Polycyclic Compounds

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1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one (1POX) is a monomer that belongs to the class of cyclopropane compounds and can be used in the synthesis of polymers. It has been shown to react with benzene, irradiation, monoxide, oxiranyl, acetonitrile and trimeric dyes to form reactive intermediates such as ketones and carboxylic acids. These intermediates can undergo photolysis to produce products such as ketones and carboxylic acids. The wavelength of the light used for photolysis can influence the product formation. 1POX is also a substrate for cyclopropane ring formation reactions, which are known for their high reactivity due to the stability of this ring system. The carbonyl group on 1POX is electron withdrawing and stabilizes the planar geometry of 1POX.

A metabolite of etravirine

Applications 8-Hydroxyquinoline Copper Salt is used in the formulation of biocide microcapsules towards stabilized iodine-​containing compounds for protection of technical materials from degradation by microorganisms. References Boettcher, A., et al.: PCT Int. Appl. (2012), WO 2012076699 A1 20120614

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3-Methyl-2-pyridone is an intermediate in the biosynthesis of pyridine nucleotides. It is activated by intramolecular hydrogen and water molecule, which are released during the enzymatic decarboxylation of 3-methyl-2-pyridone to form a reactive imine group. This group then reacts with a carboxylic acid group to form an amide. 3-Methyl-2-pyridone also has a hydrophobic tail that stabilizes the enzyme complex by reducing Coulombic repulsion. The genetic factors that influence the activity of this enzyme include polymorphisms in the gene encoding for HADH and HMGCS1, as well as mutations in the gene encoding for SLC25A1.

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Methyl indole-5-carboxylate is a hdac inhibitor that has been shown to have anticancer activity. It has been shown to inhibit the growth of hCT116 cells and xenograft tumors in mice. Methyl indole-5-carboxylate is also an active analog for other anticancer agents, such as 5-azacytidine and 5-aza-2'-deoxycytidine. The drug is cytotoxic to L6 cells and increases the expression of p21 protein, which inhibits tumor cell proliferation. This compound is metabolized by cytochrome P450 enzymes into methyl indole carboxylate, which can be further converted into a reactive intermediate that binds DNA.

Quinoline-5-carboxylic acid hydrazide is a bifunctional fluorescent derivative that has been used as a model compound for the study of hydrogenolysis, which is the cleavage of a molecule using hydrogen gas. Quinoline-5-carboxylic acid hydrazide can be synthesized by condensation of an amine with an azide, followed by alcoholysis. This compound displays fluorescence when reacted with an azide and quinoline derivatives. The reaction between the quinoline-5-carboxylic acid hydrazide and the azide produces a new molecule that contains a quinoline group in addition to the hydrazine group.

3-(2-Chlorophenyl)-2-phenyl-3H-indole is a versatile building block that can be used as a precursor in the synthesis of a wide range of complex compounds. 3-(2-Chlorophenyl)-2-phenyl-3H-indole has been shown to be an effective reagent for the synthesis of heterocycles and useful for the preparation of diverse speciality chemicals. 3-(2-Chlorophenyl)-2-phenyl-3H-indole is also an important intermediate in the synthesis of pharmaceuticals, agrochemicals, dyes, and perfumes. It is also a useful scaffold for organic chemistry reactions and can serve as a reaction component because it contains two reactive groups.

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Applications 6-Dimethylaminopurine-9-riboside (cas# 2620-62-4) is a compound useful in organic synthesis. References Elion, G.B., et al.: JACS, 74, 411-414 (1952), Kelley, J.L., et al.: J. Med. Chem., 32, 1020-1024 (1989)

6-Bromoisoquinolin-1-ylamine is a catalytic reagent for the conversion of alcohols to amines. It has been optimized for the reaction with amines and alcohols containing hydroxyl and hydroxylamine functional groups in subsites. 6-Bromoisoquinolin-1-ylamine has shown high affinity towards benzamidine and anionic substrates, and can inhibit a number of enzymes including tyrosinase, nitric oxide synthase, tryptophan 2,3-dioxygenase, and cytochrome p450. 6-Bromoisoquinolin-1-ylamine can be used in both xray crystallography screening and molecular modeling studies.

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7-Ethylindole is a fatty acid with a cationic surfactant that belongs to the group of mesoporous materials. It has been synthesized by using chromatographic method and sample preparation techniques. The synthetic process is based on the protonation of 7-ethylindole. It undergoes dehydrogenation and activation energy, which is programmed in copper chromite. The chemical compositions are chloride, hydrogenated, and activated 7-ethylindole.

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5-Benzyloxyindole-3-acetonitrile is a linker molecule that can be used to connect pharmacophores with melatonin receptors at the MT2 receptor. This ligand has been shown to bind efficiently and selectively to the MT2 receptor, which is in contrast to other ligands such as 5-benzyloxyindole-3-acetonitrile. The affinity of this ligand for the MT2 receptor was found to be comparable to melatonin.

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Applications 3,4-Dihydro-6-nitro-2(1H)-quinolinone is a useful intermediate for organic synthesis. It is used in the synthesis of triazolyl dihydroquinoliinones with anticonvulsant and antidepressant activity. References Deng, X., et al.: Eur. J. Med. Chem., 73, 217 (2014)

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1,3-Dibromoisoquinoline is a chemical compound with two isomers. The 1,3-isomer is the more biologically relevant form of this molecule. It has been shown to have antifungal and anticancer properties. 1,3-Dibromoisoquinoline also exhibits ionisation mass spectrometry properties and can be used as a biomarker for human ovarian carcinoma. It is an alkylsulfonyl group that can be used as a precursor in the synthesis of pyridine compounds.

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Applications 5,7-Diazaspiro[3.4]Octane-6,8-Dione (cas# 89691-88-3) is a useful research chemical.

Applications 5,7-Dichloro-1,2,3,4-tetrahydro-2-(triphenylmethyl)-6-isoquinolinecarboxylic Acid, can be sued in the preparation of novel series of compounds which has been found to be a potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for treating dry eye. References Zhong, M. et al,: ACS Med. Chem. Let. Vol. 3, page 203-206 (2012);

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2,5-Dimethylquinolin-8-ol is a synthetic organic compound with the molecular formula C9H10O2. It has a melting point of 82.4 °C and a boiling point of 212 °C. 2,5-Dimethylquinolin-8-ol has an empirical formula of C9H10O2 and a molecular weight of 154.18 g/mol. The chemical structure is shown below: The mechanism for the formation of 2,5-dimethylquinolin-8-ol is unknown, but it may be due to the following two mechanisms: 1) 2,5-dimethylquinolin-8-ol may form from the reaction between methoxy and chloro groups in an aluminium salt. This reaction requires heat or light to proceed. 2) Dimeric 2,5 methyl quinoline can form from hydroxy quinoles by a thermal ring closure process. This reaction requires heat to proceed

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Applications 3-(4-Aminobutyl)-1H-indole-5-carbonitrile could be a useful reagent for preparing CNS agents. References Boettcher, H., et al.: Ger. Offen. (1992), DE 4101686 A1

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5-Benzyloxyindole is an inhibitor molecule that binds to the active site of cytochrome P450 and inhibits the enzyme's ability to catalyze reactions. This compound has potent inhibitory activity against a number of enzymes, including amide and hydroxyl groups, chloride ion channels, and electrochemical studies. 5-Benzyloxyindole also shows potential as a cancer treatment agent due to its ability to inhibit cell proliferation. It was shown in cell culture studies using human colon cancer cells that this molecule inhibited the growth of cancer cells by blocking DNA synthesis, leading to apoptosis or programmed cell death. 5-Benzyloxyindole is synthesized through an acylation reaction between benzoyl chloride and indole. The product can be purified through recrystallization or chromatography on silica gel.

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2-Azaspiro[4.4]nonane (2-APN) is a diterpene that is found in a variety of plants, including Acacia berlandieri and Acacia rigidula. 2-APN has been shown to act as a linker in the biosynthesis of serotonin, which can bind with 5-HT1A receptors. The long chain of 2-APN makes it efficient for binding to 5-HT1A receptors with high affinity. 2-APN has been shown to be an effective ligand for 5-HT1A receptors by x-ray structures and receptor activity studies on rat brain tissue. This compound also inhibits the cyclooxygenase enzyme COX1 and COX2, which are responsible for the production of prostaglandins involved in inflammation and pain. The imine formed from 2-APN and an amine donor reacts through an E2 elimination reaction mechanism to produce an aziridine ring system

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7,8-Difluoroquinoline is a reagent that is used for the synthesis of pyridine derivatives and is also hydrolyzed in the presence of base. This compound has been shown to have antimicrobial activity against Salmonella typhimurium and can be used as a starting material for synthesis of many other compounds. 7,8-Difluoroquinoline has a carbonyl group at position 2, which can be modified by reactions with other molecules. It also has mutagenic properties and is not active against Ta100 cells.

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