Polycyclic Compounds

Applications 5,7-Dichloro-4-hydroxyquinoline is an intermediate in synthesizing Quinoxyfen-d4 (Q765502), an isotope labelled Quinoxyfen acts as an agricultural fungicide. References Corrales, M., et al.: Food Chem. Toxicol., 48, 3471 (2010); Lagunas-Allue, L., et al.: Anal. Bioanal. Chem., 398, 1509 (2010); Wong, J., et al.: J. Agric. Food Chem., 58, 5897 (2010)

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Ethyl 4-Hydroxy-7-(trifluoromethyl)quinoline-3-carboxylate is an isomeric, hydroxylamine and chloride salt of the heterocyclic compound ethyl 7-(trifluoromethyl)quinoline-3-carboxylate. The hydroxylamine moiety of the molecule has shown to be cytotoxic against human colorectal carcinoma cells (HCT 116), with a potency similar to that of 5FU. In addition, hydroxylamine has been shown to induce apoptosis in cancer cell lines, which may be due to its ability to inhibit DNA synthesis and protein synthesis.

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2,3-Dihydro-1H-isoindole-1-carboxylic acid is an acidic molecule that can be found in high concentrations in the blood. It is also a metabolite of isoindolines, which are an important class of drugs used to treat chronic hypertension. 2,3-Dihydro-1H-isoindole-1-carboxylic acid belongs to the group of structural formula categorized as an enolate; this group is a type of enzyme inhibitor that blocks enzymes involved in the production of cholesterol. 2,3-Dihydro-1H-isoindole-1-carboxylic acid has been shown to inhibit the activity of two enzymes: cytochrome P450 and sterol C5 reductase. The mechanism behind this inhibition is homologous with other known inhibitors such as 3-(2′,4′dichlorophenyl)acrylic acid (methaz

Applications 6-Hydroxy-1H-indole-3-carboxylic acid (cas# 24370-78-3) is a useful research chemical.

6-Chloro-7-azaindole is a boronic acid that has been used in control experiments to study the mechanism of hepatitis. This compound binds to factor receptor and prevents the growth of cells. 6-Chloro-7-azaindole has been shown to inhibit the production of virus and reduce the replication of replicons. It also inhibits the activities of various growth factors, including hepatocyte growth factor (HGF), fibroblast growth factor 2 (FGF2), and epidermal growth factor (EGF). 6-Chloro-7-azaindole has been shown to inhibit cell proliferation by increasing levels of caspase 3, an enzyme that plays a role in apoptosis.

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2-Chloro-6-Fluoro-4-Methylquinoline is a quinoline derivative that has been shown to be mutagenic. It is metabolized by the liver into an enamine, which reacts with oxygen to form a mutagenic epoxide. This compound is metabolized through a number of metabolic transformations, including oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. 2-Chloro-6-Fluoro-4-Methylquinoline also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

6-Nitroindoline is a nitro compound that inhibits the polymerization of nitrite. It is an acidic acceptor and has been used as an agrochemical to inhibit nitrification in soil. 6-Nitroindoline has been shown to be mutagenic, which may be due to its ability to form covalent bonds with DNA bases or alkylate DNA bases. 6-Nitroindoline can also undergo borohydride reduction, which is the conversion of a compound into a more reduced form by reaction with borohydride.

Pyridoxal 3-Fluorobenzoyl Hydrazone is a chemical compound that belongs to the group of hydrazides. It is an enteric, nucleophilic and acid-uncomplexed compound, which reacts with metal ions to form a complex. Pyridoxal 3-Fluorobenzoyl Hydrazone has been shown to have antimicrobial activity against mycobacterial cells and has been used in the treatment of tuberculosis. The drug also inhibits bacterial growth by reacting with the mycobacterial cell wall, thereby preventing the synthesis of lipids and proteins necessary for bacterial growth.

Tert-Butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate is a modification of tert-butyl 7-oxa-3,8,9,10-tetrahydrobenzo[f]quinoline-3,7(6H)-dicarboxylate (TBA) that has been synthesized by the ring opening of a cyclic ester with an amine. TBA is a chiral molecule and this modification was carried out for the purpose of obtaining enantiomerically pure derivatives. The diastereomers were obtained in high yield and were found to be reproducible. The synthesis of TBA is also carried out using piperidine as a synthetic base. This compound shows pharmacophores that are similar to those found in natural products with antibacterial activity such as magnesein and epigallocatechin gallate.

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5-Nitroindazole is a nitro compound that has been shown to have antineoplastic properties. It inhibits the division of cells by binding to DNA and preventing the formation of hydrogen bonds between purine bases, ultimately preventing DNA replication. 5-Nitroindazole has also been shown to inhibit mitochondrial membrane potential and induce apoptosis in human cancer cells. The antimicrobial activities of 5-nitroindazole are due to its chemical structure which allows for hydrogen bonding with cell walls or other components of bacteria. It is also possible that this compound exerts its action by reacting with nitric acid to form a hydroxyl radical, which can cause oxidative damage to bacterial membranes.

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Piperazin-1-yl-[4-[[7-(trifluoromethyl)quinolin-4-yl]amino]phenyl]methanone (AZD0530) is a novel, potent and selective inhibitor of the enzyme DNA methyltransferase 1 (DNMT1), which is important for cancer cell proliferation. AZD0530 inhibits the growth of malignant cells in vitro and in vivo. It has been shown to inhibit the progression of renal cell carcinoma in mice. AZD0530 has also been shown to be effective against other types of cancer cells, including pancreatic, breast, and leukemia cells. AZD0530 is currently being evaluated as a potential therapeutic agent for treatment of cancers with DNMT1 mutations.

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Quinolin-3-ylmethanol (QM) is a fluorescent compound that has been used as an antibacterial agent. It has been shown to have strong binding affinity for bacterial cell walls and is able to permeate the cell wall by protonation of the phenolic hydroxyl group. QM also has the ability to react with reactive functional groups in bacterial cell walls and can cause crosslinking. The fluorescence of QM is quenched when it binds to bacteria, so it can be used as a probe for determining the effectiveness of antibiotics. Quinolin-3-ylmethanol's high lipophilicity allows it to penetrate cancer cells more effectively than other compounds. This property makes it potentially useful in cancer therapy and imaging.

(1S,3S,4R)-2-Azabicyclo[2.2.1]heptane-3-carboxylic acid is a chiral catalyst for the asymmetric allylic oxidation of proline derivatives to the corresponding allylic alcohols. The catalytic asymmetric allylic oxidation can be used to produce α-amino acids and cyclohexene derivatives from inexpensive starting materials. The tertiary butyl group on this molecule provides steric protection for the active site of the catalyst during the reaction process. It also has a chiral center that allows for an enantioselective reaction by binding with a copper ion in order to form a complex that accelerates the oxidation process.

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6-Methoxyindole-2-carboxylic acid methyl ester is a pyrroloquinoline alkaloid with cytotoxic and antiproliferative activities. It inhibits the growth of cancer cells in culture by inducing apoptosis and cell cycle arrest. 6-Methoxyindole-2-carboxylic acid methyl ester has been shown to be effective against breast cancer cell lines in vitro and to inhibit the proliferation of breast cancer cells in vivo. This compound also inhibits the growth of a number of other cancer cell lines such as prostate, colon, lung, liver, stomach, and leukemia. The mechanism of action for this compound is thought to be due to its ability to act as an intramolecular quencher of reactive oxygen species (ROS) or as an inhibitor of DNA synthesis through inhibition of ribonucleotide reductase activity.

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1-Chloroisoquinoline is a nitrogenous organic compound that belongs to the group of quinolines. It is an acetylcholinesterase inhibitor and has been shown to have biological properties, such as receptor activity, in studies on rats. 1-Chloroisoquinoline has been studied for its use in treating autoimmune diseases such as hepatitis or multiple sclerosis. This drug also inhibits the activity of ns3 protease, which is an enzyme that degrades proteins involved in inflammation. 1-Chloroisoquinoline's light emission property can be used to create a fluorescent probe.

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(+)-Phyllodulcin is a natural sweetener, which is predominantly derived from the leaves of the Hydrangea macrophylla var. thunbergii, commonly referred to as the sweet hydrangea. As a compound, it functions primarily as a sweetening agent by interacting with taste receptors on the human tongue, offering a sweetness intensity significantly greater than sucrose. This compound holds potential as a sugar substitute in various industries owing to its plant-based origin and intense sweetness profile. Being a natural product, its extraction and purification involve phytochemical techniques aimed at preserving its structural integrity while maximizing yield. Its uses extend into food and beverage formulation, where it's considered viable for low-calorie and diabetic-friendly products. Research into the health effects and metabolic pathways of (+)-Phyllodulcin is ongoing, with a focus on safety, efficacy, and potential benefits over synthetic sweeteners. Its mode of action and applicability make it an area of interest for scientists exploring sustainable dietary sweetening alternatives.

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2-Bromoquinoline is an antimicrobial agent that binds to bacterial receptors. It is a bifunctional molecule with two reactive groups: a hydroxyl group and a nitrogen atom. 2-Bromoquinoline has been shown to inhibit the growth of various bacteria, including Mycobacterium tuberculosis, Staphylococcus epidermidis and Streptococcus pyogenes, by preventing the formation of a proton gradient across the bacterial membrane. 2-Bromoquinoline also inhibits hyperproliferative diseases such as amyloidosis in mice by binding to amyloid fibrils. This drug has been shown to cause DNA damage in mammalian cells, which may be due to its ability to form hydrogen bonds with methyl ethyl groups on DNA bases.

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Chelating agent used to detect aqueous copper ions by electrochemiluminescence

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5-Geranyloxy-7-methoxycoumarin is a naturally occurring compound known as a coumarin derivative, which is primarily sourced from specific plant species such as those within the Rutaceae family. This compound is characterized by its unique chemical structure that incorporates both geranyloxy and methoxy functional groups, conferring specific biological activities. In terms of its mode of action, 5-geranyloxy-7-methoxycoumarin's effects are attributed to its ability to modulate enzymatic pathways and interact with cellular receptors, influencing inflammatory responses and exhibiting potential anticancer properties. Research indicates that it can affect cell signaling pathways, leading to reduced cell proliferation or increased apoptosis in certain cancer cell lines. The compound's applications span various fields, including pharmaceuticals, where it is explored for its role in drug development targeting specific inflammatory disorders and cancers. Additionally, its presence in essential oils lends credence to its incorporation in studies focusing on natural product-based formulations and therapeutic interventions. As ongoing research uncovers more about its bioactivities, this coumarin derivative continues to be a subject of interest for developing novel therapeutic agents.

Angelicin is a furanocoumarin compound, which is derived from various plant sources, particularly within the Apiaceae family. The source of angelicin is often linked to traditional medicinal plants, where it is extracted and subsequently isolated for scientific investigation. Angelicin's mode of action involves intercalating within DNA strands, thereby affecting transcription and replication processes. This action is understood to be primarily photoactivated, leading to the formation of covalent bonds with DNA upon exposure to ultraviolet light, which can result in cross-linking. The uses and applications of angelicin are diverse, with its prominent roles evident in phototherapy, where it is employed for its photosensitizing properties. It serves an important function in the treatment of skin disorders such as psoriasis and vitiligo by modulating cell proliferation and differentiation. Additionally, angelicin is studied for its potential anti-inflammatory and antitumor activities, making it a compound of interest in oncological and pharmacological research. The ongoing exploration of its mechanisms and therapeutic potential serves as a catalyst for novel therapeutic strategies, defining its significance in medicinal chemistry.

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Ethyl 2-methylindole-3-carboxylate is a multisubstituted indole that is produced by the catalyzed reaction of ethyl acetoacetate and potassium carbonate. This compound contains two methyl groups, one carboxyl group, and one carboxylic acid group. Ethyl 2-methylindole-3-carboxylate is obtained by heating the corresponding ketone in a sealed tube with potassium carbonate, producing the desired product as a white solid. The yield of this reaction is about 82%.

Applications 6-Chloroisatin (cas# 6341-92-0) is a useful research chemical. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

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Coixol (MBOA) is a muscle relaxant, anti-convulsant, enhances vole reproduction, stimulates ovulation, and regulates mucin in airway cells.

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Ethyl 4,5-dichloro-1H-indole-2-carboxylate is an organic chemical compound that is a reaction component, reagent, and useful scaffold in the synthesis of pharmaceuticals. It has been shown to have high quality and be a versatile building block for the synthesis of complex compounds. This chemical can be used as a speciality chemical or research chemical.

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