{2-[(4-Carboxyphenyl)amino]-2-oxoethyl}-1H-indole-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

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1-(Dichloroacetyl)-1,2,3,4-Tetrahydroquinolin-6-Ol is an antiamebic. It inhibits the growth of Entamoeba histolytica by inhibiting the phospholipase activity and the synthesis of cell wall lipids. This drug has been shown to be effective against infected hamsters in a hamster model. 1-(Dichloroacetyl)-1,2,3,4-Tetrahydroquinolin-6-Ol inhibits the growth of Entamoeba histolytica by binding to its phospholipase enzyme and preventing it from synthesizing cell wall lipids. The compound also binds to the esterase enzyme that breaks down fatty acids and glycerides in bacteria.

Applications 4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents. References Fu, Y., Zhongguo Xinyao Zazhi, 22, 26 (2013); Liu, M., Adv. Mat. Res., 396, 1490 (2012); Camp, R., et al.: Cancer, 86, 2259 (1999);

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1-Acetylindoline is an endogenous compound that has been shown to have antioxidative activity. It is also a precursor of indole-3-acetic acid and has been shown to reduce the production of proinflammatory cytokines in vitro. 1-Acetylindoline has been found to have hypoglycemic effects in rats, which may be due to its ability to inhibit the release of insulin from pancreatic beta cells. This substance also possesses peptide hormone activities, being a potent inhibitor of prolactin release in vitro. 1-Acetylindoline has also been shown to have antihyperproliferative effects on prostate cancer cells by inducing cell cycle arrest and apoptosis.

Please enquire for more information about 6-Bromo-1-(3-methoxypropyl)-3-methyl-1H-indazole including the price, delivery time and more detailed product information at the technical inquiry form on this page

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2,4-Dichloro-6-methoxyquinoline is an antibacterial agent that selectively inhibits gram-negative bacteria. It binds to the ribosomal RNA of the bacterial cell and inhibits protein synthesis by stopping the formation of a ribosomal complex with the enzyme cell wall synthesis. 2,4-Dichloro-6-methoxyquinoline has been shown to be effective against Gram negative organisms such as Escherichia coli, Salmonella enterica, Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa. This drug also has a high degree of stability in air and light which makes it suitable for use in topical formulations. 2,4-Dichloro-6-methoxyquinoline is not active against Gram positive organisms such as Staphylococcus aureus or Streptococcus pyogenes.

Please enquire for more information about Benzyl 1,2,3,4-tetrahydroquinolin-7-ol including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Ethyl 2,3-dimethyl-1h-indole-5-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

9-(4'-Hydroxyaminophenyl)-9H-pyrido[3,4-b]indole is a heterocyclic amine that has been shown to be genotoxic in animal studies. 9-(4'-Hydroxyaminophenyl)-9H-pyrido[3,4-b]indole is formed during the cooking of meat at high temperatures and can be found in high concentrations in meats cooked at high temperatures. This chemical has been shown to cause chromosomal aberrations, induce DNA strand breaks and inhibit DNA repair enzymes. 9-(4'-Hydroxyaminophenyl)-9H-pyrido[3,4-b]indole may also have carcinogenic effects on humans.

Please enquire for more information about 2-(4-Chlorophenyl)-8-methylquinoline-4-carbonyl chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-(4-Isobutoxyphenyl)-6,8-dimethylquinoline-4-carbonyl chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

2-Propylquinoline-4-carboxylic acid is an organic compound that has been shown to have antibacterial, antiviral, and antitubercular properties. It has also been shown to have antidepressant and antimicrobial activities. 2-Propylquinoline-4-carboxylic acid belongs to the class of hydrazides and hydrazones that are derived from a chemical reaction between an amino group and a carbonyl group in which a water molecule is eliminated. The chemical structures of this compound include the hydrazide, hydrazone, and oxime derivatives. 2-Propylquinoline-4-carboxylic acid has been shown to be active against protozoa such as trypanosomes, leishmania, amoeba, and giardia in laboratory tests. It also exhibits antiinflammatory activity by inhibiting prostaglandin synthesis in rat peritoneal mast cells.

Please enquire for more information about 6-Pyridin-3-Yl-1H-Indazole including the price, delivery time and more detailed product information at the technical inquiry form on this page

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4,4'-Dinitro-2,2'-bipyridine-N,N'-dioxide is a fine chemical with a high quality. It is a versatile building block with a wide range of applications in research and as a reagent. The compound is used in the synthesis of organic compounds and many other products. This product can be used as an intermediate for the production of more complex compounds or scaffolds. 4,4'-Dinitro-2,2'-bipyridine-N,N'-dioxide has been shown to be useful in the synthesis of pharmaceuticals and agrochemicals.

2-Amino-1-methylimidazo[4,5-f]quinoline (IQ) is a heterocyclic amine that can be found in cooked meat. It has been shown to have genotoxic effects in animals and mammalian cells, as well as genotoxic effects in the bacterial model organism, typhimurium. 2-Amino-1-methylimidazo[4,5-f]quinoline is structurally similar to nitroarenes, which are known to be reactive and genotoxic. The chemical reacts with DNA bases and forms adducts; these adducts can lead to mutations or cell death. IQ has been shown to cause mutations at the thymidine kinase locus of DNA and is mutagenic.

Please enquire for more information about Ethyl L-octahydroindole-2-carboxylateHCl including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Please enquire for more information about 2-(4-Chlorophenyl)-8-methylquinoline-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Please enquire for more information about 1-Acetyl-8-allyl-1,2,3,4-tetrahydroquinoline including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Quinoline-8-carbaldehyde (QCA) is a pharmaceutical drug that inhibits the growth of human tumor cells in culture. QCA is a fluorescent probe that binds to copper ions, forming a copper complex. This compound has been shown to have significant cytotoxicity against liver cells and synchronous fluorescence in living cells. QCA also has biological properties that are similar to epidermal growth factor, which may be due to its ability to activate tyrosine kinase receptors. The mechanism studies for this drug have been conducted using hydrochloric acid and showed that it inhibits the expression of EGF-R mRNA.

Please enquire for more information about 2-[3-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-isoindole-1,3-dione including the price, delivery time and more detailed product information at the technical inquiry form on this page

Meranzin, a bioactive from TCM CSS, targets alpha 2-adrenoceptor, affects AMPA-ERK1/2-BDNF pathway, and may prevent atherosclerosis and depression.

Tert-Butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride (TBDAHC) is a fine chemical that is an intermediate for the synthesis of other compounds. TBDAHC is a versatile building block that can be used in research chemicals, reaction components, and specialty chemicals. It is also a useful scaffold for making complex compounds and useful building blocks. The compound has high quality and can be used as a reagent in organic chemistry.

Please enquire for more information about 3-(2,6,6-Trimethyl-4-oxo-5,6,7-trihydroindolyl)benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

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2,2'-Biquinoline-4,4'-dicarboxylic acid disodium salt is a model system for studying the sequence and hydrogen bonding interactions of polymers. It is a biocompatible polymer that has been shown to have inhibitory properties in response to atherosclerotic lesions. 2,2'-Biquinoline-4,4'-dicarboxylic acid disodium salt has shown optical properties that can be used as a signal in recording sequences. This polymerase chain reaction (PCR) substrate is able to bind with DNA and protein molecules when they are present in an appropriate buffer. The sequence of 2,2'-biquinoline-4,4'-dicarboxylic acid disodium salt is controlled by the coordination geometry of the metal ions involved in its formation.

7-Methylindole is a biochemical substance that is synthesized in the body. It is produced in the liver, and it can be found in the brain, heart, and kidney. 7-Methylindole has been shown to have cancer-fighting properties. 7-Methylindole binds to DNA by methylating nucleic acid bases, which causes a change in the genetic code. This leads to tumor cells being more sensitive to treatment with other substances that inhibit DNA synthesis or repair, such as anthranilate and 5-methoxyindole.

Applications tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate (cas# 203661-69-2) is a useful research chemical.

Please enquire for more information about 1-(2-Chloro-6-fluorobenzyl)-1H-indole-3-carbaldehyde including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-(5-Chloro-2-thienyl)-6-methylquinoline-4-carbonyl chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Please enquire for more information about 4,5-Dimethoxy-1H-indole-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

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2-Amino-4-methyl-Quinoline-3-carbonitrile is a potent antitumor drug that belongs to the class of quinolines. It inhibits DNA synthesis and protein synthesis, leading to cell death. 2-Amino-4-methyl-Quinoline-3-carbonitrile has been shown to be effective against a number of cancer cell lines, including human breast cancer cells and leukemia cells. The pharmacological activity of this compound may be due to its ability to form formic acid and nitrous oxide in vivo, which can lead to DNA damage and inhibition of protein synthesis. This drug also has a high degree of homology with other quinolines, such as chloroquine, which have been used as an antimalarial agent for decades.

Doxorubicin is a drug that is used in the treatment of cancer. It binds to DNA and RNA, causing double-stranded breaks and inhibiting protein synthesis. Doxorubicin also inhibits the activity of anhydrase, an enzyme involved in glycolysis. Doxorubicin has been shown to have anticancer activity in vitro and in vivo. The drug has been shown to be effective against many types of cancer cells, including breast cancers, leukemia, lymphomas, and sarcomas. In addition, doxorubicin can bind to retinoic acid receptors on the surface of cancer cells which leads to cell death by apoptosis.

Please enquire for more information about 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline including the price, delivery time and more detailed product information at the technical inquiry form on this page

Quinoline Ethiodide is a chemical compound that has the formula CHN. It is a yellow liquid. Quinoline Ethiodide is used in the preparation of emulsions, unsymmetrical dyes, and arsenious anhydride. It is also used as a reagent for the preparation of active methylene compounds, thiourea, nicotine, ethanol solutions, anions, hydrofluoric acid, methyl groups, triethyl orthoformate, cyanines and other organic compounds containing nitrogen atoms. Quinoline Ethiodide can be prepared by adding hydrochloric acid to quinoline in ethyl alcohol solution with triethyl orthoformate as catalyst.

Applications 2-(1-Cyanoethyl)indole-13C215N is an isotope labelled intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals. References Pezzuto, J.M., et al.: Biochem., 20, 298 (1981), Takeda, K., et al.: Chem. Pharm. Bull., 29, 1280 (1981),

Decursinol is a coumarin derivative, which is sourced from the roots of the plant Angelica gigas, commonly found in East Asia. The compound is recognized for its biochemical properties, specifically as a secondary metabolite in the umbelliferous family. Its mode of action involves the inhibition of key inflammatory pathways, notably through the suppression of pro-inflammatory cytokines and enzymes such as COX-2 and NF-κB. This molecular interaction effectively reduces inflammatory responses at the cellular level. The use of Decursinol spans various scientific applications, primarily focusing on its potential therapeutic effects in treating inflammatory-related conditions. Research indicates significant promise in conditions such as arthritis, neuroinflammation, and other chronic inflammatory diseases. Its ability to mitigate oxidative stress further accentuates its relevance in neuroprotective studies. As ongoing research continues to elucidate its mechanisms and expand its applications, Decursinol represents a promising candidate in the development of novel anti-inflammatory therapeutics.

1-Phenanthrol is a naturally occurring phenanthrene derivative that is used in the treatment of cervical cancer. It has been shown to be effective in the chemiluminescence method using urine samples, which indicates that it may have an effect on the body's metabolism. 1-Phenanthrol has also been shown to inhibit the production of s-phenylmercapturic acid, which is a metabolite of aromatic amines. This inhibition may be due to its receptor binding properties as it binds to and activates the peroxisome proliferator-activated receptor alpha (PPARα) and PPARγ. 1-Phenanthrol also inhibits angiotensin II type 1 receptors and can cause vasorelaxation by reducing blood pressure.

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2-Aminoquinoline is a metabolic inhibitor that is used to treat disorders caused by an excess of copper in the body. It reacts with copper and forms a blue solution. This reaction can be monitored by adding 2-aminoquinoline to a solution containing copper chloride and an indicator, such as starch or phenolphthalein. The formation of the blue complex between 2-aminoquinoline and copper chloride indicates that the drug has successfully inhibited the enzyme responsible for the disorder. 2-Aminoquinoline binds to copper ions and prevents them from being able to bind to other proteins in order to form enzymes, which are necessary for cellular function. This binding leads to apoptosis (cell death) by inhibiting protein synthesis. 2-Aminoquinoline also inhibits epidermal growth factor (EGF) activity, which may lead to skin cancer. It blocks EGF receptors on cells and prevents them from signaling downstream pathways involved in cell proliferation, leading to

Applications 4,6,7,8-Tetrahydro-2,5(1H,3H)-quinolinedione (cas# 5057-12-5) is a compound useful in organic synthesis.

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4-Bromo-2-methylquinoline is a synthetically useful coupling agent that reacts with anilines and aryl halides to form chlorides, bromides, or iodides. It is more efficient than the related coupling agents 4-bromo-2-chloroquinoline and 4-chloro-2-methylquinoline. The reaction proceeds under mild conditions, with catalysts such as metal salts or base. 4-Bromo-2-methylquinoline can be used in reactions involving anhydrous solvents, but it is also soluble in water and organic solvents such as dichloromethane.

7-(Diethylamino)-3-(1-methyl-2-benzimidazolyl)coumarin is a fluorescent dye, which is synthesized through chemical derivatization of coumarin compounds. Originating from coumarin, a naturally occurring compound in plants, this dye is particularly noted for its ability to fluoresce under UV and visible light. The mode of action involves its excited electron state, which emits light upon returning to a ground state, making it useful for applications requiring visualization under a microscope or spectrometer. This photophysical property is central to its role as a reporter in various biological and chemical assays. Primarily, this compound finds applications in the fields of biochemistry and molecular biology for its utility in fluorescence microscopy, flow cytometry, and cell viability assays. It is an integral tool for tracing biochemical pathways, analyzing cellular components, and assessing physiological functions in living cells. By conjugating with specific biomolecules, researchers can obtain detailed information on molecular interactions and dynamics within complex biological systems, aiding in a deeper understanding of biological processes.

Applications 1-(5-Fluoropentyl)-1H-indole-3-carbonyl Chloride is an intermediate for the synthesis of Methyl 2-(1-(5-Fluoropentyl)-1H-indole-3-carboxamido)-3-phenylpropanoate (M224944), which is a useful intermediate for organic synthesis.

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1H-Indazole-3-carbonitrile belongs to a class of drugs that inhibit the activity of acetyl-coa carboxylase, an enzyme involved in the synthesis of fatty acids. It has been shown to be effective against hypertonia and modulated diabetics. 1H-Indazole-3-carbonitrile also inhibits viral replication and is used as an antiviral agent. This drug has been found to be effective against HIV infection and may be useful for treating cardiovascular diseases such as cancer or diabetes.

(1R,4S,5S,8R)-8-[(Z)-2-[2,4-Bis(Trifluoromethyl)Phenyl]Ethenyl]-4,8-Dimethyl-6,7-Dioxabicyclo[3.3.1]Nonan-3-One is a sesquiterpene lactone that has been shown to have anti-cancer effects against human liver cancer cells. This compound is an analog of the natural product artemisinin and is structurally similar to the herb Artemisia annua L. It has been shown to inhibit cell growth in vitro and in vivo by binding to the p450 enzymes in the liver and blocking their activity. The low bioavailability of this compound is due to its high degree of chemical structure complexity which inhibits absorption from the gut. (1R,4S,5S,8R)-8-[(Z)-2-[2,

3-Chloro-6-(2-hydroxyethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (3CPE) is an experimental drug that has been shown to have disordered properties. It is a hydrogen bond donor, which means it can form bonds with other compounds through hydrogen bonding. 3CPE has been shown to be a chain molecule and exhibits hydrogen bonding in the crystal structure. The crystal data for 3CPE show that it has a nitro group on the second carbon atom of the pyrazole ring, which may explain its antibacterial activity.