Polycyclic Compounds

6,6'-Dibromo-2,2'-bipyridine is a synthetic molecule that is used to produce amines. It can be synthesized in a cross-coupling reaction involving the reaction of an amine with bromine and a palladium catalyst. 6,6'-Dibromo-2,2'-bipyridine reacts with formaldehyde to form 2,4-diaminobiphenyls. This reaction is catalyzed by acid or base. 6,6'-Dibromo-2,2'-bipyridine has been shown to be reactive and photoexcited. Its photophysical properties make it a useful synthetic intermediate for the production of amines.

Esculetin dibenzyl ether is a chemical compound, which is a derivative of esculetin, a natural coumarin obtained chiefly from plant sources such as the bark of horse chestnut and other similar species. The source of esculetin dibenzyl ether is typically synthesized from natural precursors through chemical modifications, allowing for the exploration of its structural analogs. The mode of action of esculetin dibenzyl ether involves interactions at the molecular level with various biological pathways. Its structural attributes allow for the potential modulation of enzyme activity, antioxidant properties, and interactions with cellular signaling mechanisms, which are areas of considerable interest in scientific research. This compound finds uses primarily in research applications, serving as a tool for investigating the biological activities and therapeutic potential of coumarin derivatives. Specifically, it is used in the study of anti-inflammatory, antioxidant, and potential anticancer properties, making it valuable in drug discovery and development contexts. Its application is crucial in elucidating the mechanistic pathways of natural compounds and their synthetic analogs in biological systems.

Monomethyl triazeno imidazole carboxamide (MTIC) is a drug that is used to treat cancer. It has been shown to inhibit the proliferation of tumor cells and induce apoptosis by inhibiting the expression of proteins, such as Bcl-2, which are involved in regulating mitochondrial membrane potential. MTIC has also been shown to inhibit protein synthesis and cell signaling pathways, such as the PI3K/Akt pathway. The use of MTIC for diagnosis purposes can be achieved using electrochemical impedance spectroscopy. A concentration-time curve can be obtained by incubating a biological sample with MTIC and measuring cell response using an impedance spectrophotometer. The clinical properties of MTIC include its ability to be administered orally or intravenously, have low toxicity, and inhibit the growth of tumor cells in vivo and in vitro.

3-[2-(Dimethylamino)Ethoxy]-1-[3-(Trifluoromethyl)Phenyl]-1H-Indazole is an aporphine alkaloid with anti-cancer, trypanocidal and antineoplastic activities. It binds to DNA as a potent inhibitor of DNA synthesis and RNA polymerase. 3-[2-(Dimethylamino)Ethoxy]-1-[3-(Trifluoromethyl)Phenyl]-1H-Indazole inhibits cell proliferation by binding to the beta subunit of human DNA polymerase II, blocking the extension of the 3'-end of the growing DNA strand. In addition, it prevents transcription by inhibiting RNA polymerase from transcribing messenger RNA (mRNA). 3-[2-(Dimethylamino)Ethoxy]-1-[3-(Trifluoromethyl)Phenyl]-1H-Indazole also has antiplas

L-Indoline-2-carboxylic acid is a chiral organic compound that can be used as an asymmetric synthesis substrate. It is a nitro compound that has been shown to inhibit the growth of bacteria in the environment, such as Pseudomonas aeruginosa and Escherichia coli. L-Indoline-2-carboxylic acid is found to have a stereoselective nitro group at position 3, which means it can be used for the production of l-phenylalanine from nitrobenzene. It also has conformational properties and can be immobilized on an agarose gel. This chemical may be involved in ganglion cell death due to its ability to induce deformation of these cells in culture. L-Indoline-2-carboxylic acid also has enzymatic activity when it acts as a substrate for enzymes such as chymotrypsin or trypsin.

Applications 2’,3’,5’-Tri-O-benzoyl Xanthine-13C5 is an intermediate used in the synthesis of Xanthosine-13C5 (X742102), which is the labeled analogue of Xanthosine (X742100), the deamination product of Guanosine. It is also a potential biomarker for detecting radiation exposure. References Magasanik, B, et al.: J. Bio. Chem., 206, 83 (1954);

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Indoline is a drug that belongs to the class of drugs used for treating diabetes mellitus. It is an orally active hypoglycemic agent, which lowers blood sugar by stimulating insulin release from the pancreas. Indoline also has inhibitory properties against replication of viruses and cancer cells, and can be used to treat autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. Indoline is a precursor to the anti-cancer drug indoramin. The synthesis of indoline involves a Suzuki coupling reaction with hydroxylated indole substituted with two chlorine atoms or two bromine atoms. This coupling reaction yields both the 2-chloroindoline and 2-bromoindoline products in a 1:1 ratio.

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7-Bromo-1H-indazole is a brominated indazole with an unusual amino acid sequence. It can be used as a building block for the synthesis of new compounds that have potential as medicines. 7-Bromo-1H-indazole has been investigated in cancer cell lines, and it has been shown to inhibit the growth of these cells by inhibiting the production of chloride ions. The molecular modeling of this compound has also shown that it may bind to the chloride channel on cancer cells, preventing chloride ions from entering or leaving the cell. The X-ray crystal structures show that 7-bromoindazole binds with hydrogen bonds to azobisisobutyronitrile (AIBN) and ruthenium complex, which are both potential anticancer drugs.

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Stability Hygroscopic Applications 2-Amino-6-mercaptopurine-9-D-riboside Hydrate (cas# 345909-25-3) is a compound useful in organic synthesis.

2-Hydroxyquinoline is a coumarin derivative that has inhibitory properties against a variety of human pathogens, including the causative agent of malaria. It binds to the active site of the enzyme xanthine oxidase, which catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid. 2-Hydroxyquinoline inhibits this reaction, preventing the accumulation of uric acid in the blood and urine. This compound also has potential anticancer activity due to its ability to inhibit tumor cell proliferation in human prostate cancer cells. 2-Hydroxyquinoline is metabolized by cytochrome P450 enzymes and has pharmacokinetic properties that include an inhibitory dose (ID50) of 1mg/kg.

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5-Bromo-1-methyl-1H-indole-2,3-dione is a molecule that belongs to the group of mesomeric transition compounds. It is a solid at room temperature and can be used in cross-coupling reactions with a variety of metal catalysts. This compound was used in the synthesis of oxoindoles, which are potent inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 5-Bromo-1-methyl-1H-indole-2,3-dione has also been shown to inhibit carbamazepine metabolism in humans.

1-Hydrazinoisoquinoline is a pressor agent that binds to the α- and β-adrenergic receptors in the body. It also inhibits the enzyme aldehyde oxidase, which reduces nitrite to nitric oxide. This drug has been shown to increase blood pressure by acting on the carotid artery, which may be due to its ability to inhibit noradrenaline release from nerve endings. 1-Hydrazinoisoquinoline is metabolized through glucuronidation, forming a glucuronide conjugate with glutathione, which is excreted in urine.

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2-Phenylindole is an experimental drug that inhibits the reuptake of serotonin by binding to the serotonin transporter. It is also a potential treatment for cancer, as it inhibits tumor growth and metastasis. The chemical stability of 2-phenylindole has been studied in a number of solvents, including water, hydrochloric acid, and calcium stearate. The structural analysis of this compound has been conducted using nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. These studies have elucidated the pharmacokinetic properties of this compound. 2-Phenylindole binds to estrone sulfate receptors with inhibitory properties on HIV infection.

The 8-(Difluoromethoxy)-1-Ethyl-6-Fluoro-7-[4-(2-Methoxyphenyl)Piperazin-1-Yl]-4-Oxoquinoline-3-Carboxylic Acid is a proton pump inhibitor that blocks the H+/K+ ATPase enzyme, which is required for acid secretion. The inhibition of this enzyme leads to decreased acid production and an increased pH in the stomach. 8-(Difluoromethoxy)-1-Ethyl-6-Fluoro-7-[4-(2-Methoxyphenyl)Piperazin-1-Yl]-4-Oxoquinoline-3 Carboxylic Acid has been shown to be effective in reducing gastric acidity in patients with gastroesophageal reflux disease (GERD). In addition, this medication is used to treat Zollinger Ellison syndrome

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5,7-Dibromo-1H-indole-2,3-dione is a selenium compound that has been synthesized to be used as an analog of vinblastine. It has anti-cancer activities and has been shown to inhibit the growth of primary tumor cells in mice. 5,7-Dibromo-1H-indole-2,3-dione also has pharmacokinetic properties that are similar to those of vinblastine sulfate. This compound can be used in cancer research as a test compound for assessing anticancer activity.

5-Fluoroindole-3-carboxylic acid is an indole derivative with a dihedral, planar and stacking geometry. This compound has a carboxyl group that stabilizes the molecule by forming hydrogen bonds with neighboring molecules. 5-Fluoroindole-3-carboxylic acid can be used as a starting material to synthesize other organic compounds. The compound can be found in methanol, which is produced by fermentation of glucose or other carbohydrates.

Applications 6-Chloro-3,4-dihydro-4-hydroxy-3-(phenylsulfonyl)-4-(trifluoromethyl)-2(1H)-quinolinone is an intermediate in the synthesis of novel quinolinones as HIV-1 reverse transcriptase inhibitors. References Patel, M., et al.: Bioorg. Med. Chem. Lett., 11, 1943 (2001);

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4,7-Dichloroquinoline 1-oxide is a chlorine compound that is soluble in water. It is noncombustible and has a weak odor. 4,7-Dichloroquinoline 1-oxide is an organic synthesis intermediate that can be used to make 4,7-dichloroaniline. This compound can be found naturally in the environment as a byproduct of the chlorination of phenols and other aromatic compounds. 4,7-Dichloroquinoline 1-oxide also occurs as an isomer of 2,4-dichlorophenol. Crystals are formed when this substance is heated with potassium hydroxide.

(1R,3S,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane is a versatile building block that can be used in the synthesis of complex compounds. It is a reagent and speciality chemical with applications in research or as a useful intermediate in the synthesis of other chemicals. (1R,3S,5S)-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane is also a useful scaffold for the synthesis of other compounds with specific properties such as high quality and usefulness as reaction components.

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Applications 2-BROMOPHENANTHRENE (cas# 62162-97-4) is a useful research chemical.

Applications 1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridyl)quinoline-3-carboxylic Acid Ethyl Ester is an intermediate in the synthesis of Rosoxacin (R693580), an antibacterial agent used against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae. References Koba, M., et. al.: J. Mol. Modeling, 16, 327 (2010)

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2,4-Dichloro-6-methylquinoline (2,4-DMCQ) is a potent anti-cancer agent that has been shown to induce apoptosis in squamous carcinoma cells. It is an oxychloride with a molecular weight of 293.88 g/mol and a melting point of 174.7 °C. 2,4-DMCQ also inhibits the growth of various tumor cell lines in vitro through the induction of apoptosis, as well as by inhibiting DNA synthesis and protein synthesis. Additionally, 2,4-DMCQ inhibits annexin V binding and phosphatidylserine externalization. The crystal structure of 2,4-DMCQ has been determined using X-ray crystallography techniques at high resolution (1.9 Å). 2,4-DMCQ belongs to the cyclic family of compounds with a planar ring system displaying two different conformations: one conformation displays the methyl

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Seselin is a natural product from Plumbago zeylanica. Seselin shows anti-inflammatory and antiviral activity.

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