Polycyclic Compounds

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(1R,5R,6R)-2-Amino-4-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid is a synthetic compound that is used in the study of the brain and nervous system. It is a noncompetitive inhibitor of the metabotropic glutamate receptor 2/3 (mGlu2/3) that blocks glutamate mediated excitatory neurotransmission by binding to postsynaptic mGlu2/3 receptors and preventing glutamate from activating them. This drug has been shown to have antipsychotic effects, which are thought to be related to its ability to inhibit dopamine release in the nucleus accumbens. In addition, this drug has been shown to act as an antagonist at the 5HT1A serotonin receptor in rat cortical slices and as a partial agonist at 5HT2A serotonin receptor in rat prefrontal cortex slices. Finally, this drug has also been shown to bind

2-Chloro-3-(chloromethyl)quinoline is a nonclassical, tetracyclic molecule with a structural analysis section. It is structurally related to chalcones and conformational analysis of 2-chloro-3-(chloromethyl)quinoline has been performed by chiral synthesis, nuclear magnetic resonance spectroscopy and X-ray crystallography. This drug has been shown to initiate the synthesis of natural products, heterocycles, and synthetic molecules that are used in drug development. Organizes the skeleton of 2-chloro-3-(chloromethyl)quinoline into rings A, B, C, D, E, F.

Methyl (1R,2S,3S)-8-(3-Fluoropropyl)-3-(4-Iodophenyl)-8-Azabicyclo[3.2.1]Octane-2-Carboxylate is a potent dopamine receptor agonist with a high affinity for the D2 and D3 receptors in the brain. It has been shown to have antiparkinsonian effects in animal models of Parkinson's disease by increasing dopamine levels in the prefrontal cortex and striatum. This drug has also been shown to be effective in clinical studies for the diagnosis of Parkinson's disease. Methyl (1R,2S,3S)-8-(3-Fluoropropyl)-3-(4-Iodophenyl)-8-Azabicyclo[3.2.1]Octane-2-Carboxylate binds to both dopamine and serotonin receptors, which may account for its therapeutic effects on Parkinson

Ethyl 3-isoquinolinecarboxylate is an azide that has been synthesized and activated. It is a mesomorphic liquid with a boiling point of 116° C. With the addition of xylene, ethyl 3-isoquinolinecarboxylate yields azidoacetate. This is then reduced to dihydroisoquinolines with sodium borohydride in ethanol. The nucleophilic nature of ethyl 3-isoquinolinecarboxylate allows it to react with amines to form an enamine by transferring a proton from the nitrogen atom in the amine group to the carboxylic acid group on ethyl 3-isoquinolinecarboxylate. Ethyl 3-isoquinolinecarboxylate can also be used as a trackable substrate for chemical reactions because it contains an azide moiety, which can be detected using infrared spectroscopy or NMR spectroscopy.

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Please enquire for more information about 2-(4-sec-Butylphenyl)-6-chloroquinoline-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

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Isosibiricin is a naturally occurring lignan, which is extracted from certain plant sources. This compound is derived from the genus Daphne, traditionally known for its diverse range of biologically active constituents. Its mode of action is primarily through the modulation of key signaling pathways involved in cell proliferation and apoptosis. Isosibiricin exhibits notable inhibitory effects on specific enzymes and receptors implicated in oncogenic processes, making it a subject of interest for cancer research. The uses and applications of Isosibiricin extend into the realm of experimental oncology, where it serves as a lead compound for the development of novel chemotherapeutic agents. Its potential to interfere with malignant cell growth and induce programmed cell death without affecting normal cells positions it as a promising candidate for targeted cancer therapies. Current investigations focus on its efficacy, pharmacokinetics, and safety profiles, contributing to the burgeoning field of plant-derived anticancer compounds.

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4,10-Dioxatricyclo[5.2.1.02.6]dec-8-ene-3,5-dione (DTDE) is a hypoglycemic agent that inhibits the synthesis of fatty acids in the liver and reduces blood sugar levels by inhibiting the enzyme diacylglycerol acyltransferase 2 (DGAT2). DTDE has been shown to have antitumour activity against a human cell line and inhibits the replication of DNA and RNA by binding to amines in nucleic acid bases.

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Indole-4-Carboxylic acid is a molecule that belongs to the group of indole carboxylic acids. It is an organic compound that has a dipole moment and isomers. Indole-4-carboxylic acid can be synthesized by the saponification of indole-7-carboxylic acid, which has two functional groups: a hydroxy group and an amide group. The molecule has a chemical structure with an amide bond between the carboxyl and amino groups at one end, which forms a protonated amide. This protonated amide also has two orientations: trans and cis. The trans orientation is found in human cytochrome P450 and other proteins, while the cis orientation is found in enzymes such as tryptophan synthase, indoleamine 2,3 dioxygenase, or tyrosine hydroxylase.

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2-Amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ) is a genotoxic agent that can cause DNA damage and cell death in mammalian cells. IQ is metabolized by cytochrome P450 enzymes to reactive metabolites that bind to DNA and inhibit topoisomerase II. This leads to the formation of bulky adducts in the DNA and ultimately causes cell death. IQ has been shown to be carcinogenic in mice, as it induced liver lesions and t-cell lymphomas. The drug has also been used as a model system for the study of carcinogenesis caused by 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP).

2,8-Dibromoquinoline is an amide that is used as a cocatalyst in palladium-catalyzed cross-coupling reactions. It is a proton donor and can assist with the activation of hydrogen. 2,8-Dibromoquinoline has been shown to inhibit the target enzyme, phosphofructokinase, by binding to its pharmacophore. This causes the inhibition of ATP synthesis and leads to cell death. The intramolecular hydrogen bond of this compound stabilizes the active form and allows for copolymerization with other molecules.

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Alloisoimperatorin is a naturally occurring furanocoumarin compound, which is extracted from certain plant species, primarily those belonging to the Apiaceae family. As a type of coumarin derivative, it is synthesized through intricate plant metabolic pathways involving the precursors umbelliferone and isopentenyl pyrophosphate, among others. The mode of action of alloisoimperatorin is not completely elucidated, but it is believed to exert biological effects through modulation of enzymatic activities and interference with cellular signaling pathways. Its interaction with cytochrome P450 enzymes and perturbation of calcium ion channels might contribute to its diverse biological activities. Alloisoimperatorin is of considerable interest for its potential pharmacological applications, particularly in the fields of anti-inflammatory and anti-cancer research. It has been explored for its inhibitory effects on tumor cell proliferation and its capability to induce apoptosis in vitro. Additionally, due to its structural properties, it may serve as a precursor or inspiration for the development of novel therapeutic agents. Further research is necessary to fully understand its mechanisms and to evaluate its efficacy and safety in clinical contexts.

Applications tert-​Butyl 6-​Hydroxy-​2-​azaspiro[3.3]​heptane-​2-​carboxylate is a reactant used in the synthesis of pharmaceuticals such as CNS penetrant CXCR2 antagonists for the potential treatment of CNS demyelinating. References Xu, H. et al.: ACS Med. Chem. Lett., 7, 397 (2016);

Ticarcillin is a drug that belongs to the group of antimicrobial agents. It is used as an antibiotic for the treatment of infections caused by gram-positive bacteria, such as Staphylococcus aureus and Clostridium perfringens. Ticarcillin has been shown to have no effect against some gram-negative bacteria, such as Pseudomonas aeruginosa. Ticarcillin binds to bacterial ribosomes and inhibits protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division. Ticarcillin has been shown to be effective in treating tissue infections in mice, although it is not active against bowel disease-causing bacteria such as Escherichia coli or Shigella species. Ticarcillin also has been shown to cause resistance in mutant strains of Staphylococcus aureus and Escherichia coli through multidrug efflux pumps that pump out tetracycline

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Applications α-Furil is an important industrial chemical that is used as a building block for synthesis in the pharmaceutical industry. α-Furil is also part of a group of diketones that act as skin sensitizers. References Roberts, D., et al.: Contact Dermatitis, 41, 14 (1999); Wang, L., et al.: Adv. Mat. Res., 554, 764 (2012)

Bis(tetrabutylammonium) Dihydrogen Bis(isothiocyanato)bis(2,2'-bipyridyl-4,4'-dicarboxylato)ruthenium(II) is a polymer film that is used to convert solar energy into electrical energy. It is made from ruthenium and bipyridine-based dyes that are sensitive to light. When exposed to sunlight, the electrons in the metal ions are excited and create a photocurrent. This can be converted into an electrical current by connecting it to a load. The quantum theory of light has been applied for this purpose by considering the electron as a photon with a wavelength of 400 nm. This property has also been studied using electrochemical impedance spectroscopy and kinetic data analysis. The polymer film has also been laser ablated in order to study its transport properties and hydrogen fluoride has been used as an electrolyte to study its dye-sens

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2-Hydroxyisoquinoline-1,3(2H,4H)-dione (2HIQ) is a potent anti-viral agent that has been shown to inhibit the replication of viruses in cell cultures. 2HIQ inhibits viral replication by binding to the enzyme reverse transcriptase and inhibiting its ability to synthesize DNA from RNA. This drug also has inhibitory properties against human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). 2HIQ binds to the active site of the enzyme HIV reverse transcriptase, which is a key enzyme in viral replication. It also binds to HCV NS5B polymerase, which is an essential protein in HCV replication. These interactions lead to inhibition of viral replication and thus prevention of disease progression.

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Lactone

Halquinol, a mixture of 5,7-dichloro-8-quinolinol, 5-chloro-8-quinolinol, 7-chloro-8-quinolinol and 8-hydroxyquinoline, is an important intermediate in organic synthesis. It has been used as a reagent in the synthesis of a variety of complex compounds. Halquinol has also been used as a building block for the synthesis of many other chemical products. The CAS number for halquinol is 806769-4.

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6-Methoxy-1,2,3,4-Tetrahydroquinoline is a compound that belongs to the class of alkanoic acid and is used as a polymerase chain reaction (PCR) reagent. It can be used in culture media for the growth of thallus or probiotic bacteria. 6-Methoxy-1,2,3,4-Tetrahydroquinoline has been shown to have insecticidal properties when applied as a chemical pesticide. It has also been shown to be effective in wastewater treatment and signal peptide preparation. 6-Methoxy-1,2,3,4-Tetrahydroquinoline can be found in plants as well as some insects such as beetles.

1,10-Phenanthroline-2,9-dicarbaldehyde is a supramolecular complex that has been shown to have anticancer activity. It has been shown to inhibit the proliferation of mcf-7 cells and induce apoptosis in these cells. The compound also exhibits cytotoxic effects against other cancer cell lines. 1,10-Phenanthroline-2,9-dicarbaldehyde is an amine molecule that binds copper ions. This binding prevents the formation of reactive oxygen species and mitochondrial membrane potential. 1,10-Phenanthroline-2,9-dicarbaldehyde can also be used as a probe for microscopy experiments as it has a very high extinction coefficient at 400 nm.

3,4-Dihydroisoquinolin-2(1H)-ylacetic acid is a chemical compound with the molecular formula of C8H11NO2. It is a useful scaffold for the synthesis of complex compounds and research chemicals. 3,4-Dihydroisoquinolin-2(1H)-ylacetic acid is also a versatile building block for the preparation of fine chemicals. It is used as a reaction component in many organic reactions and can be used as a speciality chemical or reagent due to its high quality.

5-Bromo-8-methylquinoline is a molecule that belongs to the class of isomeric quinoline derivatives. It can be prepared by reacting chloroform with benzyl alcohol in the presence of catalytic amounts of sulfuric acid and nitric acid. 5-Bromo-8-methylquinoline has a molecular weight of 222.5, a melting point of 150°C, and an optical rotation of +41°C. Its spectrum shows peaks at 248, 295, and 330 nm for the chlorine atoms. The compound has three substituents: two methyl groups and one bromine atom. 5-Bromo-8-methylquinoline can be used in the synthesis of other quinoline derivatives by substitution reactions with amines or alcohols in an organic solvent such as ethanolamine or acetone under acidic conditions.

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8-[3-(4-Fluorobenzoyl)propyl]-1-(4-fluorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one is a pharmaceutical agent that is used for the diagnosis of fatty alcohol and fatty acid metabolism disorders. It has been shown to be a substrate for the transporter gene, which is responsible for the transport of substances into cells. 8-[3-(4-Fluorobenzoyl)propyl]-1-(4-fluorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one also exhibits activity as a gamma aminobutyric acid (GABA) receptor antagonist and antidepressant drug. This compound has been shown to have neutral pH properties and can be mixed with other pharmaceutical preparations such as serotonin in order to control depression symptoms.

Applications 9-oxo-9H-Thioxanthene-4-carboxylic acid (cas# 51762-56-2) is a useful research chemical.

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Isoimperatorin is a naturally occurring furanocoumarin, which is a phytochemical compound found in certain plants, particularly within the Apiaceae family, such as Angelica dahurica. It is extracted from these botanical sources through processes like solvent extraction. Isoimperatorin exhibits a diverse mode of action, including the inhibition of various enzymes and modulation of signaling pathways. It has demonstrated significant effects on cytochrome P450 enzymes, potentially influencing drug metabolism. Additionally, Isoimperatorin has shown antioxidant properties and the ability to interfere with cell proliferation and apoptosis mechanisms. Isoimperatorin is extensively studied for its potential therapeutic applications. Research indicates promising uses in pharmacology, particularly in areas involving anti-inflammatory, anticancer, and antimicrobial effects. Its ability to interact with enzymatic processes suggests potential roles in drug development and metabolic studies. Additionally, Isoimperatorin is of interest in the field of agriculture as a natural pesticide due to its bioactivity against certain pests. Ongoing research continues to explore its full spectrum of biological activities and possible applications in both medical and industrial domains.

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